scholarly journals Pulmonary hypertension – prevalence, risk factors, and its association with vascular calcification in chronic kidney disease and hemodialysis patients

2020 ◽  
Vol 31 (2) ◽  
pp. 380
Author(s):  
Elayaperumal Indhumathi ◽  
N Nithiya ◽  
Dhakshinamoorty Jagadeswaran ◽  
Varadharajan Jayaprakash ◽  
Matcha Jayakumar
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Pulmonary Hypertension ◽  
Kidney Disease ◽  
Vascular Calcification ◽  
Hemodialysis Patients ◽  
Hypertension Prevalence

scholarly journals Prevalence and Risk Factors for Chronic Kidney Disease in Family Relatives of a Cameroonian Population of Hemodialysis Patients: A CrossSectional Study

2019 ◽  
Vol 4 (1) ◽  
pp. 12-17
Author(s):  
Mazou Ngou Temgoua ◽  
Gloria Ashuntantang ◽  
Marie José Essi ◽  
Joël Nouktadie Tochie ◽  
Moussa Oumarou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Fasting Blood Glucose ◽  
Hemodialysis Patients ◽  
Biological Data ◽  
Sub Saharan Africa ◽  
Herbal Remedies ◽  
Maintenance Hemodialysis ◽  
Number Of Patients

Background: In sub-Saharan Africa (SSA), the trend in the number of patients admitted for maintenance hemodialysis is on the rise. The identification of risk factors for chronic kidney disease (CKD) ensures adequate primary and secondary preventive measures geared at reducing the burden of CKD in low-resource settings. A family history of CKD is an established risk factor for CKD in high-income countries. However, data on family predisposition to CKD is scarce in the literature on SSA. Objective: The current study aimed to determine the prevalence and risk factors of CKD in family relatives of a Cameroonian population of hemodialysis patients (HDP) followed-up in a major hemodialysis referral center in Cameroon. Methods: The current cross-sectional study was conducted over four months on a consecutive sample of first-degree family relatives of end-stage renal disease patients undergoing maintenance hemodialysis at the hemodialysis unit of the General Hospital of Yaoundé. For each participating family relative, socio-demographic characteristics, clinical data, and biological data including fasting blood glucose, proteinuria, and serum creatinine were collected. Results: A total of 82 first-degree family relatives of HDP were recruited. The prevalence of CKD among the participants was 15.8%. The main identified risk factors for CKD were age (P = 0.0015), female gender (P = 0.0357), hypertension (P = 0.0004), regular intake of herbal remedies (P = 0.0214), and diabetes mellitus (P = 0.0019). Conclusion: Overall, the current findings suggest an urgent need for population education, routine screening of CKD, and the identification of risk factors in first-degree family relatives of HDP in Cameroon.

scholarly journals Association of Serum Phosphate and Related Factors in ESRD-Related Vascular Calcification

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Cai-Mei Zheng ◽  
Kuo-Cheng Lu ◽  
Chia-Chao Wu ◽  
Yung-Ho Hsu ◽  
Yuh-Feng Lin
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Calcification ◽  
Cardiovascular Complications ◽  
Serum Phosphate ◽  
Related Factors ◽  
Therapeutic Prevention ◽  
Esrd Patients

Vascular calcification is common in ESRD patients and is important in increasing mortality from cardiovascular complications in these patients. Hyperphosphatemia related to chronic kidney disease is increasingly known as major stimulus for vascular calcification. Hyperphosphatemia and vascular calcification become popular discussion among nephrologist environment more than five decades, and many researches have been evolved. Risk factors for calcification are nowadays focused for the therapeutic prevention of vascular calcification with the hope of reducing cardiovascular complications.

Fractional excretion of phosphorus and vascular calcification in stage 3 chronic kidney disease

2018 ◽  
Vol 67 (3) ◽  
pp. 674-680 ◽  
Author(s):  
Manuel Jiménez Villodres ◽  
Guillermo García Gutiérrez ◽  
Patricia García Frías ◽  
José Rioja Villodres ◽  
Mónica Martín Velázquez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Cardiovascular Risk Factors ◽  
Vascular Calcification ◽  
Fractional Excretion ◽  
X Rays ◽  
Abdominal Radiography ◽  
Vascular Comorbidity

The role of renal excretion of Pi in relation to vascular calcification (VC) in patients in the early stages of chronic kidney disease (CKD) is controversial. Thus, we determine the relation between fractional excretion of phosphorus (FEP) and VC, measured using two methods in a cross-sectional study of patients with stage 3 CKD. We recorded demographic data, anthropometry, comorbidities and active treatment. We measured 24-hour urine FEP and, in serum, measured fibroblast growth factor 23 (FGF23), α-Klotho, intact parathyroid hormone (iPTH), calcium and phosphorus. VC was measured by lateral abdominal radiography (Kauppila index (KI)) and CT of the abdominal aorta (measured in Agatston units). In 57% of subjects, abnormal VC was present when measured using CT, and in only 17% using lateral abdominal radiography. Factors associated with VC using CT were age, cardiovascular risk factors, vascular comorbidity, microalbuminuria and levels of FGF23, phosphorus and calcium x phosphorus product (CaxP); although only age (OR 1.25, 95% CI 1.11 to 1.41), smoking (OR 21.2, CI 4.4 to 100) and CaxP (OR 1.21, CI 1.06 to 1.37) maintained the association in a multivariate analysis. By contrast, only age (OR 1.35, 95% CI 1.07 to 1.74), CaxP (OR 1.14, CI 1.13 to 1.92) and FEP (OR 1.07,95% CI 1004 to 1.14) were associated with abnormal VC in the lateral abdominal radiography. In conclusion, in patients with stage 3 CKD, the detection of VC by abdominal CT is more sensitive than conventional X-rays. Moreover, CaxP is associated with cardiovascular risk factors and vascular comorbidity; quantification of FEPi in these patients provides additional clinical information in advanced VC detected by KI.

scholarly journals Lanthionine, a Novel Uremic Toxin, in the Vascular Calcification of Chronic Kidney Disease: The Role of Proinflammatory Cytokines

2021 ◽  
Vol 22 (13) ◽  
pp. 6875
Author(s):  
Alessandra Fortunata Perna ◽  
Luigi Russo ◽  
Vittoria D’Esposito ◽  
Pietro Formisano ◽  
Dario Bruzzese ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Calcification ◽  
Hemodialysis Patient ◽  
Calcium Score ◽  
Hemodialysis Patients ◽  
Agatston Score ◽  
Uremic Toxin ◽  
Total Calcium

Vascular calcification (VC) is a risk factor for cardiovascular events and mortality in chronic kidney disease (CKD). Several components influence the occurrence of VC, among which inflammation. A novel uremic toxin, lanthionine, was shown to increase intracellular calcium in endothelial cells and may have a role in VC. A group of CKD patients was selected and divided into patients with a glomerular filtration rate (GFR) of <45 mL/min/1.73 m2 and ≥45 mL/min/1.73 m2. Total Calcium Score (TCS), based on the Agatston score, was assessed as circulating lanthionine and a panel of different cytokines. A hemodialysis patient group was also considered. Lanthionine was elevated in CKD patients, and levels increased significantly in hemodialysis patients with respect to the two CKD groups; in addition, lanthionine increased along with the increase in TCS, starting from one up to three. Interleukin IL-6, IL-8, and Eotaxin were significantly increased in patients with GFR < 45 mL/min/1.73 m2 with respect to those with GFR ≥ 45 mL/min/1.73 m2. IL-1b, IL-7, IL-8, IL-12, Eotaxin, and VEGF increased in calcified patients with respect to the non-calcified. IL-8 and Eotaxin were elevated both in the low GFR group and in the calcified group. We propose that lanthionine, but also IL-8 and Eotaxin, in particular, are a key feature of VC of CKD, with possible marker significance.

Nutritional risk factors among hemodialysis patients with Chronic kidney disease (West Algeria) Sidi-Bel

2016 ◽  
Vol 6 (4) ◽  
pp. 119-123
Author(s):  
Fatima Hamara ◽  
Karima Bereksi Reguig ◽  
Abdelhamid Bedjaoui ◽  
Abbes Bouterfas
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Daily Intake ◽  
Hemodialysis Patients ◽  
Significant Rise ◽  
Nutritional Risk ◽  
Biological Parameters ◽  
Dietary Recommendations ◽  
West Algeria

The purpose of this study was to examine the nutritional status among the subjects attained by chronic kidney disease The overall included sample con-tained a group of 391 patients, hospitalized for hemodialysis at the nephro-logy division of the Hassani Abdelkader CHU Sidi-Bel-Abbes in the Western of Algeria. The obtained results indicated that men 57.69 % were more affected that women 42.30 % with a sex ratio of 1.36. The chronic kidney disease was more prevalent among older range 47 years. The biological parameters de-monstrated no significant rise of the urea amount with a rate of 2.20 ± 1.04 (g/l) among men and 1.98 ± 1.02 (g/l) among women. The average of creatininemy was approximatively 110.75 ± 56.49 (mg/l) for men 97.01 ± 48.47 (mg/l) for women. The creatinin clearance is 10.33 ± 7.95 (ml/min/1.73 m2) for man and 9.15 ± 6.29 (ml/min/1.73 m2) for woman. In addition, the glo-merular flow of filtration was decreased at the two sexes and confirms a disturbance of the renal function. The correlation between serum of creati-nine and clearance in both sexes is important for both men R = 0.458 and women: R = 0.731. The relation is inversely proportional between creatinine and clearance values. The evaluation of food consumption, indicates that daily intake energy exceeds dietary recommendations, characterized by overconsumption lipid and carbohydrate and protein deficiency. Intakes of vitamins are usually covered. But the mineral intake is not covered. Overall, healthcare is essential for the present population to prevent serious compli-cations of this disease.

Risk factors for pulmonary hypertension at the predialysis stage of chronic kidney disease

2016 ◽  
Vol 88 (6) ◽  
pp. 33
Author(s):  
T. E. Rudenko ◽  
M. P. Vasilyeva ◽  
N. I. Solomakhina ◽  
I. M. Kutyrina
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Pulmonary Hypertension ◽  
Kidney Disease

P1433VALIDATION OF A SERUM CALCIFICATION PROPENSITY TEST FOR THE PREDICTION OF ALL-CAUSE MORTALITY AMONG DIALYSIS PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Rosa Ramos Sanchez ◽  
Adam Zawada ◽  
Melanie Wolf ◽  
Abraham Rincon Bello ◽  
Elisabet Masso Jimenez ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Calcification ◽  
Hemodialysis Patients ◽  
Sensitivity Analyses ◽  
In Vitro Test ◽  
Dialysis Vintage ◽  
All Cause Mortality ◽  
Unselected Cohort

Abstract Background and Aims Vascular calcification as cause of vascular stiffness is a major contributor to the high cardiac burden among stage 5 chronic kidney disease dialysis (CKD5HD) patients. Early identification of patients with high calcification propensity is crucial for proper risk stratification and management of these patients. Recently, a novel in vitro test (T50-test) was developed which determines calcification propensity of human serum and predicts mortality among ND-CKD (non-dialysis chronic kidney disease) patients, kidney transplant recipients and CKD5HD patients suffering from secondary hyperparathyroidism. We now evaluated whether these results can be confirmed in an unselected cohort of CKD5HD patients and can be used in the future for improving care of these patients. Method This prospective clinical study included 776 incident and prevalent hemodialysis patients from 8 Fresenius Medical Care NephroCare centers in Cataluña (Spain). T50 was determined at Calciscon AG, all other clinical data were retrieved from the European Clinical Database (EuCliD®). After their baseline T50 measurement, patients were followed for two years for the occurrence of the primary endpoint all-cause mortality. The association between T50 and all-cause mortality was examined by using proportional subdistribution hazards regression modelling accounting for kidney transplantation as competing event. In sensitivity analyses we adjusted for age, sex, vascular access (fistula/graft, catheter), treatment modality (HD, HDF), Charlson comorbidity index and dialysis vintage. Results Mean age of the study population was 72.2 years and 63.8% were male. 42.5% had diabetes and 55.0% past history of cardiovascular disease. Mean T50 was 283.4 min among the total cohort. During follow-up, 185 (23.8%) patients died. Patients who reached the endpoint had a significantly lower T50 at baseline as compared to those who survived during follow-up (269.6 vs 287.7 min, p = 0.001). A cross-validated model (mean c statistic: 0.5767) identified T50 as a linear predictor of all-cause-mortality (subdistribution hazard ratio (per min): 0.9957, 95% CI [0.9933;0.9981]). T50 remained a significant predictor of all-cause mortality after adjusting for relevant confounding in sensitivity analyses. Conclusion In this prospective study, we confirmed that T50 is an independent predictor of all-cause mortality among a large unselected cohort of hemodialysis patients. T50 may be used to identify patients with high vascular calcification propensity and mortality risks and may help physicians to implement a personalized and more precise renal replacement therapy option.

Vascular calcification in chronic kidney disease

2010 ◽  
Vol 119 (3) ◽  
pp. 111-121 ◽  
Author(s):  
Adrian Covic ◽  
Mehmet Kanbay ◽  
Luminita Voroneanu ◽  
Faruk Turgut ◽  
Dragomir N. Serban ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Arterial Stiffness ◽  
Vascular Calcification ◽  
Mineral Metabolism ◽  
Left Ventricular ◽  
Arterial Calcification ◽  
Pathophysiological Mechanism ◽  
Cardiovascular Morbidity And Mortality

VC (vascular calcification) is highly prevalent in patients with CKD (chronic kidney disease), but its mechanism is multifactorial and incompletely understood. In addition to increased traditional risk factors, CKD patients also have a number of non-traditional cardiovascular risk factors, which may play a prominent role in the pathogenesis of arterial calcification, such as duration of dialysis and disorders of mineral metabolism. The transformation of vascular smooth muscle cells into chondrocytes or osteoblast-like cells seems to be a key element in VC pathogenesis, in the context of passive calcium and phosphate deposition due to abnormal bone metabolism and impaired renal excretion. The process may be favoured by the low levels of circulating and locally produced VC inhibitors. VC determines increased arterial stiffness, left ventricular hypertrophy, a decrease in coronary artery perfusion, myocardial ischaemia and increased cardiovascular morbidity and mortality. Although current therapeutic strategies focus on the correction of phosphate, calcium, parathyroid hormone or vitamin D, a better understanding of the mechanisms of abnormal tissue calcification may lead to development of new therapeutic agents, which could reduce VC and improve cardiovascular outcome in CKD patients. The present review summarizes the following aspects: (i) the pathophysiological mechanism responsible for VC and its promoters and inhibitors, (ii) the methods for detection of VC in patients with CKD, including evaluation of arterial stiffness, and (iii) the management of VC in CKD patients.

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