The Relationship between Liver Dysfunction, Electrocardiographic Abnormalities and Metabolism in Rat

A 64-year-old woman was admitted to hospital due to protracted diarrhea and liver dysfunction. The patient was diagnosed as Churg-Strauss syndrome (CSS) due to asthma, paranasal sinusitis, hypereosinophilia, and polyneuropathy. There was a history of taking montelukast, a leukotriene receptor antagonist (LTRA), which is thought to have some relationship with CSS. The liver biopsy specimen showed eosinophilic infiltration and centrolobular fatty change. In this paper, we review the relationship between LTRA and CSS. Several lines of evidence suggest that leukotriene plays an important role in maintaining neural tissues. We also review the potential relationship between centrolobular fatty change and pivoxil-containing antibiotics, which was prescribed for sinusitis before admission. Carnitine deficiency induced by pivoxil-containing agents may cause impaired fatty acid oxidation in mitochondria.

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The relationship among periodontal condition, serum lipid, and electrocardiographic abnormalities in the elderly: A prospective cohort study

Open Journal of Stomatology ◽

10.4236/ojst.2013.38076 ◽

2013 ◽

Vol 03 (08) ◽

pp. 457-463 ◽

Cited By ~ 2

Author(s):

Lisdrianto Hanindriyo ◽

Akihiro Yoshihara ◽

Toshinobu Hirotomi ◽

Hideo Miyazaki

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Serum Lipid ◽

The Elderly ◽

Periodontal Condition ◽

The Relationship ◽

Electrocardiographic Abnormalities

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Global Lysine Acetylome Analysis of LPS-Stimulated HepG2 Cells Identified Hyperacetylation of PKM2 as a Metabolic Regulator in Sepsis

International Journal of Molecular Sciences ◽

10.3390/ijms22168529 ◽

2021 ◽

Vol 22 (16) ◽

pp. 8529

Author(s):

Ann-Yae Na ◽

Sanjita Paudel ◽

Soyoung Choi ◽

Jun Hyung Lee ◽

Min-Sik Kim ◽

...

Keyword(s):

Liver Dysfunction ◽

Lactate Level ◽

Hepg2 Cells ◽

Lactate Concentration ◽

Lysine Acetylation ◽

Post Translational Modification ◽

Glycolysis Pathway ◽

The Relationship ◽

Causative Link ◽

Lps Treatment

Sepsis-induced liver dysfunction (SILD) is a common event and is strongly associated with mortality. Establishing a causative link between protein post-translational modification and diseases is challenging. We studied the relationship among lysine acetylation (Kac), sirtuin (SIRTs), and the factors involved in SILD, which was induced in LPS-stimulated HepG2 cells. Protein hyperacetylation was observed according to SIRTs reduction after LPS treatment for 24 h. We identified 1449 Kac sites based on comparative acetylome analysis and quantified 1086 Kac sites on 410 proteins for acetylation. Interestingly, the upregulated Kac proteins are enriched in glycolysis/gluconeogenesis pathways in the Kyoto Encyclopedia of Genes and Genomes (KEGG) category. Among the proteins in the glycolysis pathway, hyperacetylation, a key regulator of lactate level in sepsis, was observed at three pyruvate kinase M2 (PKM2) sites. Hyperacetylation of PKM2 induced an increase in its activity, consequently increasing the lactate concentration. In conclusion, this study is the first to conduct global profiling of Kac, suggesting that the Kac mechanism of PKM2 in glycolysis is associated with sepsis. Moreover, it helps to further understand the systematic information regarding hyperacetylation during the sepsis process.

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Prevalence of electrocardiographic abnormalities and the relationship bewtween alcohol use and electrocardiographic-left ventricular hypertrophy in older Chinese people : the Guangzhou biobank cohort study

10.5353/th_b4578964 ◽

2010 ◽

Author(s):

Meijing Long

Keyword(s):

Cohort Study ◽

Alcohol Use ◽

Left Ventricular Hypertrophy ◽

Ventricular Hypertrophy ◽

Left Ventricular ◽

Chinese People ◽

Older Chinese ◽

The Relationship ◽

Electrocardiographic Abnormalities

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Efficacy and adverse events related to the initial dose of methimazole in children and adolescents with Graves’ disease

Annals of Pediatric Endocrinology & Metabolism ◽

10.6065/apem.2142046.023 ◽

2021 ◽

Vol 26 (3) ◽

pp. 199-204

Author(s):

Hyun Gyung Lee ◽

Eun Mi Yang ◽

Chan Jong Kim

Keyword(s):

Adverse Events ◽

Children And Adolescents ◽

Liver Dysfunction ◽

Initial Dose ◽

Graves Disease ◽

Group A ◽

The Mean ◽

Group B ◽

The Relationship ◽

Mean Time

Purpose: The first-line antithyroid drug for children and adolescents with Graves’ disease (GD) is methimazole (MMI). This study evaluated the relationship between the initial MMI dose and the clinical course of GD after treatment.Methods: We studied the efficacy of the initial MMI dose and the relationship between the initial MMI dose and adverse events (AEs). We retrospectively enrolled 22 males and 77 females and divided those subjects into 3 groups according to the initial dose of MMI: <0.4 mg/kg/day (group A; n=32); 0.4–0.7 mg/kg/day (group B; n=39); and >0.7 mg/kg/day (group C; n=28).Results: The mean time to the normalization of free thyroxine (fT4) levels upon initial treatment was 5.64, 8.61, and 7.98 weeks in groups A, B, and C, respectively (P=0.116). The incidence of liver dysfunction, neutropenia, and skin rash was 12.5%, 20.5%, and 42.9% in groups A, B, and C, respectively (P=0.018). Neutropenia, as a severe AE, was absent in group A, but its prevalence was 7.7% in group B and 21.4% in group C (P=0.015). When comparing only groups B and C, the incidences of liver dysfunction and neutropenia were higher in group C (P=0.04 and P=0.021, respectively).Conclusion: The mean time to the normalization of fT4 levels did not differ among the 3 groups, but the incidence of AEs was higher in the groups that received high MMI doses. High doses of MMI (>0.7 mg/kg/day) should be reconsidered as an initial treatment for children and adolescents with GD.

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