scholarly journals Endocrine Disturbances Induced by Low-Dose Organophosphate Exposure in Male Wistar Rats

2021 ◽  
Vol 17 (2) ◽  
pp. 177-185
Author(s):  
C Cobilinschi
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Endocrine Disturbances ◽  
Male Wistar Rats

Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Tosan Peter Omayone ◽  
Samuel Babafemi Olaleye
Keyword(s):  
Acetic Acid ◽  
Untreated Control ◽  
Wistar Rats ◽  
Low Dose ◽  
Healing Process ◽  
Beneficial Effects ◽  
Male Wistar Rats ◽  
Haematological Changes ◽  
Therapeutic Properties ◽  
Histopathological Effects

Abstract Objectives Vanadium has been reported to possess relevant therapeutic properties such as anti-diabetic and anti-tumoral. This study aimed at determining the effects of vanadium on experimentally induced colitis in rats. Methods Forty-five male Wistar rats (103 ± 3.90 g, n=15) were used for this study and were divided into three groups. Group 1 (Untreated control) had nothing added to their drinking, while groups 2 and 3 received sodium metavanadate at a dose of 50 and 200 mg/L respectively in their drinking water for 10 weeks. Colitis was thereafter induced by intra colonic administration of 1.50 mL of 6% acetic acid. Animals were sacrificed on day 0 (pre-induction), three- and seven-days post induction. Blood samples were collected for haematological variables and the distal 8 cm of the colon was collected for macroscopic, histological and biochemical (malondialdehyde-MDA, superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase- GPx and nitrite concentration- NO) assessment. Results Low dose vanadium proved beneficial in ameliorating acetic acid-induced colitis by improving both histopathological and haematological changes. Gross observation showed a faster healing rate in vanadium treated groups (50 and 200 mg/L) compared with untreated control at day 3 (40 and 26.20 vs. 2.50%) and day 7 (80 and 66.70 vs. 42%) respectively. Vanadium also appears to exert its beneficial effects on acetic acid-induced colitis via up regulation of antioxidant enzymes (SOD, CAT, GPx) and NO while decreasing the over production of MDA. Conclusions Vanadium at small concentration functions as an essential trace element and may be able to promote healing process during ulcerative colitis.

Characterization of sleep-pattern and neuro-immune-endocrine markers at 24 hour post-injection of a single low dose of lipopolysaccharide in male Wistar rats

2018 ◽  
Vol 320 ◽  
pp. 15-18
Author(s):  
Francisco Nachón-García ◽  
Gabriela Hurtado-Alvarado ◽  
Mario E. Acosta-Hernández ◽  
Carolina Peña-Escudero ◽  
Sergio Priego-Fernández ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Sleep Pattern ◽  
Post Injection ◽  
Male Wistar Rats

scholarly journals Cell proliferation and apoptosis in Wistar rat kidney after renal mass ablation and low-dose irradiation

Medicina ◽  
2010 ◽  
Vol 46 (3) ◽  
pp. 204
Author(s):  
Marina Aunapuu ◽  
Andres Arend ◽  
Mai Ots ◽  
Mara Pilmane
Keyword(s):  
Cell Proliferation ◽  
Wistar Rats ◽  
Low Dose ◽  
Rat Kidney ◽  
Wistar Rat ◽  
Control Group ◽  
Dose Irradiation ◽  
Proliferation And Apoptosis ◽  
Male Wistar Rats ◽  
Distal Tubules

Cell proliferation and apoptosis in the remnant rat kidney after treatment with lowdose irradiation was investigated. Material and methods. In the first group (n=9), adult male Wistar rats underwent 5/6 nephrectomy (NPX); in the second group (n=9), NPX was combined with low-dose irradiation. Rats without surgery and irradiation formed the control group (n=9). Results. Hypertension and proteinuria induced by NPX were decreased by 3-Gy irradiation. The 5/6 NPX rats showed a dramatic increase in proliferating and apoptotic cells in the glomeruli and in the distal tubules at week 2, which was significantly decreased by low-dose irradiation. Conclusion. The data demonstrate that low-dose irradiation is a factor slowing the process of chronic renal injury.

Attenuation of ischemia-reperfusion-induced gastric ulcer by low-dose vanadium in male Wistar rats

Life Sciences ◽  
2020 ◽  
Vol 259 ◽  
pp. 118272
Author(s):  
Tosan Peter Omayone ◽  
Adeola Temitope Salami ◽  
James Olukayode Olopade ◽  
Samuel Babafemi Olaleye
Keyword(s):  
Gastric Ulcer ◽  
Wistar Rats ◽  
Low Dose ◽  
Ischemia Reperfusion ◽  
Male Wistar Rats

Chronic low-dose glucocorticoid treatment increases subcutaneous abdominal fat, but not visceral fat, of male Wistar rats

Life Sciences ◽  
2017 ◽  
Vol 190 ◽  
pp. 29-35 ◽  
Author(s):  
Patricia Pereira Nunes ◽  
Sandra Andreotti ◽  
Flaviane de Fátima Silva ◽  
Rogério Antonio Laurato Sertié ◽  
Rennan de Oliveira Caminhotto ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Wistar Rats ◽  
Low Dose ◽  
Abdominal Fat ◽  
Glucocorticoid Treatment ◽  
Male Wistar Rats

scholarly journals Protective effects of phytomediated synthesized magnesium hydroxide nanomaterials using Monodora myristica against diabetes-associated hepatopathy, nephropathy and neuropathy in streptozotocin-exposed rat

2021 ◽  
Author(s):  
Olakunle Bamikole Afolabi ◽  
Omotade I Oloyede ◽  
Bukola T Aluko ◽  
Jonathan Johnson
Keyword(s):  
Diabetes Mellitus ◽  
Wistar Rats ◽  
Low Dose ◽  
Diabetic Rats ◽  
Enzymatic Antioxidants ◽  
Protective Effects ◽  
Control Groups ◽  
Male Wistar Rats ◽  
Monodora Myristica ◽  
Standard Techniques

Abstract There is recently a fast growing interest in green nanotechnology as a better approach for managing diabetes mellitus (DM) and its associated complications. This study therefore aimed at exploring the protective potentials of biogenic phytomediated magnesium-based nanoparticles using Monodora myristica seed (Mg(OH)2NP-Mm) against streptozotocin-induced diabetic hepatopathy, nephropathy and neuropathy in Wistar rats. Mg(OH)2NP-Mm was biosynthesized and characterized using standard techniques. Forty-eight (48) adult male Wistar rats weighing 150-200 g, were indiscriminately grouped into eight (8) groups of six (6) rats (n=6) each. Diabetes was induced with a low dose of streptozotocin (STZ) (55 mg/kg bw) and diabetic animals administered 50, 100, 150 and 200 mg/kg bw Mg(OH)2NP-Mm for 21 days, while control groups received glibenclamide (5 mg/kg bw) and Mg(OH)2-STD (150 mg/kg bw), respectively. In this study, treatment with Mg(OH)2NP-Mm caused a significant (p < 0.05) improvement in fasting blood sugar (FBG), serum hepatic biomarkers (AST, ALT and ALP activities), renal clearance markers (creatinine and urea), total protein (TP) and bilirubin. Enzymatic and non-enzymatic antioxidants, as well as histomorphological examinations indicated a significant (p < 0.05) restoration of the hepatic, renal and brain tissues. This finding therefore, hypothesizes attenuation of redox imbalance which probably could be the basis for the protective effect demonstrated by Mg(OH)2NP-Mm in the tissues examined from STZ-induced diabetic rats.

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