Exenatide Treatment Reduces Thyroid Gland Volume, but Has No Effect on the Size Of Thyroid Nodules

Abstract. Thyroid function and thyroid gland volume, ultrasonically determined, were investigated in 27 hyperthyroid patients with solitary autonomous thyroid nodules before and during one year after 131I-treatment. Total thyroid volume decreased gradually from 40.9 ± 3.5 ml (mean ± sem) before treatment to 23.9 ± 1.8 ml (P < 0.001) at 3 months after 131I-treatment. No further change was observed. All but two patients received only one dose of 131I, and in spite of a significant decrease also of the non-adenoma side of the gland, none became hypothyroid. We conclude that 131I-therapy has an important place in the treatment of solitary autonomous thyroid nodules since all our patients became euthyroid within 3 months, only 2 of 27 patients needed more than one dose of 131I, no cases of hypothyroidism occurred, and thyroid volume was substantially decreased.

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Effect of Thyroid Gland Volume in Preoperative Detection of Suspected Malignant Thyroid Nodules in a Multinodular Goiter—Invited Critique

Archives of Surgery ◽

10.1001/archsurg.143.6.563 ◽

2008 ◽

Vol 143 (6) ◽

pp. 563

Author(s):

Orlo H. Clark

Keyword(s):

Thyroid Gland ◽

Multinodular Goiter ◽

Thyroid Nodules ◽

Gland Volume ◽

Thyroid Gland Volume

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Effect of Thyroid Gland Volume in Preoperative Detection of Suspected Malignant Thyroid Nodules in a Multinodular Goiter

Archives of Surgery ◽

10.1001/archsurg.143.6.558 ◽

2008 ◽

Vol 143 (6) ◽

pp. 558 ◽

Cited By ~ 20

Author(s):

Yeşim Erbil

Keyword(s):

Thyroid Gland ◽

Multinodular Goiter ◽

Thyroid Nodules ◽

Gland Volume ◽

Thyroid Gland Volume

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ULTRASONOGRAPHIC MEASUREMENT OF THYROID GLAND VOLUME IN TURKISH NEONATES AND ASSESSMENT OF REGIONAL DIFFERENCES

Yeditepe Medical Journal ◽

10.15659/yeditepemj.15.10.135 ◽

2014 ◽

Author(s):

Sibel Bayramoglu ◽

Sema Aksoy ◽

Akgun Unat ◽

Fatma Beyazal Celiker ◽

Seyma Yıldız ◽

...

Keyword(s):

Thyroid Gland ◽

Regional Differences ◽

Gland Volume ◽

Thyroid Gland Volume

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Can Thyroid Ultrasonography Predict Substernal Extension or Tracheal Compression in Goiters?

Canadian Association of Radiologists Journal ◽

10.1016/j.carj.2018.07.007 ◽

2018 ◽

Vol 69 (4) ◽

pp. 422-429

Author(s):

Hedyeh Ziai ◽

Nicole L. Lebo ◽

Ania Z. Kielar ◽

Michael J. Odell

Keyword(s):

Thyroid Gland ◽

Characteristic Curve ◽

Area Under The Curve ◽

Thyroid Volume ◽

Classification Systems ◽

Tracheal Compression ◽

Gland Volume ◽

The Us ◽

Thyroid Gland Volume ◽

Preoperative Ct

Purpose To determine whether an ultrasonography (US)-defined thyroid volume can accurately predict substernal extension or tracheal narrowing. Methods After research ethics approval, we identified patients with thyroid nodules investigated with both US and computed tomography (CT). Reviewers assigned scores for both substernal extension and tracheal compression on CT using pre-established classification systems. Statistical analysis with receiver operating characteristic curve analysis was performed to find the US-determined thyroid volume thresholds that correlated with each substernal extension and tracheal compression. Results This study included 120 patients (mean age 63.4 years; SD ± 15.9; 67% female). Thirty-five patients (29%) had substernal extension. The mean US total thyroid gland volume in patients with and without substernal extension were 92.4 and 37.6 cm3, respectively ( P < .001). 86% of patients with substernal extension had tracheal narrowing vs. 27% of patients without substernal extension ( P < .0001). A cutoff dominant gland volume of ≥37.5 cm3 showed 83% sensitivity and 79% specificity for substernal extension (area under the curve [AUC] = 0.84). A total thyroid gland volume threshold of ≥37.8 cm3 showed 89% sensitivity and 87% specificity for any degree of tracheal narrowing (AUC = 0.90). Conclusions This study suggests that US volumes may be used as a predictor to identify those patients with thyroid enlargement who are most at risk of substernal extension and tracheal compression and who may benefit from preoperative CT imaging for optimal surgical and anesthetic planning.

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