scholarly journals Systemic steroids and intratympanic steroids perfusion as an initial therapy for idiopathic sudden sensorineural hearing loss, a comparative study

2014 ◽  
Vol 30 (3) ◽  
pp. 215 ◽  
Author(s):  
Mohamed Mosleh ◽  
Wael Wageeh ◽  
Maha Abou-Elew ◽  
Hesham Fathy ◽  
MahmoudA El Hassan ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Comparative Study ◽  
Sensorineural Hearing Loss ◽  
Initial Therapy ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Systemic Steroids ◽  
Intratympanic Steroids

Intratympanic steroids as a salvage treatment for sudden sensorineural hearing loss? A meta-analysis

2014 ◽  
Vol 272 (10) ◽  
pp. 2777-2782 ◽  
Author(s):  
Jia Hui Ng ◽  
Roger Chun Man Ho ◽  
Crystal Shuk Jin Cheong ◽  
Adele Ng ◽  
Heng Wai Yuen ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Meta Analysis ◽  
Salvage Treatment ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Intratympanic Steroids

Intratympanic methylprednisolone as first-line therapy in sudden sensorineural hearing loss: preliminary results from a case–control series

2011 ◽  
Vol 125 (10) ◽  
pp. 1004-1008 ◽  
Author(s):  
I Dallan ◽  
S Fortunato ◽  
A P Casani ◽  
E Panicucci ◽  
S Berrettini ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Case Control ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
First Line ◽  
Control Series ◽  
First Line Therapy ◽  
Line Therapy ◽  
Intratympanic Steroids

AbstractBackground:Sudden sensorineural hearing loss is a true audiological emergency, and its management is much discussed. Currently, no single therapy has been proven effective according to evidence criteria. Recently, intratympanic application of steroids has been increasingly used in refractory cases; however, it has only rarely been reported as first-line therapy.Materials and methods:Twenty consecutive patients with sudden sensorineural hearing loss treated between July 2008 and January 2010 were enrolled in this prospective, case–control study. Ten patients were treated with intratympanic steroids and 10 with systemic ‘shotgun’ therapy (including steroids, pentoxifylline, low molecular weight heparin and vitamin E). The two groups were homogeneous in all respects. Pure tone averages were assessed before and after treatment for both groups.Results:There were no statistically significant differences between the two groups.Conclusion:Intratympanic steroids seem to offer a valid alternative to systemic therapy, with few risks, in sudden sensorineural hearing loss patients, and we recommend their use as first-line therapy.

Long-term follow up of sudden sensorineural hearing loss patients treated with intratympanic steroids: audiological and quality of life evaluation

2014 ◽  
Vol 128 (8) ◽  
pp. 669-673 ◽  
Author(s):  
I Dallan ◽  
S Fortunato ◽  
A P Casani ◽  
E Bernardini ◽  
S Sellari-Franceschini ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Glasgow Benefit Inventory ◽  
Intratympanic Steroids

AbstractObjective:To evaluate the long-term stability of intratympanic steroids and investigate the ‘real’ impact of sudden sensorineural hearing loss on patients.Method:A total of 14 patients treated with intratympanic steroids were evaluated by audiometric and vestibular examinations. The modified Glasgow Benefit Inventory was used to evaluate quality of life changes after intratympanic steroid treatment.Results:There was no significant difference between pure tone average post-intratympanic steroids and at follow up. The general Glasgow Benefit Inventory score was not significantly associated with the presence of tinnitus or dizziness, or with patient age. The change in pure tone average after intratympanic steroid treatment did not correlate with social or physical scores, but correlated strongly with the general Glasgow Benefit Inventory score (p = 0.0023). Intratympanic steroid administration led to a stable improvement in hearing. Quality of life assessment showed that patients can feel satisfaction regardless of the hearing outcome. Patients who regained a social hearing level expressed greater satisfaction than patients without serviceable hearing. Overall, quality of life improvement was not related to hearing improvement.Conclusion:Sudden sensorineural hearing loss is devastating. Considering the audiological effects alone ignores the ‘human’ perspective. Audiological success can correlate with poor quality of life outcome.

scholarly journals Management of sudden sensorineural hearing loss: a prospective study of 30 patients

2017 ◽  
Vol 3 (4) ◽  
pp. 837
Author(s):  
Sunil N. Khot ◽  
Priyadarshini G. ◽  
Ayisha Kunnumal
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Complete Recovery ◽  
Positive Influence ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Intravenous Methylprednisolone ◽  
Improvement Rate ◽  
Systemic Steroids ◽  
A Prospective Study

<p class="abstract"><strong>Background:</strong> Sudden sensorineural hearing loss (SNHL) is sensorineural hearing loss of 30 dB or more over at least three contiguous audiometric frequencies that develop over a period of few hours to three days. The purpose of study is to make a protocol for treatment.</p><p class="abstract"><strong>Methods:</strong> 30 cases of sudden SNHL who presented to OPD of Government Medical College, Miraj between December 2015 to April 2017 were included. Detailed history taking and ENT examination was done. All patients were admitted and started on intravenous methylprednisolone. If hearing improvement was not observed, intratympanic methylprednisolone (ITS) was administered.  </p><p class="abstract"><strong>Results:</strong> 50% patients had recovery with intravenous Methylprednisolone and 50% had no recovery. “No recovery” patients were subjected to ITS, of which 20% had complete, 30% partial and 50% no recovery. Among no recovery patients of ITS, 10% had hearing loss greater than 90 dB with improvement rate of 0%; 40% had hearing loss of 90 - 50 dB with improvement rate of 50%; 50% had hearing loss of 50-30 dB with improvement rate of 60%. Among 15 cases of ITS, mean number of days between onset of symptom and starting ITS was 13 days for complete recovery patients; 17.3 days for partial or slight recovery; 20.6 days for no recovery.</p><p><strong>Conclusions:</strong> Hearing loss less than 90 dB and earlier ITS has positive influence on hearing recovery. Systemic steroids are currently the mainstay of initial treatment. ITS is an effective treatment modality for patients who fail to respond to systemic steroids.</p>

Intratympanic Steroids for Treatment of Sudden Hearing Loss after Failure of Intravenous Therapy

2007 ◽  
Vol 137 (1) ◽  
pp. 74-78 ◽  
Author(s):  
Guillermo Plaza ◽  
Carlos Herráiz
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Standard Treatment ◽  
Sudden Hearing Loss ◽  
Sudden Onset ◽  
Sudden Sensorineural Hearing Loss ◽  
Steroid Treatment ◽  
Sensorineural Hearing ◽  
Intravenous Steroid ◽  
Intratympanic Steroids

OBJECTIVE: We sought to describe our experience with intratympanic steroid treatment of sudden sensorineural hearing loss after failure of intravenous steroid treatment. STUDY DESIGN AND SETTING: We conducted a nonrandomized prospective clinical trial. Fifty patients presenting with sudden onset idiopathic hearing loss were treated intravenously over five days. After this period, patients with treatment failure (18 cases) were offered intratympanic steroid treatment. Nine patients refused, whereas the other nine patients received three weekly injections of methylprednisolone. Recovery of hearing was reported as improvement of more than 15 dB in pure tone average. RESULTS: Intratympanic steroid treatment improved hearing loss in five patients (55%). This is significant compared with those patients who refused intratympanic treatment, who showed no further improvement ( P < 0.05). No serious adverse effects were observed. CONCLUSION: Intratympanic steroids significantly improve the recovery outcome of sudden hearing loss that had not recovered after intravenous steroid treatment. SIGNIFICANCE: Intratympanic steroids are an effective and safe therapy in sudden sensorineural hearing loss cases that are refractory to standard treatment.

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