scholarly journals Evaluation of Dynamic Disulphide/Thiol Homeostasis in Silica Exposed Workers

2017 ◽  
Vol 34 (2) ◽  
pp. 102-107 ◽  
Author(s):  
Meşide Gündüzöz ◽  
Ceylan Bal ◽  
Murat Büyükşekerci ◽  
Salim Neşelioğlu ◽  
Türkan Nadir Öziş ◽  
...  
Keyword(s):  
Exposed Workers ◽  
Thiol Homeostasis

The compromise of dynamic disulfide/thiol homeostasis as a biomarker of oxidative stress in trichloroethylene exposure

2016 ◽  
Vol 35 (9) ◽  
pp. 915-920 ◽  
Author(s):  
C Bal ◽  
M Büyükşekerci ◽  
C Koca ◽  
ER Ağış ◽  
S Erdoğan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trichloroacetic Acid ◽  
Exposed Group ◽  
Control Group ◽  
The Novel ◽  
Automated Method ◽  
Exposed Workers ◽  
Novel Method ◽  
Thiol Homeostasis ◽  
Healthy Nonsmoker

In this study, we aimed to investigate disulfide/thiol homeostasis in trichloroethylene (TCE) exposure. The study was carried out in 30 nonsmoker TCE-exposed workers with a variety of occupations. Additionally, 30 healthy nonsmoker volunteers were recruited as the control group. TCE exposure was determined by measuring urinary trichloroacetic acid (TCA) concentration. Median urinary TCA levels of exposed workers (20.5 mg/L) were significantly higher than control subjects (5 mg/L). Thiol and disulfide concentrations were determined using a novel automated method. Disulfide/thiol ratio was significantly higher in the exposed group ( p < 0.001). Thiol/disulfide homeostasis was found to be disturbed in TCE-exposed workers. We predict that in TCE-exposed workers this disturbance can be a therapeutic target, and the efficiency of the treatment can easily be monitored by the novel method we used.

Conventional and high-resolution CT in asymptomatic asbestos-exposed workers

1994 ◽  
Vol 35 (3) ◽  
pp. 226-229 ◽  
Author(s):  
Pierre Gevenois ◽  
P. De Vuyst ◽  
S. Dedeire ◽  
J. Cosaert ◽  
R. Vande Weyer ◽  
...  
Keyword(s):  
High Resolution ◽  
High Resolution Ct ◽  
Exposed Workers

ALDH2 Genetic Polymorphism and Urinary Hippuric Acid Concentration in Toluene Exposed Workers

1997 ◽  
Vol 9 (2) ◽  
pp. 332
Author(s):  
Oh Choon Kwon ◽  
Ree Joo ◽  
Jung Jeung Lee ◽  
Chang Yoon Kim ◽  
Jong Hak Chung ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Acid Concentration ◽  
Hippuric Acid ◽  
Exposed Workers

Relationship between lead exposure indices and renal functions in lead exposed workers

1993 ◽  
Vol 5 (1) ◽  
pp. 58 ◽  
Author(s):  
Kyu Dong Ahn ◽  
Sung Soo Lee ◽  
Byung Kook Lee ◽  
Doo Hie Kim
Keyword(s):  
Lead Exposure ◽  
Renal Functions ◽  
Exposed Workers

Prevalence of Thyroid Diseases in an Occupationally Radiation Exposed Group: A Cross-Sectional Study in a University Hospital of Southern Italy

2019 ◽  
Vol 19 (6) ◽  
pp. 803-808 ◽  
Author(s):  
Luigi Vimercati ◽  
Luigi De Maria ◽  
Francesca Mansi ◽  
Antonio Caputi ◽  
Giovanni M. Ferri ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Healthcare Workers ◽  
Southern Italy ◽  
Cross Sectional Study ◽  
Thyroid Diseases ◽  
University Hospital ◽  
Control Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Exposed Workers

Background: Thyroid diseases occur more frequently in people exposed to ionizing radiation, but the relationship between occupational exposure to ionizing radiation and thyroid pathologies still remains unclear. Objective: To evaluate the prevalence of thyroid diseases in healthcare workers exposed to low-level ionizing radiation compared with a control group working at the University Hospital of Bari, Southern Italy, and living in the same geographical area, characterized by mild iodine deficiency. Methods: We ran a cross-sectional study to investigate whether healthcare workers exposed to ionizing radiation had a higher prevalence of thyroid diseases. Four hundred and forty-four exposed healthcare workers (241 more exposed, or “A Category”, and 203 less exposed, or “B Category”) and 614 nonexposed healthcare workers were enrolled during a routine examination at the Occupational Health Unit. They were asked to fill in an anamnestic questionnaire and undergo a physical examination, serum determination of fT3, fT4 and TSH, anti-TPO ab and anti-TG ab and ultrasound neck scan. Thyroid nodules were submitted to fine needle aspiration biopsy when indicated. Results: The prevalence of thyroid diseases was statistically higher in the exposed workers compared to controls (40% vs 29%, adPR 1.65; IC95% 1.34-2.07). In particular, the thyroid nodularity prevalence in the exposed group was approximately twice as high as that in the controls (29% vs 13%; adPR 2.83; IC95% 2.12-3.8). No statistically significant association was found between exposure to ionizing radiation and other thyroid diseases. Conclusion: In our study, mild ionizing radiation-exposed healthcare workers had a statistically higher prevalence of thyroid diseases than the control group. The results are likely due to a closer and more meticulous health surveillance programme carried out in the ionising radiation-exposed workers, allowing them to identify thyroid alterations earlier than non-exposed health staff.

scholarly journals P.2.20 Epidemic of bladder cancer in japanese male workers exposed mainly to ortho-toluidine

2019 ◽  
Vol 76 (Suppl 1) ◽  
pp. A93.1-A93
Author(s):  
Makiko Nakano ◽  
Kazuyuki Omae ◽  
Yoko Eitaki ◽  
Satoko Iwasawa ◽  
Kota Fukai ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Aromatic Amine ◽  
Aromatic Amines ◽  
Organic Dyes ◽  
Cross Sectional Study ◽  
International Agency ◽  
Gross Hematuria ◽  
Cross Sectional ◽  
Exposed Workers ◽  
Medical Histories

BackgroundIn 2012, ortho-toluidine (OT) was listed as a Group 1 carcinogen by the International Agency for Research on Cancer, based on epidemiologic observations in workers co-exposed to OT and aromatic amines. Between 2014 and 2017, 10 cases of bladder cancer (BC) were identified in Japanese males working at two plants of the same company manufacturing intermediates of organic dyes and pigments.ObjectiveTo describe the features of the BC epidemic at the plants.MethodsWe conducted a cross-sectional study of 76 OT and/or aromatic amine-exposed workers including the 10 BC cases at the plants in 2017. The co-exposed aromatic amines were para-toluidine, ortho-anisidine, aniline, 2,4-dimethylaniline, and/or ortho-chloroaniline. Details of each worker’s job-site histories were obtained from the company records. Past medical symptoms and histories were checked in physician interviews. The subjects were divided into the BC group (n=10) and the non-BC group (n=66) and compared. No quantitative exposure data were available. The surrogate level of exposure to each aromatic amine was calculated as the summed job-weight-month in each process in each job-year.ResultsThe mean ages of the non-BC and BC groups were 50 and 56 years and the durations of employment were 23 and 20 years, respectively. The smoking rate in both groups was 80%. Significantly higher rates of gross hematuria (70%) and cystitis (70%) were identified in the BC group’s past medical histories. In the BC group, the surrogate levels of exposure to OT were higher than those of exposures to other aromatic amines. The surrogate levels were high in the job processes of filtering, rinsing, drying and packing products.ConclusionsThe subjects with BC were associated with a high surrogate level of exposure to OT. OT-exposed workers with past histories of gross hematuria and cystitis need a careful follow-up.

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