scholarly journals Solid state synthesis, characterization and anti- microbial studies of some transition metal complexes of a schiff base ligand derived from parabenzoquinone and glycine

2021 ◽  
Vol 14 (1) ◽  
pp. 64-70
Author(s):  
M.A. Kurawa ◽  
J. Jaafar
Keyword(s):  
Schiff Base ◽  
Transition Metal Complexes ◽  
Spectroscopic Analysis ◽  
Conductivity Measurement ◽  
Antimicrobial Activities ◽  
Decomposition Temperature ◽  
Significant Activity ◽  
Infrared Spectroscopic Analysis ◽  
High Concentrations ◽  
Bacteria And Fungi

Schiff base was synthesized by mixing parabenzoquinone and glycine mechanochemically. Its corresponding complexes of Cu, Co and Mn were synthesized by grinding metal (II) carbonates. The synthesized compound were characterized by elemental analysis, infrared spectroscopy, melting/decomposition temperature determination and conductivity measurements .The infrared spectroscopic analysis of the ligand shows a peak at 1620cm-1 confirm the presence of azomethane while the shift to 1602 cm-1,1623.15cm-1, 1635.69cm-1 in Mn, Cu, Co complexes respectively confirmed bond formation from azo-group to metal. The melting point temperature of the ligand at 128.20oC show that it is stable at low temperature while the decomposition temperature of Mn, Cu, Co complexes at 1900C,188.40C,2050C shows that they are stable conductivity measurement shows that the complexes were found to be non-electrolytic as compared with the theoretical values. The ligand and its respective complexes showed antimicrobial activities against some bacteria and fungi at high concentrations(1000 μg/disc and 500μg/disc) respectively while some showed no activity at all concentrations. However, Co complex shows significant activity against all the species at low concentration (250μ/disc).

scholarly journals Synthesis and Evaluation of Schiff Bases of 4-Amino-5-(chlorine substituted phenyl)-4H-1,2,4-triazole-3-thione as Antimicrobial Agents

2020 ◽  
Vol 41 (1) ◽  
pp. 26-35
Author(s):  
Kishor Devkota ◽  
Govinda Pathak ◽  
Bhushan Shakya
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Triazole Ring ◽  
Antimicrobial Activities ◽  
Biologically Active ◽  
Spectral Techniques ◽  
Schiff Base Derivatives ◽  
Bacteria And Fungi ◽  
Different Strains

Triazole ring system has attracted a continuously growing interest of synthetic organic chemists and those dealing with the medicinal compounds due to its versatile potential to interact with biological systems. Schiff bases are also considered as one of the most biologically active compounds.  The aim of the present study was to synthesize new Schiff bases bearing triazole nucleus and to assess their antimicrobial activities. Four new Schiff base derivatives of 1,2,4-triazole-3-thione were synthesized by combining two different pharmacophores viz. triazole nucleus and Schiff base moiety and were characterized by spectral techniques (UV, FT-IR, and NMR). The Schiff bases were evaluated for antibacterial (Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae) and antifungal (Candida albicans) activities. The synthesized compounds exhibited good to moderate activities against different strains of bacteria and fungi tested.

scholarly journals Synthesis, Characterization and Antimicrobial Evaluation of Mn(II) and Zn(II) Schiff base Complexes with p-hydroxypropiophenone moiety

2019 ◽  
Vol 1 ◽  
pp. 202-208
Author(s):  
S A Agbese ◽  
G A Shallangwa ◽  
S O Idris
Keyword(s):  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Metal Complexes ◽  
Biological Activities ◽  
Electronic Spectroscopy ◽  
Conductivity Measurement ◽  
Molar Conductivity ◽  
Schiff Base Complexes ◽  
Significant Activity ◽  
Imine Bond

The Schiff base was synthesized by condensing 4-aminopyridine with 4-hydroxypropiophenone. The synthesized ligand was characterized by proton and carbon-13 NMR spectroscopy, electronic spectroscopy and FTIR.The result of the FTIR showed the presence of a band at 1643.41cm-1 assigned to the azomethine bond, also the result of the 1HNMR and 13CNMR gave credence to the successful synthesis of the Schiff base. The Mn(II) and Zn(II) complexes were characterized by UV-visible analysis, FTIR, molar conductivity measurement and magnetic susceptibility test. The results of the FTIR suggest that the metal complexes possess coordinated water molecules and the shift in the wavenumber of the azomethine linkage in the spectra of the complexes shows that the nitrogen of the imine bond participated in the coordination to the metal centre. The magnetic susceptibility measurement shows that the metal complexes possess octahedral geometry. The molar conductivity test shows that the complexes are nonelectrolytic in nature and the metal to ligand ratio is 1:2. The synthesized ligand and the metal complexes were evaluated for biological activities against some organisms. The Zn(II) complex showed significant activity against the test organisms.

scholarly journals Synthesis, Characterization and Biological Evaluation of Schiff Base Transition Metal Complexes Derived from 4-Nitrobenzene-1,2-diamine and 5-Chloroisatin

2020 ◽  
Vol 32 (9) ◽  
pp. 2324-2328
Author(s):  
NETRA PAL SINGH ◽  
KAUSHAL KUMAR ◽  
GAJENDRA KUMAR ◽  
ANUROOP KUMAR
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Magnetic Moments ◽  
Biological Evaluation ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Bacteria And Fungi

A series of transition metal complexes of the type [MLX2], where M = Mn(II), Fe(II), Co(II), Ni(II), X = Cl–/CH3COO– and L = Schiff base derived from 4-nitrobenzene-1,2-diamine and 5-chloroisatin have been synthesized and characterized by elemental analysis, molar conductance, IR, UV-visible, magnetic moments measurement, 1H & 13C NMR and mass spectral studies. On the basis of physico-chemical studies and spectral evaluation, an octahedral geometry have been proposed for all metal(II) complexes. The antimicrobial activity of ligand and its metal complexes have been additionally screened against bacteria and fungi. Metal(II) complexes show good activity as compared to ligand towards studied microorganisms and also metal complexes checked for their catalytic properties for benzoylation of phenol.

Zeolite-encapsulated Mn(II) Complex: A New Nano Catalyst for the Synthesis of Modafinil and Its Derivatives

2019 ◽  
Vol 16 (7) ◽  
pp. 541-549 ◽  
Author(s):  
Mohammad Javad Taghizadeh ◽  
Huoman Karimi ◽  
Akbar Mirzaie
Keyword(s):  
Thermal Analysis ◽  
Schiff Base ◽  
Spectroscopic Analysis ◽  
Zeolite Y ◽  
Reflectance Spectroscopy ◽  
X Ray Diffraction ◽  
X Ray ◽  
Infrared Spectroscopic Analysis ◽  
Nano Catalyst ◽  
N2 Sorption

The Mn-hydrazone Schiff base encapsulated into NaY has been prepared and characterized as a new heterogeneous catalyst. Elemental analysis, UV-Vis, infrared spectroscopic analysis, diffused reflectance spectroscopy, thermal analysis, small angle X-ray diffraction, and N2 sorption demonstrate the existence of Mn-hydrazone schiff base in the nanopores of zeolite-Y. MnII(Hsal- hrz)/Y, which showed excellent catalytic property in oxidation with various sulfide compounds including important drugs such as adrafinil and modafinil, using hydroperoxide-urea (UHP) as oxidant. Thioanisole conversion was high (98%).

Synthesis, Antimicrobial Evaluation of Substituted Indole and Nitrobenzenamine based Cr(III), Mn(III) and Fe(III) Metal Complexes

Drug Research ◽  
2021 ◽  
Author(s):  
Preeti Sharma ◽  
Varun Kumar Singh ◽  
Gajendra Kumar
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Magnetic Measurements ◽  
Magnetic Moments ◽  
Salmonella Typhi ◽  
Antimicrobial Activities ◽  
Antimicrobial Evaluation ◽  
Aspergillus Sp ◽  
Bacteria And Fungi

AbstractSchiff base ligand (E)-5-methyl-3-(1-(4-nitrophenylimino)ethyl)-1H-indol-2-amine was synthesized by the condensation of 1-(2-amino-5-methyl-1H-indol-3-yl)ethanone and 4-nitrobenzenamine in methanol at 70 oC. The prepared Schiff base ligand doped with Cr(III), Mn(III) and Fe(III) ion, respectively and it is denoted as [M(C34H32N8O4)X]X2. The complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structural configuration have been determined by various spectroscopic (electronic, IR, 1H NMR, 13C NMR, GCMS) techniques. Electronic and magnetic moments of the complexes indicate that the geometry of the metal center was five coordinate square pyramidal. These metal complexes were also tested for their antimicrobial activities to assess their inhibiting potential against Staphylococcus aureus, Bacillus subtilis (positive bacteria) and Pseudomonas aeruginosa, Escherichia coli, Salmonella typhi (negative bacteria) and fungi Rizoctonia sp., Aspergillus sp., Penicillium sp. [Cr(C34H32N8O4)OAc](OAc)2 shows best antimicrobial activity against all the pathogens.

GREEN SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF MIXED LIGAND COMPLEXES OF Co (II), Ni (II) and V(III) METALS USING SOME AMINO ACIDS AS LIGANDS

2021 ◽  
Vol 4 (4) ◽  
pp. 191-199
Author(s):  
N. S. Gwaram ◽  
A. Salisu ◽  
Muhammad Manir
Keyword(s):  
Amino Acids ◽  
Metal Complexes ◽  
Conductivity Measurement ◽  
Antimicrobial Activities ◽  
Decomposition Temperature ◽  
Infrared Analysis ◽  
Antimicrobial Studies ◽  
Mixed Ligands ◽  
Method Of Continuous Variation ◽  
Job's Method

Co (II), Ni (II) and V (III) metal complexes were synthesized mechanochemically using L-Leucine, L-Tyrosine and Creatinine as mixed ligands. The metals and the ligands were grounded using an agate mortar with a pestle. The compounds formed were characterized using their melting/decomposition temperature, solubility, magnetic susceptibility, conductivity measurement, Infrared analysis and scanning electron microscope (SEM). The Metal – ligand ratios were investigated via Job’s method of continuous variation. The shifts of bands (for instance 1693-1677 cm-1 to 1674-1607 cm-1) in C=O and the appearance of new bands in the complexes (683-669 and 713-750 cm-1 indicates the complexation. The lower conductivity measurement values (15.00 to 32.40) µS.cm-1 suggested the non-electrolytic nature of the complexes. The magnetic effective value of the metal complexes showed that all the three complexes are paramagnetic and octahedral. It was concluded that the amino acids (ligands) coordinated in a bidentate way through the nitrogen from the amino group and oxygen from carboxylate. The complexes were screened for their antimicrobial activities against two bacterial isolates (Streptococcus pneumoniae and Klebsiella pneumoniae). All the complexes exhibited good activity against the organisms

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