Studies on the Host-Parasite Relationship between Schistosoma Mansoni and the Snail Australorbis Glabratus *

1965 ◽  
Vol 14 (6) ◽  
pp. 931-976 ◽  
Author(s):  
Chia-Tung Pan
Keyword(s):  
Schistosoma Mansoni ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Host Parasite

Susceptibilities of Various Snail Intermediate Hosts of Schistosoma mansoni to Different Strains of the Parasite

1965 ◽  
Vol 39 (4) ◽  
pp. 363-376 ◽  
Author(s):  
M.F.A. Saoud
Keyword(s):  
Puerto Rico ◽  
Schistosoma Mansoni ◽  
Intermediate Hosts ◽  
Considerable Evidence ◽  
The Past ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Different Strains ◽  
Host Parasite ◽  
Comprehensive Studies

In the past two decades, considerable evidence has accumulated in the literature about the differences in the susceptibility of various intermediate hosts of Schistosoma mansoni to different strains of the parasite. Comprehensive studies on this aspect of host-parasite relationship have been published by Files & Cram (1949), Abdel-Malek (1950) and Files (1951). The results of more recent studies have been reported by Wright (1962) and Saoud (1964).In the present paper, the writer has studied the susceptibility of four intermediate hosts of S. mansoni from Brazil, Puerto Rico, Egypt and Tanganyika to some strains of the parasite.

scholarly journals Purification of a chymotrypsin-like enzyme present on adult Schistosoma mansoni worms from infected mice and its characterization as a host carboxylesterase

Parasitology ◽  
2016 ◽  
Vol 143 (5) ◽  
pp. 646-657 ◽  
Author(s):  
JOSEPH E. IGETEI ◽  
SUSAN LIDDELL ◽  
MARWA EL-FAHAM ◽  
MICHAEL J. DOENHOFF
Keyword(s):  
Schistosoma Mansoni ◽  
Normal Mouse ◽  
Polyacrylamide Gel Electrophoresis ◽  
Sodium Dodecyl ◽  
Mouse Serum ◽  
Mouse Blood ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
General Esterase ◽  
Host Parasite

SUMMARYA serine protease-like enzyme found in detergent extracts of Schistosoma mansoni adult worms perfused from infected mice has been purified from mouse blood and further characterized. The enzyme is approximately 85 kDa and hydrolyses N-acetyl-DL-phenylalanine β-naphthyl–ester, a chromogenic substrate for chymotrypsin-like enzymes. The enzyme from S. mansoni worms appears to be antigenically and enzymatically similar to a molecule that is present in normal mouse blood and so is seemingly host-derived. The enzyme was partially purified by depleting normal mouse serum of albumin using sodium chloride and cold ethanol, followed by repeated rounds of purification by one-dimensional sodium dodecyl sulphate polyacrylamide gel electrophoresis. The purified material was subjected to tandem mass spectrometry and its derived peptides found to belong to mouse carboxylesterase 1C. Its ability to hydrolyse α- or β-naphthyl acetates, which are general esterase substrates, has been confirmed. A similar carboxylesterase was purified and characterized from rat blood. Additional evidence to support identification of the enzyme as a carboxylesterase has been provided. Possible roles of the enzyme in the mouse host–parasite relationship could be to ease the passage of worms through the host's blood vessels and/or in immune evasion.

scholarly journals Infection of Mice Lacking Interleukin-7 (IL-7) Reveals an Unexpected Role for IL-7 in the Development of the Parasite Schistosoma mansoni

1999 ◽  
Vol 67 (8) ◽  
pp. 4183-4190 ◽  
Author(s):  
Isabelle Wolowczuk ◽  
Sophie Nutten ◽  
Olivier Roye ◽  
Myriam Delacre ◽  
Monique Capron ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Humoral Response ◽  
Interleukin 7 ◽  
Intradermal Administration ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Host Parasite ◽  
Deficient Mice ◽  
Specific Humoral Response

ABSTRACT A single intradermal administration of recombinant interleukin-7 (IL-7) has been shown to aggravate the course of murine schistosomiasis, to favor the development of Th2-associated antibodies specific for the parasite, and to alter migration kinetics and/or migratory route of the parasite within its vertebrate host. Here we show that after infection of IL-7-deficient mice with Schistosoma mansoni, the predominant parasite-specific humoral response follows a Th1 pattern, and the development of the parasite is greatly impaired. In IL-7-deficient mice, increased numbers of larvae reach the lungs and fewer larvae reach the liver, compared to control mice. In the absence of IL-7, female worms show an altered fecundity, leading to decreased numbers of eggs trapped in the tissues and to an amelioration of the pathology of the infected host. The most striking observation is the blockade of parasite growth in an IL-7-defective environment, leading to dwarf male and female worms. The results of this study have important implications for the role of IL-7 in the host-parasite relationship and show how parasites can disable or evade the host immune response.

scholarly journals The tegument of Schistosoma mansoni: genes, antigens and the host-parasite relationship

1998 ◽  
Vol 93 (suppl 1) ◽  
pp. 85-86 ◽  
Author(s):  
Edneide M Xavier ◽  
Norma Lucena-Silva ◽  
Roberto P Werkhauser ◽  
Gloria R Franco ◽  
Ricardo AA Lira Santos ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Host Parasite

scholarly journals Host-parasite relationship between Biomphalaria amazonica (Paraense, 1966) and Schistosoma mansoni (Sambon, 1907)

2016 ◽  
Vol 77 (2) ◽  
pp. 340-346 ◽  
Author(s):  
L. F. Simões ◽  
L. D. B. Bastos ◽  
E. A. F. Camargo ◽  
M. F. Neves ◽  
A. X. Linhares ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Potential Vector ◽  
Potential Host ◽  
The North ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Host Parasite

Abstract Biomphalaria amazonica is a planorbid species considered a potential host of Schistosoma mansoni. It is widely distributed in the Neotropical zone, particularly in the North and Centre-West of Brazil and in the North of Bolivia. The aim of the present study was to determine the host-parasite relationship between B. amazonica and S. mansoni (BH and SJ strains). Specimens of B. amazonica and their snail-conditioned water were examined in terms of their ability to attract miracidia. The infectivity of the mollusks was determined by exposing them to 20 miracidia of both strains. Sporocyst development and amebocyte reactions were studied after each mollusk specimen was exposed to 100 miracidia. Although no cercariae were eliminated, specimens of B. amazonica proved capable of attracting 77% of the miracidia they were exposed to. Viable sporocysts with no amebocyte reaction were found 96 hours after the exposure to miracidia. These results indicate the susceptibility of B. amazonica to the BH and SJ strains of S. mansoni, and therefore demonstrate the importance of this planorbid species as a potential vector of the trematode in the areas where it occurs.

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