Outcomes of Treatment in Patients with Severe Postmenopausal Osteoporosis: The Effects of Teriparatide Treatment on Bone Mineral Density, Back Pain and Biochemical Parameters

The only available treatment for celiac disease is life-long gluten exclusion. We conducted a cross-sectional age- and gender-matched study in 64 celiac adults on a long-term (>1 year) gluten-free diet and 74 non-celiac volunteers from Spain, using dietary, anthropometric, and biochemical parameters, as well as assessing bone mineral density and physical activity. Celiac adults had deficient intake (below 2/3 of the recommended intake) for folates, vitamin E, and iodine and low intake of calcium (below 80% of the recommended intake). Iron intake was also below 2/3 of the recommended intake in celiac women. Vitamin D intake was extremely low, and 34% of celiac patients had moderately deficient plasma levels. According to bone mineral density, celiac women may be more prone to osteopenia and osteoporosis. However, we found a perfectly analogous nutritional status scenario in celiac as compared to healthy volunteers, with the dietary deviations found being similar to those of the Spanish population, i.e., both groups followed a high-lipid, high-protein, and low-carbohydrate diet. Values for biochemical parameters were found within the reference ranges. Celiac disease had no influence on body weight, but body fat in celiac patients tended to be higher. According to our results, vitamin D, calcium, folates, vitamin E, iodine, and iron nutritional status should be specifically assessed and monitored in the celiac population.

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Impact of three-dimensional chemoradiation on pelvic bone mineral density, low back pain, and disability in cervical cancer: a prospective study

International Journal of Gynecological Cancer ◽

10.1136/ijgc-2020-002290 ◽

2021 ◽

pp. ijgc-2020-002290

Author(s):

Divyesh Kumar ◽

Raviteja Miriyala ◽

Bhavana Rai ◽

Pooja Bansal ◽

Arun S Oinam ◽

...

Keyword(s):

Bone Mineral Density ◽

Cervical Cancer ◽

Low Back Pain ◽

Back Pain ◽

Femoral Neck ◽

Bone Mineral ◽

Menopausal Status ◽

Pelvic Bone ◽

Low Back ◽

Mineral Density

ObjectiveTo prospectively analyze the effect of three-dimensional chemoradiation on the bone mineral density of pelvic bones and its association with low back pain and disability in patients with locally advanced cervical cancer.MethodsIn biopsy proven locally advanced cervical cancer patients, bone mineral density and T scores for lumbar vertebrae 5, dorsal thoracic vertebrae 12, and T scores for the femoral neck were analyzed. Low back pain was scored using the visual analog scale while disability scoring was done using the Oswestry low back pain disability scale. Furthermore, a subgroup analysis for patients (classified according to menopausal status) was performed.ResultsIn total, 106 patients were analyzed. A statistically significant decline in mean bone mineral density was observed at all three sites (vertebrae 5 and 12, and the femoral neck) post-chemoradiation therapy compared with pretreatment bone mineral density (0.671 vs 0.828, −2.083 vs −1.531, −2.503 vs −1.626; all p<0.001). Similarly, in subgroup analyses, at all three sites, pre-menopausal patients showed a statistically significant association (0.876 vs 0.697, −1.203 vs −0.2.761, –1.403 vs −2.232; all p<0.001) while a non-significant association was observed for post-menopausal patients at vertebrae 12 (−1.707 vs −1.719; p=0.09) with a statistically significant association at vertebrae 5 and the femoral neck (0.803 vs 0.656, –1.746 vs −2.648; p<0.01). Although statistically significant low back pain and disability scores were observed overall and irrespective of menopausal status, no correlation between bone mineral density and low back pain and disability was observed.ConclusionPelvic bone mineral density decreases significantly after chemoradiation, irrespective of menopausal status. However, no correlation with low back pain and disability was observed. Pelvic bone mineral density analysis should be considered before chemoradiation in cervical cancer.

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Plasma miRNA levels correlate with sensitivity to bone mineral density in postmenopausal osteoporosis patients

Biomarkers ◽

10.3109/1354750x.2014.935957 ◽

2014 ◽

Vol 19 (7) ◽

pp. 553-556 ◽

Cited By ~ 66

Author(s):

Hongqiu Li ◽

Zhe Wang ◽

Qin Fu ◽

Jing Zhang

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Osteoporosis ◽

Bone Mineral ◽

Mineral Density ◽

Plasma Mirna

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Influence of Estrogen-Progestin Treatment on Back Pain and Disability Among Slim Premenopausal Women With Low Lumbar Spine Bone Mineral Density

Spine ◽

10.1097/00007632-199904010-00018 ◽

1999 ◽

Vol 24 (7) ◽

pp. 704-708 ◽

Cited By ~ 8

Author(s):

Eero S. Kyllönen ◽

H. Kalervo Väänänen ◽

J. Heikki V. Vanharanta ◽

Jorma E. Heikkinen

Keyword(s):

Bone Mineral Density ◽

Back Pain ◽

Lumbar Spine ◽

Bone Mineral ◽

Premenopausal Women ◽

Spine Bone Mineral Density ◽

Mineral Density ◽

Progestin Treatment

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Inflammatory Markers as a Predictor of Postmenopausal Osteoporosis

Sultan Qaboos University Medical Journal [SQUMJ] ◽

10.18295/squmj.11.2021.145 ◽

2021 ◽

Author(s):

Asma Al Salmani ◽

Asma Al Shidhani ◽

Nouf M Al-Alawi ◽

Arwa A Al Sulaimi ◽

Maha A Al-Hashemi

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Osteoporosis ◽

Bone Mineral ◽

Inflammatory Markers ◽

Neutrophil To Lymphocyte Ratio ◽

Mineral Density ◽

Platelet To Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

T Score ◽

Inflammatory Status

Objectives: Postmenopausal osteoporosis is a progressive metabolic bone disease resulting from estrogen deficiency. However, due to the silent nature of the disease, there is an urgent need for a simple, early predictive marker. This study, conducted between January 2017 to December 2019, aimed to assess the potential of three factors—specifically, the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR)—as inflammatory markers of bone mineral density (BMD) loss. Methods: A retrospective cross-sectional study was conducted among 450 postmenopausal Omani women undergoing dual-energy X-ray absorptiometry at the Sultan Qaboos University Hospital, Muscat, Oman. Participants were allocated into groups based on lumbar spine BMD t-score values. A receiver-operating characteristic curve was used to find the area under the curve (AUC). Multivariate logistic regression was performed to identify independent predictors of low BMD. Results: A total of 65 (14.4%), 164 (36.4%), and 221 (49.1%) women were allocated to the control, osteopenia, and osteoporosis groups, respectively. No significant differences in PLR, MLR, and NLR values were observed based on group allocation. BMD t-score values were reversely correlated with age (P = 0.007) and PLR (P = 0.004), and positively correlated with body mass index (BMI) (P <0.001). The AUC was 0.59. However, the only independent predictors of low BMD were age (>65 years) and BMI (<25 kg/m2). Conclusion: None of the three inflammatory biomarkers studied were found to be useful prognostic indicators of bone loss. Further research is recommended to reject or support theories regarding the role of inflammatory status in the pathogenesis. Keywords: inflammatory markers, neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, Bone mineral density, osteoporosis

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