Contrast visual acuity in patients with retinitis pigmentosa assessed by a contrast sensitivity tester

Purpose. To determine the effects of cataract surgery on contrast visual acuity and retinal sensitivity in patients with retinitis pigmentosa. Methods. Retinal sensitivity and contrast visual acuity were determined by microperimetry (MAIA) and contrast sensitivity acuity tester (CAT-CP), respectively, before and after cataract surgery. The significance of the correlations between visual acuity, retinal sensitivity, contrast visual acuity, improvements after surgery, and macular structure before and after cataract surgery was determined. Results. Retinal sensitivity and contrast visual acuity were significantly improved after cataract surgery. The correlations among postoperative visual acuity, postoperative retinal sensitivities, and preoperative ellipsoid zone length were significant. The postoperative retinal sensitivity of the central 10° and the ellipsoid zone length was particularly significantly correlated. Preoperative contrast visual acuity and the amount of improvement and preoperative retinal sensitivity and the amount of improvement were significantly negatively correlated. The contrast visual acuity under both the 100% and 10% photopic and mesopic conditions improved significantly after cataract surgery. Conclusions. Cataract surgery in retinitis pigmentosa patients with preserved ellipsoid zones significantly improved retinal sensitivity and contrast visual acuity. Cataract surgery can be expected to improve retinal sensitivity and contrast visual acuity under various conditions, even if preoperative visual parameters are low, as long as the ellipsoid zone is preserved.

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Contrast Sensitivity and Color Vision in Eyes With Retinitis Pigmentosa and Good Visual Acuity: Correlations With SD-OCT Findings

Ophthalmic Surgery Lasers and Imaging ◽

10.3928/15428877-20121001-07 ◽

2012 ◽

Vol 43 (6) ◽

pp. S44-S53 ◽

Cited By ~ 4

Author(s):

Georgia G. Yioti ◽

Chris D. Kalogeropoulos ◽

Miltiadis B. Aspiotis ◽

Maria I. Stefaniotou

Keyword(s):

Visual Acuity ◽

Retinitis Pigmentosa ◽

Contrast Sensitivity ◽

Color Vision ◽

Good Visual Acuity ◽

Sd Oct

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Correlation between Contrast Sensitivity and Visual Acuity in Retinitis pigmentosa Patients

Ophthalmologica ◽

10.1159/000059627 ◽

2002 ◽

Vol 216 (3) ◽

pp. 185-191 ◽

Cited By ~ 6

Author(s):

Kiyoshi Akeo ◽

Yoshiki Hiida ◽

Masamichi Saga ◽

Rikako Inoue ◽

Yoshihisa Oguchi

Keyword(s):

Visual Acuity ◽

Retinitis Pigmentosa ◽

Contrast Sensitivity

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Effect of incompatible light on modified class B night vision goggle-aided visual acuity and contrast sensitivity.

PsycEXTRA Dataset ◽

10.1037/e422132004-001 ◽

1997 ◽

Author(s):

Randall W. Gibb ◽

Jack D. Reising

Keyword(s):

Visual Acuity ◽

Contrast Sensitivity ◽

Night Vision ◽

Class B

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Pediatric Cataract Surgery: Comparison between Ages at Surgery and Contrast Sensitivity Outcomes

Ophthalmologica Indonesiana ◽

10.35749/journal.v43i1.138 ◽

2019 ◽

Vol 43 (1) ◽

pp. 50

Author(s):

Aquirina Caesari Putri ◽

Rozalina Loebis

Keyword(s):

Visual Acuity ◽

Cataract Surgery ◽

Contrast Sensitivity ◽

Cataract Extraction ◽

Significant Negative Correlation ◽

Natural World ◽

P Value ◽

Pediatric Cataract ◽

Low Contrast ◽

Significant Difference

Background: Pediatric cataracts are major causes of children’s blindness. Surgery has proven to be beneficial in terms of visual function prognosis. Contrast sensitivity evaluation after surgery is as important as visual acuity considering that natural world consists of various objects in low-to-medium contrasts. The purpose of this study is to analyze the difference of contrast sensitivity outcomes based on ages at surgery. Method: Retrospective data of children with pediatric developmental cataract from July 2013 to November 2015 were collected. All children who underwent cataract surgery at 60-months-old or less were randomized into two groups, ≤24 months and >24-to-60 months. Contrast sensitivity was then examined with preferential-looking method using Hiding Heidi low-contrast test face chart. The main outcome measures were contrast sensitivity of both groups. Age-at-evaluation, cataract onset, duration of follow-up, duration of deprivation and visual acuity were also noted. Result: Of 14 children (23 eyes), 11 eyes (47,8%) were in ≤24 months group, 12eyes (52,2%) were in >24-to-60 months group. All eyes underwent cataract extraction and similar type of intraocular lens implantation. Mean age-at-surgery was 28,2 months±16,8 (SD). Mean contrast sensitivity for each group was 47,50 %±42,29 and 18,33%±27,38, respectively, with p-value 0,031. Further analysis of Spearman’s correlation test demonstrated significant negative correlation (rs = -0,559; p = 0,006) between the two groups. Conclusion: There was statistically significant difference in contrast sensitivity between those who underwent surgery at ≤24 months and >24-to-60 months. Children who underwent surgery at older ages tend to have better contrast sensitivity afterwards.

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Clinical Phenotype of PDE6B-Associated Retinitis Pigmentosa

International Journal of Molecular Sciences ◽

10.3390/ijms22052374 ◽

2021 ◽

Vol 22 (5) ◽

pp. 2374

Author(s):

Laura Kuehlewein ◽

Ditta Zobor ◽

Katarina Stingl ◽

Melanie Kempf ◽

Fadi Nasser ◽

...

Keyword(s):

Visual Acuity ◽

Genetic Testing ◽

Retinitis Pigmentosa ◽

Fundus Autofluorescence ◽

Retinal Disease ◽

New Drugs ◽

Autofluorescence Imaging ◽

Full Field ◽

Tertiary Referral Center ◽

The Right

In this retrospective, longitudinal, observational cohort study, we investigated the phenotypic and genotypic features of retinitis pigmentosa associated with variants in the PDE6B gene. Patients underwent clinical examination and genetic testing at a single tertiary referral center, including best-corrected visual acuity (BCVA), kinetic visual field (VF), full-field electroretinography, full-field stimulus threshold, spectral domain optical coherence tomography, and fundus autofluorescence imaging. The genetic testing comprised candidate gene sequencing, inherited retinal disease gene panel sequencing, whole-genome sequencing, and testing for familial variants by Sanger sequencing. Twenty-four patients with mutations in PDE6B from 21 families were included in the study (mean age at the first visit: 32.1 ± 13.5 years). The majority of variants were putative splicing defects (8/23) and missense (7/23) mutations. Seventy-nine percent (38/48) of eyes had no visual acuity impairment at the first visit. Visual acuity impairment was mild in 4% (2/48), moderate in 13% (6/48), and severe in 4% (2/48). BCVA was symmetrical in the right and left eyes. The kinetic VF measurements were highly symmetrical in the right and left eyes, as was the horizontal ellipsoid zone (EZ) width. Regarding the genetic findings, 43% of the PDE6B variants found in our patients were novel. Thus, this study contributed substantially to the PDE6B mutation spectrum. The visual acuity impairment was mild in 83% of eyes, providing a window of opportunity for investigational new drugs. The EZ width was reduced in all patients and was highly symmetric between the eyes, making it a promising outcome measure. We expect these findings to have implications on the design of future PDE6B-related retinitis pigmentosa (RP) clinical trials.

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Improved CoChR Variants Restore Visual Acuity and Contrast Sensitivity in a Mouse Model of Blindness under Ambient Light Conditions

Molecular Therapy ◽

10.1016/j.ymthe.2019.04.002 ◽

2019 ◽

Vol 27 (6) ◽

pp. 1195-1205 ◽

Cited By ~ 14

Author(s):

Tushar H. Ganjawala ◽

Qi Lu ◽

Mitchell D. Fenner ◽

Gary W. Abrams ◽

Zhuo-Hua Pan

Keyword(s):

Visual Acuity ◽

Mouse Model ◽

Contrast Sensitivity ◽

Ambient Light ◽

Light Conditions

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The impact of cataract surgery on depressive symptoms for bilateral cataract patients in Ho Chi Minh City, Vietnam

International Psychogeriatrics ◽

10.1017/s1041610213001907 ◽

2013 ◽

Vol 26 (2) ◽

pp. 307-313 ◽

Cited By ~ 6

Author(s):

Kien Gia To ◽

Lynn B. Meuleners ◽

Michelle L. Fraser ◽

Dat Van Duong ◽

Dung Van Do ◽

...

Keyword(s):

Visual Acuity ◽

Depressive Symptoms ◽

Cataract Surgery ◽

Contrast Sensitivity ◽

Depression Scale ◽

Epidemiological Studies ◽

Ho Chi Minh City ◽

Bilateral Cataract ◽

Vietnamese Population ◽

The Impact

ABSTRACTBackground:Depression is common among older populations with cataract. However, the impact of cataract surgery on depression in both developed and developing countries remains unclear. The aim of this study is to determine the impact of cataract surgery on depressive symptoms and to examine the association between objective visual measures and change in depressive symptoms after surgery among a Vietnamese population in Ho Chi Minh City.Methods:A cohort of older patients with bilateral cataract were assessed the week before and one to three months after first eye surgery only or first- and second-eye cataract surgeries. Visual measures including visual acuity, contrast sensitivity, and stereopsis were obtained. Depressive symptoms were assessed using the 20-item Center for Epidemiological Studies-Depression Scale (CES-D). Descriptive analyses and a generalized estimating equations (GEE) analysis were undertaken to determine the impact of cataract surgery on depressive symptoms.Results:Four hundred and thirteen participants were recruited into the study before cataract surgery. Two hundred and forty-seven completed the follow-up assessment after surgery. There was a significant decrease (improvement) of one point in the depressive symptoms score (p = 0.04) after cataract surgery, after accounting for potential confounding factors. In addition, females reported a significantly greater decrease (improvement) of two points in depressive symptom scores (p = 0.01), compared to males. However, contrast sensitivity, visual acuity, and stereopsis were not significantly associated with change in depressive symptoms scores. First-eye cataract surgery or both-eye cataract surgery did not modify the change in depressive symptoms score.Conclusion:There was a small but significant improvement in depressive symptoms score after cataract surgery for an older population in Vietnam.

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