scholarly journals Efficacy of directly observed treatment short-course intermittent regimen in spinal tuberculosis

2012 ◽  
Vol 46 (2) ◽  
pp. 138 ◽  
Author(s):  
Rejith Valsalan ◽  
MK Raveendran ◽  
Sibin Surendran ◽  
Rajesh Purushothaman ◽  
Balaji Zacharia
Keyword(s):  
Spinal Tuberculosis ◽  
Short Course ◽  
Directly Observed Treatment ◽  
Intermittent Regimen

scholarly journals Spinal Tuberculosis – Directly Observed Treatment and Short Course or Daily Anti Tubercular Therapy -Are We Over Treating?

2018 ◽  
Vol 12 (1) ◽  
pp. 380-388 ◽  
Author(s):  
Ravinder Kumar Banga ◽  
Jagdeep Singh ◽  
Anshul Dahuja ◽  
Radhe Shyam Garg
Keyword(s):  
Pain Score ◽  
Neurological Deficit ◽  
Spinal Tuberculosis ◽  
Treatment Modalities ◽  
Randomised Control Trial ◽  
P Value ◽  
Short Course ◽  
Directly Observed Treatment ◽  
Anti Tubercular Therapy

Study Design: Prospective randomised control trial. Purpose: To compare the effectiveness of Directly Observed Treatment and Short Course (DOTS) and Daily Anti Tubercular Therapy (ATT) in spinal tuberculosis with no neurological deficit. Overview of Literature: Spinal tuberculosis is rampant in India with a major cause of morbidity and mortality. There is a lot of conflict regarding management with anti tubercular drugs, the regimen to be followed and the duration the drugs needed for complete cure. Material and Methods: This prospective study was conducted during the period of 2006 to 2009. Thirty cases of spinal tuberculosis were randomly divided equally into two groups of fifteen each and treated with DOTS and Daily ATT and compared at the end of follow up on clinical, radiological and Erythrocyte Sedimentation Rate values (ESR). Results: Pain score on Visual Analogue Scale (VAS) exhibits that mean pain score was 5.93+_1.54 at start and 0.64+_1.01 at the end of follow up with 89.39% change with DOTS therapy whereas mean pain score was 7.08 +_1.61at start of therapy and 0.69+_0.95 at end of follow up with 91.73% change in patients treated with Daily ATT with p value >0.05 (not significant). The radiological recovery in patients with DOTS and Daily ATT have similar results after 1.5 years with p value > 0.05 showing that the radiological recovery by both treatment modalities are comparable. Mean change in ESR scores in DOTS therapy patients and patients on daily ATT were 74.57+_9.34% and 75.69+_9.38% change with p value >0.05 which was not significant. Conclusion: DOTS therapy is an effective means of management of spinal tuberculosis cases with no neurological involvement, however its efficacy in patients with neurological deficit is further to be evaluated.

scholarly journals Results of management of spinal tuberculosis according to middle path regime and short course chemotheraphy

2017 ◽  
Vol 3 (5) ◽  
pp. 966
Author(s):  
Jairam D. Jagiasi ◽  
Mihir R. Patel
Keyword(s):  
Spinal Tuberculosis ◽  
Antibiotic Sensitivity ◽  
Control Program ◽  
Drug Regimen ◽  
Skeletal Tuberculosis ◽  
National Tuberculosis Control Program ◽  
Short Course ◽  
National Tuberculosis ◽  
Directly Observed Treatment ◽  
A Prospective Study

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Vertebral tuberculosis is the most common form of skeletal tuberculosis and it contributes about 50 percent of all cases of skeletal tuberculosis. The purpose of this study is to delineate the importance of middle path regime and short course chemotheraphy in the management of spine tuberculosis.</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A prospective study was conducted which included 44 patients diagnosed as tuberculous spondylitis. Management was started as per middle path regime and drugs were given as per the revised national tuberculosis control program (RNTCP) regime category I under directly observed treatment, short-course (DOTS) therapy. Specimen was collected and studied for smear, culture, antibiotic sensitivity and histopathology. ATT was stopped at the end of 6 months as per DOTS schedule and MRI was done at the end of therapy</span>.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Dorsal spine lesions were found in 33 patients. 8 patients were smear positive and 38 patients were culture positive of whom 26 patients were sensitive to first line ATT drugs. 12 patients had MDR tuberculosis and were sensitive to 2<sup>nd</sup> line ATT drugs. 6 patients having negative culture were diagnosed from histopathology. All patients on 1<sup>st</sup> line ATT had satisfactory result. Only 8 patients with MDR tuberculosis recovered neurologically. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">It is mandatory to do obtain tissue biopsy and examine culture, sensitivity and histopathology. Recently there is an increasing tendency in multidrug resistance cases and total drug resistant cases. By doing culture and sensitivity of the specimen we can find out the number of MDR cases and initiate proper drug regimen to avoid further complication and mortality.</span></p>

scholarly journals Nonadherence to tuberculosis treatment and associated factors among patients using directly observed treatment short-course in north-west Nigeria: A cross-sectional study

2021 ◽  
Vol 9 ◽  
pp. 205031212198949
Author(s):  
Cylia Nkechi Iweama ◽  
Olaoluwa Samson Agbaje ◽  
Prince Christian Ifeanachor Umoke ◽  
Chima Charles Igbokwe ◽  
Eyuche Lawretta Ozoemena ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Cross Sectional Study ◽  
Medication Nonadherence ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
North West ◽  
Short Course ◽  
Directly Observed Treatment

Introduction: Tuberculosis is a public health problem in Nigeria. One of the most effective ways of controlling tuberculosis is the directly observed treatment short-course. However, some factors influence tuberculosis patients’ treatment nonadherence via directly observed treatment short-course. The study objective was to assess medication nonadherence and associated factors among tuberculosis patients in north-west Nigeria. Methods: A cross-sectional study enrolled tuberculosis patients using directly observed treatment short-course in public health facilities in Kano and Kaduna States from January 2015 to June 2016. The sample selection was conducted via a multistage sampling procedure. Data were collected using tuberculosis patients’ demographic and clinical characteristics forms, well-validated structured instruments, and medical records. SPSS version 20 was used for data analysis. Logistic and multivariable logistic regression analyses to determine factors of medication nonadherence ( P < 0.05) Results: Complete responses from 390 patients out of the 460 patients recruited for the study were used for data analyses. The mean age was 51.5 (standard deviation = ±13.8) years. The mean tuberculosis medication adherence questionnaire score was 4.35 ± 1.12. The prevalence of nonadherence to tuberculosis medication was 30.5%. Multivariable logistic regression analysis showed that having a monthly income between #100,000 and #199, 000 (adjusted odds ratio = 0.01; 95% confidence interval: 0.00–0.13), being widowed (adjusted odds ratio = 26.74, 95% confidence interval: 2.92–232.9), being married (adjusted odds ratio = 120.49, 95% confidence interval: 5.38–271.1), having a distance <5 km to directly observed treatment short-course center from home (adjusted odds ratio = 0.06, 95% confidence interval: 0.00–0.01), having a tuberculosis/HIV co-infection (adjusted odds ratio = 0.01, 95% confidence interval: 0.12–0.35), use of antiretroviral treatment and cotrimoxazole prophylaxis therapy medications (adjusted odds ratio = 24.9, 95% confidence interval: 19.6–304.3) were associated with tuberculosis medication nonadherence. Conclusion: Tuberculosis medication nonadherence was high among the patients. Thus, patient-specific adherence education, attenuation of potential factors for tuberculosis medication nonadherence, and continual resource support for tuberculosis patients are needed to improve treatment outcomes.

Consumption of spine by tuberculosis in the era of directly observed treatment, short-course and genomic diagnosis

2020 ◽  
Author(s):  
A. Divya ◽  
Dhaval P. Shukla ◽  
Veenakumari H. Bahubali ◽  
Rose Dawn Bharath ◽  
B.N. Nandeesh ◽  
...  
Keyword(s):  
Short Course ◽  
Directly Observed Treatment

scholarly journals Patients’ Experience of Tuberculosis Treatment Using Directly Observed Treatment, Short-Course (DOTS): A Qualitative Study

2015 ◽  
Vol 17 (4) ◽  
Author(s):  
Masoud Behzadifar ◽  
Masoud Mirzaei ◽  
Meysam Behzadifar ◽  
Abouzar Keshavarzi ◽  
Maryam Behzadifar ◽  
...  
Keyword(s):  
Qualitative Study ◽  
Tuberculosis Treatment ◽  
Short Course ◽  
Directly Observed Treatment ◽  
Patients Experience

scholarly journals FAKTOR-FAKTOR PENYEBAB KONVERSI BAKTERI TAHAN ASAM NEGATIF PADA PENGOBATAN TUBERKULOSA

2017 ◽  
Vol 10 (1) ◽  
pp. 19
Author(s):  
Diah Hermayanti
Keyword(s):  
Cross Sectional ◽  
Short Course ◽  
Directly Observed Treatment

Latar belakang : Pengendalian TBC di Indonesia, dilaksanakan dengan strategi Directly Observed Treatment Short Course (DOTS). Prinsip pengobatan TBC strategi DOTS menggunakan obat anti tuberkulosa (OAT) yang diberikan dalam bentuk kombinasi dari beberapa jenis, dalam jumlah cukup, dan dosis tepat selama 6 – 8 bulan. Penderita dikategorikkan sebagai kasus konversi BTA negatif bila dalam pemeriksaan ulangan BTA masih dijumpai kuman BTA positif dalam sputumnya.Tujuan : mengeksplorasi lebih lanjut faktor-faktor yang diduga dapat menyebabkan terjadinya konversi BTA negatif pada akhirmasa intensif pengobatan dan pada penderita dengan kategori gagal. Metode : Penelitian deskriptif observasional dengan pendekatan studi cross sectional, yang dilakukan di Poli Puskesmas Kedung Kandang Malang. Hasil penelitian : didapatkan 4 penderita yang masuk kriteria konversi BTA negatif dengan pendidikan 75% SD dan 25% SMP; status gizi berdasarkan IMT 75% termasuk kriteria kurus; 100% taat berobat; dan pada semua pemeriksaan kultur sputum tidak dijumpai pertumbuhan kuman. Kesimpulan : Status sosial ekonomi dan status gizi penderita TBC dengan konversi BTA negatif adalah rendah, namun kepatuhannya berobat cukup tinggi. Resistensi kuman TBC terhadap OAT program jangka pendek pada penelitian tidak dapat dievaluasi oleh karena tidak ada pertumbuhan kuman pada semua sampel sputum penderita.Kata kunci : DOTS, OAT, BTA, Konversi negative

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