scholarly journals Short and Medium Term Results of Posterior Segmental Instrumentation and Posterolateral Fusion in Female Patients with Spondylolisthesis: A Clinical Trial

2018 ◽  
Vol 19 (4) ◽  
pp. 328-335
Author(s):  
Zahir Kızılay ◽  
Abdullah Topcu ◽  
Yavuz Selim Aydın ◽  
Osman Berber ◽  
Hakan Öztürk
Keyword(s):  
Clinical Trial ◽  
Posterolateral Fusion ◽  
Medium Term ◽  
Female Patients ◽  
Segmental Instrumentation

scholarly journals GPX3 methylation is associated with hematologic improvement in low-risk myelodysplastic syndrome patients treated with Pai-Neng-Da

2020 ◽  
Vol 48 (9) ◽  
pp. 030006052095689
Author(s):  
Shujun Yang ◽  
Tong Gao ◽  
Zhonghua Zheng ◽  
Binbin Lai ◽  
Lixia Sheng ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Myelodysplastic Syndrome ◽  
Methylation Level ◽  
Hematological Parameters ◽  
Low Risk ◽  
Controlled Clinical Trial ◽  
Platelet Response ◽  
Female Patients ◽  
Platelet Counts ◽  
Male Patients

Objective The aim of this prospective randomized controlled clinical trial was to explore the relationship between GPX3 methylation and Pai-Neng-Da (PND) in the treatment of patients with low-risk myelodysplastic syndrome (MDS). Methods There were 82 low-risk MDS patients who were randomly divided into the following two groups: androl, thalidomide, and PND capsule (ATP group, n = 41); or androl and thalidomide (AT group, n = 41). Hemoglobin and neutrophil and platelet counts and changes in GPX3 methylation level were assessed. Results The plasma hemoglobin level increased in both groups after treatment. However, the platelet count increased only in the ATP group. Patients in the ATP group had a better platelet response than the AT group, and GPX3 methylation markedly decreased after treatment with ATP but not after treatment with AT. Moreover, male patients had a significantly lower GPX3 methylation level than female patients, while platelet counts from male patients increased dramatically after the ATP regimens compared with female patients. GPX3 methylation changes were negatively correlated with platelet changes in ATP group. Conclusion PND can improve hematological parameters and decrease the GPX3 methylation level. Decreasing GPX3 methylation is associated with the hematologic response that includes platelet in GPX3 methylation. China Clinical Trial Bureau (ChiCTR; http://www.chictr.org.cn/ ) registration number: ChiCTR-IOR-15006635.

scholarly journals Effect of hand reflexology on anxiety and physiological variables among patients hospitalized in the cardiac care unit: A randomized placebo controlled clinical trial

2017 ◽  
Vol 8 (4) ◽  
pp. 35 ◽  
Author(s):  
Zohre Rahmani ◽  
Nahid Rejeh ◽  
Majideh Heravi-Karimooi ◽  
Seyed Davood Tadrisi ◽  
Mojtaba Vaismoradi
Keyword(s):  
Clinical Trial ◽  
Placebo Group ◽  
Intervention Group ◽  
Anxiety Level ◽  
Cardiac Care ◽  
Controlled Clinical Trial ◽  
Female Patients ◽  
Coronary Syndrome ◽  
Physiological Variables ◽  
Cardiac Care Unit

Background and objective: Admission to the cardiac care unit may cause physiological and psychological problems in patients. This study aimed to investigate the effect of hand reflexology on anxiety and physiological variables among female patients with acute coronary syndrome hospitalized in the cardiac care unit.Methods: This randomized placebo controlled clinical trial was conducted on 90 female patients hospitalized in the cardiac care unit in an urban area of Iran. The patients were chosen using a convenient sampling method and then were randomly assigned into intervention (n = 45) and placebo (n = 45) groups. While the intervention group received hand reflexology for 20 minutes, the placebo group received a simple touch of hand without the stimulation of reflexology points.  Demographic data was collected at the beginning of the study using face-to-face interviews with the patients. The anxiety level was assessed using the Spielberger’s State-Trait Anxiety Inventory (STAI) immediately after the intervention and 30 min after the intervention. Also, physiological variables including respiratory rate, heart rate, blood pressure and oxygen saturation were measured before, immediately after the intervention and 30 minutes after the intervention. Descriptive and inferential statistics were used for data analysis.Results: There was no statistically significant difference between the intervention and placebo groups before the intervention (p > .05). The anxiety level in the intervention group was significantly lower than that of the placebo group immediately after the intervention and 30 minutes after the intervention (p < .05, η = 0.090). However, no statistically significant differences in physiological variables between the groups were observed (p > .05).Conclusions: Hand reflexology influenced the level of anxiety. Therefore, nurses can use hand reflexology as a method for reducing patients’ anxiety along with other nursing interventions.

scholarly journals The effect of intraoperative lidocaine versus esmolol infusion on postoperative analgesia in laparoscopic cholecystectomy: A randomized clinical trial

2019 ◽  
Author(s):  
Joshan Lal Bajracharya ◽  
Asish Subedi ◽  
Krishna Pokharel ◽  
Balkrishna Bhattarai
Keyword(s):  
Clinical Trial ◽  
Laparoscopic Cholecystectomy ◽  
Early Period ◽  
Multimodal Analgesia ◽  
Opioid Consumption ◽  
Double Blind ◽  
Female Patients ◽  
Double Blind Clinical Trial ◽  
Elective Laparoscopic Cholecystectomy ◽  
Sparing Effect

Abstract Background: As a part of multimodal analgesia for laparoscopic cholecystectomy, administration of systemic lidocaine is a well-known technique. Similarly, esmolol has been found to have an opioid sparing effect in the perioperative setting. The aim of the study was to compare opioid consumption after an intraoperative infusion of lidocaine or esmolol in female patients undergoing elective laparoscopic cholecystectomy. Methods: In this prospective, randomized, double-blind clinical trial, 90 female patients scheduled for elective laparoscopic cholecystectomy received either IV lidocaine bolus 1.5 mg/kg at induction followed by infusion of 1.5 mg/ kg/hr or IV bolus of esmolol 0.5 mg/kg at induction followed by infusion of 5-15 µg/kg/min till the end of surgery. Standard anaesthetic protocol was followed. Postoperatively, patients received either IV morphine or tramadol to maintain VAS scores ≤ 3. The primary outcome was opioid consumption in the first 24 h after surgery. Pain and sedation scores, time to first perception of pain and void, and incidence of nausea/vomiting were secondary parameters measured up to 24 h postoperatively. Results: Two patients in each group were excluded from the analysis. The postoperative median morphine consumption in patients receiving lidocaine and esmolol was 1.5 (1-2) mg and 1 (0-1.5) mg respectively (p=0.27). The median pain scores at various time intervals were comparable between the two groups (p>0.05). More patients receiving lidocaine were sedated in the PACU than those receiving esmolol (p<0.05); however, no difference was detected later. Conclusion: There was no difference in postoperative opioid requirement and VAS score for pain in the first 24 h of surgery between the lidocaine and esmolol group. Patients receiving lidocaine were more sedated than those receiving esmolol in the early period after surgery.

Characteristics of adult multiple myeloma patients receiving carfilzomib in a U.S. community oncology setting.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e19517-e19517
Author(s):  
Robert M. Rifkin ◽  
Rohan Medhekar ◽  
Khalid Mezzi ◽  
Kathleen Aguilar ◽  
Thomas Wilson ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Multiple Myeloma ◽  
Real World ◽  
Older Patients ◽  
Patient Characteristics ◽  
Refractory Multiple Myeloma ◽  
Female Patients ◽  
Community Oncology ◽  
The Us ◽  
Baseline Characteristics

e19517 Background: Carfilzomib (K) is indicated for treatment of relapsed or refractory multiple myeloma (MM). We studied the characteristics of patients receiving K in the US Oncology Network’s (USON) EHR database. Methods: Patients ≥18 years who received a K-containing regimen between 11/01/2013-02/29/2016, were not in a clinical trial, and had ≥2 visits at a USON clinic were eligible. Baseline characteristics were compared between patients who received a K-based doublet, triplet or other regimen (monotherapy or >3 treatments). Results: Of the 718 patients who received a K-based regimen during the study period, 219 (30.5%) had doublet regimens, 287 (40.0%) received triplet regimens and 212 (29.5%) received other regimens; 494 (68.8%) received regimens with ≥3 therapies. Mean age was 69.7 and 64.7 years among patients on doublets and triplets, respectively. A higher proportion of female patients received doublets (53.0%) (Table). There were no differences in ISS stage or number of comorbidities across patients receiving doublets, triplets, or other regimens. Conclusions: In this real-world analysis of K-regimens, a majority of patients received triplet regimens. Older patients received doublet regimens more frequently. The influence of regimen on outcomes controlling for patient characteristics and prior treatments among MM patients receiving K-based regimens should be studied. [Table: see text]

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