Compensated 131I-therapy of solitary autonomous thyroid nodules: effect on thyroid size and early hypothyroidism

1986 ◽  
Vol 113 (2) ◽  
pp. 226-232 ◽  
Author(s):  
Laszlo Hegedüs ◽  
Dagmar Veiergang ◽  
Steen Karstrup ◽  
Jens Mølholm Hansen
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Thyroid Nodules ◽  
Thyroid Volume ◽  
131I Therapy ◽  
Important Place ◽  
Gland Volume ◽  
Thyroid Gland Volume ◽  
One Year ◽  
Hyperthyroid Patients

Abstract. Thyroid function and thyroid gland volume, ultrasonically determined, were investigated in 27 hyperthyroid patients with solitary autonomous thyroid nodules before and during one year after 131I-treatment. Total thyroid volume decreased gradually from 40.9 ± 3.5 ml (mean ± sem) before treatment to 23.9 ± 1.8 ml (P < 0.001) at 3 months after 131I-treatment. No further change was observed. All but two patients received only one dose of 131I, and in spite of a significant decrease also of the non-adenoma side of the gland, none became hypothyroid. We conclude that 131I-therapy has an important place in the treatment of solitary autonomous thyroid nodules since all our patients became euthyroid within 3 months, only 2 of 27 patients needed more than one dose of 131I, no cases of hypothyroidism occurred, and thyroid volume was substantially decreased.

Can Thyroid Ultrasonography Predict Substernal Extension or Tracheal Compression in Goiters?

2018 ◽  
Vol 69 (4) ◽  
pp. 422-429
Author(s):  
Hedyeh Ziai ◽  
Nicole L. Lebo ◽  
Ania Z. Kielar ◽  
Michael J. Odell
Keyword(s):  
Thyroid Gland ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Thyroid Volume ◽  
Classification Systems ◽  
Tracheal Compression ◽  
Gland Volume ◽  
The Us ◽  
Thyroid Gland Volume ◽  
Preoperative Ct

Purpose To determine whether an ultrasonography (US)-defined thyroid volume can accurately predict substernal extension or tracheal narrowing. Methods After research ethics approval, we identified patients with thyroid nodules investigated with both US and computed tomography (CT). Reviewers assigned scores for both substernal extension and tracheal compression on CT using pre-established classification systems. Statistical analysis with receiver operating characteristic curve analysis was performed to find the US-determined thyroid volume thresholds that correlated with each substernal extension and tracheal compression. Results This study included 120 patients (mean age 63.4 years; SD ± 15.9; 67% female). Thirty-five patients (29%) had substernal extension. The mean US total thyroid gland volume in patients with and without substernal extension were 92.4 and 37.6 cm3, respectively ( P < .001). 86% of patients with substernal extension had tracheal narrowing vs. 27% of patients without substernal extension ( P < .0001). A cutoff dominant gland volume of ≥37.5 cm3 showed 83% sensitivity and 79% specificity for substernal extension (area under the curve [AUC] = 0.84). A total thyroid gland volume threshold of ≥37.8 cm3 showed 89% sensitivity and 87% specificity for any degree of tracheal narrowing (AUC = 0.90). Conclusions This study suggests that US volumes may be used as a predictor to identify those patients with thyroid enlargement who are most at risk of substernal extension and tracheal compression and who may benefit from preoperative CT imaging for optimal surgical and anesthetic planning.

scholarly journals Ultrasonographic estimation of Thyroid gland volume in healthy subjects of interior Sindh (Province of Pakistan).

2020 ◽  
Vol 27 (01) ◽  
pp. 185-190
Author(s):  
Jawad Ali Memon
Keyword(s):  
Thyroid Gland ◽  
Reference Values ◽  
Healthy Subjects ◽  
Local Population ◽  
Thyroid Volume ◽  
Gland Volume ◽  
Experienced Radiologist ◽  
Sindh Province ◽  
Thyroid Gland Volume ◽  
The Mean

Ultrasonography is the most common & easy method to estimate the thyroid gland volume. There is wide variation in the volume of the thyroid gland in normal individuals of different ages, sex, races & geography location. Objectives: To estimate the ultrasonographic thyroid gland volume & its reference range in healthy volunteers of interior Sindh, province of Pakistan. Study Design: Cross Sectional Prospective study. Setting: Conducted in Department of Radiology of PUMHS Nawabshah. Period: From 15 August 2017 to 15 February 2018. Material & Methods: Total 102 healthy subjects were included. The subjects having history of any thyroid disease or surgery, systematic disease, iodine deficiency or taking any drug were excluded. Every subject’s thyroid ultrasound was performed by experienced radiologist & thyroid gland volume of each lobe was calculated. Results: The mean total thyroid gland volume of all study subjects was 9.14+2.97 cm3. The mean volume of right lobe is significantly larger than that of left lobe (5.27+3.82 vs 3.82+1.41, p< 0.005). The mean thyroid volume of the male subjects was larger than in the females (11.67+3.06 vs 8.50+2.87 cm3), the difference between both sexes was statistically significant (p< 0.005) (Table-I). There was no statistically correlation was found between thyroid gland volume with body mass index ((p< 0.005). Conclusion: We tried to contribute to establish the reference values for our local population and further large studies are required to establish national wide reference values of thyroid gland volume.

scholarly journals Normative data of thyroid volume-ultrasonographic evaluation in clinically asymptomatic Nigerian adults at Benue state university teaching hospital, Makurdi

2021 ◽  
Vol 8 (7) ◽  
pp. 864
Author(s):  
Chia D. Msuega ◽  
Aondoaseer A. Ugande ◽  
Kator P. Iorpagher ◽  
Ochekawo I. Obekpa ◽  
Abdullahi A. Abdullahi
Keyword(s):  
Thyroid Gland ◽  
Normative Data ◽  
Thyroid Volume ◽  
Left Lobe ◽  
University Teaching ◽  
Steady Increase ◽  
Female Population ◽  
Gland Volume ◽  
Thyroid Gland Volume ◽  
The Mean

Background: Thyroid gland volume is highly variable among communities. Current study was aimed to determine the local normative data on thyroid volume, assessed by ultrasonography in asymptomatic Nigerian adults.Methods: A prospective cross-sectional study conducted at a tertiary hospital between February 2020 to February 2021, which included 500 clinically asymptomatic adults in Makurdi, North-Central Nigeria. Age specific reference values for thyroid volume were obtained. Structured questionnaire was used to obtain information on other variables that could influence thyroid gland volume. The data obtained, including that from blood tests of thyroid function was collated and analysed using SPSS 23, with p=0.05.Results: The mean total thyroid gland volume for both lobes in the entire population of the study was 6.91±2.41 cm3. The mean thyroid volume for both lobes in males 7.09±2.60 cm3 was higher than that of females 6.73±2.38 cm3. The mean right and left lobe volumes were 3.56±1.14 cm3 and 3.35±1.10 cm3 respectively. The right lobe volume was significantly greater than the left lobe (p=0.000). There was a consistent steady increase in thyroid gland volume with increasing age for the general, male and female population until at least the 5th or 6th decade. The total thyroid gland volume significantly correlated with the individual’s body parameters. Highest correlation was found with height (r=0.256, p<0.05)).Conclusions: Ultrasonography was valuable in the determination of thyroid gland volume and normal values were different in various communities.

scholarly journals Low dose oral iodized oil for control of iodine deficiency in children

2000 ◽  
Vol 84 (2) ◽  
pp. 139-141 ◽  
Author(s):  
Michael Zimmermann ◽  
Pierre Adou ◽  
Toni Torresani ◽  
Christophe Zeder ◽  
Richard Hurrell
Keyword(s):  
Thyroid Gland ◽  
Low Dose ◽  
Thyroid Volume ◽  
Thyroid Stimulating Hormone ◽  
World Health ◽  
School Age Children ◽  
Iodized Oil ◽  
Post Intervention ◽  
Gland Volume ◽  
Thyroid Gland Volume

In areas where iodized salt is not available, oral iodized oil is often used to correct I deficiency despite a lack of consensus on the optimal dose or duration of effect, particularly in children, a main target group. Annual doses ranging from 400 to 1000 mg have been advocated for school-age children. Because lower doses of iodized oil have been shown to be effective in treating I deficiency in adults, the aim of this study was to evaluate the efficacy and safety of a low dose of oral iodized oil in goitrous I-deficient children. Goitrous children (n 104, mean age 8·4 years, range 6–12 years, 47 % female) received 0·4 ml oral iodized poppyseed-oil containing 200 mg I. Baseline measurements included I in spot urines (UI), serum thyroxine (T4), whole blood thyroid-stimulating hormone (TSH), and thyroid-gland volume using ultrasound. At 1, 5, 10, 15, 30 and 50 weeks post-intervention, UI, TSH and T4 were measured. At 10, 15, 30 and 50 weeks, thyroid-gland volume was remeasured. At 30 and 50 weeks the mean percentage change in thyroid volume from baseline was -35 % and -41 % respectively. The goitre rate fell to 38 % at 30 weeks and 17 % at 50 weeks. No child showed signs of I-induced hypo- or hyperthyroidism. UI remained significantly increased above baseline for the entire year (P < 0·001); the median UI at 50 weeks was 97 μg/l, at the World Health Organization cut-off value (100 μg/l) for I-deficiency disorders risk. In this group of goitrous children, an oral dose of 200 mg I as Lipiodol (Guerbert, Roissy CdG Cedex, France) was safe and effective for treating goitre and maintaining normal I status for at least 1 year.

scholarly journals Determination of Relationship between Thyroid Gland Volume and Anthropometric Indices

2019 ◽  
pp. 1-12
Author(s):  
A. J. Salaam ◽  
S. M. Danjem ◽  
A. A. Salaam ◽  
H. A. Angba ◽  
P. O. Ibinaiye
Keyword(s):  
Thyroid Gland ◽  
Thyroid Volume ◽  
Left Lobe ◽  
The Body ◽  
Gland Volume ◽  
Thyroid Gland Volume ◽  
Right Lobe ◽  
Males And Females ◽  
The Mean ◽  
The Right

Objective: To sonographically determine the thyroid gland volume in normal adults in Jos University Teaching Hospital, as well as how it relates to anthropometric factors. Background: The thyroid gland is one of the largest endocrine glands in the body weighing about 10-25g.  It regulates the rate of metabolism and controls the growth and rate of function of many other systems in the body. These it does, by producing thyroid hormones, principally thyroxine (T4) and triiodothyronine (T3). The accurate estimation of the size of the thyroid is very important for the evaluation and management of thyroid disorders. Thus, knowing the normal size in a geographic location would form a baseline for detecting abnormalities. Ultrasonography is a cheap, readily available, easy to perform and non-invasive method to image the thyroid gland, hence its use in this resource-limited setting. Methods: This is a cross-sectional study of sonographic measurement of thyroid gland volume on 400 normal (healthy) adults in Jos, Plateau State, Northern part of Nigeria. All examinations were performed using LOGIC 5, a real-time ultrasound machine using a 10MHZ linear transducer and ultrasound transmission gel to act as a coupling gel. Measurements of each lobe and isthmus were obtained in longitudinal (length), transverse (width) and depth(breath) in centimetres (cm). Blood samples were taken for thyroid function tests. The weight and heights were obtained. The data obtained were statistically analyzed using SPSS software version 17. The results were presented in forms of tables, graphs and chart. Results: The mean thyroid volume for males   6.03 cm3±2.22 was higher than that of females 5.62 cm3±2.14. The mean right lobe volume (RLV) was 3.09 cm3±1.47 and that of males and females were 3.16 cm3 ±1.34 and 3.04 cm3 ±1.55 respectively. The mean left lobe volume (LLV) was 2.69 cm3 ± 1.37 and that of males and females were 2.89 cm3±1.32 and 2.57 cm3±1.39 respectively. The right lobe volume was significantly greater than the left lobe(p=0.000). The total mean isthmus volume was 0.27 cm3±0.31. The mean isthmus volume in males 0.3±0.28 is significantly higher than that of females 0.24±0.23 (p=0.025). The BMI increases in females with increasing age. BMI and BSA are higher in males. Conclusion: The volume obtained in this study was slightly lower than those reported by previous studies in Nigerian adults. The right lobe volume was higher than that of the left and the volume was higher in males compared to females. Anthropometric parameters were noted to affect the thyroid volume.

ULTRASONOGRAPHIC MEASUREMENT OF THYROID GLAND VOLUME IN TURKISH NEONATES AND ASSESSMENT OF REGIONAL DIFFERENCES

2014 ◽  
Author(s):  
Sibel Bayramoglu ◽  
Sema Aksoy ◽  
Akgun Unat ◽  
Fatma Beyazal Celiker ◽  
Seyma Yıldız ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Regional Differences ◽  
Gland Volume ◽  
Thyroid Gland Volume
Sign in / Sign up

Export Citation Format

Share Document