scholarly journals Rapid diagnosis and shorter regimen for multidrug-resistant tuberculosis: A priority to improve treatment outcome

Lung India ◽  
2017 ◽  
Vol 34 (1) ◽  
pp. 1 ◽  
Author(s):  
Rajendra Prasad ◽  
Nikhil Gupta ◽  
Amitabh Banka
Keyword(s):  
Treatment Outcome ◽  
Multidrug Resistant ◽  
Rapid Diagnosis ◽  
Improve Treatment ◽  
Improve Treatment Outcome ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
A Priority

Time to Sputum Culture Conversion in Multidrug-Resistant Tuberculosis: Predictors and Relationship to Treatment Outcome

2006 ◽  
Vol 144 (9) ◽  
pp. 650 ◽  
Author(s):  
Timothy H. Holtz ◽  
Maya Sternberg ◽  
Steve Kammerer ◽  
Kayla F. Laserson ◽  
Vija Riekstina ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Multidrug Resistant ◽  
Sputum Culture ◽  
Sputum Culture Conversion ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Culture Conversion

Genotypic Resistance of Pyrazinamide but Not Minimum Inhibitory Concentration Is Associated With Longer Time to Sputum Culture Conversion in Patients With Multidrug-resistant Tuberculosis

2020 ◽  
Author(s):  
Johanna Kuhlin ◽  
Lina Davies Forsman ◽  
Mikael Mansjö ◽  
Michaela Jonsson Nordvall ◽  
Maria Wijkander ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Multidrug Resistant ◽  
Sputum Culture ◽  
Sputum Culture Conversion ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb ◽  
Culture Conversion

Abstract Background Pyrazinamide (PZA) resistance in multidrug-resistant tuberculosis (MDR-TB) is common; yet, it is not clear how it affects interim and treatment outcomes. Although rarely performed, phenotypic drug susceptibility testing (pDST) is used to define PZA resistance, but genotypic DST (gDST) and minimum inhibitory concentration (MIC) could be beneficial. We aimed to assess the impact of PZA gDST and MIC on time to sputum culture conversion (SCC) and treatment outcome in patients with MDR-TB. Methods Clinical, microbiological, and treatment data were collected in this cohort study for all patients diagnosed with MDR-TB in Sweden from 1992–2014. MIC, pDST, and whole-genome sequencing of the pncA, rpsA, and panD genes were used to define PZA resistance. A Cox regression model was used for statistical analyses. Results Of 157 patients with MDR-TB, 56.1% (n = 88) had PZA-resistant strains and 49.7% (n = 78) were treated with PZA. In crude and adjusted analysis (hazard ratio [HR], 0.49; 95% conficence interval [CI], .29-.82; P = .007), PZA gDST resistance was associated with a 29-day longer time to SCC. A 2-fold decrease in dilutions of PZA MIC for PZA-susceptible strains showed no association with SCC in crude or adjusted analyses (HR, 0.98; 95% CI, .73–1.31; P = .89). MIC and gDST for PZA were not associated with treatment outcome. Conclusions In patients with MDR-TB, gDST PZA resistance was associated with a longer time to SCC. Rapid PZA gDST is important to identify patients who may benefit from PZA treatment.

scholarly journals Rapid diagnosis of pyrazinamide-resistant multidrug-resistant tuberculosis using a molecular-based diagnostic algorithm

2014 ◽  
Vol 20 (10) ◽  
pp. 1015-1020 ◽  
Author(s):  
S.O. Simons ◽  
T. van der Laan ◽  
A. Mulder ◽  
J. van Ingen ◽  
L. Rigouts ◽  
...  
Keyword(s):  
Diagnostic Algorithm ◽  
Multidrug Resistant ◽  
Rapid Diagnosis ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals Comparison of the validity of smear and culture conversion as a prognostic marker of treatment outcome in patients with multidrug-resistant tuberculosis

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0197880 ◽  
Author(s):  
Kefyalew Addis Alene ◽  
Kerri Viney ◽  
Hengzhong Yi ◽  
Emma S. McBryde ◽  
Kunyun Yang ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Prognostic Marker ◽  
Multidrug Resistant ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Culture Conversion
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