scholarly journals The limitless role of p53 in cell cycle machinery: Good news or bad news?

2006 ◽  
Vol 5 (9) ◽  
pp. 1090-1093 ◽  
Author(s):  
Paraskevi Vogiatzi ◽  
Marco Cassone ◽  
Giovanni Abbadessa ◽  
Pier Paolo Claudio
2019 ◽  
Vol 13 (1) ◽  
pp. 211-212
Author(s):  
Patrick Craddock

Media, Information and Development in Papua New Guinea is one of the most interesting books I have on Pacific media. It is a collection of different writers, some of whom are current or former journalists. Several of the authors have direct media links as staff working with the Divine Word University in Madang, a private Christian institution. For the uninitiated, the opening chapter gives an outline of the media landscape in PNG. Other chapters explore media ownership, journalism education and the role of media national development. 


2020 ◽  
Vol 21 (2) ◽  
pp. 395 ◽  
Author(s):  
Ruth Martín ◽  
Vilte Stonyte ◽  
Sandra Lopez-Aviles

Eukaryotic cells make the decision to proliferate, to differentiate or to cease dividing during G1, before passage through the restriction point or Start. Keeping cyclin-dependent kinase (CDK) activity low during this period restricts commitment to a new cell cycle and is essential to provide the adequate timeframe for the sensing of environmental signals. Here, we review the role of protein phosphatases in the modulation of CDK activity and as the counteracting force for CDK-dependent substrate phosphorylation, in budding and fission yeast. Moreover, we discuss recent findings that place protein phosphatases in the interface between nutritional signalling pathways and the cell cycle machinery.


2004 ◽  
Vol 137 (1) ◽  
pp. 127-140 ◽  
Author(s):  
Rosa Maria Barrôco ◽  
Kris Van Poucke ◽  
Jan H.W. Bergervoet ◽  
Lieven De Veylder ◽  
Steven P.C. Groot ◽  
...  

2016 ◽  
Vol 17 (4) ◽  
pp. 353-360
Author(s):  
Gholamreza Kordestani ◽  
Maryam Taqiporian ◽  
Vahid Biglari ◽  
Vahid Minaei

Timely recognition of losses and expenses compared to revenues and increased values precipitates future expenses to match with current revenues. Thus, timely recognition of losses acts to reduce the persistence of earnings. However, it is expected that a more timely recognition of negative cash flows, as bad news, increase the power of earnings for predicting future cash flows. This study investigates the effects of the timely recognition of bad news (loss) versus the good news on the decrease of the persistence of earnings, and the effect of negative cash flows on forecasting future cash flows. In this study, two pooling type models and a panel type model have been used to estimate the persistence of earnings and cash flows. Seventy eight firms that were listed in the Tehran Stock Exchange during the period 2003–2010 were duly reviewed. The results of this research proved that the timely recognition of loss does not affect the persistence and the power of earnings for the purpose of forecasting future cash flows. The findings imply that conservatism does not distort persistence of earnings.


2018 ◽  
Vol 93 (6) ◽  
pp. 181-201 ◽  
Author(s):  
Jonathan C. Glover ◽  
Haijin H. Lin

ABSTRACT We study intertemporal incentive properties of conditional accounting conservatism. Conservatism has detrimental and beneficial properties. In our first model, conservatism introduces downward bias in the first period; any understatement of first-period performance is reversed in the second period. A conservative bias is not costly in the first period but instead is costly in the second period when a new manager may be rewarded for the performance of his predecessor. In an extension on learning, we illustrate a beneficial role of conservatism in fine-tuning incentives. In the second model, conservatism is modeled as recognizing effort-independent bad news early and good news late. Recognizing bad news early can be optimal because of intertemporal rent shifting, which improves incentives via an “incentive spillback.” We also study overlapping projects (a multi-task setting) in which an interior accounting system can be optimal to avoid making one of the overlapping projects an incentive bottleneck. JEL Classifications: D21; D74; D82; D86.


Legal Studies ◽  
1987 ◽  
Vol 7 (2) ◽  
pp. 169-193 ◽  
Author(s):  
Margaret Brazier

Until recently claims for damages by patients against their doctors were rare in England. Patients who did pursue such claims often found scant sympathy from Her Majesty's judges. The clinical judgment of the medical practitioner was accorded something very like immunity from suit. Since 1980 the pace of medical litigation has quickened dramatically. Patients seem less and less willing to accept without complaint the results of unsuccessful or injurious treatment. They are more and more inclined to question their doctor's judgment. Medical litigation and scrutiny of medical decision making is highly newsworthy in 1987. The practice of medical litigation looks set to become profitable for lawyers. To the cynical oberver all this might look like good news for lawyers and bad news for doctors.


2014 ◽  
Vol 6 (2) ◽  
pp. 81-100
Author(s):  
T. J. Mawson

In recent ‘secular’ Epistemology, much attention has been paid to formulating an ‘anti-luck’ or ‘safety’ condition; it is now widely held that such a condition is an essential part of any satisfactory post-Gettier reflection on the nature of knowledge. In this paper, I explain the safety condition as it has emerged and then explore some implications of and for it arising from considering the God issue. It looks at the outset as if safety might be ‘good news’ for a view characteristic of Reformed Epistemology, viz. the view that if Theism is true, many philosophically unsophisticated believers probably know that it’s true. A (tentatively-drawn) sub-conclusion of my paper though suggests that as safety does not by itself turn true belief into knowledge, the recent focus on it is not quite such good news for Reformed Epistemologists as they may have hoped: it’s not that safety provides a new route by which they can reach this sort of conclusion. But safety is still good news for their view at least in the sense that there is no reason arising from considering it to count these philosophically unsophisticated believers as not knowing that there’s a God. I conclude by reflecting that good news for Reformed Epistemology is perhaps bad news for the discipline of Philosophy of Religion more generally, as there’s a possible ‘reflection destroys knowledge’-implication to be drawn. Those who have been led to their religious beliefs in at least some philosophically unsophisticated ways seem to enjoy much safer religious beliefs than those who have been led to their religious beliefs by philosophical reflection, so the discipline as a whole will be adversely affected if safety is eventually accorded the role of a necessary condition for knowledge.


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