Corneal endothelial cells and central corneal thickness in patients with neurofibromatosis type 1

Purpose: To compare the corneal endothelial cells morphology and central corneal thickness (CCT) before and after phacoemulsification in Sudanese population. Place and Duration of Study: Al-Neelain eye hospital, Khartoum, Sudan, from January 2018 to May 2018. Study Design: Observational longitudinal study. Methods: One hundred and forty eyes of 140 patients with immature senile cataract were selected by convenient sampling. The age ranged from 40 to 85 years. The patients underwent complete ocular examination including morphology of corneal endothelial cells and CCT using computerized non-contact specular microscope. Inclusion criteria for the study was eyes with normal corneal endothelial cells and cell density more than 1000 cells/mm2. We excluded patients with ocular or systemic diseases, previous history of intraocular surgery, refractive surgery or trauma as well as contact lenses wear. The patients underwent phacoemulsification by a single surgeon. The examination parameters were repeated one month after surgery. Descriptive and comparative statistical analyses were performed using SPSS for Windows Version 21.0. Results: There was significant reduction in mean endothelial cells density after phacoemulsification compared to baseline with p < 0.001. There was also significant post-operative reduction in mean endothelial cells number as compared to baseline (P value < 0.001). Mean endothelial cells hexagonality was reduced after surgery with P value of 0.003. No significant difference was found between mean coefficient variation of endothelial cells size before and after phacoemulsification (P = 0.55). Central corneal thickness showed significant increase post-operatively, P = 0.003. Conclusion: Phacoemulsification causes significant damage to corneal endothelium cells, including decrease in corneal endothelial cell density, hexagonality and cell number. Key Words: Corneal endothelium, Endothelial cell density, Central corneal thickness, Phacoemulsification.

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Biometric and refractive errors evaluation in patients with neurofibromatosis type 1

European Journal of Ophthalmology ◽

10.1177/1120672120934402 ◽

2020 ◽

pp. 112067212093440

Author(s):

Aldo Vagge ◽

Paolo Corazza ◽

Roberta Vagge ◽

Giulia Agosto ◽

Michele Iester ◽

...

Keyword(s):

Neurofibromatosis Type 1 ◽

Healthy Subjects ◽

Corneal Thickness ◽

Neurofibromatosis Type ◽

Controlled Study ◽

Control Group ◽

Refractive Errors ◽

P Values ◽

Healthy Control

Purpose: To analyze biometric changes and prevalence of refractive in patients with neurofibromatosis type 1 (NF1). Methods: Retrospective, case-controlled study involving patients affected by NF1 and healthy control subjects. Data on biometric measurements such as axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), keratometry (K1 and K2) values, and white-to-white (WTW), obtained by use of optical low-coherence reflectometry on a Lenstar LS 900® (Haag-Streit AG, Switzerland) were collected and analyzed. Cycloplegic refractions were then performed. Results: Overall, 166 eyes of 83 patients diagnosed with NF1 (mean age 21.6 ± 9.8) were enrolled and compared with 178 eyes of age-matched healthy subjects (mean age 22.6 ± 6.6). One hundred sixty-six (22.8%) and 33 of 178 (18.5%) eyes were myopic in NF1 patients and healthy subjects, respectively. The prevalence of hyperopia in the NF1 group was 12 of 166 (7.2%) whereas in the healthy control group was 14 of 178 (8.9%). Twenty-nine of 166 (17.4%) and 34 of 178 (19.1%) eyes presented astigmatism in NF1 and control group, respectively. These differences were not statistically significant ( p-values > 0.05). Refractive errors such as myopia, hyperopia, and astigmatism were similar between the two groups. The difference of AL, CCT, ACD, LT, K values, and WTW were no statistically significant between the two groups ( p-values > 0.05). Conclusion: Refractive errors and ocular biometric parameter seem not to be an addition findings of NF1.

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Changes in Corneal Endothelial Cells Morphology Due to Different Cataract Surgery Procedures: A Retrospective Study From November 2014 to November 2016

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v17i2.278 ◽

2020 ◽

Vol 17 (2) ◽

Author(s):

Ma Bariah ◽

Leong SY

Keyword(s):

Endothelial Cells ◽

Cataract Surgery ◽

Refractive Error ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Dissipated Energy ◽

Corneal Endothelial Cells ◽

Significant Difference ◽

Duration Of Surgery ◽

Snellen Chart

Introduction: The corneal endothelium is made up of an extremely thin layer of non -regenerating cells essential in keeping the cornea clear. The purpose of this study was to quantify the corneal endothelial cells morphology, visual acuity (VA) and refractive error in patients having femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification surgery (CPS). Methods: Clinical data from 56 eyes were included in this study. 28 eyes had FLACS surgery and another 28 eyes had CPS. Distance VA, refractive error, corneal thickness and endothelial cells morphology were evaluated pre-operatively and at 1 month follow up. Refractive error was determined subjectively and VA was taken using Snellen chart. Specular microscope was used to measure endothelial cells morphology and central corneal thickness. Mann Whitney test and Spearman correlation analysis were used to analyse the results. Results: There were no statistically significant difference in the mean endothelial cell density (p=0.24), mean central corneal thickness (p=0.68), mean coefficient of variance (p=0.19), mean hexagonality (p=0.44), VA (p=0.72) and postoperative refractive outcome (p=0.66) between both groups. The duration of surgery was noted to have no statistically significant difference between both groups (p=0.08), while the cumulative dissipated energy and torsional time showed a significant difference between groups (p=0.01 and p<0.01 respectively). Conclusion: This study concluded that there was no significant difference in the endothelial cells morphology in patients undergoing both cataract surgeries. Both surgeries presented similar outcomes in the patients’ eyes.

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Central Corneal Thickness and Corneal Endothelial Cells in Pseudoexfoliation Syndrome

Journal of the Korean Ophthalmological Society ◽

10.3341/jkos.2013.54.7.1060 ◽

2013 ◽

Vol 54 (7) ◽

pp. 1060 ◽

Cited By ~ 1

Author(s):

In Boem Chang ◽

Dong Won Paik ◽

Tai Jin Kim ◽

Hyo Shin Ha ◽

Jung Hyun Park

Keyword(s):

Endothelial Cells ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Pseudoexfoliation Syndrome ◽

Corneal Endothelial Cells

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Effect of short-term orthokeratology lens or ordinary frame glasses wear on corneal thickness, corneal endothelial cells and vision correction in adolescents with low to moderate myopia

BMC Ophthalmology ◽

10.1186/s12886-019-1222-y ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Shuyi Yuan ◽

Shuxian Zhang ◽

Yanglin Jiang ◽

Lihua Li

Keyword(s):

Endothelial Cells ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Control Group ◽

Corneal Curvature ◽

Corneal Endothelial Cells ◽

Short Term ◽

Naked Eye ◽

Vision Correction ◽

Experimental Group

Abstract Background We aimed to investigate the effect of short-term orthokeratology lens or frame glasses wear on corneal thickness, corneal endothelial cells and vision correction in adolescents with low to moderate myopia. Methods Data of 100 adolescents with low to moderate myopia were retrospectively analyzed. The patients were assigned into two groups. The experimental group were treated with night-wear orthokeratology lens, and control group were treated with ordinary frame glasses. Follow up was carried out at the 3rd, 6th and 12th months of treatment. The naked-eye vision, diopter, corneal curvature, intraocular pressure, axial length, endothelial cell count and central corneal thickness were examined. Complications within 12 months were observed, and corneal fluorescein staining was graded. Results The naked-eye vision of the experimental group was significantly higher than that of the control group at the 3rd, 6th and 12th months, while the diopter of the experimental group was significantly lower than that of the control group at these time points. The corneal curvature of the experimental group was significantly decreased when comparing with that of the control group at the above 3 time points. The increase of axial length in the experimental group was significantly less than that in the control group at the 6th and 12th months. Conclusions Short-term orthokeratology lens wear can effectively improve the naked-eye vision in adolescents with low to moderate myopia without significant impact on the central corneal thickness and corneal endothelial cells. It is a relatively safe method to correct myopia.

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