ROLE OF ULTRASONOGRAPHY IN THE DIAGNOSIS AND MANAGEMENT OF THYROID CANCER

Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder associated with rapidly progressing periodontitis leading to premature loss of deciduous and permanent dentition and diffuse palmoplantar keratosis. Immunologic alterations, genetic mutations, and role of bacteria are some aetiologic factors. Patients present with early periodontal destruction, so periodontists play a significant role in diagnosis and management. This paper reports a case of Papillon- Lefevre syndrome with its clinical manifestations and challenges for periodontal management which was diagnosed in dental department.

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Faculty Opinions recommendation of The emerging role of magnetic resonance imaging in the diagnosis and management of pulmonary hypertension.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1136901.593999 ◽

2008 ◽

Author(s):

Keith McNeil

Keyword(s):

Magnetic Resonance Imaging ◽

Pulmonary Hypertension ◽

Magnetic Resonance ◽

Resonance Imaging ◽

Diagnosis And Management

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The role of Hashimoto thyroiditis in predicting radioiodine ablation efficacy and prognosis of low to intermediate risk differentiated thyroid cancer

Annals of Nuclear Medicine ◽

10.1007/s12149-021-01644-1 ◽

2021 ◽

Author(s):

Domenico Albano ◽

Francesco Dondi ◽

Valentina Zilioli ◽

Maria Beatrice Panarotto ◽

Alessandro Galani ◽

...

Keyword(s):

Thyroid Cancer ◽

Treatment Response ◽

Differentiated Thyroid Cancer ◽

Hashimoto Thyroiditis ◽

Prognostic Impact ◽

Intermediate Risk ◽

Excellent Response ◽

Radioiodine Ablation ◽

One Year

Abstract Objective The baseline treatment of differentiated thyroid cancer (DTC) consists of thyroidectomy followed by postoperative risk-adapted radioiodine therapy (RAIT) when indicated. The choice of most appropriate RAI activities to administer with the aim to reach an efficient remnant ablation and reduce the risk of recurrence is yet an open issue and the detection of basal factors that may predict treatment response seems fundamental. The aim of this study was to investigate the potential role of Hashimoto thyroiditis (HT) in predicting 1-year and 5-year treatment response after RAIT and prognosis. Methods We retrospectively included 314 consecutive patients (174 low-risk and 140 intermediate-risk) who received thyroidectomy plus RAIT. One-year and 5-year disease status was evaluated according to 2015 ATA categories response based upon biochemical and structural findings. Results HT was reported histopathologically in 120 patients (38%). DTC patients with concomitant HT received a higher number of RAITs and cumulative RAI activities. Initial RAIT reached an excellent response in 63% after one year and 84% after 5 years. The rate of excellent response one year and 5-year after first RAIT was significantly lower in HT groups, compared to not HT (p < 0.001). Instead, HT did not have a prognostic role considering PFS and OS; while stimulate thyroglobulin (sTg) at ablation was significantly related to survival. Conclusions HT may affect the efficacy of RAIT in low to intermediate risk DTC, particularly reducing the successful rate of excellent response after RAIT. Instead, HT did not have a prognostic impact such as stimulated sTg.

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Role of interferon gamma release assay in the diagnosis and management of Mycobacterium tuberculosis-associated uveitis: a review

BMJ Open Ophthalmology ◽

10.1136/bmjophth-2020-000663 ◽

2021 ◽

Vol 6 (1) ◽

pp. e000663

Author(s):

Samra Rahman ◽

Muhammad Irfan ◽

M A Rehman Siddiqui

Keyword(s):

Interferon Gamma ◽

Interferon Gamma Release Assay ◽

Limited Evidence ◽

Ocular Tuberculosis ◽

Diagnosis And Management ◽

Pubmed Database ◽

Interferon Gamma Release Assays ◽

Infectious Uveitis ◽

Release Assay

Tuberculosis (TB)-associated uveitis is a common cause of infectious uveitis in the developing world. Diagnosis of TB uveitis remains a challenge. The role of interferon gamma release assays (IGRAs) is uncertain. Herein we summarise the available literature on the utility of IGRAs in the diagnosis and management of TB uveitis. We searched PubMed database from 1 August 2010 to 31 July 2020 using the following keywords alone and in combination: ‘interferon-gamma release assay’, ‘QuantiFERON’, ‘T-SPOT.TB’, ‘TB uveitis’, ‘serpiginous like choroiditis’, ‘tuberculoma’, ‘TB vasculitis’, ‘TB panuveitis’ and ‘ocular tuberculosis’. Data from 58 relevant studies were collated. The review is focused on currently marketed versions of IGRA tests: QuantiFERON-TB Gold In-Tube assay, QuantiFERON-TB Gold Plus assay (QFT-Plus) and T-SPOT.TB. We found limited evidence regarding the diagnostic utility of IGRA in patients with uveitis. No study was identified evaluating the newer QFT test—the QFT-Plus—in patients with uveitis. Similarly, there is lack of data directly comparing QFT-Plus with T-SPOT.TB specifically for the diagnosis of TB uveitis.

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