scholarly journals Granular cell tumor: An uncommon benign neoplasm

2015 ◽  
Vol 60 (3) ◽  
pp. 322 ◽  
Author(s):  
Anupam Das ◽  
Kaushik Shome ◽  
Debabrata Bandyopadhyay ◽  
Dipti Das ◽  
Abanti Saha ◽  
...  
Keyword(s):  
Granular Cell Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor

scholarly journals Granular Cell Tumor of the Tongue: A Rare Case Presentation of a 14 Years Old Girl

2021 ◽  
pp. 1-2
Author(s):  
Mansour Nacouzi ◽  
Keyword(s):  
Granular Cell Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Lateral Border ◽  
Case Presentation ◽  
Granular Cytoplasm ◽  
The Right ◽  
Sixth Decade ◽  
Mobile Tongue

Granular cell tumor or Abrikossoff ’s tumor is an infrequent tumor that can arise in most organs, and especially in the ENT area. It is a usually benign neoplasm, that can lead to a misdiagnose of malignancy. It affects both sex, between the fourth and the sixth decade. We present in this report a case of a 14 years old girl with a slowly growing lesion on the right lateral border of the mobile tongue. The biopsy showed a proliferation of large cells with a granular cytoplasm that expressed two immunohistochemistry markers: CD68 and S100 antibodies. Surgical resection was completed with a one centimeter margin.The rare issue about this case is the age of presentation: the age of the patient is 14, whereas this tumor usually affects adult patients.

Abriks's tumor in a teenager's tongue - a case report

2018 ◽  
Vol 7 (4) ◽  
pp. 1-5
Author(s):  
Przemysław Krawczyk ◽  
Daniel Majszyk ◽  
Antoni Bruzgielewicz ◽  
Kazimierz Niemczyk
Keyword(s):  
Case Report ◽  
Children And Adolescents ◽  
Malignant Transformation ◽  
Surgical Resection ◽  
Granular Cell Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Upper Airways

Granular cell tumor is benign neoplasm rarely diagnosed among young children and adolescents. The tumor developed commonly within mucous membrane of upper airways, but precise etiology is not known. Treatment is based on surgical resection of tumor and intense follow up due to risk of recurrence and malignant transformation.

scholarly journals Smooth Auricular Cutaneous Granular Cell Tumor Mimics Epidermoid Cyst

2020 ◽  
Vol 24 (2) ◽  
pp. 103-106
Author(s):  
Jeong Hwan Choi
Keyword(s):  
Schwann Cell ◽  
Epidermoid Cyst ◽  
Granular Cell Tumor ◽  
Clinical Presentation ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Complete Excision ◽  
Histopathological Evaluation ◽  
Granular Cytoplasm

Granular cell tumor (GCT) is a rare, benign neoplasm of Schwann cell origin. GCT is composed of cells with eosinophilic granular cytoplasm. GCT presents as a solitary painless nodule. Because of their subtle clinical presentation, GCTs are often misdiagnosed. This report of a 47-year-old woman with an auricular GCT serves to highlight that complete excision and histopathological evaluation should be attempted even in apparently benign cases, to ensure complete cure.

scholarly journals Retinal granular cell tumor: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jimin Park ◽  
Kyung-Ja Cho ◽  
Junyeop Lee
Keyword(s):  
Intraocular Pressure ◽  
Granular Cell Tumor ◽  
Serous Retinal Detachment ◽  
Intravitreal Bevacizumab ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Histopathological Analysis ◽  
Blurred Vision ◽  
Tumor Biopsy

Abstract Background To report a rare case of granular cell tumor invading the retina. Case presentation A 56-year-old female complained of blurred vision for 2 weeks in her left eye. An irregular-shaped retinal mass in the inferonasal and extending to the optic disc accompanied by dense exudation and extensive serous retinal detachment was observed. Several intravitreal bevacizumab injections were ineffective for stabilizing retinal exudation and intraocular pressure (IOP). Vitrectomy was performed to re-attach the retina and obtain a tumor biopsy specimen. Histopathological analysis revealed that the intraocular mass was a granular cell tumor. Immunohistochemical studies demonstrated that the tumor was positive for S100 and CD68, focal positive for neurofilaments, but negative for ERG and HMB-45. Local recurrence and distant metastasis were not found, but visual acuity had worsened to no light perception at the last visit due to uncontrolled intraocular pressure and retinal exudation after the surgery. Conclusions Granular cell tumor is a rare benign neoplasm, but it can lead to devastating visual loss if it invades the retina adjacent to the optic nerve head.

scholarly journals Solitary Granular Cell Tumor of Cecum: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Kaoutar Znati ◽  
Taoufiq Harmouch ◽  
Amal Benlemlih ◽  
Hinde Elfatemi ◽  
Laila Chbani ◽  
...  
Keyword(s):  
Granular Cell Tumor ◽  
Submucosal Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Endoscopic Examination ◽  
Cell Tumor ◽  
The Body ◽  
Screening Colonoscopy ◽  
Tract Involvement ◽  
Histological Confirmation

Granular cell tumor (GCT) was first described by Abrikossof in 1926. This tumor is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin. GCT is not common and most often affects the tongue, skin, and soft tissue, although it may occur anywhere in the body. Gastrointestinal tract involvement, and especially that of the colon, is very rare. This usually benign tumor appears as a submucosal nodule, measuring less than 2 cm in diameter and is often found incidentally during colorectal examinations. We describe the case of a 27-year-old man with a GCT in the cecum that was detected after a screening colonoscopy. Endoscopic examination revealed a yellowish submucosal tumor, 0.7 cm in diameter. An endoscopic mucosal polypectomy was done for histological confirmation and treatment.

scholarly journals Case for diagnosis

2013 ◽  
Vol 88 (6) ◽  
pp. 1005-1007 ◽  
Author(s):  
Thaiane Lima Lage ◽  
Mario Fernando Ribeiro de Miranda ◽  
Maraya de Jesus Semblano Bittencourt ◽  
Carolina Moraes Dias ◽  
Amanda Magno de Parijós ◽  
...  
Keyword(s):  
Granular Cell Tumor ◽  
S100 Protein ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Pathological Examination ◽  
S 100 ◽  
Neural Origin ◽  
The Right ◽  
American Ethnicity

Granular cell tumor is a rare benign neoplasm of neural origin. We report the case of a female patient, 27 years old presenting a brown-red nodule in the right arm, which pathological examination showed to be formed by polygonal cells with eosinophilic granular cytoplasm and immunohistochemistry positive for S100 protein and CD68. Granular cell tumor is usually solitary and in half the cases located in the head and neck areas, 30% of these in the tongue. It is most frequent between the third and fifth decades of life in women and people of African-American ethnicity. Its origination is controversial, including the possible origins in muscle, fibroblasts, neural crest, neural sheath or histiocytes. The positivity for S-100 and CD68 suggest the neural origin.

scholarly journals Metachronous Occurrence of Granular Cell Tumor in Breast Skin and Scalp: Diagnostic Challenging Differentiating Benign from Malignant and a Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Hampar Akkaya ◽  
Havva Serap Toru ◽  
Ebru Sebnem Ayva ◽  
Zulfikar Karabulut ◽  
Cicek Durusoy
Keyword(s):  
Soft Tissue ◽  
Clinical Features ◽  
Granular Cell Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Histopathological Diagnosis ◽  
Diagnostic Challenge ◽  
True Nature ◽  
Incomplete Removal

Granular cell tumor (GCT) is a Schwann cell related benign neoplasm of soft tissue. GCT is an uncommon entity that occurs in a wide variety of body sites, but it is generally presented in the skin, oral cavity, superficial soft tissue, and respiratory and digestive tracts. Most of the GCTs are benign but clinically and radiologically these may mimic malignancy. Histopathological diagnosis is gold standard for establishing the true nature of the lesion. GCT is most commonly solitary but in about 10% of cases can be multifocal, usually involving various skin and soft tissue sites versus involving various internal sites. Therefore, these can involve skin and soft tissue or submucosa and viscera. GCT is usually benign; however, local recurrence is common due to incomplete removal. Malignant cases are rarely reported in 1-2% of cases. In this study, we report clinical and histopathological findings of a 36-year-old woman with metachronous GCT in breast and scalp. The clinical features raise the question of whether these are metachronous benign GCTs or whether this is establishment of malignant behavior. The aim of this report is to present the histopathological and clinical features of GCT and the diagnostic challenge of differentiating benign from malignant GCT.

scholarly journals Granular Cell Tumor of Cecum: A Common Tumor in a Rare Site with Diagnostic Challenge

Rare Tumors ◽  
2017 ◽  
Vol 9 (2) ◽  
pp. 77-80 ◽  
Author(s):  
Meyyappa Devan Rajagopal ◽  
Debasis Gochhait ◽  
Dasarathan Shanmugan ◽  
Adarsh Wamanrao Barwad
Keyword(s):  
Granular Cell Tumor ◽  
Subcutaneous Tissue ◽  
Case Reports ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Cell Of Origin ◽  
Diagnostic Challenge ◽  
Diagnostic Difficulties ◽  
Colon And Rectum

Granular cell tumor (GCT) also known as Abrikossoff's tumor is a benign neoplasm that is usually seen in the fourth to sixth decades of life with slight female preponderance. It is most frequently seen in the oral cavity, skin, and subcutaneous tissue. Gastrointestinal tract involvement is uncommon, in which esophagus is the most commonly affected site. There are case reports of GCT in stomach, appendix, colon and rectum. In this article, we report a case of GCT involving cecum. The cell of origin in GCT is controversial. There are various pools of thoughts regarding its histogenesis, the details of which are reviewed in this article with emphasis on the diagnostic difficulties encountered in this tumor.

scholarly journals Cutaneous granular cell tumor: A case report

2019 ◽  
Vol 9 (1) ◽  
pp. 1511-1513
Author(s):  
Deliya Paudel ◽  
Ram Chandra Adhikari
Keyword(s):  
Soft Tissue ◽  
Granular Cell Tumor ◽  
Histopathological Examination ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Internal Organs ◽  
History Of ◽  
Biliary Ducts

Granular cell tumor is a rare benign neoplasm of the skin that accounts for 0.5% of all soft-tissue tumors. Granular cell tumor can affect both sexes and in any age, although it is most common in females. The common locations are the head and neck, the tongue is affected in 25% of cases but any internal organs can be affected such as soft tissue, bronchus, stomach, rectum, anus, biliary ducts. Here, we report a 58-year-old female patient who presented with a 4-year history of a slowly growing mass, with a dimension of 5 × 4 cm on her left waist, diagnosed as a Granular cell tumor at histopathological examination.

Granular Cell Tumor: An Immunohistochemical Study

1994 ◽  
Vol 80 (3) ◽  
pp. 224-228 ◽  
Author(s):  
Antonio Cavaliere ◽  
Angelo Sidoni ◽  
Ivana Ferri ◽  
Brunangelo Falini
Keyword(s):  
Granular Cell Tumor ◽  
Immunohistochemical Study ◽  
Recent Observation ◽  
Neuron Specific Enolase ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Ultrastructural Studies ◽  
S 100 ◽  
Alpha 1 Antitrypsin

Aims and background Granular cell tumor, usually a benign neoplasm, has been the object of many studies because of its uncertain histogenesis and based on many immunohistochemical and ultrastructural studies it has been suggested that it originates from the Schwann cell. Our recent observation that granular cell tumor is positive with PG-M1, a new anti-macrophage monoclonal antibody, led us to further investigate the immunophenotypic profile of the tumor. Study design We studied 11 granular cell tumors using a panel of 20 antibodies, 13 monoclonal and 7 polyclonal. Results The immunohistochemical study showed in all cases a constant diffuse positivity for S-100 protein, neuron-specific enolase, vimentin, KP1 and PG-M1, as well as occasional and focal positivity for alpha-1-antitrypsin, alpha-1-antichymotrypsin and lysozyme. Conclusions The immunophenotypic profile constantly observed could be the expression, on one hand, of the neuroectodermic nature of the neoplasm, proven by positivity for S-100 protein, neuron specific enolase and vimentin, and on the other could be the expression of the phagocytic activity of the tumor cell, proven by positivity for KP1 and PG-M1 antibodies and also by the presence of numerous phagolysosomes.

Sign in / Sign up

Export Citation Format

Share Document