The Measurement of Lung Volumes Using Body Plethysmography: A Comparison of Methodologies

2012 ◽  
Vol 57 (7) ◽  
pp. 1076-1083 ◽  
Author(s):  
Brigitte M Borg ◽  
Bruce R Thompson
Keyword(s):  
Body Plethysmography ◽  
Lung Volumes

scholarly journals Official ERS technical standard: Global Lung Function Initiative reference values for static lung volumes in individuals of European ancestry

2021 ◽  
Vol 57 (3) ◽  
pp. 2000289
Author(s):  
Graham L. Hall ◽  
Nicole Filipow ◽  
Gregg Ruppel ◽  
Tolu Okitika ◽  
Bruce Thompson ◽  
...  
Keyword(s):  
Lung Function ◽  
Lung Volume ◽  
Additive Models ◽  
European Ancestry ◽  
Reference Ranges ◽  
Body Plethysmography ◽  
Lung Volumes ◽  
Reference Equations ◽  
Gas Dilution ◽  
The Impact

BackgroundMeasurement of lung volumes across the life course is critical to the diagnosis and management of lung disease. The aim of the study was to use the Global Lung Function Initiative methodology to develop all-age multi-ethnic reference equations for lung volume indices determined using body plethysmography and gas dilution techniques.MethodsStatic lung volume data from body plethysmography and gas dilution techniques from individual, healthy participants were collated. Reference equations were derived using the LMS (lambda-mu-sigma) method and the generalised additive models of location shape and scale programme in R. The impact of measurement technique, equipment type and being overweight or obese on the derived lung volume reference ranges was assessed.ResultsData from 17 centres were submitted and reference equations were derived from 7190 observations from participants of European ancestry between the ages of 5 and 80 years. Data from non-European ancestry populations were insufficient to develop multi-ethnic equations. Measurements of functional residual capacity (FRC) collected using plethysmography and dilution techniques showed physiologically insignificant differences and were combined. Sex-specific reference equations including height and age were developed for total lung capacity (TLC), FRC, residual volume (RV), inspiratory capacity, vital capacity, expiratory reserve volume and RV/TLC. The derived equations were similar to previously published equations for FRC and TLC, with closer agreement during childhood and adolescence than in adulthood.ConclusionsGlobal Lung Function Initiative reference equations for lung volumes provide a generalisable standard for reporting and interpretation of lung volumes measurements in individuals of European ancestry.

scholarly journals Evaluation of spirometry gated CT scan to measure lung volumes in emphysema patients

2021 ◽  
pp. 00492-2021
Author(s):  
Jens T Bakker ◽  
Karin Klooster ◽  
Jan Bouwman ◽  
Gert Jan Pelgrim ◽  
Rozemarijn Vliegenthart ◽  
...  
Keyword(s):  
Ct Scan ◽  
Pearson Correlation ◽  
Ct Scanning ◽  
Breath Hold ◽  
Strongly Correlated ◽  
Body Plethysmography ◽  
Lung Volumes ◽  
Copd Patients ◽  
The Mean ◽  
Correlation Factors

IntroductionIn emphysema patients, being evaluated for bronchoscopic lung volume reduction (BLVR), accurate measurement of lung volumes is important. Total Lung Capacity (TLC) and Residual Volume (RV) are commonly measured by body-plethysmography, but can also be derived from chest computed tomography (CT). Spirometry-gated CT scanning potentially improves the agreement of CT and body-plethysmography.ObjectiveTo compare lung volumes derived from spirometry-gated CT and “breath-hold-coached” CT to the reference standard: body-plethysmography.MethodsIn this single centre retrospective cohort study, emphysema patients, evaluated for BLVR, underwent body-plethysmography, inspiration (TLC) and expiration (RV) CT-scan with spirometer guidance (“gated group”) or with breath-hold-coaching (“non-gated group”). Quantitative analysis was used to calculate lung volumes from the CT.ResultsWe included 200 patients (age 62±8 years, FEV1 29.2±8.7%, TLC 7.50±1.46 L, RV 4.54±1.07 L). The mean CT-derived TLC was 280(±340)ml lower compared to body-plethysmography in the gated group (n=100), and 590(±430)ml lower for the non-gated group (n=100) (both p<0.001). The mean CT-derived RV was 300(±470)ml higher in the gated group and 700(±720)ml higher in the non-gated group (both p<0.001). Pearson correlation factors were 0.947 for TLC gated, 0.917 for TLC non-gated, 0.823 for RV gated, 0.693 for RV non-gated, 0.539 for %RV/TLC gated and 0.204 for %RV/TLC non-gated. The differences between the gated and non-gated CT results for TLC and RV were significant for all measurements (p<0.001).ConclusionIn severe COPD patients with emphysema, CT-derived lung volumes are strongly correlated to body-plethysmography lung volumes, and especially for RV, more accurate when using spirometry-gating.

scholarly journals Utility and validity of dynamic chest radiography in cystic fibrosis (dynamic CF): an observational, non-controlled, non-randomised, single-centre, prospective study

2020 ◽  
Vol 7 (1) ◽  
pp. e000569
Author(s):  
Thomas Simon FitzMaurice ◽  
Paul Stephen McNamara ◽  
Dilip Nazareth ◽  
Caroline McCann ◽  
Ram Bedi ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Prospective Study ◽  
Chest Radiography ◽  
Whole Body ◽  
Standards Of Care ◽  
Body Plethysmography ◽  
Single Centre ◽  
Lung Volumes ◽  
Rapid Acquisition ◽  
Whole Body Plethysmography

IntroductionDynamic chest radiography (DCR) uses novel, low-dose radiographic technology to capture images of the thoracic cavity while in motion. Pulmonary function testing is important in cystic fibrosis (CF). The tolerability, rapid acquisition and lower radiation and cost compared with CT imaging may make DCR a useful adjunct to current standards of care.Methods and analysisThis is an observational, non-controlled, non-randomised, single-centre, prospective study. This study is conducted at the Liverpool Heart and Chest Hospital (LHCH) adult CF unit. Participants are adults with CF. This study reviews DCR taken during routine CF Annual Review (n=150), validates DCR-derived lung volumes against whole body plethysmography (n=20) and examines DCR at the start and end of pulmonary exacerbations of CF (n=20). The primary objectives of this study are to examine if DCR provides lung function information that correlates with PFT, and lung volumes that correlate whole body plethysmography.Ethics and disseminationThis study has received the following approvals: HRA REC (11 December 2019) and LHCH R&I (11 October 2019). Results are made available to people with CF, the funders and other researchers. Processed, anonymised data are available from the research team on request.Trial registration numberISRCTN 64994816.

scholarly journals Can the single-breath helium dilution method predict lung volumes as measured by whole-body plethysmography?

2013 ◽  
Vol 39 (6) ◽  
pp. 675-685 ◽  
Author(s):  
Patrícia Chaves Coertjens ◽  
Marli Maria Knorst ◽  
Anelise Dumke ◽  
Adriane Schmidt Pasqualoto ◽  
João Riboldi ◽  
...  
Keyword(s):  
Lung Function ◽  
Whole Body ◽  
Normal Lung ◽  
Regression Equations ◽  
Body Plethysmography ◽  
Lung Volumes ◽  
Single Breath ◽  
Normal Lung Function ◽  
Helium Dilution ◽  
Whole Body Plethysmography

OBJECTIVE: To compare TLC and RV values obtained by the single-breath helium dilution (SBHD) method with those obtained by whole-body plethysmography (WBP) in patients with normal lung function, patients with obstructive lung disease (OLD), and patients with restrictive lung disease (RLD), varying in severity, and to devise equations to estimate the SBHD results.METHODS: This was a retrospective cross-sectional study involving 169 individuals, of whom 93 and 49 presented with OLD and RLD, respectively, the remaining 27 having normal lung function. All patients underwent spirometry and lung volume measurement by both methods.RESULTS: TLC and RV were higher by WBP than by SBHD. The discrepancy between the methods was more pronounced in the OLD group, correlating with the severity of airflow obstruction. In the OLD group, the correlation coefficient of the comparison between the two methods was 0.57 and 0.56 for TLC and RV, respectively (p < 0.001 for both). We used regression equations, adjusted for the groups studied, in order to predict the WBP values of TLC and RV, using the corresponding SBHD values. It was possible to create regression equations to predict differences in TLC and RV between the two methods only for the OLD group. The TLC and RV equations were, respectively, ∆TLCWBP-SBHD in L = 5.264 − 0.060 × FEV1/FVC (r2= 0.33; adjusted r2 = 0.32) and ∆RVWBP-SBHD in L = 4.862 − 0.055 × FEV1/FVC (r2= 0.31; adjusted r2 = 0.30).CONCLUSIONS: The correction of TLC and RV results obtained by SBHD can improve the accuracy of this method for assessing lung volumes in patients with OLD. However, additional studies are needed in order to validate these equations.

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