Influence of Oral Administration of Soybean Peptide on Water Content of the Stratum Corneum, Transepidermal Water Loss and Skin Viscoelasticity

2012 ◽  
Vol 02 (03) ◽  
Author(s):  
Yoshihiro Tokudome ◽  
Madoka Kage ◽  
Fumie Hashimoto
Keyword(s):  
Oral Administration ◽  
Stratum Corneum ◽  
Water Content ◽  
Water Loss ◽  
Transepidermal Water Loss

scholarly journals Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2220
Author(s):  
Tzu-Fang Hsu ◽  
Zi-Rong Su ◽  
Yao-Hao Hsieh ◽  
Ming-Fu Wang ◽  
Mariko Oe ◽  
...  
Keyword(s):  
Placebo Group ◽  
Stratum Corneum ◽  
Water Content ◽  
Water Loss ◽  
Group Versus ◽  
Transepidermal Water Loss ◽  
Skin Condition ◽  
Joint Fluid ◽  
Controlled Study ◽  
Stratum Corneum Water Content

Hyaluronan (HA) is present in all connective tissues and organs, including the skin and joint fluid. However, few clinical trials have comprehensively evaluated the impacts of oral HA on skin conditions, including wrinkles and moisturization. In this study, we conducted a placebo-controlled, randomized, double-blind trial of daily HA (120 mg) intake for 12 weeks in 40 healthy Asian men and women (aged 35–64 years). Skin condition was determined by the evaluation of wrinkles, stratum corneum water content, the amount of transepidermal water loss, elasticity, and through image analysis. After 12 weeks, skin condition was significantly improved in terms of wrinkle assessment, stratum corneum water content, transepidermal water loss, and elasticity in the HA group compared to the placebo group. Regarding the percentage change from baseline, wrinkle assessment, stratum corneum water content, and skin elasticity were significantly improved in the HA group versus the placebo group after 8 and 12 weeks of ingestion. The present findings indicate that oral ingestion of HA may suppress wrinkles and improve skin condition.

Beneficial effects of oral supplementation with ferulic acid, a plant phenolic compound, on the human skin barrier in healthy men

2021 ◽  
pp. 1-7
Author(s):  
Atsushi Suzuki ◽  
Tomoko Nomura ◽  
Hiroko Jokura ◽  
Naoya Kitamura ◽  
Akihiko Fujii ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Stratum Corneum ◽  
Water Loss ◽  
Nervous Activity ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Sympathetic Nervous Activity ◽  
Healthy Men ◽  
Stratum Corneum Hydration ◽  
Sympathetic Nervous

Abstract. Ferulic acid (FA) is a phytochemical compound with various physiologic functions. To clarify the effect of FA intake on skin barrier function (SBF), we conducted a placebo-controlled double-blind pilot trial. Sixteen healthy subjects were divided into 2 groups (n = 8) and ingested capsules containing either FA (200 mg) or placebo daily for 2 weeks. Two measures of SBF, transepidermal water loss and stratum corneum hydration, were assessed before and 2 weeks after the start of the study. Autonomic nervous activity, which is suggested to be related to SBF, was also measured. Compared with the values obtained before the start of the study, FA intake significantly reduced transepidermal water loss (from 6.1 ± 1.1 to 4.8 ± 1.0 g/m2/h, p = 0.005) and increased stratum corneum hydration (from 30.1 ± 7.6 to 32.3 ± 8.1 a.u., p = 0.027) after 2 weeks. In addition, the amount change in sympathetic nervous activity was significantly reduced after ingesting the FA capsules compared with the placebo capsules (−0.7 ± 1.6 vs. 1.1 ± 1.4, p = 0.035). These findings suggest that FA supplementation decreases sympathetic nervous activity and strengthens SBF in healthy men.

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