scholarly journals Smooth Auricular Cutaneous Granular Cell Tumor Mimics Epidermoid Cyst

2020 ◽  
Vol 24 (2) ◽  
pp. 103-106
Author(s):  
Jeong Hwan Choi
Keyword(s):  
Schwann Cell ◽  
Epidermoid Cyst ◽  
Granular Cell Tumor ◽  
Clinical Presentation ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Complete Excision ◽  
Histopathological Evaluation ◽  
Granular Cytoplasm

Granular cell tumor (GCT) is a rare, benign neoplasm of Schwann cell origin. GCT is composed of cells with eosinophilic granular cytoplasm. GCT presents as a solitary painless nodule. Because of their subtle clinical presentation, GCTs are often misdiagnosed. This report of a 47-year-old woman with an auricular GCT serves to highlight that complete excision and histopathological evaluation should be attempted even in apparently benign cases, to ensure complete cure.

scholarly journals Granular Cell Tumor of the Tongue: A Rare Case Presentation of a 14 Years Old Girl

2021 ◽  
pp. 1-2
Author(s):  
Mansour Nacouzi ◽  
Keyword(s):  
Granular Cell Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Lateral Border ◽  
Case Presentation ◽  
Granular Cytoplasm ◽  
The Right ◽  
Sixth Decade ◽  
Mobile Tongue

Granular cell tumor or Abrikossoff ’s tumor is an infrequent tumor that can arise in most organs, and especially in the ENT area. It is a usually benign neoplasm, that can lead to a misdiagnose of malignancy. It affects both sex, between the fourth and the sixth decade. We present in this report a case of a 14 years old girl with a slowly growing lesion on the right lateral border of the mobile tongue. The biopsy showed a proliferation of large cells with a granular cytoplasm that expressed two immunohistochemistry markers: CD68 and S100 antibodies. Surgical resection was completed with a one centimeter margin.The rare issue about this case is the age of presentation: the age of the patient is 14, whereas this tumor usually affects adult patients.

scholarly journals Granular Cell Tumor: A Technical Approach for Resection of a Rare Suprasellar Mass

2020 ◽  
Vol 1 (4) ◽  
Author(s):  
Alexander J Schupper ◽  
Frank J Yuk ◽  
Hongyan Zou ◽  
Sadhna Ahuja ◽  
Nadejda M Tsankova ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Granular Cell Tumor ◽  
Clinical Presentation ◽  
Granular Cell ◽  
Cell Tumor ◽  
Patient Specific ◽  
Surgical Approaches ◽  
Technical Approach ◽  
Multiple Strategies ◽  
Current State

Abstract BACKGROUND AND IMPORTANCE Granular cell tumors (GCTs) of the sellar and suprasellar regions are rare tumors that may be managed surgically by multiple strategies. The technical approaches for these tumors have rarely been described in the literature. CLINICAL PRESENTATION We introduce the case of a patient presenting with dizziness and headaches who was found to have a suprasellar and retrochiasmatic mass and eventually underwent surgical resection. We discuss the characteristics of this tumor, and the current state of the literature. Also included are details regarding the surgical approach utilized in this case, and a discussion of the various surgical approaches for this type of tumor. CONCLUSION There are several approaches for the surgical resection of suprasellar GCTs, and the approach utilized may depend on patient and/or surgeon considerations. Patient-specific considerations must be made to ensure maximal safe resection of these lesions.

Abriks's tumor in a teenager's tongue - a case report

2018 ◽  
Vol 7 (4) ◽  
pp. 1-5
Author(s):  
Przemysław Krawczyk ◽  
Daniel Majszyk ◽  
Antoni Bruzgielewicz ◽  
Kazimierz Niemczyk
Keyword(s):  
Case Report ◽  
Children And Adolescents ◽  
Malignant Transformation ◽  
Surgical Resection ◽  
Granular Cell Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Upper Airways

Granular cell tumor is benign neoplasm rarely diagnosed among young children and adolescents. The tumor developed commonly within mucous membrane of upper airways, but precise etiology is not known. Treatment is based on surgical resection of tumor and intense follow up due to risk of recurrence and malignant transformation.

scholarly journals Congenital Granular Cell Epulis

2014 ◽  
Vol 138 (1) ◽  
pp. 128-131 ◽  
Author(s):  
Rachel Conrad ◽  
Mia C. N. Perez
Keyword(s):  
Granular Cell Tumor ◽  
Squamous Epithelium ◽  
Neuron Specific Enolase ◽  
Granular Cell ◽  
Cell Tumor ◽  
Alveolar Ridge ◽  
Careful Observation ◽  
Granular Cytoplasm ◽  
S 100 ◽  
Congenital Granular Cell Epulis

Congenital granular cell epulis is a rarely reported lesion of unknown histogenesis with a strong predilection for the maxillary alveolar ridge of newborn girls. Microscopically, it demonstrates nests of polygonal cells with granular cytoplasm, a prominent capillary network, and attenuated overlying squamous epithelium. The lesion lacks immunoreactivity for S-100, laminin, chromogranin, and most other markers except neuron-specific enolase and vimentin. Through careful observation of its unique clinical, histopathologic, and immunohistochemical features, this lesion can be distinguished from the more common adult granular cell tumor as well as other differential diagnoses.

scholarly journals Granular cell tumor: An uncommon benign neoplasm

2015 ◽  
Vol 60 (3) ◽  
pp. 322 ◽  
Author(s):  
Anupam Das ◽  
Kaushik Shome ◽  
Debabrata Bandyopadhyay ◽  
Dipti Das ◽  
Abanti Saha ◽  
...  
Keyword(s):  
Granular Cell Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor

scholarly journals Surgical Excision Of Intraoral Lipoma; Case Report

2016 ◽  
Vol 12 (12) ◽  
pp. 211
Author(s):  
Ahmed Ismail Nagy
Keyword(s):  
Case Report ◽  
Granular Cell Tumor ◽  
Clinical Presentation ◽  
Granular Cell ◽  
Surgical Excision ◽  
Cell Tumor ◽  
Lower Lip ◽  
Floor Of The Mouth ◽  
The Common ◽  
Oral Tumors

Lipoma is a common tumor of soft tissue. Its location on the oral mucosa is rare, representing 1% to 5% of benign oral tumors although it is the most mesenchymal tumor of the trunk and proximal portions of extremities. Lipoma of the oral cavity may occur in any region. The buccal mucosa, tongue, and floor of the mouth are among the common locations. The clinical presentation is typically as an asymptomatic yellowish mass. The overlying epithelium is intact, and superficial blood vessels are usually evident over the tumor. Other benign connective tissue lesions such as granular cell tumor, neurofibroma, traumatic fibroma and salivary gland lesions (mucocele and mixed tumor) might be included in differential diagnosis. We present a case report of oral lipoma in the left side of the lower lip in 18 years old Saudi patient.

scholarly journals Granular Cell Tumor of the Breast: Clinical Presentation, Pathological Diagnosis and Treatment

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Scardina L ◽  
◽  
Di Leone A ◽  
Sanchez AM ◽  
D’Archi S ◽  
...  
Keyword(s):  
Peripheral Nerves ◽  
Benign Breast Disease ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Breast Disease ◽  
Cell Tumor ◽  
Wide Resection ◽  
Margin Assessment ◽  
Radiological Findings ◽  
Granular Cytoplasm

Introduction: Granular cell tumor is a rare neoplasm of soft tissue and only in 1% of cases, it can shows a malignant behaviour. It is presumed to be a tumor originating from perineural or putative Schwann cells of peripheral nerves. Materials and Methods: We reviewed five patients affected by Granular cell tumor of the breast treated between January 2011 and January 2021 at the Fondazione Policlinico Universitario Agostino Gemelli IRCCS of Rome, Italy. Results: All of the granular cell tumors presented as solitary, painless and firm lump, highly suggestive of malignancy. The radiological findings were heterogeneous and non-specific. All lesions presented as masses, more clearly evident on ultrasound as hypoechoic lesions, with irregular shape, blurred contours and borderline features. The tumors were composed of large polygonal cells with abundant eosinophilic granular cytoplasm and small, central nuclei, being immunohistochemically positive for S100, Vimentin (with variable staining), CD56; negative for HMB45, MelanA, AE1/AE3, EMA, and Desmin. Conclusion: Granular cell tumor is a rare, usually benign breast disease that can have very similar characteristics to breast cancer both clinically and radiologically. Treatment of choice consists in wide resection or lumpectomy with margin assessment (no ink on tumor).

scholarly journals Retinal granular cell tumor: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jimin Park ◽  
Kyung-Ja Cho ◽  
Junyeop Lee
Keyword(s):  
Intraocular Pressure ◽  
Granular Cell Tumor ◽  
Serous Retinal Detachment ◽  
Intravitreal Bevacizumab ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Histopathological Analysis ◽  
Blurred Vision ◽  
Tumor Biopsy

Abstract Background To report a rare case of granular cell tumor invading the retina. Case presentation A 56-year-old female complained of blurred vision for 2 weeks in her left eye. An irregular-shaped retinal mass in the inferonasal and extending to the optic disc accompanied by dense exudation and extensive serous retinal detachment was observed. Several intravitreal bevacizumab injections were ineffective for stabilizing retinal exudation and intraocular pressure (IOP). Vitrectomy was performed to re-attach the retina and obtain a tumor biopsy specimen. Histopathological analysis revealed that the intraocular mass was a granular cell tumor. Immunohistochemical studies demonstrated that the tumor was positive for S100 and CD68, focal positive for neurofilaments, but negative for ERG and HMB-45. Local recurrence and distant metastasis were not found, but visual acuity had worsened to no light perception at the last visit due to uncontrolled intraocular pressure and retinal exudation after the surgery. Conclusions Granular cell tumor is a rare benign neoplasm, but it can lead to devastating visual loss if it invades the retina adjacent to the optic nerve head.

scholarly journals Solitary Granular Cell Tumor of Cecum: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Kaoutar Znati ◽  
Taoufiq Harmouch ◽  
Amal Benlemlih ◽  
Hinde Elfatemi ◽  
Laila Chbani ◽  
...  
Keyword(s):  
Granular Cell Tumor ◽  
Submucosal Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Endoscopic Examination ◽  
Cell Tumor ◽  
The Body ◽  
Screening Colonoscopy ◽  
Tract Involvement ◽  
Histological Confirmation

Granular cell tumor (GCT) was first described by Abrikossof in 1926. This tumor is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin. GCT is not common and most often affects the tongue, skin, and soft tissue, although it may occur anywhere in the body. Gastrointestinal tract involvement, and especially that of the colon, is very rare. This usually benign tumor appears as a submucosal nodule, measuring less than 2 cm in diameter and is often found incidentally during colorectal examinations. We describe the case of a 27-year-old man with a GCT in the cecum that was detected after a screening colonoscopy. Endoscopic examination revealed a yellowish submucosal tumor, 0.7 cm in diameter. An endoscopic mucosal polypectomy was done for histological confirmation and treatment.

scholarly journals Granular Cell Tumor Presenting as a Tracheal Mass in a 17-year-old Female

2008 ◽  
Vol 23 (1) ◽  
pp. 39-40
Author(s):  
Jose M. Carnate ◽  
Audie G. Silva
Keyword(s):  
Tumor Cells ◽  
Granular Cell Tumor ◽  
S100 Protein ◽  
Granular Cell ◽  
Surgical Excision ◽  
Cell Tumor ◽  
Granular Cytoplasm ◽  
History Of ◽  
Infiltrative Growth Pattern ◽  
One Year

Granular cell tumors involving the trachea are rare. We present the case of a seventeen year old female with a one year history of gradually worsening dyspnea necessitating a tracheotomy. A suprastomal intraluminal tracheal mass was excised. Histologic sections (Figure 1) show a poorly circumscribed neoplasm infiltrating through the tracheal cartilage. It is composed of polygonal to somewhat elongated tumor cells that have small, dark nuclei. The cytoplasm is ample, eosinophilic and strikingly granular in quality. The cell borders are ill-defined creating a `syncytial’ pattern of dark nuclei scattered in a sea of granular cytoplasm. The diagnosis was a granular cell tumor. Immunohistochemistry (Figure 2) revealed strong, diffuse cytoplasmic positivity for S100 protein, attesting to its neural crest histogenesis. The infiltrative growth pattern may momentarily raise the question of malignancy but this is dispelled by awareness that infiltration is the natural history for all granular cell tumors, benign or malignant. Histologically, malignancy is diagnosed if three or more of the following are present: necrosis, spindling of tumor cells, vesicular nuclei with large nucleoli, greater than 2 mitoses per ten high power fields, high nucleus-to-cytoplasm ratio and nuclear pleomorphism. None was present in our case. Surgical excision remains the mainstay of treatment.

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