scholarly journals Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2220
Author(s):  
Tzu-Fang Hsu ◽  
Zi-Rong Su ◽  
Yao-Hao Hsieh ◽  
Ming-Fu Wang ◽  
Mariko Oe ◽  
...  
Keyword(s):  
Placebo Group ◽  
Stratum Corneum ◽  
Water Content ◽  
Water Loss ◽  
Group Versus ◽  
Transepidermal Water Loss ◽  
Skin Condition ◽  
Joint Fluid ◽  
Controlled Study ◽  
Stratum Corneum Water Content

Hyaluronan (HA) is present in all connective tissues and organs, including the skin and joint fluid. However, few clinical trials have comprehensively evaluated the impacts of oral HA on skin conditions, including wrinkles and moisturization. In this study, we conducted a placebo-controlled, randomized, double-blind trial of daily HA (120 mg) intake for 12 weeks in 40 healthy Asian men and women (aged 35–64 years). Skin condition was determined by the evaluation of wrinkles, stratum corneum water content, the amount of transepidermal water loss, elasticity, and through image analysis. After 12 weeks, skin condition was significantly improved in terms of wrinkle assessment, stratum corneum water content, transepidermal water loss, and elasticity in the HA group compared to the placebo group. Regarding the percentage change from baseline, wrinkle assessment, stratum corneum water content, and skin elasticity were significantly improved in the HA group versus the placebo group after 8 and 12 weeks of ingestion. The present findings indicate that oral ingestion of HA may suppress wrinkles and improve skin condition.

scholarly journals Moisturizing effect of a cosmetic formulation containing pequi oil (Caryocar brasiliense) from the Brazilian cerrado biome

2014 ◽  
Vol 50 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Wanessa Costa Silva Faria ◽  
Gabriel Azevedo de Brito Damasceno ◽  
Márcio Ferrari
Keyword(s):  
Stratum Corneum ◽  
Water Content ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Skin Barrier Function ◽  
Brazilian Cerrado ◽  
Single Application ◽  
Caryocar Brasiliense ◽  
Stratum Corneum Water Content

Caryocar brasiliense, popularly known in Brazil as “pequi”, is a species widely distributed in the Brazilian Cerrado. The seeds are surrounded by a woody endocarp coated with a yellow fleshy mesocarp rich in oil and vitamin A, whose oil has a useful role in the treatment of skin aging and protection of human skin against UV-induced damage and skin hydration. The aim of this study was to evaluate the effect of cosmetic formulations containing pequi oil (Caryocar brasiliense) on skin hydration, after a single application. Hydration effect assessment was performed by applying the formulations under study (Control – no formulation, vehicle, and vehicle + pequi oil) onto forearm skin of 30 human volunteers. Skin capacitance and Transepidermal Water Loss (TEWL) measurements were analyzed before, and at 1, 2 and 3 hours after, a single application. Evaluation results of a single application of the vehicle containing pequi oil showed an increase in stratum corneum water content, indicating a skin moisturizing effect. Results of the evaluation of immediate effects of TEWL demonstrated that the vehicle containing pequi oil significantly increased skin moisture during the 3 h evaluation period. The formulations containing pequi oil showed clinical efficacy, increasing stratum corneum water content and enhancing skin barrier function.

Oral Supplementation of Collagen Peptides Improves Skin Hydration by Increasing the Natural Moisturizing Factor Content in the Stratum Corneum: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2021 ◽  
Vol 34 (3) ◽  
pp. 115-127
Author(s):  
Miho Miyanaga ◽  
Taro Uchiyama ◽  
Akira Motoyama ◽  
Nobuhiko Ochiai ◽  
Osamu Ueda ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Water Content ◽  
Transepidermal Water Loss ◽  
Skin Condition ◽  
Controlled Clinical Trial ◽  
Skin Thickness ◽  
Skin Elasticity ◽  
Oral Ingestion ◽  
Double Blind ◽  
Collagen Peptides

<b><i>Introduction:</i></b> We aimed to investigate the effect of orally ingested collagen peptides (CPs) on skin condition and elucidate their mechanism of action. <b><i>Methods:</i></b> A randomized, placebo-controlled, double-blind trial was conducted in 99 healthy Japanese women, aged 35–50 years. The subjects were randomized into 3 groups (33 subjects/group) to receive 1 or 5 g of CP or placebo once daily for 12 weeks. Skin water content, transepidermal water loss (TEWL), skin elasticity, and skin thickness were evaluated before treatment and after 4, 8, and 12 weeks of treatment. The level of natural moisturizing factor (NMF) constituents in the stratum corneum (SC) was quantified before treatment and after 12 weeks of treatment. <b><i>Results:</i></b> Oral ingestion of CP increased the water content in the SC and epidermis and decreased TEWL. Furthermore, the NMF level in the SC was increased. However, skin elasticity and skin thickness remained unchanged. <b><i>Conclusions:</i></b> The improvement in skin water content following the oral ingestion of CP can be attributed to an increase in the level of NMF in the SC. <b><i>Trial Registration:</i></b> UMIN000030375 (retrospectively registered).

The beneficial effect of Cannabis Sativa seed oil on the epidermis

2021 ◽  
Vol 01 ◽  
Author(s):  
Anna Olejnik ◽  
Aleksandra Galarda ◽  
Joanna Goscianska
Keyword(s):  
Water Loss ◽  
Seed Oil ◽  
Unsaturated Fatty Acids ◽  
Cannabis Sativa ◽  
Transepidermal Water Loss ◽  
Skin Condition ◽  
Moisture Loss ◽  
Non Invasive ◽  
Oil Formulation

Background: Cannabis Sativa seed oil has become more and more popular in cosmetic industry mainly due to the high content of antioxidants and unsaturated fatty acids that are desirable in formulations because they prevent moisture loss and reduce the occurrence of dry skin. Objective: The aim of this study was to determine the effect of Cannabis Sativa seed oil on skin parameters such as hydration and transepidermal water loss. Methods: The in vivo tests on volunteers with combination skin were performed by using non-invasive methods by using corneometer and tewameter. Results: The obtained results proved that Cannabis Sativa seed oil improved skin condition. The transepidermal water loss decreased because the lipophilic components of the oil formulation tend to form an occlusive layer on the epidermis surface. The highest increase in skin hydration was observed after one week of treatment. Conclusion: These results confirmed that Cannabis Sativa seed oil has strong moisturizing properties and can be recommended as a natural based skin conditioning agent.

scholarly journals Acetyl hexapeptide-3 in a cosmetic formulation acts on skin mechanical properties - clinical study

2015 ◽  
Vol 51 (4) ◽  
pp. 901-909 ◽  
Author(s):  
Kassandra Azevedo Tadini ◽  
Daiane Garcia Mercurio ◽  
Patrícia Maria Berardo Gonçalves Maia Campos
Keyword(s):  
Mechanical Properties ◽  
Stratum Corneum ◽  
Water Content ◽  
Topical Formulations ◽  
Face Area ◽  
Cutaneous Tissue ◽  
The Face ◽  
Skin Conditions ◽  
Basic Studies ◽  
Stratum Corneum Water Content

abstract Acetyl hexapeptide-3 has been used in anti-aging topical formulations aimed at improving skin appearance. However, few basic studies address its effects on epidermis and dermis, when vehiculated in topical formulations. Thus, the objective of this study was to determine the clinical efficacy of acetyl hexapeptide-3 using biophysical techniques. For this purpose, formulations with and without acetyl hexapeptide-3 were applied to the ventral forearm and the face area of forty female volunteers. Skin conditions were evaluated after 2 and 4-week long daily applications, by analyzing the stratum corneum water content and the skin mechanical properties, using three instruments, the Corneometer(r) CM 825, CutometerSEM 575 and ReviscometerRV600. All formulations tested increased the stratum corneum water content in the face region, which remained constant until the end of the study. In contrast, only formulations containing acetyl hexapeptide-3 exhibit a significant effect on mechanical properties, by decreasing the anisotropy of the face skin. No significant effects were observed in viscoelasticity parameters. In conclusion, the effects of acetyl hexapeptide-3 on the anisotropy of face skin characterize the compound as an effective ingredient for improving conditions of the cutaneous tissue, when used in anti-aging cosmetic formulations.

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