Preparation and Characterization of Novel Drug-Inserted-Montmorillonite Chitosan Carriers for Ocular Drug Delivery

The biomineral-binding alendronate-chitosan conjugate (Scheme 1) was developed as a novel drug delivery system. Alendronate was conjugated to the hydroxyl groups of chitosan, thereby maintaining the amino groups of chitosan intact. By means of FT-IR and 1H NMR, the characterization was conducted to confirm the successful synthesis of alendronate-chitosan conjugate.

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Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Frontiers in Bioengineering and Biotechnology ◽

10.3389/fbioe.2020.601246 ◽

2020 ◽

Vol 8 ◽

Author(s):

Haozhe Yu ◽

Wenyu Wu ◽

Xiang Lin ◽

Yun Feng

Keyword(s):

Drug Delivery ◽

Structural Instability ◽

Ocular Drug Delivery ◽

Synthesis Process ◽

Ocular Tissues ◽

Drug Solubilization ◽

Physiological Structure ◽

Ocular System ◽

Novel Drug ◽

Drug Nanocarriers

Ocular drug delivery is one of the most challenging issues in ophthalmology because of the complex physiological structure of the eye. Polysaccharide-based nanomaterials have been extensively investigated in recent years as ideal carriers for enhancing the bioavailability of drugs in the ocular system because of their biocompatibility and drug solubilization. From this perspective, we discuss the structural instability of polysaccharides and its impact on the synthesis process; examine the potential for developing bioactive polysaccharide-based ocular drug nanocarriers; propose four strategies for designing novel drug delivery nanomaterials; and suggest reviewing the behavior of nanomaterials in ocular tissues.

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Formulation and Characterization of Atropine Sulfate in Albumin–Chitosan Microparticles for In Vivo Ocular Drug Delivery

Journal of Pharmaceutical Sciences ◽

10.1002/jps.24380 ◽

2015 ◽

Vol 104 (5) ◽

pp. 1677-1690 ◽

Cited By ~ 23

Author(s):

Richard T. Addo ◽

Kwame G. Yeboah ◽

Rodney C. Siwale ◽

Aladin Siddig ◽

Alphia Jones ◽

...

Keyword(s):

Drug Delivery ◽

Atropine Sulfate ◽

Ocular Drug Delivery ◽

Chitosan Microparticles

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Development and Characterization of 99mTc-timolol Maleate for Evaluating Efficacy of In Situ Ocular Drug Delivery System

AAPS PharmSciTech ◽

10.1208/s12249-009-9238-x ◽

2009 ◽

Vol 10 (2) ◽

pp. 540-546 ◽

Cited By ~ 20

Author(s):

Himanshu Gupta ◽

M. Aqil ◽

R. K. Khar ◽

Asgar Ali ◽

Aseem Bhatnagar ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Ocular Drug Delivery ◽

Timolol Maleate

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Advancement in Ocular Drug Delivery System to Overcome Ocular Barrier

International Journal of Pharmaceutical Sciences Review and Research ◽

10.47583/ijpsrr.2021.v71i02.015 ◽

2021 ◽

Vol 71 (2) ◽

Author(s):

Supriya Nikam ◽

Abhilasha Ghule ◽

Akash Inde ◽

Anjali Jambhulkar

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Ocular Drug Delivery ◽

Direct Access ◽

Ocular Delivery ◽

Hydrophilic Drugs ◽

Delivery Planning ◽

Delivery Routes ◽

Novel Drug

The Ocular drug delivery system (ODDS) is the prominently challenging system faced by pharmaceutical researchers. Ophthalmic preparations are available in buffered, sterile and isotonic solutions. For the ocular delivery of drugs, various types of dosage forms are prepared and dispensed. As the drops are easier for the administration likewise more prescribed dosage form is the eye drop solution. For obtaining prolonged therapeutic effect ointment, suspensions and gelled systems are also used. The presence of various barriers as anatomical, physiological and physiochemical barriers makes difficulties in delivery of drugs in at the intended sites. Scientists invented alternate delivery routes to direct access at intended target sites. Second invention involves development of novel drug delivery systems providing better permeability, treatability and controlled release at target site. The liposomal delivery is beneficial because they have the ability of envelopment and both hydrophobic and hydrophilic drugs are suitable for delivery to both the anterior and posterior segment of the eye. Therefore, the uses of this alternative approach become quite a necessary. This formulation of novel devices will definitely help to the overcome ocular barriers and side effects with conventional topical drops. Current reviews on the conventional formulations of ocular delivery and their advancements followed by current nanotechnology based on the formulation developments. The recent incident with other ocular drug delivery planning consists of in situ gels, implants, contact lens and nano wafers are discussed. Drug delivery at ophthalmic route has been proven significant advancement for the future perspectives.

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Casuarina equisetifoliaExtract Loaded Phytosomes: Optimization, Characterization andIn vivoEvaluation of Antidiabetic and Antihyperlipidemic Activities in Wistar Rats

Drug Delivery Letters ◽

10.2174/2210303109666190118162157 ◽

2019 ◽

Vol 9 (2) ◽

pp. 116-133 ◽

Cited By ~ 1

Author(s):

Anjana Rani ◽

Sunil Kumar ◽

Roop K. Khar

Keyword(s):

Drug Delivery ◽

Particle Size ◽

Therapeutic Efficacy ◽

Entrapment Efficiency ◽

Herbal Extract ◽

Casuarina Equisetifolia ◽

Novel Drug

Background:Herbal extracts have brilliant in-vitro activity but less in-vivo action in light of their macromolecular size and poor lipid solubility bringing about poor absorption and low bioavailability. These issues can be corrected by designing novel drug delivery systems. Phytosomes provide better absorption and bioavailability when compared to conventional herbal extract.Objective:This paper deals with the preparation, optimization and characterization of Phytosome of plant extract and in vivo assessment of antidiabetic and antihyperlipidemic activity for improved therapeutic efficacy having sufficient stability.Methods:Preliminary distinctive strategies were utilized to get ready Phytosome and antisolvent precipitation method was chosen. The formulation was guided by a full factorial design to study the effect of Independent variable on various dependent variables and resulted in an optimised product. Response contour plots were generated for each response factor to predict a phytosomal composition that yields phytosome formulation having least particle size and maximum entrapment efficiency.Results:Mean particle size, entrapment efficiency and Span value were found to be 295 ± 0.53nm, 82.43 ± 1.65% and 0.34 ± 0.14 respectively. Zeta potential was found to be 19.35mv, indicating the formation of stable formulation. In vitro release study described that the drug release follows the Korsmeyer- Peppas kinetic model. The results proved that Phytosomes of Casuarina equisetifolia extract exhibited more antidiabetic potential and antihyperlipidemic properties as compared to crude Casuarina extract.Conclusion:Phytosomes of Casuarina equestifolia extract was successfully formulated having good entrapment efficiency and physico-chemical characterization of the optimized product, confirming the formation of stable formulation. In vivo antidiabetic activity confirmed better potential of the optimised formulation. Consequently, it has been presumed that Phytosomes of Casuarina equisetifolia extract serve as a useful novel drug delivery system and provide more therapeutic efficacy than conventional plant extracts.

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