Case Report: Atypical Cutaneous Presentation of Human T-cell Lymphotropic Virus Type 1-Related Adult T-cell Lymphoma

2021 ◽  
Author(s):  
Gianluca Avallone ◽  
Mattia Trunfio ◽  
Luca Mastorino ◽  
Andrea Agostini ◽  
Martina Merli ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Significant Risk ◽  
Clinical Work ◽  
Lower Limbs ◽  
Interferon Α ◽  
Adult T Cell Leukemia ◽  
Human T Cell ◽  
Diagnostic Delays

Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus endemic in many parts of the world. Because of migration, cases of HTLV-1 in non-HTLV-1 endemic countries have been increasingly reported. Clinical presentation of HTLV-1 infection is highly variable, with a significant risk of diagnostic delays. Skin can be the first site affected by HTLV-1-related manifestations such as cutaneous involvement of adult T-cell leukemia/lymphoma (ATLL) and infective dermatitis associated with HTLV-1. A 32-year-old Nigerian man was admitted to the infectious disease department for high fever, asthenia, lymphocytosis, and vesicular bullous lesions on both hand palms and lower limbs. After clinical work-up was performed, bacterial superinfected herpes simplex viurs-2 ulcers were the presenting sign of HTLV-1-related chronic type ATLL. Standard treatment based on interferon-α plus zidovudine was started, but it was poorly tolerated; therefore, switching to an off-label dual antiretroviral regimen was attempted. The increasing prevalence of HTLV-1 in nonendemic areas may enhance the development of alternative treatments with better efficacy and tolerability profiles.

Cardiac involvement with human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma: The NIH experience

2008 ◽  
Vol 49 (3) ◽  
pp. 439-446 ◽  
Author(s):  
Deirdre O'Mahony ◽  
Indranil Debnath ◽  
John Janik ◽  
Dara Aisner ◽  
Elaine Jaffe ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Cardiac Involvement ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Human T Cell

scholarly journals Complete Sequences of the Human T-Cell Leukemia Virus Type 1 Proviral Genomes from Newly Established Adult T-Cell Leukemia Cell Lines in Oita Prefecture, Japan

2018 ◽  
Vol 6 (25) ◽  
Author(s):  
Takuro Fukumoto ◽  
Emi Ikebe ◽  
Masao Ogata ◽  
Kazuhiro Kohno ◽  
Madoka Kuramitsu ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Adult T Cell Leukemia ◽  
Human T Cell ◽  
T Cell Leukemia Virus

ABSTRACT We report two complete proviral genome sequences of human T-cell leukemia virus type 1 (HTLV-1) isolated from the peripheral blood specimens of acute type adult T-cell leukemia (ATL) patients in Oita Prefecture, Japan.

scholarly journals Adult T-Cell Leukemia/Lymphoma in a Caucasian Patient After Sexual Transmission of Human T-Cell Lymphotropic Virus Type 1

2015 ◽  
Vol 2 (2) ◽  
Author(s):  
David Sibon ◽  
Olivier Cassar ◽  
Isabelle Duga ◽  
Chantal Brouzes ◽  
David Ghez ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Sexual Transmission ◽  
Central Africa ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Human T Cell ◽  
Cell Neoplasm

Abstract Adult T-cell leukemia/lymphoma (ATLL), a T-cell neoplasm caused by human T-cell lymphotropic virus type 1 (HTLV-1), develops in the majority of cases in individuals who were infected with HTLV-1 as young children, by their mother during prolonged breastfeeding. We report the case of a Caucasian French man, whose parents were HTLV-1-seronegative and who developed ATLL after HTLV-1 sexual transmission by a Cameroonian woman. This hypothesis was corroborated by genotyping of the patient's virus, which revealed an HTLV-1B strain, found only in Central Africa, especially in Cameroon. Thus, ATLL may develop after HTLV-1 infection during adulthood, outside breastfeeding.

scholarly journals A critical analysis of prognostic factors in North American patients with human T-cell lymphotropic virus type-1-associated adult T-cell leukemia/lymphoma

Cancer ◽  
2010 ◽  
Vol 116 (14) ◽  
pp. 3438-3446 ◽  
Author(s):  
Adrienne A. Phillips ◽  
Iuliana Shapira ◽  
Robert D. Willim ◽  
Jasotha Sanmugarajah ◽  
William B. Solomon ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
T Cell ◽  
Virus Type ◽  
North American ◽  
Critical Analysis ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Human T Cell

Adult T-cell leukemia-lymphoma in a pregnant woman diagnosed as a human T-cell lymphotropic virus type 1 carrier

2015 ◽  
Vol 42 (3) ◽  
pp. 336-340 ◽  
Author(s):  
Naoki Fuchi ◽  
Kiyonori Miura ◽  
Yoshitaka Imaizumi ◽  
Hiroo Hasegawa ◽  
Katsunori Yanagihara ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
T Cell ◽  
Virus Type ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Human T Cell

scholarly journals Oncogenic Human T-Cell Lymphotropic Virus Type 1 Tax Suppression of Primary Innate Immune Signaling Pathways

2015 ◽  
Vol 89 (9) ◽  
pp. 4880-4893 ◽  
Author(s):  
Jinhee Hyun ◽  
Juan Carlos Ramos ◽  
Ngoc Toomey ◽  
Siddharth Balachandran ◽  
Alfonso Lavorgna ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Host Defense ◽  
Innate Immune ◽  
Type I ◽  
Type I Ifn ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Human T Cell

ABSTRACTHuman T-cell lymphotropic virus type I (HTLV-1) is an oncogenic retrovirus considered to be the etiological agent of adult T-cell leukemia (ATL). The viral transactivator Tax is regarded as the oncoprotein responsible for contributing toward the transformation process. Here, we demonstrate that Tax potently inhibits the activity of DEx(D/H) box helicases RIG-I and MDA5 as well as Toll-dependent TIR-domain-containing adapter-inducing interferon-β (TRIF), which function as cellular sensors or mediators of viral RNA and facilitate innate immune responses, including the production of type I IFN. Tax manifested this function by binding to the RIP homotypic interaction motif (RHIM) domains of TRIF and RIP1 to disrupt interferon regulatory factor 7 (IRF7) activity, a critical type I IFN transcription factor. These data provide further mechanistic insight into HTLV-1-mediated subversion of cellular host defense responses, which may help explain HTLV-1-related pathogenesis and oncogenesis.IMPORTANCEIt is predicted that up to 15% of all human cancers may involve virus infection. For example, human T-cell lymphotropic virus type 1 (HTLV-1) has been reported to infect up to 25 million people worldwide and is the causative agent of adult T-cell leukemia (ATL). We show here that HTLV-1 may be able to successfully infect the T cells and remain latent due to the virally encoded product Tax inhibiting a key host defense pathway. Understanding the mechanisms by which Tax subverts the immune system may lead to the development of a therapeutic treatment for HTLV-1-mediated disease.

scholarly journals HLA-B*35 as a new marker for susceptibility to Human T-cell Lymphotropic Virus type 1 (HTLV-1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients living in Argentina

2020 ◽  
Author(s):  
Paula Benencio ◽  
Sindy A. Fraile Gonzalez ◽  
Nicolás Ducasa ◽  
Kimberly Page ◽  
Carolina A. Berini ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Adult T Cell Leukemia ◽  
Human T Cell ◽  
High Proviral Load ◽  
Host Genetic ◽  
Increased Susceptibility

Abstract Background: Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV associated myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) and Adult T cell leukemia/lymphoma (ATLL), in around 2-5% of the infected individuals. Host genetic background might play a role in disease progression. Several previous studies across many countries report HLA haplotype to be one such factor. Here, we sequenced HLA-A, -B and -C of 66 individuals by Sequence-Based Typing (SBT), and compared the frequency of different alleles among ATLL patients, HAM/TSP patients, asymptomatic carriers and non-infected individuals living in Argentina.Results: The frequency of HLA-A, -B and -C alleles largely matched that of the general population in Argentina. We identified HLA-A*02, HLA-B*35 and HLA-C*07 as associated to protection from ATLL (p=0.031), susceptibility to HAM/TSP (p<0.001) and susceptibility to ATLL (p=0.017), respectively. We also found a strong correlation between high proviral load (PVL) and disease (p=0.008), but were unable to identify any particular allele associated with high or low PVL.Conclusions: We have found HLA-A*02, HLA-B*35 and HLA-C*07 to be associated to protection from ATLL (HLA-A*02) and susceptibility to HAM/TSP (HLA-B*35) or to ATLL (HLA-C*07), respectively. Whereas HLA-A*02 protection from ATLL has already been extensively described in other regions of the world, this is the first report that links HLA-B*35 and an increased susceptibility to HAM/TSP. As for HLA-C*07 it has previously been associated to susceptibility to HAM/TSP in other countries but in our population it has been linked to ATLL.

Human T-Cell Lymphotropic Virus-Type I

1990 ◽  
Vol 11 (6) ◽  
pp. 314-318 ◽  
Author(s):  
Julie Larkin ◽  
John T. Sinnott ◽  
Joshua Weiss ◽  
Douglas A. Holt
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
Type I ◽  
Adult T Cell Leukemia ◽  
Visna Virus ◽  
Human T Cell ◽  
Immunodeficiency Virus ◽  
Hiv 1

Human T-cell lymphotropic virus type-1 (HTLV-I) is a recently recognized retrovirus identified as the cause of adult T-cell leukemia-lymphoma (ATLL) and HTLV-I-associated myelopathy (TSPI HAM). HTLV-I, a member of theRetroviridaefamily of viruses, was first described in 1980 after the isolation of the virus from a patient with a T-cell lymphoma. These pathogenic retroviruses are typically divided into theOncovirinaeandLentivirinae. The oncovirus group, including HTLV-I, HTLV-II and bovine leukemia virus (BLV), is generally associated with tumors. The lentiviruses are associated with immune deficiency and/or neurologic disease, and include agents such as the visna virus of sheep and the human immunodeficiency virus type-1 and -2 HIV-1 and HIV-2).

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