Decrease in Thyroid Hormones Secreted by Toxic Nodular Goiter Following a Decline in Insulin-like Growth Factor-1 and Growth Hormone Levels in an Acromegalic Case

2011 ◽  
Vol 7 (1) ◽  
pp. 111-120
Author(s):  
Takatoshi Saito
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Thyroid Hormones ◽  
Nodular Goiter ◽  
Insulin Like Growth Factor ◽  
Hormone Levels ◽  
Toxic Nodular Goiter

Abnormality of growth hormone and insulin-like growth factor I axis in advanced cancer patients

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 19671-19671
Author(s):  
T. Takahata ◽  
M. Munakata ◽  
Y. Sakata ◽  
K. Nakagawa ◽  
T. Mukaiyama ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Thyroid Hormones ◽  
Cancer Patients ◽  
Performance Status ◽  
Insulin Like Growth Factor ◽  
Igf I ◽  
Cancer Anorexia ◽  
Cachexia Syndrome ◽  
Igfbp 3

19671 Background: Pituitary and thyroid hormones are known to be altered in anorexia nervosa, but few hormonal studies have been performed in cancer anorexia-cachexia syndrome. This study focused on growth hormone (GH) and Insulin-like Growth Factor (IGF)-I axis in cancer patients. Methods: To investigate the relationship among performance status (PS), nutritional and hormonal status, blood sampling was performed to measure GH, IGF-I, IGF-binding protein 3(IGFBP-3), T3, T4, complete blood counts and blood chemistry profiles for 15 cancer patients in each of PS0–1, PS2, PS3 and PS4 after the informed consent was obtained. Results: A total of 58 patients were evaluated including 15 patients in PS0–1, PS2 and PS3 and 13 in PS4. Hemoglobin and albumin levels went down along with progression of PS. GH level was high and T3 was low in poor PS. T4 and IGFBP-3 were lower in PS4 than those of other PS. There is a tendency of low IGF-I and thyroid hormones and high GH levels in poor PS as compared with those of good PS (p=0.0064 for IGF-I, p<0.001 for T3, and T4, not significant for GH analyzed by ANOVA). Conclusions: Abnormal GH - IGF-I axis was more pronounced in poor PS. It is conceivable that normalization of this abnormality can improve cancer anorexia-cachexia syndrome and new drug development for such normalizing agents is warranted. No significant financial relationships to disclose.

Serum Insulin-Like Growth Factor 1 and Growth Hormone Levels of Hypoxic-Ischemic Newborns

Neonatology ◽  
2004 ◽  
Vol 85 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Mehmet Satar ◽  
Kenan Özcan ◽  
Hacer Yapıcıoğlu ◽  
Nejat Narlı
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Hormone Levels

scholarly journals Growth hormone and insulin-like growth factor-I measurements in high growth (hg) mice

1991 ◽  
Vol 58 (1) ◽  
pp. 67-74 ◽  
Author(s):  
J. F. Medrano ◽  
D. Pomp ◽  
L. Sharrow ◽  
G. E. Bradford ◽  
T. R. Downs ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Genetic Background ◽  
High Growth ◽  
Insulin Like Growth Factor ◽  
Plasma Growth Hormone ◽  
Hormone Levels ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

SummaryEffects of a recessive gene causing high growth (hg) were studied on two major components of the growth axis in mice. Plasma and pituitary levels of growth hormone and plasma levels of insulin-like growth factor I (IGF-I) were measured in three lines homozygous for hg, each compared with a control line of alike genetic background but wild type for the hg locus (Hg). Line Gh (hghg) and line GH (HgHg) are from a line which had undergone long-term selection for high postweaning weight gain; line Ch (hghg) and line CH (HgHg) were extracted from the second backcross of Gh to C57BL/6J; line L54 (hghg) was from the sixth backcross to C57BL/6J (B6) (HgHg). Pituitary GH levels and plasma IGF-I levels were measured in both sexes at 3, 4·5, 6 and 9 wk of age. Plasma growth hormone was measured in 8- to 12-wk-old males at hourly intervals from 08.00 to 17.00. Body weight in lines homozygous for hg at 6 and 9 wk of age was 10–30% greater than in control lines. The ontogeny of this increased growth depended on genetic background. Pituitary growth hormone content was 52% lower in the two hghg lines measured (lines Ch and Gh) than in control lines at 4·5, 6 and 9 wk. Plasma growth hormone levels were also much lower in hg mice, with values only 20–30% of those in their respective controls, hg lines showed consistently low plasma growth hormone levels throughout the 9 hr sampling period, while control lines expressed the characteristic pulsatile hormone secretion. In contrast, plasma IGF-I levels were greater in line Ch (hghg) than in line CH (HgHg) at 3, 4·5 and 9 wk, and were also greater in line Gh (hghg) vs. line GH (HgHg) at 6 wk of age. The results suggest that the growth enhancing effect of the hg gene occurs through an IGF-I-mediated process. In addition, the genetic background itself is also a factor in the phenotypic expression of the gene.

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