scholarly journals Type 2 Diabetes Mellitus (T2DM): Biological Overview from Pathways to Organelles and its Translation toward a Torpid Wound Healing Process

2013 ◽  
Vol 04 (07) ◽  
Author(s):  
Pedro López-Saura Gerardo Guillen-Nieto ◽  
Boris Acevedo-Castro Luis Herrera-Martínez
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Wound Healing ◽  
Type 2 Diabetes Mellitus ◽  
Healing Process ◽  
Wound Healing Process

scholarly journals Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aaiad H. A. Al-Rikabi ◽  
Desmond J. Tobin ◽  
Kirsten Riches-Suman ◽  
M. Julie Thornton
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Wound Healing ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Wounds ◽  
Dermal Fibroblasts ◽  
Necrosis Factor Alpha ◽  
Tnf Α

AbstractThe prevalence of Type 2 diabetes mellitus (T2DM) is escalating globally. Patients suffer from multiple complications including the development of chronic wounds that can lead to amputation. These wounds are characterised by an inflammatory environment including elevated tumour necrosis factor alpha (TNF-α). Dermal fibroblasts (DF) are critical for effective wound healing, so we sought to establish whether there were any differences in DF cultured from T2DM donors or those without diabetes (ND-DF). ND- and T2DM-DF when cultured similarly in vitro secreted comparable concentrations of TNF-α. Functionally, pre-treatment with TNF-α reduced the proliferation of ND-DF and transiently altered ND-DF morphology; however, T2DM-DF were resistant to these TNF-α induced changes. In contrast, TNF-α inhibited ND- and T2DM-DF migration and matrix metalloprotease expression to the same degree, although T2DM-DF expressed significantly higher levels of tissue inhibitor of metalloproteases (TIMP)-2. Finally, TNF-α significantly increased the secretion of pro-inflammatory cytokines (including CCL2, CXCL1 and SERPINE1) in ND-DF, whilst this effect in T2DM-DF was blunted, presumably due to the tendency to higher baseline pro-inflammatory cytokine expression observed in this cell type. Collectively, these data demonstrate that T2DM-DF exhibit a selective loss of responsiveness to TNF-α, particularly regarding proliferative and secretory functions. This highlights important phenotypic changes in T2DM-DF that may explain the susceptibility to chronic wounds in these patients.

Decreased expression of heat shock proteins may lead to compromised wound healing in type 2 diabetes mellitus patients

2015 ◽  
Vol 29 (4) ◽  
pp. 578-588 ◽  
Author(s):  
Kanhaiya Singh ◽  
Neeraj K. Agrawal ◽  
Sanjeev K. Gupta ◽  
Gyanendra Mohan ◽  
Sunanda Chaturvedi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Wound Healing ◽  
Type 2 Diabetes Mellitus ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Shock Proteins

scholarly journals Increased expression of endosomal members of toll-like receptor family abrogates wound healing in patients with type 2 diabetes mellitus

2015 ◽  
Vol 13 (5) ◽  
pp. 927-935 ◽  
Author(s):  
Kanhaiya Singh ◽  
Neeraj K Agrawal ◽  
Sanjeev K Gupta ◽  
Gyanendra Mohan ◽  
Sunanda Chaturvedi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Wound Healing ◽  
Type 2 Diabetes Mellitus ◽  
Toll Like Receptor ◽  
Receptor Family

Neutrophils as a source of factors that increase the length of the inflammatory phase of wound healing in patients with type 2 diabetes mellitus

2018 ◽  
Vol 64 (5) ◽  
pp. 433-438
Author(s):  
E.V. Mikhalchik ◽  
D.I. Maximov ◽  
E.M. Ostrovsky ◽  
A.V. Yaskevich ◽  
I.I. Vlasova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Wound Healing ◽  
Type 2 Diabetes Mellitus ◽  
Neutrophil Count ◽  
Control Group ◽  
Inflammatory Phase ◽  
Group 3 ◽  
Group 1

Oxidative stress and neutrophil activation leading to an increase in myeloperoxidase (MPO), elastase and neutrophil extracellular trap (NET) levels in blood are considered as pathogenic mechanisms responsible for the development of extremity damage in people with type 2 diabetes mellitus (T2DM). The aim of this study was to analyze the relationship between factors, associated with neutrophil activation, and the length of the initial phase of wound healing (the inflammatory phase) in T2DM patients. Patients were divided retrospectively into three groups depending on the damage extent: group 1 (wound on toe) < group 2 (wound on foot) < group 3 (wound on lower leg). Compared to the control group (healthy volunteers), T2DM patients at admission to hospital had significantly (p<0.05) increased levels of blood glucose and glycated hemoglobin (groups 1-3), ESR (groups 1 and 3), blood neutrophil count (groups 2 and 3), plasma MPO concentration (groups 1-3) and blood NET concentration (group 3) and decreased levels of plasma thiols (groups 1-3) and erythrocyte glutathione peroxidase activity (groups 2 and 3). The length of hospital stay after surgical procedures corresponded to the length of the inflammatory phase of the wound healing process and correlated with the number of blood neutrophils in patients before surgery (r=0.72, p<0.05). Leukocytic intoxication index depended on wound area (r=0.59, p<0.05), and it was significantly higher for groups 2 and 3 compared to the control group and group 1. The neutrophil count before surgery in T2DM patients with damage in the lower extremities correlated with the length of the inflammatory phase of wound healing. The correlation found can be attributed to an increase in extracellular MPO and NETs, which, in its turn, results from the activation and degranulation of neutrophils and netosis. Thus, the duration of the inflammatory phase of wound healing depends on specific aspects of systemic inflammation increasing oxidative/halogenative stress and intoxication.

scholarly journals Perawatan Luka Diabetes Mellitus Menggunakan Teknik Modern Dressing

2020 ◽  
Vol 9 (2) ◽  
pp. 160-172
Author(s):  
Alberikus Dimantika ◽  
Sugiyarto Sugiyarto ◽  
Yuyun Setyorini
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Wound Healing ◽  
Type 2 Diabetes Mellitus ◽  
Wound Care ◽  
Meta Analysis ◽  
Acellular Matrix ◽  
Patients With Diabetes ◽  
Artery Disease

Background: The most common complication in patients with diabetes mellitus tippe 2 (DM) is diabetic ulcers, where the tissue deformity occurs either partially (Partial Thickness) or completely (Full Thickness). If not handled properly and appropriately, ulcers can become infected. Where leg ulcers, infection, neuroarthropathy and peripheral artery disease are the causes of gangrene and lower limb amputations. The aim of this study  is to determine the effectiveness of wound healing in the treatment of diabetes mellitus wounds using modern dressing techniques. Methods: the literature review (LR) method uses meta-analysis where the data used is a database of searches using MEDLINE (PubMed), Google Scholar, Science Direct, Surgery Science and Sci-Hub. Reports published from 2010-2020 that focused on modern wound care dressings for wound healing of type 2 diabetes mellitus were identified. Results: Based on the analysis of the journal, there are nursing implications that have been compared from 10 journals, it was found that the treatment of type two diabetes mellitus wounds using modern dressing techniques is more effective in wound healing, by accelerating granulation and healing of the various types of dressings used, each of which has advantages. in terms of wound healing type 2 diabetes mellitus. Conclusion: The use of modern dressing techniques is effective in wound healing in the treatment of type 2 diabetes mellitus wounds. Researchers suggest that they be able to conduct research related to modern wound care dressings such as the use of alginate dressings, foam dressings, hydrogel dressings, moisture dressings, silver dressings, hydrophilic polyurethane foam dressings, acellular matrix dressings, and others related to wound care using modern dressing techniques. . Further research needs to be done by paying attention to the latest evidence-based practice journals to enrich knowledge about wound care with modern dressing techniques for diabetes mellitus wounds.

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