scholarly journals Hepatocyte Nuclear Factor-1 Beta Mutation-associated Newborn Onset of Glomerulocystic Kidney Disease: A Case Presentation

2021 ◽  
Author(s):  
Nilüfer Göknar ◽  
Melda Ekici Avcı ◽  
Diana Üçkardeş ◽  
Emre Keleşoğlu ◽  
Kübra Tekkuş Ermiş ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Case Presentation ◽  
Glomerulocystic Kidney Disease ◽  
Glomerulocystic Kidney ◽  
Nuclear Factor 1

scholarly journals Mutations in the Hepatocyte Nuclear Factor-1β Gene Are Associated with Familial Hypoplastic Glomerulocystic Kidney Disease

2001 ◽  
Vol 68 (1) ◽  
pp. 219-224 ◽  
Author(s):  
Coralie Bingham ◽  
Michael P. Bulman ◽  
Sian Ellard ◽  
Lisa I.S. Allen ◽  
Graham W. Lipkin ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Glomerulocystic Kidney Disease ◽  
Glomerulocystic Kidney

Phlorizin or vanadate treatment reverses impaired expression of albumin and hepatocyte nuclear factor 1 in diabetic rats

Diabetes ◽  
1996 ◽  
Vol 45 (9) ◽  
pp. 1217-1222 ◽  
Author(s):  
G. Barrera-Hernandez ◽  
I. E. Wanke ◽  
N. C. Wong
Keyword(s):  
Diabetic Rats ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Nuclear Factor 1

The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1-dependent interleukin-6-responsive element

1993 ◽  
Vol 13 (2) ◽  
pp. 1183-1193
Author(s):  
J Dalmon ◽  
M Laurent ◽  
G Courtois
Keyword(s):  
Binding Site ◽  
Acute Phase ◽  
Interleukin 6 ◽  
Constitutive Expression ◽  
Nuclear Proteins ◽  
Functional Coupling ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Tissue Specific ◽  
Nuclear Factor 1

Acute-phase reactants are liver proteins whose synthesis is positively or negatively regulated during inflammation. The main mediators of this phenomenon are glucocorticoids and interleukin-6 (IL-6), a pleiotropic cytokine that also controls hematopoiesis. Functional analysis of several acute-phase reactant promoter regions has identified two major DNA motifs used by IL-6-regulated genes. The first one corresponds to a CTGG(G/A)AA sequence, and the other is a binding site for members of the C/EBP family of nuclear proteins. We have previously shown that the human beta fibrinogen (beta Fg) promoter contains an IL-6-responsive region, located between bp -150 and -67 (P. Huber, M. Laurent, and J. Dalmon, J. Biol. Chem. 265:5695-5701, 1990). In this study, using DNase I footprinting, mobility shift assays, and mutagenesis, we demonstrate that at least three subdomains of this region are necessary to observe a full response to IL-6. The most distal contains a CTGGGAA motif, and its mutation inhibits IL-6 stimulation. Another, which is able to interact with several distinct nuclear proteins, among them members of the C/EBP family, is dispensable for IL-6 induction but plays an important role in the constitutive expression of beta Fg. Finally, a proximal hepatocyte nuclear factor 1 binding site, already described as the major determinant of beta Fg tissue-specific expression, is also required for IL-6 stimulation. These results indicate a complex interplay between nuclear proteins within the beta Fg IL-6-responsive region and suggest a tight functional coupling between the tissue-specific and inducible elements.

scholarly journals Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia

2016 ◽  
Vol 99 (1) ◽  
pp. 174-187 ◽  
Author(s):  
Nikhita Ajit Bolar ◽  
Christelle Golzio ◽  
Martina Živná ◽  
Gaëlle Hayot ◽  
Christine Van Hemelrijk ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Autosomal Dominant ◽  
Loss Of Function ◽  
Glomerulocystic Kidney Disease ◽  
Glomerulocystic Kidney

scholarly journals IDENTIFICATION OF A HEPATOCYTE NUCLEAR FACTOR 1 SITE IN THE PROXIMAL 5′ FLANKING REGION OF THE KIDNEY-SPECIFIC NA-K-CL COTRANSPORTER GENE• 2216

1996 ◽  
Vol 39 ◽  
pp. 372-372
Author(s):  
Dilys A Whyte ◽  
Susan E Quaggin ◽  
John A Payne ◽  
Bliss Forbush ◽  
Peter Igarashi
Keyword(s):  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Flanking Region ◽  
Nuclear Factor 1

scholarly journals Hepatitis C Virus Infection Suppresses GLUT2 Gene Expression via Downregulation of Hepatocyte Nuclear Factor 1 

2012 ◽  
Vol 86 (23) ◽  
pp. 12903-12911 ◽  
Author(s):  
C. Matsui ◽  
I. Shoji ◽  
S. Kaneda ◽  
I. R. Sianipar ◽  
L. Deng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Hepatitis C Virus Infection ◽  
Glut2 Gene ◽  
Nuclear Factor 1
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