Thioridazine as an Adjunct for Therapy of Multi-Drug (MDR), Extensively Drug Resistant (XDR) and Totally Drug Resistant (TDR) Pulmonary Tuberculosis Infections

2013 ◽  
Vol 03 (02) ◽  
Author(s):  
Leonard Amaral
Keyword(s):  
Pulmonary Tuberculosis ◽  
Drug Resistant ◽  
Extensively Drug Resistant

Drug-induced optic neuropathy in a case of extensively drug-resistant pulmonary tuberculosis

2018 ◽  
Vol 30 (1) ◽  
pp. 139-140 ◽  
Author(s):  
Proteesh Rana ◽  
Vandana Roy ◽  
Jamshed Ahmad
Keyword(s):  
Pulmonary Tuberculosis ◽  
Optic Neuritis ◽  
Male Patient ◽  
Optic Neuropathy ◽  
High Dose ◽  
Drug Resistant ◽  
Drug Reactions ◽  
Drug Induced ◽  
Toxic Optic Neuropathy ◽  
Extensively Drug Resistant

Abstract We report a 26-year-old male patient diagnosed with extensively drug-resistant pulmonary tuberculosis presenting with reversible bilateral toxic optic neuropathy induced by the use of linezolid along with high-dose isoniazid. The case emphasizes the importance of recognizing toxic optic neuritis in patients on antitubercular therapy. Prompt recognition and treatment of such adverse drug reactions will reduce the associated morbidity.

scholarly journals Mycobacterium tuberculosis whole genome sequence data support repurposing antileprosy antibiotic as antituberculosis

2020 ◽  
Author(s):  
Jamal SAAD ◽  
Jenny GALLOU ◽  
Nathalie BERIRU ◽  
Michel DRANCOURT ◽  
Sophie BARON
Keyword(s):  
Pulmonary Tuberculosis ◽  
In Silico ◽  
Antibiotic Susceptibility ◽  
Sequence Data ◽  
Multidrug Resistant ◽  
Whole Genome Sequence ◽  
Drug Resistant ◽  
Routine Method ◽  
Extensively Drug Resistant ◽  
Sequence Variations

Background We implanted WGS as the routine method to profile the antibiotic susceptibility of M. tuberculosis isolates focusing on in silico resistance to antileprosy drugs that we recently proposed to reposition for the treatment of pulmonary tuberculosis. Methods We prospectively performed WGS of 112 M. tuberculosis isolates recovered from respiratory tract samples of 106 patients diagnosed with pulmonary tuberculosis between 2017 and 2019 and defined their antibiotic susceptibility profile to 17 antibiotics including antileprotics drugs. Results We incidentally observed 08 sequence variations in 07 genes, specific to seven sublineages. Altogether, we observed 09 (8%) rifampicin-resistant, 05 (4.4%) multidrug-resistant and 02 (1.7%) extensively-drug resistant isolates; whereas only one isolate exhibited in silico resistance to clofazimine. Conclusion These results support repurposing of antileprosis antibiotics as antituberculosis; and offer new targets for genotyping M. tuberculosis.

Compassionate Use of Bedaquiline in the Treatment of Extensively Drug-Resistant Pulmonary Tuberculosis

CHEST Journal ◽  
2014 ◽  
Vol 146 (4) ◽  
pp. 132A ◽  
Author(s):  
Melissa Lesko ◽  
Mauricio Danckers Degregori ◽  
Rosemary Adamson ◽  
Eric Leibert
Keyword(s):  
Pulmonary Tuberculosis ◽  
Drug Resistant ◽  
Compassionate Use ◽  
Extensively Drug Resistant
Sign in / Sign up

Export Citation Format

Share Document