Prevalence of ABO blood group phenotypes and antibody titers of the blood donor population in and around Puducherry

Background: Few studies focused on the study of blood groups in Gabon. This study aimed to determine the phenotypic frequency of ABO and Rhesus antigens in blood donors of Libreville and to assess the association between ABO blood groups and transfusion-transmitted infections.Materials and Methods: The study of ABO and Rhesus blood groups concerned 4,744 blood donors. ABO and Rhesus phenotyping were obtained using monoclonal monospecific antisera: anti-A, anti-B, anti-AB, anti-D, anti-E, anti-C, anti-c, and anti-e with an automate (QWALYS® 3, DIAGAST, France) or a card gel (ID Card, BIO-RAD) according to manufacturer’s instructions.Results: The phenotypic frequency of blood group antigens A, B, AB and O were respectively 21.0%; 17.6%; 2.6% and 58.9%. Those of rhesus antigens D, d, C, c, E and e were 97.7%; 2.3%; 15.9%; 99.9%; 17.6%; 99.3%, respectively. The prevalence of ABO and Rh antigens in Gabonese donors reported here are significantly different from those of neighboring countries. No association was found between the prevalence of HIV, HCV and syphilis and ABO blood groups. Instead, HBV seroprevalence was twice as high among non-O blood groups donors compared with blood group O donors [OR = 2 (CI 1.26 to 3.2), p = 0.003].Conclusions: This study provides new data on phenotypic frequency of ABO and Rh blood groups in a representative sample of the Gabonese blood donor population. It suggests a significant association between ABO blood group and HBV infection.

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Frequency of Mia (MNS7) and Classification of Mia-Positive Hybrid Glycophorins in an Australian Blood Donor Population

Transfusion Medicine and Hemotherapy ◽

10.1159/000504026 ◽

2019 ◽

Vol 47 (4) ◽

pp. 279-287

Author(s):

Genghis H. Lopez ◽

Brett Wilson ◽

Robyn M. Turner ◽

Glenda M. Millard ◽

Nicole S. Fraser ◽

...

Keyword(s):

Blood Group ◽

Blood Donor ◽

Asian Population ◽

Blood Group System ◽

Genes Encoding ◽

Donor Population ◽

Melting Analysis ◽

Hybrid Genes ◽

High Degree ◽

Group Profile

Background: MNS blood group system genes GYPA and GYPB share a high degree of sequence homology and gene structure. Homologous exchanges between GYPA and GYPB form hybrid genes encoding hybrid glycophorins GP(A-B-A) and GP(B-A-B). Over 20 hybrid glycophorins have been characterised. Each has a distinct phenotype defined by the profile of antigens expressed including Mia. Seven hybrid glycophorins carry Mia and have been reported in Caucasian and Asian population groups. In Australia, the population is diverse; however, the prevalence of hybrid glycophorins in the population has never been determined. The aims of this study were to determine the frequency of Mia and to classify Mia-positive hybrid glycophorins in an Australian blood donor population. Method: Blood samples from 5,098 Australian blood donors were randomly selected and screened for Mia using anti-Mia monoclonal antibody (CBC-172) by standard haemagglutination technique. Mia-positive red blood cells (RBCs) were further characterised using a panel of phenotyping reagents. Genotyping by high-resolution melting analysis and DNA sequencing were used to confirm serology. Result: RBCs from 11/5,098 samples were Mia-positive, representing a frequency of 0.22%. Serological and molecular typing identified four types of Mia-positive hybrid glycophorins: GP.Hut (n = 2), GP.Vw (n = 3), GP.Mur (n = 5), and 1 GP.Bun (n = 1). GP.Mur was the most common. Conclusion: This is the first comprehensive study on the frequency of Mia and types of hybrid glycophorins present in an Australian blood donor population. The demographics of Australia are diverse and ever-changing. Knowing the blood group profile in a population is essential to manage transfusion needs.

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Prevalence of Weak D (Du) in Blood Donors in a Referral Teaching Hospital

International Journal of Medical and Dental Sciences ◽

10.18311/ijmds/2017/18841 ◽

2017 ◽

Vol 6 (2) ◽

pp. 1509

Author(s):

H. S. Lamba ◽

Kulbir Kaur ◽

Kulwant Kaur ◽

Amarjit Singh Vij

Keyword(s):

Patient Care ◽

Blood Group ◽

Teaching Hospital ◽

Blood Donors ◽

Blood Product ◽

Blood Group Antigen ◽

Abo Blood Group ◽

Blood Samples ◽

Donor Population ◽

Gel Technique

Background: Rh D is the most important Blood Group antigen after ABO Blood group antigen for transfusion purpose. All negative blood units by routine methods must be tested to detect weak D using IAT method. When the test for D and Du is positive, the label should read Rh(D) Positive . When the test for D and Du is negative, the label should read Rh(D) Negative.Objective: To know the prevalence of weak D in the donor population. No study has been done in this part of the country earlier. It will help in the knowledge of weak D, which is very important for better patient care and prevent allo-immunzation in blood recipients.Materials and Methods: Blood samples were tested by ID Gel technique or by tube method with two anti D reagents - anti-D IgM monoclonal and blend of anti-D IgM&amp;IgG. All negative samples were further tested for weak D in IAT phase by LISS/Coombs' gel card.Results: A total of 13043 samples were tested from January 2011 to December 2013. 12196 were Rh positive and 847 were Rh D negative. Weak D was positive in 8 samples.Conclusion: The study shows the prevalence of weak D as 0.07% in blood donors who were primarily from in and around Jalandhar in Punjab. These donors may have posed problem to the recipients of blood and blood product and their detection prevented them from alloimunisation.

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ABO blood group and SARS‐CoV‐2 antibody response in a convalescent donor population

Vox Sanguinis ◽

10.1111/vox.13070 ◽

2021 ◽

Author(s):

Evan M. Bloch ◽

Eshan U. Patel ◽

Christi Marshall ◽

Kirsten Littlefield ◽

Ruchika Goel ◽

...

Keyword(s):

Antibody Response ◽

Blood Group ◽

Abo Blood Group ◽

Donor Population

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Comparison of antibody titers using conventional tube technique versus column agglutination technique in ABO blood group incompatible renal transplant

Asian Journal of Transfusion Science ◽

10.4103/0973-6247.214343 ◽

2017 ◽

Vol 11 (2) ◽

pp. 131 ◽

Cited By ~ 1

Author(s):

Amardeep Pathak ◽

Amit Bhangale ◽

Smita Pawar ◽

Tarun Jeloka

Keyword(s):

Renal Transplant ◽

Blood Group ◽

Abo Blood Group ◽

Antibody Titers

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DISTRIBUTION OF BLOOD GROUP IN BLOOD DONOR POPULATION IN WEST BENGAL

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2018/776 ◽

2018 ◽

Vol 7 (31) ◽

pp. 3445-3447

Author(s):

Arpita Chatterjee Halder ◽

Alpana De ◽

Saibendu Kumar Lahiri

Keyword(s):

Blood Group ◽

Blood Donor ◽

West Bengal ◽

Donor Population

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Distribution of Blood Types and ABO Gene Frequencies in Egypt

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqz131.006 ◽

2019 ◽

Vol 152 (Supplement_1) ◽

pp. S153-S153

Author(s):

Mohamed Abdelmonem ◽

Amira Fyala ◽

Ayman Boraik ◽

Mohamed Shedid ◽

Amira Husseiny Mohamed ◽

...

Keyword(s):

Blood Group ◽

Blood Groups ◽

Transfusion Practice ◽

Abo Blood Group ◽

Blood Group System ◽

Gene Frequencies ◽

Future Health ◽

Egyptian Population ◽

Naturally Occurring ◽

Donor Population

Abstract ABO blood group was first discovered by Landsteiner in 1901. Currently, there are more than 30 blood group systems, but ABO system remains the most clinically important of all blood groups in transfusion practice. The ABO blood group system antibodies are naturally occurring without any exposure to RBCs through transfusion or pregnancy, unlike the other blood group systems. Method The study was performed on a total of 40,591 healthy blood donors in Egypt. ABO and Rh (D) groupings were performed on all donors’ samples. Data on the frequency of ABO and Rh(D) blood groups were reported in numbers and percentages. Results The study showed that type A is the most common blood group (35.12%) in Egypt followed by O at 31.94%, followed by B at 23.12%, while AB had the least prevalence at 9.74%; A > O > B > AB. Our study showed that 91.78% of the donor population were Rh positive and 8.22% were Rh negative. The frequencies of the IA, IB, and IO alleles were calculated using the Hardy-Weinberg law of equilibrium. The calculated gene frequencies are 0.2537 for IA (p), 0.1812 for IB (q), and 0.5651 for IO (r). In the Egyptian population, O (r) records the highest value, followed by B (q) and A (p); O > B > A. The homozygous types were as follows: OO, 31.94%; AA, 6.43%; and BB, 3.28%. The heterozygous types were AO, 28.67%; BO, 20.47%; and AB, 9.78%. Conclusions The study provides the first accurate ABO gene frequency data as well as information on the distribution of ABO blood group Rh groups of various alleles in the Egyptian population. This information is very helpful in the effective management of the blood bank inventory. It will help transfusion services planning for future health challenge and improve blood transfusion practice.

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