Attenuation of ischemia-reperfusion-induced gastric ulcer by low-dose vanadium in male Wistar rats

Life Sciences ◽  
2020 ◽  
Vol 259 ◽  
pp. 118272
Author(s):  
Tosan Peter Omayone ◽  
Adeola Temitope Salami ◽  
James Olukayode Olopade ◽  
Samuel Babafemi Olaleye
Keyword(s):  
Gastric Ulcer ◽  
Wistar Rats ◽  
Low Dose ◽  
Ischemia Reperfusion ◽  
Male Wistar Rats

Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Tosan Peter Omayone ◽  
Samuel Babafemi Olaleye
Keyword(s):  
Acetic Acid ◽  
Untreated Control ◽  
Wistar Rats ◽  
Low Dose ◽  
Healing Process ◽  
Beneficial Effects ◽  
Male Wistar Rats ◽  
Haematological Changes ◽  
Therapeutic Properties ◽  
Histopathological Effects

Abstract Objectives Vanadium has been reported to possess relevant therapeutic properties such as anti-diabetic and anti-tumoral. This study aimed at determining the effects of vanadium on experimentally induced colitis in rats. Methods Forty-five male Wistar rats (103 ± 3.90 g, n=15) were used for this study and were divided into three groups. Group 1 (Untreated control) had nothing added to their drinking, while groups 2 and 3 received sodium metavanadate at a dose of 50 and 200 mg/L respectively in their drinking water for 10 weeks. Colitis was thereafter induced by intra colonic administration of 1.50 mL of 6% acetic acid. Animals were sacrificed on day 0 (pre-induction), three- and seven-days post induction. Blood samples were collected for haematological variables and the distal 8 cm of the colon was collected for macroscopic, histological and biochemical (malondialdehyde-MDA, superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase- GPx and nitrite concentration- NO) assessment. Results Low dose vanadium proved beneficial in ameliorating acetic acid-induced colitis by improving both histopathological and haematological changes. Gross observation showed a faster healing rate in vanadium treated groups (50 and 200 mg/L) compared with untreated control at day 3 (40 and 26.20 vs. 2.50%) and day 7 (80 and 66.70 vs. 42%) respectively. Vanadium also appears to exert its beneficial effects on acetic acid-induced colitis via up regulation of antioxidant enzymes (SOD, CAT, GPx) and NO while decreasing the over production of MDA. Conclusions Vanadium at small concentration functions as an essential trace element and may be able to promote healing process during ulcerative colitis.

Characterization of sleep-pattern and neuro-immune-endocrine markers at 24 hour post-injection of a single low dose of lipopolysaccharide in male Wistar rats

2018 ◽  
Vol 320 ◽  
pp. 15-18
Author(s):  
Francisco Nachón-García ◽  
Gabriela Hurtado-Alvarado ◽  
Mario E. Acosta-Hernández ◽  
Carolina Peña-Escudero ◽  
Sergio Priego-Fernández ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Low Dose ◽  
Sleep Pattern ◽  
Post Injection ◽  
Male Wistar Rats

scholarly journals Cell proliferation and apoptosis in Wistar rat kidney after renal mass ablation and low-dose irradiation

Medicina ◽  
2010 ◽  
Vol 46 (3) ◽  
pp. 204
Author(s):  
Marina Aunapuu ◽  
Andres Arend ◽  
Mai Ots ◽  
Mara Pilmane
Keyword(s):  
Cell Proliferation ◽  
Wistar Rats ◽  
Low Dose ◽  
Rat Kidney ◽  
Wistar Rat ◽  
Control Group ◽  
Dose Irradiation ◽  
Proliferation And Apoptosis ◽  
Male Wistar Rats ◽  
Distal Tubules

Cell proliferation and apoptosis in the remnant rat kidney after treatment with lowdose irradiation was investigated. Material and methods. In the first group (n=9), adult male Wistar rats underwent 5/6 nephrectomy (NPX); in the second group (n=9), NPX was combined with low-dose irradiation. Rats without surgery and irradiation formed the control group (n=9). Results. Hypertension and proteinuria induced by NPX were decreased by 3-Gy irradiation. The 5/6 NPX rats showed a dramatic increase in proliferating and apoptotic cells in the glomeruli and in the distal tubules at week 2, which was significantly decreased by low-dose irradiation. Conclusion. The data demonstrate that low-dose irradiation is a factor slowing the process of chronic renal injury.

scholarly journals Protective outcomes of low-dose doxycycline on renal function of Wistar rats subjected to acute ischemia/reperfusion injury

2018 ◽  
Vol 1864 (1) ◽  
pp. 102-114 ◽  
Author(s):  
Aline L. Cortes ◽  
Sabrina R. Gonsalez ◽  
Lilimar S. Rioja ◽  
Simone S.C. Oliveira ◽  
André L.S. Santos ◽  
...  
Keyword(s):  
Renal Function ◽  
Reperfusion Injury ◽  
Wistar Rats ◽  
Low Dose ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Acute Ischemia

Gastroprotective activity of essential oils from turmeric and ginger

2015 ◽  
Vol 26 (1) ◽  
Author(s):  
Vijayasteltar B. Liju ◽  
Kottarapat Jeena ◽  
Ramadasan Kuttan
Keyword(s):  
Gastric Ulcer ◽  
Antioxidant Enzymes ◽  
Essential Oils ◽  
Wistar Rats ◽  
Histopathological Examination ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Degree Of Protection ◽  
Male Wistar Rats ◽  
Different Doses

AbstractTurmeric (Turmeric and ginger were evaluated for their antiulcer activity against ethanol-induced ulcers in male Wistar rats at different doses: 100, 500 and 1000 mg/kg body weight. Ethanol was used to induce gastric ulcer in Wistar rats. Parameters such as ulcer index, histopathology and levels of antioxidant enzymes such as glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase and glutathione (GSH) levels were measured to assess the degree of protection produced by the essential oils.TEO and GEO inhibited ulcer by 84.7% and 85.1%, respectively, as seen from the ulcer index. Reduced antioxidant enzymes such as GPx, SOD, catalase and GSH produced by alcohol administration were significantly (p<0.001) increased by simultaneous administration of TEO and GEO. Histopathological examination showed that ethanol-induced lesions such as necrosis, erosion and hemorrhage of the stomach wall were significantly reduced after oral administration of essential oils.Results suggest that TEO and GEO could reduce the gastric ulcer in rat stomach as seen from the ulcer index and histopathology of the stomach. Moreover, oxidative stress produced by ethanol was found to be significantly reduced by TEO and GEO.

Chronic low-dose glucocorticoid treatment increases subcutaneous abdominal fat, but not visceral fat, of male Wistar rats

Life Sciences ◽  
2017 ◽  
Vol 190 ◽  
pp. 29-35 ◽  
Author(s):  
Patricia Pereira Nunes ◽  
Sandra Andreotti ◽  
Flaviane de Fátima Silva ◽  
Rogério Antonio Laurato Sertié ◽  
Rennan de Oliveira Caminhotto ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Wistar Rats ◽  
Low Dose ◽  
Abdominal Fat ◽  
Glucocorticoid Treatment ◽  
Male Wistar Rats

scholarly journals Remote ischemic conditioning enhances heart and brain antioxidant defense

2020 ◽  
Vol 19 ◽  
Author(s):  
Felipe Lobato da Silva Costa ◽  
Renan Kleber Costa Teixeira ◽  
Vitor Nagai Yamaki ◽  
André Lopes Valente ◽  
Sandro Percário ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Wistar Rats ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Antioxidant Defenses ◽  
Early Reperfusion ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning ◽  
Protection Mechanisms ◽  
Male Wistar Rats

Abstract Background Ischemia-reperfusion injury contributes to morbidity after revascularization procedures. Along with early reperfusion, tissue conditioning by alternating intervals of brief ischemia-reperfusion episodes is considered the best approach to limit tissue damage. Remote ischemic conditioning is conducted remotely, in tissues other than those under ischemia. Despite this, remote ischemic conditioning protection mechanisms are poorly understood, which can lead to misapplication. Objectives To assess whether remote ischemic conditioning works in the heart and brain through enhancement of cells’ antioxidant defenses and whether the response is sustained or temporary. Methods Twenty-one male Wistar rats were assigned to three groups (n = 7): SHAM: same procedure as the other groups, but no remote ischemic conditioning was carried out. RIC 10: heart and brain were harvested 10 minutes after the remote ischemic conditioning protocol. RIC 60: heart and brain were harvested 60 minutes after the remote ischemic conditioning protocol. The remote ischemic conditioning protocol consisted of 3 cycles of 5 min left hindlimb ischemia followed by 5 min left hindlimb perfusion, lasting 30 min in total. Heart and brain samples were used to measure the tissue antioxidant capacity. Results Remote ischemic conditioning increased heart and brain antioxidant capacity after 10 minutes (0.746 ± 0.160/0.801 ± 0.227 mM/L) when compared to SHAM (0.523 ± 0.078/0.404 ± 0.124 mM/L). No enhancement of heart or brain antioxidant capacity was detected 60 minutes after remote ischemic conditioning (0.551 ± 0.073/0.455 ± 0.107 mM/L). Conclusions Remote ischemic conditioning temporarily enhances heart and brain antioxidant defenses in male Wistar rats.

scholarly journals The histochemical and biochemical effects of coconutmilk in Wistar rats with ethanol-induced gastric ulcer

2019 ◽  
Vol 8 (2) ◽  
pp. 1558-1569
Author(s):  
Omojola A. Tolulope ◽  
Ofusori A. David ◽  
Edward S. Sylvester ◽  
Umeaku Ugochukwu
Keyword(s):  
Gastric Ulcer ◽  
Wistar Rats ◽  
Coconut Milk ◽  
Equivalent Amount ◽  
Ulcer Index ◽  
Ethanol Group ◽  
Biochemical Effects ◽  
Single Oral Administration ◽  
Male Wistar Rats ◽  
Group 1

This study aimed at investigating the histochemical and biochemical effects of coconut milk in Wistar rats’ model of ethanol-induced gastric ulcer with a view to evaluating the antiulcerogenic potential of coconut milk in the management of gastric ulcer. Thirty male Wistar rats weighing between 150-180g were recruited for the study and divided into six groups of 5 rats each. All the groups were fasted for 24-hours after which group-1 received single oral administration of normal saline at 5ml/kg, while groups 2-6 received equivalent amount of ethanol. Twenty-four hours later, Groups-3, 4, 5 received oral graded doses of coconut milk at 30, 50, 70 mg/kg respectively while group 6 received omeprazole administration at 10 mg/kg every 12-hours for a period of 21 days. The ulcer index as well as Prostalglandin-E2 and Nitric Oxide concentrations was significantly (p < 0.05) lowered following treatment with omeprazole and coconut milk, when compared with the ethanol group. Coconut milk administration also attenuated the ethanol-induced histochemical distortions of the gastric pylorus. This study concluded that  coconut milk administration ameliorated ethanol-induced gastric ulcer and serves as a potential choice in the treatment of the condition.Keywords: Gastric ulcer, Ethanol, Coconut Milk, Omeprazole, Histochemical, Biochemical

Sign in / Sign up

Export Citation Format

Share Document