Male gender as an independent risk factor for laparoscopic cholecystectomy: An outcome analysis at a teaching institute

This paper was designed to investigate the gender dependent risk of complication in patients undergoing laparoscopic cholecystectomy for acute cholecystitis. Laparoscopic cholecystectomy is the standard procedure for benign gallbladder disorders. The role of gender as an independent risk factor for complicated laparoscopic cholecystectomy remains unclear. A retrospective single-center analysis of laparoscopic cholecystectomies performed for acute cholecystitis over a 5-year period in a community hospital was performed. Within the period of examination, 1884 laparoscopic cholecystectomies were performed. The diagnosis was acute cholecystitis in 779 cases (462 female, 317 male). The male group was significantly older (P = 0.001). Surgery lasted significantly longer in the male group (P = 0.008). Conversion was done in 35 cases (4.5%). There was no significant difference in the rate of conversion between both groups. However the rate of conversion was significantly higher in male patients > 65 years (P = 0.006). The length of postoperative hospital stay was significantly longer in the male group (P = 0.007), in the group > 65 years (P = 0.001) and following conversion to open surgery (P = 0.001). The male gender was identified as an independent risk factor for prolonged laparoscopic cholecystectomy on multivariate analysis. The male gender could be an independent risk factor for complicated or challenging surgery in patients undergoing laparoscopic cholecystectomy for acute cholecystitis.

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Sleep apnoea is a risk factor for severe COVID-19

BMJ Open Respiratory Research ◽

10.1136/bmjresp-2020-000845 ◽

2021 ◽

Vol 8 (1) ◽

pp. e000845

Author(s):

Satu Strausz ◽

Tuomo Kiiskinen ◽

Martin Broberg ◽

Sanni Ruotsalainen ◽

Jukka Koskela ◽

...

Keyword(s):

Risk Factor ◽

Independent Risk Factor ◽

Causes Of Death ◽

Meta Analysis ◽

Sleep Apnoea ◽

Male Gender ◽

Multivariate Logistic Regression Model ◽

Multivariate Logistic Regression ◽

Obstructive Sleep ◽

Positive Controls

BackgroundObstructive sleep apnoea (OSA) is associated with higher body mass index (BMI), diabetes, older age and male gender, which are all risk factors for severe COVID-19.We aimed to study if OSA is an independent risk factor for COVID-19 infection or for severe COVID-19.MethodsOSA diagnosis and COVID-19 infection were extracted from the hospital discharge, causes of death and infectious diseases registries in individuals who participated in the FinnGen study (n=260 405). Severe COVID-19 was defined as COVID-19 requiring hospitalisation. Multivariate logistic regression model was used to examine association. Comorbidities for either COVID-19 or OSA were selected as covariates. We performed a meta-analysis with previous studies.ResultsWe identified 445 individuals with COVID-19, and 38 (8.5%) of them with OSA of whom 19 out of 91 (20.9%) were hospitalised. OSA associated with COVID-19 hospitalisation independent from age, sex, BMI and comorbidities (p-unadjusted=5.13×10−5, OR-adjusted=2.93 (95% CI 1.02 to 8.39), p-adjusted=0.045). OSA was not associated with the risk of contracting COVID-19 (p=0.25). A meta-analysis of OSA and severe COVID-19 showed association across 15 835 COVID-19 positive controls, and n=1294 patients with OSA with severe COVID-19 (OR=2.37 (95% 1.14 to 4.95), p=0.021).ConclusionRisk for contracting COVID-19 was the same for patients with OSA and those without OSA. In contrast, among COVID-19 positive patients, OSA was associated with higher risk for hospitalisation. Our findings are in line with earlier works and suggest OSA as an independent risk factor for severe COVID-19.

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Male gender is an independent risk factor for major infection after severe blunt trauma

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2004.05.166 ◽

2004 ◽

Vol 199 (3) ◽

pp. 77

Author(s):

Jeffrey L. Johnson ◽

Ernest Moore ◽

David Ciesla ◽

Catherine Cothren ◽

Angela Sauaia

Keyword(s):

Risk Factor ◽

Blunt Trauma ◽

Independent Risk Factor ◽

Male Gender ◽

Major Infection

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DOES MALE GENDER INCREASE THE RISK OF LAPAROSCOPIC CHOLECYSTECTOMY?

ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) ◽

10.1590/0102-672020190001e1438 ◽

2019 ◽

Vol 32 (2) ◽

Cited By ~ 1

Author(s):

Júlio Cezar Uili COELHO ◽

Giuliano Ohde DALLEDONE ◽

Wagner SCHIEL ◽

Jacqueline de Pauli BERBARDIN ◽

Christiano M. P. CLAUS ◽

...

Keyword(s):

Risk Factor ◽

Laparoscopic Cholecystectomy ◽

Acute Cholecystitis ◽

Perioperative Complications ◽

Male Gender ◽

Female Group ◽

Intraoperative Complication ◽

Study Protocols ◽

Conversion To Open Cholecystectomy

ABSTRACT Background: Laparoscopic cholecystectomy is the preferable treatment for chronic or acute cholecystitis. Some factors may increase the rate of laparoscopic conversion to open cholecystectomy and perioperative complications. The role of gender as a risk factor for laparoscopic cholecystectomy is controversial. Aim: To evaluate the role of the gender on the operative findings and outcome of laparoscopic cholecystectomy. Method: All patients who underwent laparoscopic cholecystectomy for chronic or acute cholecystitis were included. Demographic, clinical, laboratory, imaging exams, intraoperative and postoperative data were obtained and analyzed. The data was obtained retrospectively from electronic medical records and study protocols. Results: Of a total 1,645 patients who were subjected to laparoscopic cholecystectomy, 540 (32.8%) were men and 1,105 (67.2%) were women. Mean age was similar in both genders (p=0.817). Operative time has longer in the male (72.48±28.50) than in the female group (65.46±24.83, p<0.001). The rate of acute cholecystitis was higher in the male (14.3%) than in the female group (5.1%, p<0.001). There was no difference between the genders in regard to the rate of conversion (p=1.0), intraoperative complication (p=1.0), postoperative complication (p=0.571), and operative mortality (p=1.0). Conclusion: Male gender is not an independent risk factor for laparoscopic conversion and perioperative complications.

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Advanced age is an independent risk factor for increased morbidity and mortality following open and laparoscopic cholecystectomy: A comparative analysis of 155,365 cholecystectomies from National Inpatient Sample (NIS) Database (2004-2008)

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2011.06.015 ◽

2011 ◽

Vol 213 (3) ◽

pp. S15

Author(s):

Robin Lee ◽

Sachin Patil ◽

Ronald Chamberlain

Keyword(s):

Risk Factor ◽

Laparoscopic Cholecystectomy ◽

Comparative Analysis ◽

Independent Risk Factor ◽

Morbidity And Mortality ◽

Advanced Age ◽

National Inpatient Sample

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Is male gender a risk factor for bile duct injury during laparoscopic cholecystectomy?

Langenbeck s Archives of Surgery ◽

10.1007/s00423-003-0407-1 ◽

2003 ◽

Vol 388 (4) ◽

pp. 261-264 ◽

Cited By ~ 9

Author(s):

Juha M. Gr�nroos ◽

Matti T. H�m�l�inen ◽

Jukka Karvonen ◽

Risto Gullichsen ◽

Simo Laine

Keyword(s):

Risk Factor ◽

Laparoscopic Cholecystectomy ◽

Bile Duct ◽

Bile Duct Injury ◽

Male Gender

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The Epidemiology of Myeloproliferative Neoplasms in New Zealand between 2010 and 2017: Insights from the New Zealand Cancer Registry

Current Oncology ◽

10.3390/curroncol28020146 ◽

2021 ◽

Vol 28 (2) ◽

pp. 1544-1557

Author(s):

Chris Varghese ◽

Tracey Immanuel ◽

Anna Ruskova ◽

Edward Theakston ◽

Maggie L. Kalev-Zylinska

Keyword(s):

Risk Factor ◽

New Zealand ◽

Cancer Registry ◽

Independent Risk Factor ◽

Myeloproliferative Neoplasms ◽

Demographic Data ◽

Philadelphia Chromosome ◽

Ethnic Disparities ◽

Male Gender ◽

Polycythaemia Vera

Background: There is a paucity of data on ethnic disparities in patients with the classical Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs): polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF). Methods: This study analysed the demographic data for PV, ET and PMF collected by the New Zealand Cancer Registry (NZCR) between 2010 and 2017. Results: We found that the NZCR capture rates were lower than average international incidence rates for PV and ET, but higher for PMF (0.76, 0.99 and 0.82 per 100,000, respectively). PV patients were older and had worse outcomes than expected, which suggests these patients were reported to the registry at an advanced stage of their disease. Polynesian patients with all MPN subtypes, PV, ET and PMF, were younger than their European counterparts both at the time of diagnosis and death (p < 0.001). Male gender was an independent risk factor for mortality from PV and PMF (hazard ratios (HR) of 1.43 and 1.81, respectively; p < 0.05), and Māori ethnicity was an independent risk factor for mortality from PMF (HR: 2.94; p = 0.006). Conclusions: New Zealand Polynesian patients may have increased genetic predisposition to MPN, thus we advocate for modern genetic testing in this ethnic group to identify the cause. Further work is also required to identify modifiable risk factors for mortality in MPN, in particular those associated with male gender and Māori ethnicity; the results may benefit all patients with MPN.

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Prevalence and Risk Factors Associated With Preeclampsia, Low Birth Weight and Postpartum Hemorrhage in Northern Ghana

10.21203/rs.3.rs-109200/v1 ◽

2020 ◽

Author(s):

Benjamin Ahenkorah ◽

Samuel Sakyi ◽

Gideon Helegbe ◽

Eddie Owiredu ◽

Winfred Ofosu ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Birth Weight ◽

Vaginal Delivery ◽

Postpartum Hemorrhage ◽

Maternal Age ◽

Independent Risk Factor ◽

Male Gender ◽

Northern Ghana ◽

Maternal Complications

Abstract Background: The study evaluated the risks for developing low birth weight (LBW), preeclampsia (PE) and postpartum hemorrhage (PPH) in relation to maternal socio-demographic, obstetric characteristics and clinical laboratory information obtained at 1st antenatal care (ANC) visit.Methods: The study included 268 pregnant women attending 1st ANC visit at the Bolgatanga Regional Hospital. Structured questionnaires were used to obtain socio-demographic and obstetric data from respondents. The main variables were LBW, PPH, PE, mode of delivery, residency, gestational age at 1st ANC visit, maternal age, sickling positivity, Hb at 1st ANC visit, Hb genotype and G6PD status. Odds ratio [OR, 95% confidence interval (CI)] for the association between sociodemographic, obstetric characteristics and clinical variables in relation to PE, LBW and PPH were assessed using logistic regression model.Results: The prevalence of PE, LBW and PPH were 25.4% (68/268), 15.7% (42/268) and 6.0% (16/268), respectively. For PE, delayed 1st ANC visit (AOR=16.82, 95% CI (3.61-78.5), p=0.000) and younger maternal age (AOR= 15.19, 95% CI (1.85-124.56), p=0.011) were independently associated with higher odds whereas vaginal delivery (AOR=0.32, 95% CI (0.15-0.71), p=0.015) was independently associated with reduced odds. Delayed 1st ANC visit (AOR=0.12, 95% CI (0.03-0.47)), p=0.002) independently reduced the risk of PPH whereas the male gender (AOR=7.75, 95% CI (1.60-37.51), p=0.011) independently increased the risk of PPH. Lastly, delayed 1st ANC visit (AOR=3.26, 95% CI (1.05-10.10), p=0.041) was independently associated with increased odds of LBW whereas vaginal delivery (AOR=0.36, 95% CI (0.17-0.74), p=0.006) was an independent risk factor for LBW in the multivariate model.Conclusion: The study identified delayed ANC visit as an independent risk factor for PE, LBW and PPH in Northern Ghana. Vaginal delivery and younger maternal age were also independent risk factors for PE. Additionally, the male gender was independently associated with PPH whereas vaginal delivery was independently associated with LBW. We recommend that public health education for pregnant women that highlights the importance of early ANC visit be enhanced. This will facilitate early identification and intervention for women with risk of foeto-maternal complications. Younger women should be educated on the dangers 48 of early marriages with its attendant foeto-maternal complications.

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An observational study to assess male gender as an isolated risk factor in the laparoscopic cholecystectomy

International Surgery Journal ◽

10.18203/2349-2902.isj20213133 ◽

2021 ◽

Vol 8 (8) ◽

pp. 2382

Author(s):

Bhupen Songra ◽

Amit Kumar ◽

Mohit Jain ◽

Gaurav Jalendra

Keyword(s):

Risk Factor ◽

Laparoscopic Cholecystectomy ◽

Gall Bladder ◽

Wall Thickness ◽

Bladder Wall ◽

Male Gender ◽

P Value ◽

Bladder Wall Thickness ◽

Gall Bladder Wall ◽

Difficult Cholecystectomy

Background: Laparoscopic cholecystectomy is the procedure of choice for majority of patients with gall bladder disease. The aim of the study was to investigate the role of male gender as an isolated risk factor responsible for the increased peri-operative morbidity of laparoscopic cholecystectomy by excluding associated risk factors.Methods: This was a prospective observational descriptive study 60 cases of elective laparoscopic cholecystectomy admitted to the S. M. S. Hospital from July 2019 to May 2020 were included.Results: The most common age group in male was 41-50 years and in female was 51-60 years. Impacted stones and gall bladder wall thickness >4 mm was causes of difficult cholecystectomy and evenly distributed in both sexes. Operative time (p value=0.268), visual analogue score on day 1 (p value=0.307) and hospital stay (p value=0.376) was more in male group but not statistically significant.Conclusions: Impacted stone and gall bladder wall thickness >4 mm were only factors associated with difficult laparoscopic cholecystectomy and excludes male gender as an isolated risk factor for difficult cholecystectomy however large-scale studies may provide different results.

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