scholarly journals ABO blood group and SARS‐CoV‐2 antibody response in a convalescent donor population

Vox Sanguinis ◽  
2021 ◽  
Author(s):  
Evan M. Bloch ◽  
Eshan U. Patel ◽  
Christi Marshall ◽  
Kirsten Littlefield ◽  
Ruchika Goel ◽  
...  
Keyword(s):  
Antibody Response ◽  
Blood Group ◽  
Abo Blood Group ◽  
Donor Population

scholarly journals Longitudinal SARS-CoV-2 Seroconversion Course and Antibody Levels by Blood Groups in Convalescent Plasma Donors in Turkey

2021 ◽  
Author(s):  
Aziz Karaca ◽  
Mustafa Nuri Günçıkan ◽  
Nazlı Nadire Sözmen ◽  
Gizem Gökçe Karadağ ◽  
Mustafa Yılmaz
Keyword(s):  
Antibody Response ◽  
Blood Group ◽  
Antibody Level ◽  
Time Course ◽  
Blood Groups ◽  
Group Method ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Igg Antibody ◽  
Rh Blood Group

Objective: The present study investigates the seroconversion time course of the IgG antibody against SARS-CoV-2 and ascertains whether its levels change according to the patient’s ABO blood group. Method: A total of 36,003-convalescent plasma (CP) donations of 12,315 Turkish Red Crescent CP donors were analyzed. The ABO blood group of the CP donors was determined by Gel Centrifugation; and IgG was measured using the Euroimmun anti-SARS-CoV-2 ELISA. The differences in the distributions of mean IgG ratios among the different ABO blood groups were analyzed with One-Way ANOVA and Independent Samples T-test. Results: Among the CP donors, 98.4% were male. An antibody response to SARS-CoV-2 was noted-although in a few CP donors- on the 244th day, and a significant association between the ABO blood groups and the mean IgG ratios was noted (p: 0.001). The highest (mean±SD) antibody level was observed in the AB blood group (39.5±15.7), followed by the B (37.9±11.5) and the A blood groups (36.6±10.7), while the lowest value was recorded in the O blood group (34.4±11.5). Significant differences between all paired groups were noted in pairwise comparisons. The Rh (-) blood group (37.4±13.6) had a significantly higher antibody level than the Rh (+) blood group (36.3±11.2) (p: 0.005). Conclusion: An antibody response to SARS-CoV-2 was noted in a CP donor on the 244th day. The average IgG ratios were higher in the CP donors with the AB blood group, but lower in the O blood group. These results may be considered a valuable indication of the effectiveness of CP therapy used for the treatment of COVID-19 patients with clinically relevant blood types.

scholarly journals Prevalence of Weak D (Du) in Blood Donors in a Referral Teaching Hospital

2017 ◽  
Vol 6 (2) ◽  
pp. 1509
Author(s):  
H. S. Lamba ◽  
Kulbir Kaur ◽  
Kulwant Kaur ◽  
Amarjit Singh Vij
Keyword(s):  
Patient Care ◽  
Blood Group ◽  
Teaching Hospital ◽  
Blood Donors ◽  
Blood Product ◽  
Blood Group Antigen ◽  
Abo Blood Group ◽  
Blood Samples ◽  
Donor Population ◽  
Gel Technique

<p><strong>Background:</strong> Rh D is the most important Blood Group antigen after ABO Blood group antigen for transfusion purpose. All negative blood units by routine methods must be tested to detect weak D using IAT method. When the test for D and D<sup>u</sup> is positive, the label should read Rh(D) Positive . When the test for D and D<sup>u</sup> is negative, the label should read Rh(D) Negative.</p><p><strong>Objective:</strong> To know the prevalence of weak D in the donor population. No study has been done in this part of the country earlier. It will help in the knowledge of weak D, which is very important for better patient care and prevent allo-immunzation in blood recipients.</p><p><strong>Materials and Methods:</strong> Blood samples were tested by ID Gel technique or by tube method with two anti D reagents - anti-D IgM monoclonal and blend of anti-D IgM&amp;amp;IgG. All negative samples were further tested for weak D in IAT phase by LISS/Coombs' gel card.</p><p><strong>Results:</strong> A total of 13043 samples were tested from January 2011 to December 2013. 12196 were Rh positive and 847 were Rh D negative. Weak D was positive in 8 samples.</p><p><strong>Conclusion:</strong> The study shows the prevalence of weak D as 0.07% in blood donors who were primarily from in and around Jalandhar in Punjab. These donors may have posed problem to the recipients of blood and blood product and their detection prevented them from alloimunisation.</p>

scholarly journals Prevalence of ABO blood group phenotypes and antibody titers of the blood donor population in and around Puducherry

2021 ◽  
Vol 8 (1) ◽  
pp. 28
Author(s):  
Abhishekh Basavarajegowda ◽  
Sridhar Gopal ◽  
Sujitha Kannan ◽  
Rajendra Kulkarni
Keyword(s):  
Blood Group ◽  
Blood Donor ◽  
Abo Blood Group ◽  
Donor Population ◽  
Antibody Titers

scholarly journals ABO blood group type does not influence the level of SARS-CoV-2 antibody response in convalescent plasma donors

2021 ◽  
Author(s):  
Klemen Žiberna ◽  
Katerina Jazbec ◽  
Mojca Jež ◽  
Polonca Mali ◽  
Urška Rahne Potokar ◽  
...  
Keyword(s):  
Antibody Response ◽  
Blood Group ◽  
Neutralizing Antibody ◽  
Antibody Test ◽  
Abo Blood Group ◽  
Serological Tests ◽  
Course Of Disease ◽  
Group Type ◽  
Group A ◽  
Blood Group Type

The association of ABO blood group types with the COVID-19 disease has been confirmed by several studies, with the blood group A-type patients being more susceptible and prone to more severe clinical course of disease. Similarly, some authors explored the association of ABO-types and the levels of anti-SARS-CoV-2 antibodies in convalescents. The recent reports mostly support a theory that non-O blood group convalescents present with higher levels of anti-SARS-CoV-2 antibodies. Since these findings were based on small convalescent cohorts, we quantified the anti-SARS-CoV-2 antibodiy levels in four larger cohorts of total 3185 convalescent plasma donors with three commercial serological tests and one standard neutralizing antibody test. The majority of donors had undergone a mild form of disease and the median time of sampling was 66 days after the onset of COVID-19 symptoms. None of the antibody quantitation methods showed an association of the ABO blood group types with the level of anti-SARS-CoV-2 antibodies. The same result is evident in the group of vaccinated individuals (n=370) as well as in the groups stratified into three post-COVID-19 periods (0-60, 60-120, and 120-180 days). In conclusion we can state that the ABO blood group type does not influence the level of SARS-CoV-2 antibody response in COVID-19 convalescent plasma donors.

Distribution of Blood Types and ABO Gene Frequencies in Egypt

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S153-S153
Author(s):  
Mohamed Abdelmonem ◽  
Amira Fyala ◽  
Ayman Boraik ◽  
Mohamed Shedid ◽  
Amira Husseiny Mohamed ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Groups ◽  
Transfusion Practice ◽  
Abo Blood Group ◽  
Blood Group System ◽  
Gene Frequencies ◽  
Future Health ◽  
Egyptian Population ◽  
Naturally Occurring ◽  
Donor Population

Abstract ABO blood group was first discovered by Landsteiner in 1901. Currently, there are more than 30 blood group systems, but ABO system remains the most clinically important of all blood groups in transfusion practice. The ABO blood group system antibodies are naturally occurring without any exposure to RBCs through transfusion or pregnancy, unlike the other blood group systems. Method The study was performed on a total of 40,591 healthy blood donors in Egypt. ABO and Rh (D) groupings were performed on all donors’ samples. Data on the frequency of ABO and Rh(D) blood groups were reported in numbers and percentages. Results The study showed that type A is the most common blood group (35.12%) in Egypt followed by O at 31.94%, followed by B at 23.12%, while AB had the least prevalence at 9.74%; A > O > B > AB. Our study showed that 91.78% of the donor population were Rh positive and 8.22% were Rh negative. The frequencies of the IA, IB, and IO alleles were calculated using the Hardy-Weinberg law of equilibrium. The calculated gene frequencies are 0.2537 for IA (p), 0.1812 for IB (q), and 0.5651 for IO (r). In the Egyptian population, O (r) records the highest value, followed by B (q) and A (p); O > B > A. The homozygous types were as follows: OO, 31.94%; AA, 6.43%; and BB, 3.28%. The heterozygous types were AO, 28.67%; BO, 20.47%; and AB, 9.78%. Conclusions The study provides the first accurate ABO gene frequency data as well as information on the distribution of ABO blood group Rh groups of various alleles in the Egyptian population. This information is very helpful in the effective management of the blood bank inventory. It will help transfusion services planning for future health challenge and improve blood transfusion practice.

scholarly journals Does ABO blood group influence antibody response to SARS‐CoV ‐2 vaccination?

Vox Sanguinis ◽  
2021 ◽  
Author(s):  
Costanza Vicentini ◽  
Valerio Bordino ◽  
Alessandro Roberto Cornio ◽  
Davide Meddis ◽  
Savina Ditommaso ◽  
...  
Keyword(s):  
Antibody Response ◽  
Blood Group ◽  
Abo Blood Group ◽  
Group Influence

scholarly journals ABO, Rhesus blood groups and transfusion-transmitted infections among blood donors in Gabon

2018 ◽  
Vol 13 (1) ◽  
pp. 12 ◽  
Author(s):  
Christ-Dominique Ngassaki-Yoka ◽  
Jophrette Mireille Ntsame Ndong ◽  
Cyrille Bisseye
Keyword(s):  
Blood Group ◽  
Blood Donor ◽  
Representative Sample ◽  
Blood Donors ◽  
Blood Groups ◽  
Abo Blood Group ◽  
Blood Group Antigens ◽  
Abo Blood Groups ◽  
Donor Population ◽  
Monospecific Antisera

Background: Few studies focused on the study of blood groups in Gabon. This study aimed to determine the phenotypic frequency of ABO and Rhesus antigens in blood donors of Libreville and to assess the association between ABO blood groups and transfusion-transmitted infections.Materials and Methods: The study of ABO and Rhesus blood groups concerned 4,744 blood donors. ABO and Rhesus phenotyping were obtained using monoclonal monospecific antisera: anti-A, anti-B, anti-AB, anti-D, anti-E, anti-C, anti-c, and anti-e with an automate (QWALYS® 3, DIAGAST, France) or a card gel (ID Card, BIO-RAD) according to manufacturer’s instructions.Results: The phenotypic frequency of blood group antigens A, B, AB and O were respectively 21.0%; 17.6%; 2.6% and 58.9%. Those of rhesus antigens D, d, C, c, E and e were 97.7%; 2.3%; 15.9%; 99.9%; 17.6%; 99.3%, respectively. The prevalence of ABO and Rh antigens in Gabonese donors reported here are significantly different from those of neighboring countries. No association was found between the prevalence of HIV, HCV and syphilis and ABO blood groups. Instead, HBV seroprevalence was twice as high among non-O blood groups donors compared with blood group O donors [OR = 2 (CI 1.26 to 3.2), p = 0.003].Conclusions: This study provides new data on phenotypic frequency of ABO and Rh blood groups in a representative sample of the Gabonese blood donor population. It suggests a significant association between ABO blood group and HBV infection.

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