Choriocarcinoma with negative urinary and serum beta human chorionic gonadotropin (β HCG) : A case report

ABSTRACT Objectives The aim of our study was to observe the levels of serum beta-human chorionic gonadotropin (β-hCG) in cases of preeclampsia and eclampsia in the 3rd trimester of pregnancy and to compare it with the level of serum β-hCG in normotensive controls and also to find out if any correlation exists between the levels of β-hCG and the severity of the disease. Materials and methods A case—control study of 130 cases of pregnancy-induced hypertension (PIH), out of which 100 were cases of preeclampsia and 30 were those of eclampsia, was conducted with 100 normotensive antenatal cases as controls. Patients admitted as preeclampsia or eclampsia were subjected for the study of β-hCG from 28 weeks onwards depending on the gestational age at the time of admission. Normotensive patients coming as outpatients were taken as controls and their β-hCG estimation was done. Results The β-hCG levels in hypertensive patients were found to be significantly higher than that of the controls. There was a significant correlation with the severity of the disease. A significant positive correlation was found with the systolic BP, diastolic BP, alanine transaminase, aspartate transaminase, and serum bilirubin whereas a significant inverse correlation was found with high-density lipoprotein (HDL) and platelet counts. Conclusion Beta-human chorionic gonadotropin rises significantly in the cases of PIH and the rise correlates with the severity of hypertension and the derangement of laboratory parameters. As it has a low sensitivity and specificity, it is not a very useful tool as a diagnostic or prognostic indicator for preeclampsia. How to cite this article Tiwari P, Saraogi P, Sahni S, Sahu B, Badkur P. A Study of Human Chorionic Gonadotropin in the Pathogenesis of Hypertensive Disorders of Pregnancy. J South Asian Feder Obst Gynae 2016;8(4):282-285.

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Recurrent Molar Pregnancy: An Obstetric Dilemma?

International Journal of Infertility & Fetal Medicine ◽

10.5005/jp-journals-10016-1043 ◽

2012 ◽

Vol 3 (2) ◽

pp. 63-64 ◽

Cited By ~ 1

Author(s):

Lakshmi Rathna Marakani ◽

Sirisha Rao Gundabattula

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Nulliparous Woman ◽

Molar Pregnancy ◽

Persistent Disease ◽

Beta Human Chorionic Gonadotropin ◽

Β Hcg

ABSTRACT Approximately 1% of women with a molar pregnancy may have a recurrence. Chemotherapy is not indicated for recurrent molar pregnancies. An adequate interconception interval is important to ensure that the serum beta-human chorionic gonadotropin (β-hCG) from a new pregnancy does not interfere with the follow-up of the molar pregnancy that is done to detect persistent disease. We discuss the case of a nulliparous woman who had four molar pregnancies and her future reproductive options. How to cite this article Marakani LR, Gundabattula SR. Recurrent Molar Pregnancy: An Obstetric Dilemma? Int J Infertility Fetal Med 2012;3(2):63-64.

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Evaluating the agreement of ultrasound imaging and beta-human chorionic gonadotropin (β-hCG) measurement in confirming completed medical abortion: cross-sectional study

Qatar Medical Journal ◽

10.5339/qmj.2021.22 ◽

2021 ◽

Vol 2021 (2) ◽

Author(s):

Mahboubeh Peracheh ◽

Batool Teymouri ◽

Narjes Noori ◽

Taraneh Arbabzadeh ◽

Marzieh Ghasemi

Keyword(s):

Ultrasound Imaging ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Transvaginal Ultrasound ◽

Medical Abortion ◽

First Trimester ◽

Cross Sectional ◽

Predictive Values ◽

Beta Human Chorionic Gonadotropin ◽

Β Hcg

Objective: Clinical methods that are generally used to evaluate the completeness of medical abortion are not reliable. Ultrasound imaging and beta-human chorionic gonadotropin (β-hCG) measurements are used to diagnose completed medical abortion, but a precise evaluation of these two methods has shown contradictory results. The purpose of this study is to evaluate the agreement of serum β-hCG measurement and ultrasound imaging to confirm complete medical abortion. Materials and Methods: This study was conducted on pregnant women who had been referred to our center for medical abortion from 2015 to 2017. All cases occurred in the first trimester of pregnancy. They obtained one or two doses of vaginal misoprostol for medical abortion. Success rate of medical abortion was measured by both transvaginal ultrasound imaging and consecutive serum β-hCG measurements two to four weeks after initial treatment. Results: Among the 275 women who completed the study, complete medical abortion was confirmed by serum β-hCG in 231 women (84.3%) and transvaginal ultrasound imaging in 195 women (70.8%) after two weeks. All remaining cases completed the medical abortion after an additional two weeks, confirmed by both transvaginal ultrasound imaging and serum β-hCG. The sensitivity, specificity, positive, and negative predictive values of β-hCG were 95.2%, 86.7%, 84%, and 70%, respectively; and these values for transvaginal ultrasound imaging were 68.5% 64.5%,77%, and 30.%, respectively, for the diagnosis of completed medical abortion. Conclusion: Serum β-hCG measurement is as effective as transvaginal ultrasound imaging to confirm successful medical abortion in early pregnancy.

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Testosterone and Estradiol Concentrations in Paired Maternal and Cord Sera and Their Correlation with the Concentration of Chorionic Gonadotropin

PEDIATRICS ◽

10.1542/peds.64.5.604 ◽

1979 ◽

Vol 64 (5) ◽

pp. 604-608

Author(s):

Robert Penny ◽

Albert F. Parlow ◽

S. Douglas Frasier

Keyword(s):

Regression Analysis ◽

Sex Difference ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Cord Serum ◽

Beta Human Chorionic Gonadotropin ◽

Β Hcg

Testosterone (T) and estradiol (E2) concentrations were determined and correlated with beta human chorionic gonadotropin (β-HCG) concentrations in 43 paired maternal and cord sera (22 female and 21 male infants). Mean (± SD) maternal E2 concentrations were significantly (P < .005) higher when the sex of the fetus was male than when the sex of the fetus was female (20.6 ± 3.9 vs 13.5 ± 3.2 ng/ml). Maternal T concentrations were not significantly different when related to the sex of the fetus (males, 114.8 ± 60.7 vs females, 113.8 ± 54.5 ng/100 ml, P > .1). Regression analysis did not show a significant correlation between maternal T or E2 concentrations and maternal β-HCG concentrations. Mean cord serum T and E2 concentrations of male infants were significantly greater than that of female infants (T, 38.8 ± 8.5 vs 25.8 ± 7.1 ng/100 ml, P < .005; E2, 9.1 ± 3.3 vs 6.6 ± 2.0 ng/ml, P < .005). Regression analysis showed a significant (P < .005) correlation between cord β-HCG concentrations and E2 concentrations for male infants (r = .7) and female infants (r = .6). A significant correlation between cord β-HCG concentrations and T concentrations was found for male infants (r = .5; P < .01) but not for female infants (r = .3; P > .05). There was no correlation between maternal and infant E2 concentrations (males, r = .3, P > .05; females, r = .3, P > .2) or T concentrations (males, r = .02, P > 0.4; females, r = .06, P > .3). These data (1) confirm the sex difference in cord serum T and E2 concentrations, (2) indicate that the lower β-HCG concentrations in mothers of male infants are associated with E2 concentrations which are greater than those in mothers of female infants, and (3) are consistent with an influence of β-HCG on fetal T and E2 secretion.

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A 10-year retrospective single-center study of alpha-fetoprotein and beta-human chorionic gonadotropin in Romanian children with (para)gonadal tumors and cysts

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2021-0382 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Usiwoma O. Ataikiru ◽

Emil R. Iacob ◽

Ingrith Miron ◽

Calin M. Popoiu ◽

Eugen S. Boia

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Malignant Tumors ◽

Germ Cell Tumors ◽

Area Under The Curve ◽

Alpha Fetoprotein ◽

Full Potential ◽

Tumor Type ◽

Beta Human Chorionic Gonadotropin ◽

Β Hcg

Abstract Objectives Malignant tumor is a top-ranking cause of pediatric (>1-year) mortality in America and Europe. Among pediatric tumors, germ cell tumors (GCT) and gonadal tumors rank fourth (6%) by the Surveillance, Epidemiology, and End Results (SEER) program (seer.cancer.gov). Continuous research on tumor markers harnesses their full potential in tumor detection and management. We evaluated the effectiveness of beta-human chorionic gonadotropin (β-hCG) and Alpha-fetoprotein (AFP) in Romanian children with (para)gonadal tumors and cysts, determining their accuracy in detecting malignancy, tumor-type, stage, complications, prognosis, and treatment response. Methods A 10-year retrospective study of AFP and β-hCG in 134 children with cysts and (para)gonadal tumors aged one month to 17 years was performed. Results AFP/β-hCG was unelevated in patients with cysts and nonmalignant tumors. Forty-eight/86 patients (43 GCT and 5 non-GCT) with malignant tumors had elevated AFP/β-hCG, 3/48 patients had recurrences, and 25/48 had mixed-GCT (68% had elevated AFP + β-hCG). All 30 patients with Yolk sac tumors (YST) or their components had elevated AFP. Area under the curve, sensitivity and specificity for GCT were: AFP + β-hCG- 0.828, 67.2%, 100%; AFP- 0.813, 64.1%, 100%; and β-hCG- 0.664, 32.8%, 100%. Two patients whose AFP/β-hCG levels remained elevated died. Common mixed-GCT components were YST-80% and embryonal carcinoma-72%. Thirty of 34 metastasis cases were GCT, with 26/34 patients having elevated AFP/β-hCG. Conclusions AFP/β-hCG detects malignant GCT and can determine tumor-type. GCT patients with markedly elevated AFP + β-hCG had poor prognosis, especially if recurrence or metastasis was present. Recurrence is unrelated to elevated AFP/β-hCG. The tumor components and quantity present determine AFP/β-hCG values in mixed-GCT.

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