scholarly journals Diagnostic dilemmas in Epstein-Barr virus hepatitis mimicking autoimmune hepatitis: A case report

2020 ◽  
Vol 9 (5) ◽  
pp. 2502
Author(s):  
Ekta Gupta ◽  
Krithiga Ramachandran ◽  
Reshu Agarwal ◽  
Chhagan Bihari ◽  
Vikram Bhatia
2019 ◽  
Vol 12 (5) ◽  
pp. e228356 ◽  
Author(s):  
Marika Valota ◽  
Friedrich Thienemann ◽  
Benjamin Misselwitz

Acute hepatitis remains a diagnostic challenge, and numerous infectious, metabolic and autoimmune diseases need to be effectively excluded. We present a case of a young woman with malaise, fever, jaundice and deranged liver function tests. Testing for Epstein–Barr virus (EBV) virus capsid antigen IgM/IgG was positive. Total IgG was elevated, along with positive serology for anti-hepatitis A virus (HAV)-IgM, antinuclear antibodies (ANAs) and soluble liver antigen (SLA) leading to the differential diagnosis of acute hepatitis A and autoimmune hepatitis. No specific treatment was started and liver function gradually improved. At week 4, HAV IgG and IgM were negative. At month 4, ANA and SLA were negative and total IgG normalised; EBV nuclear antigen became positive. Testing for EBV is an investigation required at baseline in acute hepatitis and physicians should carefully evaluate serological results, including those for viral and autoimmune hepatitis that may be falsely positive in infectious mononucleosis.


1996 ◽  
Vol 21 (2) ◽  
pp. 123-126
Author(s):  
U. BALDARI ◽  
A. ASCARI RACCAGNI ◽  
B. CELLI ◽  
M. GIOVANNA RIGHINI

1997 ◽  
Vol 3 (6) ◽  
pp. 460-464 ◽  
Author(s):  
Elennora PM Corssmit ◽  
Maureen A Leverstein-Van Hall ◽  
Peter Portegies ◽  
Piet Bakker

2009 ◽  
Vol 55 (5) ◽  
pp. 332-334 ◽  
Author(s):  
G. Ventura ◽  
M.B. Lucia ◽  
F. Damiano ◽  
R. Cauda ◽  
L.M. Larocca

2013 ◽  
Vol 3 (1) ◽  
pp. 74-75
Author(s):  
Fatih Akin ◽  
Celebi Kocaoglu ◽  
Ece Selma Solak ◽  
Halil Ozdemir ◽  
Bayram Pektas ◽  
...  

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Paulina Cybulska ◽  
Andy Ni ◽  
Carolina Jimenez-Rivera

Introduction. Clinical presentation of viral hepatitis ranges from mild symptoms to fulminant hepatitis. Our aim is to describe clinical presentation and outcomes of children with viral hepatitis from the Eastern Ontario/Western Quebec regions of Canada. Methods. Retrospective chart review of children diagnosed with viral hepatitis at our institution from January 1, 1998, to December 31, 2007. Results. There were 261 charts reviewed, only 64 had a confirmed viral etiology: 34 (53%) hepatitis B (HBV), 16 (25%) hepatitis C (HCV), 4 (6.3%) hepatitis A (HAV), 7 (11%) cytomegalovirus (CMV), and 3 (4.7%) Epstein-Barr virus (EBV). Children with HBV presented at a mean age of 6.4±4.6 years. Spontaneous seroconversion (appearance of HBVeAb and loss of HBVeAg) occurred in 21/34 (61.7%). Children with acute hepatitis (HAV, CMV, and EBV) presented with mild abdominal pain, jaundice, and fevers. Overall outcome was excellent. Conclusion. Acute and chronic hepatitis in children has a benign course; moreover, HBV spontaneous seroconversion is common in pediatric patients.


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