Sustained acoustic medicine; sonophoresis for nonsteroidal anti-inflammatory drug delivery in arthritis

Background: Arthritis pain is primarily managed by nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac. Topical diclofenac gel is limited in efficacy due to its limited penetration through the skin. This study investigates the use of a multihour, wearable, localized, sonophoresis transdermal drug delivery device for the penetration enhancement of diclofenac through the skin. Materials & methods: A commercially available, sustained acoustic medicine (sam®) ultrasound device providing 4 h, 1.3 W, 132 mW/cm2, 3 MHz ultrasound treatment was evaluated for increasing the drug delivery of diclofenac gel through a human skin model and was compared with standard of care topical control diclofenac gel. Results: Sonophoresis of the diclofenac gel for 4 h increases diclofenac delivery by 3.8× (p < 0.01), and penetration by 32% (p < 0.01). Conclusion: Sustained acoustic medicine can be used as a transdermal drug-delivery device for nonsteroidal anti-inflammatory drugs.

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Design and development of transdermal drug delivery of nonsteroidal anti-inflammatory drugs: Lornoxicam

Journal of Reports in Pharmaceutical Sciences ◽

10.4103/jrptps.jrptps_51_19 ◽

2019 ◽

Vol 8 (2) ◽

pp. 277

Author(s):

HN Shivakumar ◽

RuchiraS Kotian

Keyword(s):

Drug Delivery ◽

Transdermal Drug Delivery ◽

Design And Development ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Design and Analyses of a Transdermal Drug Delivery Device (TD3) †

Sensors ◽

10.3390/s19235090 ◽

2019 ◽

Vol 19 (23) ◽

pp. 5090 ◽

Cited By ~ 1

Author(s):

Jennifer García ◽

Ismael Ríos ◽

Faruk Fonthal Rico

Keyword(s):

Drug Delivery ◽

Transdermal Drug Delivery ◽

Computer Aided Design ◽

Micro Electro Mechanical System ◽

Discharge Process ◽

Microneedle Array ◽

Delivery Device ◽

Drug Delivery Device ◽

Computational Fluid Dynamics Cfd ◽

Aided Design

In this paper, we introduce a novel type of transdermal drug delivery device (TD3) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD3 has shown to be capable of delivering a volumetric flow of 2.92 × 10−5 cm3/s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion.

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