The relationship between hemoglobin A1C levels and sputum conversion time in indonesian patients with new cases of pulmonary tuberculosis

Introduction: Pulmonary tuberculosis is a contagious bacterial infection that involves the lungs and it may spread to other organs. Sputum smear and culture conversion are important indicators for the effectiveness of treatment and the infectivity of the patient. The present study aims to find sputum smear and culture conversion time and the factors that influence the conversion time among tuberculosis patients at National Tuberculosis Centre in Nepal. Methods: A total of 54 patients, who were diagnosed with laboratory confirmed pulmonary tuberculosis and under antitubercular therapy were monitored for sputum smear and culture conversion time. The blood specimens from each patient were processed for hemoglobin, platelets, erythrocyte sedimentation rate and blood glucose levels. Patient’s clinical history, risk factors that prolong conversion time and sociodemographic information were also collected by direct interview. Results: The mean sputum smear and culture conversion were found to be 54.4 days and 45.5 days respectively. Old age, smoking habit, low body mass index value, Treatment category II, initial bacillary load and abnormal erythrocyte sedimentation rate values were found to be associated with long sputum conversion time. Radiographic involvement of only left lungs, presence of fewer symptoms, aged between 15-45 years, having normal weight, without smoking habit and being married, were found to be associated with short sputum conversion time. Conclusions: The sputum microscopy, old age, smoking habit, low body mass index value, treatment category II, initial bacillary load and abnormal erythrocyte sedimentation rate value had been found to be significantly associated with long sputum conversion time.

Download Full-text

Zinc and vitamin A supplementation fails to reduce sputum conversion time in severely malnourished pulmonary tuberculosis patients in Indonesia

Nutrition Journal ◽

10.1186/1475-2891-9-41 ◽

2010 ◽

Vol 9 (1) ◽

Cited By ~ 31

Author(s):

Trevino A Pakasi ◽

Elvina Karyadi ◽

Ni Made Desy Suratih ◽

Michael Salean ◽

Nining Darmawidjaja ◽

...

Keyword(s):

Vitamin A ◽

Pulmonary Tuberculosis ◽

Vitamin A Supplementation ◽

Tuberculosis Patients ◽

Sputum Conversion ◽

Conversion Time

Download Full-text

Baseline Characteristics of Patients and the Effect of Fixed-Dose Combination Chemotherapy on Sputum Conversion Time in Active Pulmonary Tuberculosis: A Preliminary Study in Kandy District, Sri Lanka

SAARC Journal of Tuberculosis Lung Diseases and HIV/AIDS ◽

10.3126/saarctb.v5i1.3076 ◽

2010 ◽

Vol 5 (1) ◽

pp. 1-6

Author(s):

KAS Jayawardena ◽

M Samarathunga

Keyword(s):

Sri Lanka ◽

Pulmonary Tuberculosis ◽

Conversion Rate ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Heavy Smoking ◽

Active Pulmonary Tuberculosis ◽

Sputum Conversion ◽

Dose Combination ◽

Conversion Time

Main Objective: To evaluate the effect of Fixed-Dose Combination (FDC) drugs on sputum conversion time in active tuberculosis. Method: A prospective study of 58 active pulmonary tuberculosis patients in Kandy District Sri Lanka. Results: The mean sputum conversion time was 3.836 weeks (SD 2.599) and the median was 4.00 weeks. The sputum conversion rate at the end of 8 weeks was 96.36%. Initial bacillary load indicated by sputum smear grading was highly correlated with sputum conversion time (r = 0.531 P = 0.000). Gender was associated with sputum conversion time. Women had significantly shorter sputum conversion time. (T value =2.23, P = 0.03, Df = 48). Heavy smoking was associated with delayed sputum conversion in male patients (p = 0.01). Conclusion: Use of FDC in active pulmonary tuberculosis yields high sputum conversion rate with a mean sputum conversion time of 3.4 weeks. Faster sputum conversion among women may be attributed to their stronger genetic constitution and healthy lifestyles. Heavy smoking is associated with delayed sputum conversion. Key words: FDC Drugs; sputum conversion time; pulmonary tuberculosis; Sri Lanka DOI: 10.3126/saarctb.v5i1.3076 SAARC J. Tuber. Lung Dis. HIV/AIDS 2008 Vol.5(1) 1-6

Download Full-text

Vitamin D receptor gene polymorphisms and sputum conversion time in pulmonary tuberculosis patients

Tuberculosis ◽

10.1016/j.tube.2007.03.001 ◽

2007 ◽

Vol 87 (4) ◽

pp. 295-302 ◽

Cited By ~ 55

Author(s):

C. Babb ◽

L. van der Merwe ◽

N. Beyers ◽

C. Pheiffer ◽

G. Walzl ◽

...

Keyword(s):

Vitamin D ◽

Pulmonary Tuberculosis ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Receptor Gene ◽

Vitamin D Receptor Gene ◽

Tuberculosis Patients ◽

Sputum Conversion ◽

Conversion Time ◽

Receptor Gene Polymorphisms

Download Full-text

A Decade of Disparities in Diabetes Technology Use and HbA1c in Pediatric Type 1 Diabetes: A Trans-Atlantic Comparison

10.2337/figshare.12808301 ◽

2020 ◽

Author(s):

Ananta Addala ◽

Marie Auzanneau ◽

Kellee Miller ◽

Werner Maier ◽

Nicole Foster ◽

...

Keyword(s):

Type 1 Diabetes ◽

Technology Use ◽

Hemoglobin A1c ◽

Diabetes Technology ◽

Design And Methods ◽

Relationship Of ◽

The Relationship ◽

Pediatric Type 1 Diabetes

Objective: As diabetes technology use in youth increases worldwide, inequalities in access may exacerbate disparities in hemoglobin A1c (HbA1c). We hypothesized an increasing gap in diabetes technology use by socioeconomic status (SES) would be associated with increased HbA1c disparities. Research Design and Methods: Participants aged <18 years with diabetes duration ≥1 year in the Type 1 Diabetes Exchange (T1DX, US, n=16,457) and Diabetes Prospective Follow-up (DPV, Germany, n=39,836) registries were categorized into lowest (Q1) to highest (Q5) SES quintiles. Multiple regression analyses compared the relationship of SES quintiles with diabetes technology use and HbA1c from 2010-2012 and 2016-2018. Results: HbA1c was higher in participants with lower SES (in 2010-2012 & 2016-2018, respectively: 8.0% & 7.8% in Q1 and 7.6% & 7.5% in Q5 for DPV; and 9.0% & 9.3% in Q1 and 7.8% & 8.0% in Q5 for T1DX). For DPV, the association between SES and HbA1c did not change between the two time periods, whereas for T1DX, disparities in HbA1c by SES increased significantly (p<0.001). After adjusting for technology use, results for DPV did not change whereas the increase in T1DX was no longer significant. Conclusions: Although causal conclusions cannot be drawn, diabetes technology use is lowest and HbA1c is highest in those of the lowest SES quintile in the T1DX and this difference for HbA1c broadened in the last decade. Associations of SES with technology use and HbA1c were weaker in the DPV registry.

Download Full-text

Relationship Of Patient's Motivation Concerning Prevention Of Transmission With Compliance With The Use Of Mask On Lung Tuberculosis Patients

Jurnal Kesehatan dr. Soebandi ◽

10.36858/jkds.v6i2.123 ◽

2018 ◽

Vol 6 (2) ◽

pp. 30-35

Author(s):

Ade Ella Nur Rizky Oktaviyanti

Keyword(s):

Pulmonary Tuberculosis ◽

Health Center ◽

Disease Transmission ◽

Positive Direction ◽

Individual Motivation ◽

Tuberculosis Patients ◽

Correlation Test ◽

Patient Motivation ◽

Relationship Of ◽

The Relationship

One of the factors that influence compliance is individual motivation. There are still many pulmonary tuberculosis patients who do not wear masks, this can have an impact on disease transmission. Poor individual motivation can affect someone's compliance. The purpose of this research is to determine the relationship of patient motivation regarding prevention of transmission with adherence to the use of masks in patients with pulmonary tuberculosis in Rambipuji Health Center, Jember Regency. This research uses descriptive correlative type of research. In this study using a cross-sectional approach. The sample of this study was taken using simple random sampling, namely pulmonary tuberculosis patients at the Rambipuji Health Center in Jember Regency, totaling 105 patients but only 50 patients were used as samples. This research was conducted by giving a questionnaire to pulmonary tuberculosis patients to find out the patient's motivation about preventing transmission by adhering to the use of masks. The results of the study were analyzed using the Lambda Correlation Test, the results of the analysis found that the motivation of patients was good motivation (22%), patient motivation was sufficient (56%), and patient motivation was less motivation (22%). Whereas adherence to the use of masks in pulmonary tuberculosis patients is compliant (36%), and non-compliant (64%). The Lambda Correlation Test results obtained from the variable compliance with ρ = 0.389 positive direction with a value of ρ count of 0.027 <0.05 which means there is a relationship between patient motivation about prevention of transmission with compliance with the use of masks in patients with pulmonary tuberculosis in Rambipuji Health Center, Jember District. It is recommended that further studies be able to conduct more in-depth research related to the relationship of patient motivation regarding the prevention of transmission with adherence to the use of masks in pulmonary tuberculosis patients

Download Full-text

The Relationship Between Inflammatory Marker Levels and Pulmonary Tuberculosis Severity

Inflammation ◽

10.1007/s10753-014-9978-y ◽

2014 ◽

Vol 38 (2) ◽

pp. 691-696 ◽

Cited By ~ 22

Author(s):

Ozlem Abakay ◽

Abdurrahman Abakay ◽

Hadice Selimoglu Sen ◽

Abdullah C. Tanrikulu

Keyword(s):

Pulmonary Tuberculosis ◽

Inflammatory Marker ◽

The Relationship

Download Full-text

Factors Influencing Sputum Conversion among Smear-Positive Pulmonary Tuberculosis Patients in Morocco

ISRN Pulmonology ◽

10.1155/2013/486507 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 6

Author(s):

Khalid Bouti ◽

Mohammed Aharmim ◽

Karima Marc ◽

Mouna Soualhi ◽

Rachida Zahraoui ◽

...

Keyword(s):

Pulmonary Tuberculosis ◽

Stepwise Regression ◽

Control Measures ◽

Sputum Smear ◽

Tuberculosis Patients ◽

Infection Control Measures ◽

Factors Influencing ◽

Smear Positive Pulmonary Tuberculosis ◽

Sputum Conversion ◽

A Prospective Study

Background. Sputum smear-positive pulmonary tuberculosis patients expel infectious viable bacilli for a period following the commencement of treatment. Objective. To determine the time to sputum smear conversion and study the factors influencing it. Design. A prospective study was undertaken at our hospital in Rabat over a six-month period on a cohort of 119 sputum smear positive patients. Patients were followed up fortnightly. At each followup, specimens were collected and processed for microscopy using standard protocol. Results. 96.6% of our patients completed the study (4 deaths). Sputum conversion rate was 42% after two weeks, 73% after one month, and 95% after two months. Univariate and stepwise regression analysis showed that patients who had high smear grading, miliary, and bilateral radiologic lesions were more likely to undergo delayed sputum conversion (P<0.05). Other factors were thought to influence sputum conversion but were not statistically proven in our study. Conclusion. Since viable bacilli continue to be expelled for up to two months, infection control measures should be maintained for such a time. Patients with high smear grading, miliary, and bilateral radiologic lesions need to be monitored more closely.

Download Full-text