scholarly journals Fatal congenital anaplasmosis associated with bovine viral diarrhoea virus (BVDV) infection in a crossbred calf

2011 ◽  
Vol 82 (3) ◽  
Author(s):  
A. R. Pypers ◽  
D. E. Holm ◽  
J. H. Williams
Keyword(s):  
Diagnostic Tests ◽  
Case Reports ◽  
Natural Infection ◽  
Clinical Signs ◽  
Bovine Viral Diarrhoea Virus ◽  
Clinical Findings ◽  
Bovine Viral Diarrhoea ◽  
Academic Hospital ◽  
Experimental Induction ◽  
Diarrhoea Virus

Clinical disease resulting from the vertical transmission of Anaplasma marginale has only been reported on 5 occasions despite studies demonstrating successful in utero transmission. During the reported experimental induction of congenital anaplasmosis in calves, the outcome was variable but mostly led to inapparent or mild infection. There are previous case reports of fatal congenital anaplasmosis following natural infection. The clinical findings in a 2-day-old calf presented to the Onderstepoort Veterinary Academic Hospital with clinical signs of congenital anaplasmosis, which was unresponsive to treatment, are described. Subsequent post mortem diagnostic tests revealed that this calf was co-infected with bovine viral diarrhoea virus (BVDV). It is postulated that immunosuppression resulting from BVDV infection predisposed to severe, fatal anaplasmosis in this calf.

scholarly journals Co-infection with bovine viral diarrhoea virus and Anaplasma marginale in a dairy cattle herd may lead to acute bovine anaplasmosis

2016 ◽  
Vol 61 (No. 9) ◽  
pp. 504-515
Author(s):  
A. Szabara ◽  
J. Majer ◽  
L. Ozsvari ◽  
C. Jakab ◽  
W. Baumgartner
Keyword(s):  
Dairy Cattle ◽  
Age Groups ◽  
Clinical Signs ◽  
Bovine Viral Diarrhoea Virus ◽  
Anaplasma Marginale ◽  
Cattle Herd ◽  
Bovine Viral Diarrhoea ◽  
Serological Tests ◽  
Diarrhoea Virus ◽  
Dairy Cattle Herd

This report describes an acute exacerbation of subclinical anaplasmosis manifesting itself in clinical signs in a large number of animals after infection with bovine viral diarrhoea virus (BVDV). The simultaneous transmission of BVDV and Anaplasma was unintended and most likely the result of a vaccination operation in a large Holstein-Friesian dairy cattle herd in Hungary. From Day 35 after the first vaccination, a total of 33 cows developed fever, depression, general weakness, lack of appetite, a sudden drop of milk production, anaemia, icterus, and tachypnoea on exercise. In addition, a total of seven abortions and three stillbirths occurred. Between Days 30 and 35 after the second vaccination four cows showed clinical signs typical of anaplasmosis, and two stillbirths occurred. The presence of Anaplasma marginale infection was demonstrated by haematological, biochemical, PCR and haemocytological examinations of blood samples collected from animals showing clinical signs as well as by necropsy. To assess the prevalence of infection in the herd, a specified number of animals belonging to different age groups were subjected to serological tests. The rate of seropositive animals was substantially higher (50%) in the older (3- to 4-year-old and more than 4-year-old) age groups than in the younger cows (10–30%). This study has demonstrated for the first time that if bovine animals susceptible to both A. marginale and BVDV are infected by the two pathogens roughly at the same time, the immunosuppressive effect of BVDV will support the progression of A. marginale infection and manifestation of the disease resulting in acute clinical signs.

scholarly journals Detection of bovine viral diarrhoea virus in specimens from cattle in South Africa and possible association with clinical disease

2004 ◽  
Vol 75 (2) ◽  
Author(s):  
N. Kabongo ◽  
M. Van Vuuren
Keyword(s):  
Southern Africa ◽  
National Park ◽  
Virus Isolation ◽  
Clinical Signs ◽  
Bovine Viral Diarrhoea Virus ◽  
Kruger National Park ◽  
Clinical Disease ◽  
Bovine Viral Diarrhoea ◽  
Poor Growth ◽  
Diarrhoea Virus

Studies covering all aspects of bovine viral diarrhoea virus (BVDV) have been conducted in several countries in Europe, Asia and America. In southern Africa, more information is required about the nature of BVDV infection, the prevalence of different strains and the economic importance of the disease. The presence of BVDV in southern Africa has been known since the early 1970s through serological surveys but few reports confirming its presence by virus isolation and correlation with clinical disease are available. Specimens (n = 312) collected in 1998/99, from live and dead cattle from different farming systems, were obtained from private practitioners, feedlot consultants and abattoirs throughout the country. Specimens (n=37) from African buffaloes (Syncerus caffer) in the Kruger National Park were also included. All specimens were processed for virus isolation in cell culture with confirmation by means of immunofluorescent antibody tests and some also by means of an antigen capture ELISA. BVDV was isolated from 15 (4.7 %) cattle and were all noncytopathic biotypes. BVDV was not detected in 37 lymph nodes obtained from buffaloes in the Kruger National Park. Of the clinical signs in cattle from which virus were isolated, respiratory signs was the most frequent (10/15), followed by diarrhoea (5/15). Abortion, congenital malformations, haemorrhagic diarrhoea and poor growth were also included as criteria for selection of animals for specimen collection, but no BVD viruses were isolated from cattle manifesting these clinical signs.

scholarly journals Co-infections with bovine herpesvirus type 5 and bovine viral diarrhoea virus

2006 ◽  
Vol 58 (5) ◽  
pp. 699-707 ◽  
Author(s):  
F.R. Spilki ◽  
T.C. Silva ◽  
P.A. Esteves ◽  
M.B. Teixeira ◽  
H.B.C.R. Batista ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Bovine Herpesvirus ◽  
Bovine Viral Diarrhoea Virus ◽  
Bovine Viral Diarrhoea ◽  
Herpesvirus Type ◽  
Diarrhoea Virus ◽  
Series Of Experiments ◽  
Bovine Herpesvirus Type 5

During a series of experiments attempting to reproduce clinically apparent bovine herpesvirus type 5 (BoHV-5) infections, a group of calves was inadvertently infected with bovine viral diarrhoea virus (BVDV). Another group of calves was infected with BoHV-5 only. This paper reports the outcome of such infections. Two out of six calves solely infected with BoHV-5 displayed moderate to severe clinical signs. Three out of four calves of the group co-infected with BoHV-5 and BVDV developed severe clinical signs, two of them died. BoHV-5 virus was isolated to higher titres and for a longer period from the group of calves infected with both viruses. These results suggest that BVDV may enhance clinical signs induced by BoHV-5 and may also play a role in extending the period of BoHV-5 shedding.

scholarly journals Modulation of sex hormone secretion in cows by acute infection with bovine viral diarrhoea virus

Reproduction ◽  
2002 ◽  
pp. 281-289 ◽  
Author(s):  
MD Fray ◽  
GE Mann ◽  
EC Bleach ◽  
PG Knight ◽  
MC Clarke ◽  
...  
Keyword(s):  
Acute Infection ◽  
Hormone Secretion ◽  
Clinical Signs ◽  
Bovine Viral Diarrhoea Virus ◽  
Early Embryo ◽  
Follicular Phase ◽  
Endocrine Function ◽  
Bovine Viral Diarrhoea ◽  
Diarrhoea Virus

Bovine viral diarrhoea virus (BVDV) is a major pathogen of cattle and is responsible for considerable reproductive loss. In this study, the in vivo responses in six multiparous cows were investigated after a non-cytopathogenic BVDV challenge (strain Pe 515; 5 x 10(6) tissue culture infective dose 50) given 9 days before a synchronized ovulation. Six similar cows challenged with non-infectious culture medium served as controls. The experimental noncytopathogenic BVDV infection was followed by a viraemia and leucopenia at days 5-9 after challenge, but no other clinical signs of infection were detected. However, the BVDV infection altered endocrine function. Mean LH pulse frequency immediately before CIDR withdrawal was lower (P < or = 0.05) in the BVDV-infected (2.17 +/- 0.34 pulses per 8 h) compared with the sham-infected (4.83 +/- 1.04 pulses per 8 h) animals. At day 3 after CIDR withdrawal, plasma oestradiol concentrations remained high (P < 0.05) in the infected cows (2.19 +/- 0.51 pg ml(-1)) compared with the sham-infected controls (0.72 +/- 0.29 pg ml(-1)). However, there was no difference in the peak oestradiol concentration (BVDV: 2.31 +/- 0.29 versus sham: 2.34 +/- 0.41 pg ml(-1)). In addition, non-cytopathogenic BVDV significantly (P < 0.05) increased the duration of the interval between ovulation and onset of the postovulatory progesterone increase (values 1.0 ng ml(-1)) (BVDV: 3.0 +/- 0.26 versus sham: 4.0 +/- 0.26 days). The viral infection also significantly (P < 0.01) decreased mean plasma progesterone concentrations between day 3 and day 11 after ovulation (BVDV: 2.59 +/- 0.32 versus sham: 4.13 +/- 0.27 ng ml(-1)). These data show that non-cytopathogenic BVDV viraemias during the follicular phase can modulate the secretion of gonadotrophins and sex steroids, in particular progesterone, during a synchronized oestrous cycle. Therefore, viraemias during the follicular phase may reduce the fertility of cattle by disrupting the capacity of the ovulatory follicle to form a competent corpus luteum, thereby compromising early embryo development and maternal recognition of pregnancy.

Pathological lesions of lambs infected in utero with bovine viral diarrhoea virus type 1c (BVDV-1c)

2021 ◽  
Vol 188 (3) ◽  
pp. 187-196
Author(s):  
Caitlin A. Evans ◽  
Lucy Woolford ◽  
Farhid Hemmatzadeh ◽  
Michael P. Reichel ◽  
Peter D. Cockcroft
Keyword(s):  
Virus Type ◽  
Bovine Viral Diarrhoea Virus ◽  
In Utero ◽  
Bovine Viral Diarrhoea ◽  
Pathological Lesions ◽  
Diarrhoea Virus

Bovine viral diarrhoea virus 1b infection associated with congenital tremor and hypomyelination in Holstein calves

2021 ◽  
pp. 109047
Author(s):  
Laura Gallina ◽  
Michel C. Koch ◽  
Arcangelo Gentile ◽  
Ida Treglia ◽  
Cristiano Bombardi ◽  
...  
Keyword(s):  
Bovine Viral Diarrhoea Virus ◽  
Bovine Viral Diarrhoea ◽  
Diarrhoea Virus ◽  
Holstein Calves ◽  
Congenital Tremor

A survey for bvdv antibodies in cattle farms in Slovakia and genetic typing of bvdv isolates from imported animals

2003 ◽  
Vol 51 (2) ◽  
pp. 229-236 ◽  
Author(s):  
Š. Vilček ◽  
Jana Mojžišová ◽  
Viera Bajová ◽  
Š. Paulík ◽  
L. Strojný ◽  
...  
Keyword(s):  
Bovine Viral Diarrhoea Virus ◽  
Computer Assisted ◽  
Serological Survey ◽  
Bovine Viral Diarrhoea ◽  
Rt Pcr ◽  
Serum Samples ◽  
Genetic Typing ◽  
Diarrhoea Virus ◽  
Pcr Products ◽  
Cattle Farms

A serological survey for bovine viral diarrhoea virus (BVDV) antibodies on a collection of 1295 serum samples obtained from 6-12 months old cattle originating from 45 farms in Slovakia was carried out. On 13 farms more than 90% of the examined animals were seropositive, on 14 farms 71-90% seroprevalence was observed, on 13 farms only 50-70% animals were found to be positive for BVDV antibodies, while the remaining 5 farms showed fewer than 50% seropositive animals. The average incidence of BVDV antibodies (around 70%) was similar as determined 30 years ago. Of 84 serum samples from seronegative animals originating from 14 farms in which 70-98% seropositivity was observed, six were positive in Ag-BVDV ELISA indicating persistently infected (PI) cattle. On a farm to which animals were imported from abroad, a BVD outbreak was observed. Of 110 animals tested, four were positive in Ag-ELISA indicating the presence of PI cattle on this farm. Genetic typing of two isolates from imported animals performed by RT-PCR (324/326 primers from 5´-UTR), sequencing of PCR products and computer-assisted phylogenetic analysis revealed that they belong to BVDV-1h group.

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