scholarly journals The comparative efficacy of decalcified allogenic bone matrix and intra-oral free osseous autografts in the treatment of periodontal intrabony defects

2013 ◽  
Vol 17 (1) ◽  
pp. 91 ◽  
Author(s):  
Vikas Jindal ◽  
AmarjitSingh Gill ◽  
Daljit Kapoor ◽  
Harinder Gupta
Keyword(s):  
Bone Matrix ◽  
Comparative Efficacy ◽  
Intrabony Defects ◽  
Allogenic Bone

Comparison of Autogenous Cortical Graft and Demineralized Allogenic Bone Matrix (DABM) in the Fixation of Segmental Prosthesis

Limb Salvage ◽  
1991 ◽  
pp. 335-343
Author(s):  
B. W. Wippermann ◽  
R. W. W. Hsu ◽  
E. Y. S. Chao ◽  
F. H. Sim
Keyword(s):  
Bone Matrix ◽  
Allogenic Bone

Current Approaches of Bone Morphogenetic Proteins in Dentistry

2015 ◽  
Vol 41 (3) ◽  
pp. 337-342 ◽  
Author(s):  
Rosa-María Díaz-Sánchez ◽  
Rosa-María Yáñez-Vico ◽  
Ana Fernández-Olavarría ◽  
Regina Mosquera-Pérez ◽  
Alejandro Iglesias-Linares ◽  
...  
Keyword(s):  
Bone Morphogenetic Proteins ◽  
Specific Growth ◽  
Bone Matrix ◽  
Bone Lesions ◽  
Allogenic Bone ◽  
Bone Morphogenic Proteins ◽  
Alloplastic Materials ◽  
Bone Response ◽  
Near Future

Bone morphogenic proteins (BMPs) are a group of osteoinductive proteins obtained from nonmineralized bone matrix; they are capable of stimulating the differentiation of pluripotent mesenchymal cells to osteoprogenitor cells. They have become a likely treatment option, given their action on regeneration and remodeling of bone lesions and increasing the bone response around alloplastic materials. It may be feasible in the near future for BMPs to replace autologous and allogenic bone grafts. The application of specific growth factors for osteoinduction without using a bone graft constitutes a real impact on bone regeneration. The use of BMP is not only focused on osteogenic regeneration: There are a variety of studies investigating other properties, such as periodontal or dental regeneration from the conservative viewpoint. In this review, we will highlight the role of the BMP in bone, periodontal and dental regeneration.

scholarly journals Pool of bovine morphogenetic proteins and guided tissue regeneration in the treatment of intrabony periodontal defects: I- Clinical measurements

2004 ◽  
Vol 12 (1) ◽  
pp. 70-77 ◽  
Author(s):  
Maria do Carmo Machado Guimarães ◽  
Euloir Passanezi ◽  
Adriana Campos Passanezi Sant'Ana ◽  
Sebastião Luiz Aguiar Greghi
Keyword(s):  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Test Group ◽  
Control Group ◽  
Collagen Membrane ◽  
Bovine Bone ◽  
Intrabony Defects ◽  
Bovine Collagen ◽  
Barrier Membrane ◽  
Clinical Measurements

The purpose of this study was to evaluate the effect of the pool of bovine BMPs on the treatment of intrabony defects. The sample comprised 15 patients aged 26 to 57 years old presenting with 10 pairs of lesions of 2 or 3 walls or 2-3 walls ³5mm, located in the same type teeth (premolar or molar) and same jaw. The test defects were treated with combination of a pool of bovine bone morphogenetic and resorbable hydroxyapatite carrier (BMPs- HA), bovine demineralized bone matrix (MB) and coverage by a bovine collagen barrier membrane. The control defects were treated with MB-HA and covered by a bovine collagen membrane. The clinical measurements at six months after therapy in the test group revealed a reduction in the mean probing pocket depth (PPD) of 1.63 ± 1.41mm (B) and 1.93 ± 0.96mm (L) and a mean change in the clinical attachment level (CAL) of 1.60 ± 1.16mm (B) and 1.46 ± 0.97mm (L). The control group showed a mean reduction of PPD of 1.93 ± 1.34mm (B) and 2.0 ± 1.51mm (L) and a mean change of CAL of 1.03 ± 1.24mm (B) and 1.30 ± 1.14 mm (L). The analysis of variance (ANOVA) demonstrated that the changes in the clinical parameters were statistically significant (p<0.05). There were no significant differences between the test and controls subjects (Student's test, p<0.005). These findings suggest that the use of a pool of bovine BMPs do not provide added effects to GTR in the treatment of intrabony defects.

Grafton Allogenic Bone Matrix

Neurosurgery ◽  
1994 ◽  
Vol 35 (2) ◽  
pp. 337-337
Author(s):  
Stephen T. Onesti
Keyword(s):  
Bone Matrix ◽  
Allogenic Bone

scholarly journals Treatment of Intrabony Defects with Anorganic Bone Matrix/P-15 or Guided Tissue Regeneration in Patients with Aggressive Periodontitis

2013 ◽  
Vol 24 (3) ◽  
pp. 204-212 ◽  
Author(s):  
Adriana C. Queiroz ◽  
Priscila Brasil da Nobrega ◽  
Fabiola S. Oliveira ◽  
Arthur B. Novaes Jr. ◽  
Mario Taba Jr. ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Bone Matrix ◽  
Group Versus ◽  
Clinical Situation ◽  
Aggressive Periodontitis ◽  
Guided Tissue Regeneration ◽  
Intrabony Defects ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Matrix Cell

Intrabony periodontal defects present a particular treatment problem, especially in patients with generalized aggressive periodontitis (G-AgP). Regenerative procedures have been indicated for this clinical situation. The aim of this study was to compare treatment outcomes of intrabony periodontal defects with either anorganic bone matrix/cell binding peptide (ABM/P-15) or guided tissue regeneration (GTR) in patients with G-AgP. Fifteen patients, with two intrabony defects ≥3 mm deep, were selected. Patients were randomly allocated to be treated with ABM/P-15 or GTR. At baseline and at 3 and 6 months after surgery, clinical and radiographic parameters and IL-1β and IL-6 gingival fluid concentrations were recorded. There was a significant probing pocket depth reduction (p<0.001) for both groups (2.27 ± 0.96 mm for ABM/P-15 group and 2.57 ± 1.06 mm for GTR group). Clinical attachment level gain (1.87 ± 0.94 mm for ABM/P-15 group and 2.09 ± 0.88 mm for GTR group) was also observed. There were no statistically significant differences in clinical parameters between the groups. The radiographic bone fill was more expressive in ABM/P-15 group (2.49 mm) than in GTR group (0.73 mm). In subtraction radiographs, the areas representing gain in density were 93.16% of the baseline defect for ABM/P-15 group versus 62.03% in GRT group. There were no statistically significant differences in inter-group and intra-group comparisons with regards to IL-1β and IL-6 quantification. Treatment of intrabony periodontal defects in patients with G-AgP with ABM/P-15 and GTR improved significantly the clinical outcomes. The use of ABM/P-15 promoted a better radiographic bone fill.

Grafton Allogenic Bone Matrix

Neurosurgery ◽  
1994 ◽  
Vol 35 (2) ◽  
pp. 337
Author(s):  
Stephen T. Onesti
Keyword(s):  
Bone Matrix ◽  
Allogenic Bone

scholarly journals In Vitro Evaluation of the Allogeneic Bone Matrix Effect on the Adipose Mesenchymal Stromal Cells Characteristics in Combined Tissue Engineering

2021 ◽  
Vol 27 (1) ◽  
pp. 53-65
Author(s):  
L. A. Cherdantseva ◽  
E. A. Anastasieva ◽  
D. Ya. Aleynik ◽  
M. N. Egorikhina ◽  
I. A. Kirilova
Keyword(s):  
Tissue Engineering ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Bone Matrix ◽  
Allogeneic Bone ◽  
Spongy Bone ◽  
Allogenic Bone ◽  
Native Bone ◽  
Deproteinized Bone

The aim of the study was to evaluate in vitro the effect of native and deproteinized compact and spongy allogenic bone matrices on the characteristics of adipose mesenchymal stromal cells (ASC) in combined tissue engineering.Material and Methods. 24 samples of native and deproteinized compact and spongy bone were examined, which were exposed to mechanical treatment, modeling, followed by sterilization of the samples by ionizing radiation and bacteriological control of sterilization. Some of the samples underwent deproteinization. The characterized cultures of human ASC were used as test cultures to assess the interaction with the bone samples. The Cytation-5 fluorescent imager and Hoechst 3334 fluorochromes (BD Pharmingen™) and calcein (Calcein AM, BD Pharmingen™) were used to characterize the degree of adhesion, migration, and viability of ASC on bone matrix samples. Matrix cytotoxicity was evaluated by MTT assay on days 1 and 7 of extraction.Results. The bone matrix samples are characterized by the absence of cytotoxicity (rank 1). ASC demonstrated good adhesion and migration on any surface of the bone matrix and preservation of cell viability during 7 days of observation. Nuclei sizes of the cells adhered to the deproteinized bone matrix of the spongy structure increased by 25–30% compared to other samples. The cells on deproteinized bone matrix had greater size (the size of the cells from nuclei 8.8 to 11.5 μm, the average size of cells nuclei from an 86.3 μm to 129,0 μm, the average perimeter of the cells nuclei from 30.7 μm to 40.7 μm) than in the native bone matrix samples.Conclusion. The results of the study of various allogeneic bone matrices demonstrate that deep purification of the bone matrix determines the absence of cytotoxicity and the most favorable conditions for the adhesion, migration, proliferation and viability of ASC. Also makes it possible to use tissue engineering based on bone matrices of different structures. Deproteinized spongy bone matrices are best suited for this purpose.

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