Diagnostic techniques for human papillomavirus detection for early diagnosis of endocervical adenocarcinoma

2021 ◽  
Vol 6 (1) ◽  
pp. 6
Author(s):  
AbdullahBandar Almutiri
Keyword(s):  
Human Papillomavirus ◽  
Early Diagnosis ◽  
Diagnostic Techniques ◽  
Endocervical Adenocarcinoma

scholarly journals Advanced and futuristic approaches for breast cancer diagnosis

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Jayanti Mishra ◽  
Bhumika Kumar ◽  
Monika Targhotra ◽  
P. K. Sahoo
Keyword(s):  
Breast Cancer ◽  
Early Diagnosis ◽  
Cancer Diagnosis ◽  
Breast Cancer Diagnosis ◽  
Diagnostic Techniques ◽  
Main Body ◽  
Detection Techniques ◽  
Initial Stage ◽  
Common Causes ◽  
Delay In Treatment

Abstract Background Breast cancer is the most frequent cancer and one of the most common causes of death in women, impacting almost 2 million women each year. Tenacity or perseverance of breast cancer in women is very high these days with an extensive increasing rate of 3 to 5% every year. Along with hurdles faced during treatment of breast tumor, one of the crucial causes of delay in treatment is invasive and poor diagnostic techniques for breast cancer hence the early diagnosis of breast tumors will help us to improve its management and treatment in the initial stage. Main body Present review aims to explore diagnostic techniques for breast cancer that are currently being used, recent advancements that aids in prior detection and evaluation and are extensively focused on techniques that are going to be future of breast cancer detection with better efficiency and lesser pain to patients so that it helps to a physician to prevent delay in treatment of cancer. Here, we have discussed mammography and its advanced forms that are the need of current era, techniques involving radiation such as radionuclide methods, the potential of nanotechnology by using nanoparticle in breast cancer, and how the new inventions such as breath biopsy, and X-ray diffraction of hair can simply use as a prominent method in breast cancer early and easy detection tool. Conclusion It is observed significantly that advancement in detection techniques is helping in early diagnosis of breast cancer; however, we have to also focus on techniques that will improve the future of cancer diagnosis in like optical imaging and HER2 testing.

scholarly journals Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus–Positive and Human Papillomavirus–Negative Tumors

2017 ◽  
Vol 141 (12) ◽  
pp. 1653-1667 ◽  
Author(s):  
Edyta C. Pirog
Keyword(s):  
Human Papillomavirus ◽  
Early Diagnosis ◽  
Cervical Adenocarcinoma ◽  
Molecular Testing ◽  
Endometrioid Adenocarcinoma ◽  
Adenocarcinoma In Situ ◽  
Depth Of Invasion ◽  
Tumor Type ◽  
Cervical Adenocarcinomas ◽  
Tumor Types

Context.— Cervical adenocarcinomas span a diverse group of tumors with several distinct histologic tumor types, which include endocervical, endometrioid, intestinal, villoglandular, gastric, signet ring, serous, clear cell, and mesonephric. Diagnosis of cervical adenocarcinoma, especially early diagnosis, poses a significant challenge. Objective.— To review the pathogenesis, diagnostic criteria, immunohistochemical markers, and differential diagnosis of various subtypes of human papillomavirus (HPV)–positive and HPV-negative cervical adenocarcinomas. The paper presents a concise summary of the issues that may be particularly difficult in histopathologic diagnosis, such as differentiating neoplastic lesions from benign mimics, determining the tumor type, differentiating early invasive lesions from adenocarcinoma in situ, measuring the depth of invasion, and, finally, differentiating primary cervical adenocarcinoma from uterine endometrioid adenocarcinoma and tumors metastatic from other primary sites. Data Sources.— The study employed a PubMed search of recently published reports. Conclusions.— Early detection of HPV-positive tumor types may be aided with the expansion of HPV testing; however, early diagnosis of HPV-negative cervical adenocarcinomas will continue to pose a challenge and may require the development of additional molecular testing techniques.

scholarly journals Absence of High-Risk Human Papillomavirus (HPV) Detection in Endocervical Adenocarcinoma with Gastric Morphology and Phenotype

2010 ◽  
Vol 177 (5) ◽  
pp. 2169-2175 ◽  
Author(s):  
Yasuki Kusanagi ◽  
Atsumi Kojima ◽  
Yoshiki Mikami ◽  
Takako Kiyokawa ◽  
Tamotsu Sudo ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Endocervical Adenocarcinoma

scholarly journals The Main Clinical Signs and Early Diagnosis of Canine Dirofilariosis in the Veterinary Practice of Farms in the Republic of Armenia

2020 ◽  
Vol 14 (3) ◽  
pp. 63-68
Author(s):  
R. V. Slobodyanik ◽  
A. L. Kryazhev
Keyword(s):  
Early Diagnosis ◽  
Blood Serum ◽  
Visual Detection ◽  
Clinical Signs ◽  
Diagnostic Techniques ◽  
Immunochromatographic Test ◽  
Test Systems ◽  
One Step ◽  
Rapid Tests ◽  
The Republic

The purpose of the research is to determine the main clinical signs of dirofilariosis in dogs, taking into account the peculiarities of animal exploitation and to analyze the efficacy and convenience of using some diagnostic techniques. Materials and methods. The main clinical signs of dirofilariosis in dogs on the farms of Armenia have been studied. The presence of microfilariae was determined in native smears and using a modified Knott method. We also used the Asan Easy Test Heartworm and SNAP 4Dx Plus Test one-step cassette rapid tests for visual detection of Dirofilaria spp. antigen in blood serum. Results and discussion. 8.5% of dogs in the farms of the Republic of Armenia are infected with Dirofilaria sp. The most infected were dogs aged 5–8 years (75%). The main symptomatic signs of dirofilariosis in dogs were established in the specific conditions of the studied region and the specifics of the specific exploitation of animals. It has been established that the immunochromatographic test systems Asan Easy Test Heartworm and SNAP 4Dx Plus Test for visual detection of canine Dirofilaria spp. antigen in blood serum are the most effective for the diagnosis of dirofilariosis.

scholarly journals Diagnostics of medullary thyroid cancer and the strategy of its management in the absence of biochemical remission

2011 ◽  
Vol 57 (6) ◽  
pp. 45-51
Author(s):  
D O Gazizova ◽  
D G Bel'tsevich ◽  
A N Tiul'pakov ◽  
O V Simakina ◽  
T V Soldatova
Keyword(s):  
Thyroid Cancer ◽  
Early Diagnosis ◽  
Successful Treatment ◽  
Medullary Thyroid Cancer ◽  
Diagnostic Techniques ◽  
Term Treatment ◽  
Medullary Thyroid ◽  
Long Term Treatment ◽  
Biochemical Remission

Early diagnosis greatly facilitates successful treatment of medullary thyroid cancer. The present paper is designed to report the results of analysis of the studies carried out with the use of various diagnostic techniques and the data obtained during the long-term treatment of the patients with this pathology in the absence of biochemical remission.

Highly sensitive detection of the human papillomavirus E6 protein by DNA-protected silver nanoclusters and the intrinsic mechanism

2019 ◽  
Vol 43 (37) ◽  
pp. 14944-14951
Author(s):  
Xiang-Yu Jia ◽  
Ya-Rong Xue ◽  
Chun-Xia Zhang ◽  
Quan Luo ◽  
Yuqing Wu
Keyword(s):  
Human Papillomavirus ◽  
Early Diagnosis ◽  
Silver Nanoclusters ◽  
Sensitive Detection ◽  
Biological Application ◽  
Intrinsic Mechanism ◽  
Highly Sensitive ◽  
Highly Sensitive Detection ◽  
E6 Protein

The present study not only supplies a good approach for the early diagnosis of HPV-related cancer but also enriches the biological application of AgNCs–dsDNA.

A cornucopia of screening and diagnostic techniques for human papillomavirus associated cervical carcinomas

2015 ◽  
Vol 222 ◽  
pp. 192-201 ◽  
Author(s):  
Memoona Ramzan ◽  
Noor ul Ain ◽  
Sadaf Ilyas ◽  
Muhammad Umer ◽  
Sadia Bano ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Diagnostic Techniques ◽  
Cervical Carcinomas

scholarly journals Immunodiagnosis and Immunotherapeutics Based on Human Papillomavirus for HPV-Induced Cancers

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhen Dong ◽  
Renjian Hu ◽  
Yan Du ◽  
Li Tan ◽  
Lin Li ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Early Diagnosis ◽  
Hpv Infection ◽  
Research Progress ◽  
Immunological Methods ◽  
Malignant Neoplasms ◽  
Single Chain ◽  
Induced Tumors ◽  
Antibody Mimics ◽  
E6 And E7

Infection with human papillomavirus (HPV) is one of the main causes of malignant neoplasms, especially cervical, anogenital, and oropharyngeal cancers. Although we have developed preventive vaccines that can protect from HPV infection, there are still many new cases of HPV-related cancers worldwide. Early diagnosis and therapy are therefore important for the treatment of these diseases. As HPVs are the major contributors to these cancers, it is reasonable to develop reagents, kits, or devices to detect and eliminate HPVs for early diagnosis and therapeutics. Immunological methods are precise strategies that are promising for the accurate detection and blockade of HPVs. During the last decades, the mechanism of how HPVs induce neoplasms has been extensively elucidated, and several oncogenic HPV early proteins, including E5, E6, and E7, have been shown to be positively related to the oncogenesis and malignancy of HPV-induced cancers. These oncoproteins are promising biomarkers for diagnosis and as targets for the therapeutics of HPV-related cancers. Importantly, many specific monoclonal antibodies (mAbs), or newly designed antibody mimics, as well as new immunological kits, devices, and reagents have been developed for both the immunodiagnosis and immunotherapeutics of HPV-induced cancers. In the current review, we summarize the research progress in the immunodiagnosis and immunotherapeutics based on HPV for HPV-induced cancers. In particular, we depict the most promising serological methods for the detection of HPV infection and several therapeutical immunotherapeutics based on HPV, using immunological tools, including native mAbs, radio-labelled mAbs, affitoxins (affibody-linked toxins), intracellular single-chain antibodies (scFvs), nanobodies, therapeutical vaccines, and T-cell-based therapies. Our review aims to provide new clues for researchers to develop novel strategies and methods for the diagnosis and treatment of HPV-induced tumors.

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