The Standardized Histogram Shift of T2 Magnetic Resonance Image (MRI) Signal Intensities of Nephroblastoma Does Not Predict Histopathological Diagnostic Information

The objective of this study is to assess standardized histograms of signal intensities of T2-weighted magnetic resonance image (MRI) modality before and after preoperative chemotherapy for nephroblastoma (Wilms’ tumor). All analyzed patients are enrolled in the International Society of Paediatric Oncology (SIOP) 2001/GPOH trial. 1 The question to be answered is whether the comparison of the histograms can add new knowledge by comparing them with the histology of the tumor after preoperative chemotherapy. Twenty-three unilateral nephroblastoma cases were analyzed. All patients were examined by MRI before and after preoperative chemotherapy treatment. T2 modalities of the MRIs were selected, and histogram changes were compared to histopathological data available after surgery. Of the 23 tumors, 22 decreased in volume following chemotherapy (median –57.99%; range 15.65 to –90.82%). The preliminary results suggest that standardized histograms of signal intensities of T2 MRI in nephroblastoma is not predicting histopathological diagnostic information and has no implications for the clinical assessment for further chemotherapy.

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Spinal Magnetic Resonance Image alterations in human T-lymphotropic virus type I-associated myelopathy patients before and after immunomodulating treatments

Journal of Neurology ◽

10.1007/s00415-003-1066-4 ◽

2003 ◽

Vol 250 (6) ◽

pp. 750-753 ◽

Cited By ~ 5

Author(s):

Yasutaka Tajima ◽

Ri-ichiro Kishimoto ◽

Kazumasa Sudoh ◽

Akihisa Matsumoto ◽

Yusei Miyazaki ◽

...

Keyword(s):

Magnetic Resonance ◽

Virus Type ◽

Magnetic Resonance Image ◽

Type I ◽

T Lymphotropic Virus ◽

Before And After

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Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study

Journal of Clinical Oncology ◽

10.1200/jco.2015.66.0001 ◽

2016 ◽

Vol 34 (26) ◽

pp. 3195-3203 ◽

Cited By ~ 50

Author(s):

Tasnim Chagtai ◽

Christina Zill ◽

Linda Dainese ◽

Jenny Wegert ◽

Suvi Savola ◽

...

Keyword(s):

Preoperative Chemotherapy ◽

International Society ◽

Copy Number ◽

Prognostic Biomarker ◽

Wilms Tumor ◽

Multivariable Analysis ◽

Paediatric Oncology ◽

Hazard Ratio ◽

Localized Disease ◽

1Q Gain

Purpose Wilms tumor (WT) is the most common pediatric renal tumor. Treatment planning under International Society of Paediatric Oncology (SIOP) protocols is based on staging and histologic assessment of response to preoperative chemotherapy. Despite high overall survival (OS), many relapses occur in patients without specific risk factors, and many successfully treated patients are exposed to treatments with significant risks of late effects. To investigate whether molecular biomarkers could improve risk stratification, we assessed 1q status and other potential copy number biomarkers in a large WT series. Materials and Methods WT nephrectomy samples from 586 SIOP WT 2001 patients were analyzed using a multiplex ligation-dependent probe amplification (MLPA) assay that measured the copy number of 1q and other regions of interest. Results One hundred sixty-seven (28%) of 586 WTs had 1q gain. Five-year event-free survival (EFS) was 75.0% in patients with 1q gain (95% CI, 68.5% to 82.0%) and 88.2% in patients without gain (95% CI, 85.0% to 91.4%). OS was 88.4% with gain (95% CI, 83.5% to 93.6%) and 94.4% without gain (95% CI, 92.1% to 96.7%). In univariable analysis, 1q gain was associated with poorer EFS (P < .001; hazard ratio, 2.33) and OS (P = .01; hazard ratio, 2.16). The association of 1q gain with poorer EFS retained significance in multivariable analysis adjusted for 1p and 16q loss, sex, stage, age, and histologic risk group. Gain of 1q remained associated with poorer EFS in tumor subsets limited to either intermediate-risk localized disease or nonanaplastic localized disease. Other notable aberrations associated with poorer EFS included MYCN gain and TP53 loss. Conclusion Gain of 1q is a potentially valuable prognostic biomarker in WT, in addition to histologic response to preoperative chemotherapy and tumor stage.

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Complete necrosis induced by preoperative chemotherapy in Wilms tumor as an indicator of low risk: Report of the International Society of Paediatric Oncology (SIOP) Nephroblastoma Trial and Study 9

Medical and Pediatric Oncology ◽

10.1002/(sici)1096-911x(200003)34:3<183::aid-mpo4>3.0.co;2-o ◽

2000 ◽

Vol 34 (3) ◽

pp. 183-190 ◽

Cited By ~ 70

Author(s):

Liliane Boccon-Gibod ◽

Annie Rey ◽

Bengt Sandstedt ◽

Jan Delemarre ◽

Dieter Harms ◽

...

Keyword(s):

Preoperative Chemotherapy ◽

International Society ◽

Wilms Tumor ◽

Paediatric Oncology ◽

Low Risk ◽

Complete Necrosis

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Effectiveness of preoperative chemotherapy in Wilms' tumor: results of an International Society of Paediatric Oncology (SIOP) clinical trial.

Journal of Clinical Oncology ◽

10.1200/jco.1983.1.10.604 ◽

1983 ◽

Vol 1 (10) ◽

pp. 604-609 ◽

Cited By ~ 192

Author(s):

J Lemerle ◽

P A Voute ◽

M F Tournade ◽

C Rodary ◽

J F Delemarre ◽

...

Keyword(s):

Clinical Trial ◽

Preoperative Chemotherapy ◽

Preoperative Radiotherapy ◽

Wilms Tumor ◽

Paediatric Oncology ◽

Controlled Clinical Trial ◽

Preoperative Treatment ◽

Treatment Groups ◽

Chemotherapy Group ◽

Unselected Population

The results of a controlled clinical trial of preoperative radiotherapy compared to chemotherapy in patients with nephroblastoma are presented. Of 397 histologically proven cases of Wilms' tumor registered at 34 centers between January 1977 and July 1979, 164 were eligible for the trial and were randomized to receive preoperative radiotherapy and chemotherapy (group R, 76 patients) or preoperative chemotherapy (group C, 88 patients). The results were evaluated in terms of the number of surgical tumor ruptures and of local tumor extent at pathologic examination, reflecting the effectiveness of the preoperative treatment. Survival and recurrence-free survival in the two treatment groups were also taken into account. The stage distribution was comparable in the two groups, with 52% stage I tumors in group R, and 43% in group C. Significant changes in the pathologic pattern were more frequent in group R than in group C (53% versus 17%). From these data it is concluded that preoperative chemotherapy is as good as preoperative radiotherapy in terms of prevention of tumor rupture. In addition, it was shown that 43% of an unselected population of patients with Wilms' tumor could be treated without any radiotherapy when chemotherapy had been given preoperatively.

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Bilateral Rhabdomyomatous Tumor Relapsed as Typical Triphasic Wilms’ Tumor

Tumori Journal ◽

10.1177/030089168707300117 ◽

1987 ◽

Vol 73 (1) ◽

pp. 85-89 ◽

Cited By ~ 4

Author(s):

Alberto Ceccamea ◽

Carlo Dominici ◽

Anna Clerico ◽

Enzo Ferrante ◽

Piero Vignetti ◽

...

Keyword(s):

Cancer Chemotherapy ◽

Preoperative Chemotherapy ◽

Renal Tumor ◽

Wilms Tumor ◽

Left Kidney ◽

Second Surgery ◽

Initial Tumor ◽

Before And After ◽

Histologic Changes ◽

Bilateral Tumor

The authors report on a child affected with bilateral renal tumor, which was treated with cancer chemotherapy before and after surgery. Twenty-eight months after the discontinuance of therapy, a neoplasm was disclosed in the left kidney and then removed. Histologically, the bilateral tumor excised by the first surgery could be classified as biphasic Wilms’ tumor, rhabdomyomatous variant, whereas the neoplasm removed by the second surgery was the typical triphasic Wilms’ tumor. The authors suggest that preoperative chemotherapy might have played a role in the histologic changes of the initial tumor. Nonetheless, it is also tempting to postulate that the two histologic variants of Wilms’ tumor could have occurred in the patient in spite of any treatment.

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Presurgical Evaluation in Magnetic Resonance Image-Negative Frontal Lobe Epilepsy

Neuropediatrics ◽

10.1055/s-0034-1390581 ◽

2014 ◽

Vol 45 (S 01) ◽

Author(s):

I. Borggräfe ◽

C. Vollmar ◽

A. Lösch ◽

B. Ertl-Wagner ◽

L. Gerstl ◽

...

Keyword(s):

Magnetic Resonance ◽

Frontal Lobe ◽

Magnetic Resonance Image ◽

Frontal Lobe Epilepsy ◽

Presurgical Evaluation

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Magnetic resonance image attributes of the bovine ovarian follicle antrum during development and regression

Reproduction ◽

10.1530/reprod/120.2.311 ◽

2000 ◽

pp. 311-323 ◽

Cited By ~ 3

Author(s):

JL Hilton ◽

GE Sarty ◽

GP Adams ◽

RA Pierson

Keyword(s):

Magnetic Resonance ◽

Relaxation Rate ◽

Follicular Fluid ◽

Magnetic Resonance Image ◽

Follicular Development ◽

Physiological Status ◽

Proton Density ◽

Dominant Follicle ◽

Rate Heterogeneity ◽

Pixel Value

The magnetic resonance images and maps of bovine ovaries acquired at defined phases of follicular development and regression were studied to determine whether magnetic resonance image attributes of the follicular antrum reflect the physiological status of dominant and subordinate ovarian follicles. Ovariectomies were performed at day 3 of wave one, day 6 of wave one, day 1 of wave two and at >/= day 17 after ovulation. The timings of ovariectomies were selected to acquire growing, early static, late static and regressing follicles of the first wave and preovulatory follicles of the ovulatory wave. Pre-selection and subordinate follicles were also available for analysis. Serum samples were taken on the day of ovariectomy and follicular fluid samples were taken after imaging. Numerical pixel value and pixel heterogeneity in a spot representing approximately 95% of the follicular antrum were quantified in T(1)- and T(2)-weighted images. T(1) and T(2) relaxation rates (T(1) and T(2)), proton density, apparent diffusion coefficients and their heterogeneities were determined from the computed magnetic resonance maps. The antra of early atretic dominant follicles showed higher T(2)-weighted mean pixel value (P < 0.008) and heterogeneity (P < 0. 01) and lower T(2) heterogeneity (P < 0.008) than growing follicles. Subordinate follicles in the presence of a preovulatory dominant follicle had higher T(1), T(1) heterogeneity, proton density, proton density heterogeneity, and lower mean pixel value in T(1)-weighted images than subordinate follicles of the anovulatory wave (P < 0.04). T(1) relaxation rate heterogeneity and proton density heterogeneity were positively correlated with follicular fluid oestradiol concentration (r = 0.4 and 0.3; P < 0.04). T(2) relaxation rate heterogeneity was positively correlated with follicular fluid progesterone concentration (r = 0.4; P < 0.008). Quantitative differences in magnetic resonance image attributes of the antrum observed among phases of follicular development and regression coincided with changes in the ability of the dominant follicle to produce steroid hormones and ovulate, and thus were indicative of physiological status and follicular health.

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