scholarly journals Synthesis, Characterization and Antimicrobial Evaluation of Mn(II) and Zn(II) Schiff base Complexes with p-hydroxypropiophenone moiety

2019 ◽  
Vol 1 ◽  
pp. 202-208
Author(s):  
S A Agbese ◽  
G A Shallangwa ◽  
S O Idris
Keyword(s):  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Metal Complexes ◽  
Biological Activities ◽  
Electronic Spectroscopy ◽  
Conductivity Measurement ◽  
Molar Conductivity ◽  
Schiff Base Complexes ◽  
Significant Activity ◽  
Imine Bond

The Schiff base was synthesized by condensing 4-aminopyridine with 4-hydroxypropiophenone. The synthesized ligand was characterized by proton and carbon-13 NMR spectroscopy, electronic spectroscopy and FTIR.The result of the FTIR showed the presence of a band at 1643.41cm-1 assigned to the azomethine bond, also the result of the 1HNMR and 13CNMR gave credence to the successful synthesis of the Schiff base. The Mn(II) and Zn(II) complexes were characterized by UV-visible analysis, FTIR, molar conductivity measurement and magnetic susceptibility test. The results of the FTIR suggest that the metal complexes possess coordinated water molecules and the shift in the wavenumber of the azomethine linkage in the spectra of the complexes shows that the nitrogen of the imine bond participated in the coordination to the metal centre. The magnetic susceptibility measurement shows that the metal complexes possess octahedral geometry. The molar conductivity test shows that the complexes are nonelectrolytic in nature and the metal to ligand ratio is 1:2. The synthesized ligand and the metal complexes were evaluated for biological activities against some organisms. The Zn(II) complex showed significant activity against the test organisms.

scholarly journals Amalgamation of Novel Schiff Base Ligand and Its Transition Metal Complexes and Their Biological Activity

2019 ◽  
pp. 1-13
Author(s):  
B. Akila ◽  
A. Xavier
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Electronic Spectroscopy ◽  
Antioxidant Properties ◽  
Salmonella Typhi ◽  
Metal Chelates ◽  
Schiff Base Complexes

Schiff base synthesized from 2-hydroxy-1-naphthaldehyde and 2-2’ (ethylene dioxy) bis ethylenediamine (L1) and its Metal complexes, [M (II) (L)6](where M= Mn(II), Ru(III), Cu(II)and V(V) L= Schiff base moiety), have been prepared and characterized by elemental analysis, spectroscopic measurements (infrared, electronic spectroscopy, 1H-NMR, EPR and Mass spectroscopy ). Elemental analysis of the metal complexes was suggested that the stoichiometry ratio is 1:1 (metal-ligand). The electronic spectra suggest an octahedral geometry for MC1and MC2 Schiff base complexes and distorted octahedral for MC3 and MC4 complexes. The Schiff base and its metal chelates have been screened for their invitro test antibacterial activity against three bacteria, gram-positive (Staphylococcus aureus) and gram-negative (Klebsiella pheneuammonia and Salmonella typhi). Two strains of fungus (Aspergillus niger and Candida albicans). The metal chelates were shown to possess more anti fungal activity compare then antibacterial activity and antioxidant properties. The complexes are highly active than the free Schiff-base ligand.    

scholarly journals A review on versatile applications of novel Schiff bases and their metal complexes

2019 ◽  
Vol 8 (4) ◽  
pp. 675-681
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Carbonyl Compounds ◽  
Biological Activities ◽  
Schiff Base Complexes ◽  
Amino Compound ◽  
Azomethine Group ◽  
Catalytic Activities ◽  
Schiff Base Metal Complexes

Metal complexes synthesized from Schiff bases and furthermore Schiff bases are versatile in nature. Such types of compounds were prepared from the condensation of an amino compound with carbonyl compounds (aldehyde or ketone) during which the carbonyl group is replaced by an imine or azomethine group. Schiff bases and their derivatives are widely employed in industries, polymers, dyes and medicative and pharmaceutical fields and additionally exhibit biological activities like antibacterial, antifungal, anti-inflammatory, antimalarial, antiviral, and antipyretic properties. Many Schiff base metal complexes exhibit glorious catalytic activities in numerous mechanisms. Their several applications in homogenous and heterogeneous catalysis were according troughout last decade. Several Schiff base complexes were helpful for their application as catalysts in reactions involving at high temperatures because of the high thermal and moisture stabilities. This text totally based on literature review with examples of the most promising applied Schiff bases and their complexes in several areas, summarizing the applications of Schiff bases and their numerous derivatives and complexes.

Synthesis, Characterization and Biological Activities of a Schiff Base Derived from 2-[(1,3-benzothiazol-2-yl)sulfanyl]-N-[4-(hydrazinecarbonyl)phenyl]acetamide and its Complexes with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) Ions

2019 ◽  
Vol 70 (2) ◽  
pp. 596-601
Author(s):  
Aqsa Gulzar ◽  
Tariq Mahmud ◽  
Liviu Mitu ◽  
Rubina Munir ◽  
Muhammad Imran ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Schiff Base ◽  
Metal Complexes ◽  
13C Nmr ◽  
Biological Activities ◽  
Electronic Spectroscopy ◽  
Transition Metal Ions ◽  
Magnetic Data ◽  
Schiff Base Metal Complexes ◽  
Metal Ligand

A new Schiff base ligand from 2-[(1,3-benzothiazol-2-yl)sulfanyl]-N-[4-(hydrazinecarbonyl)phenyl]acetamide (BHA) and its five metal complexes with transition metal ions [Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)] have been synthesized. The resulting compounds were subsequently characterized by FTIR, UV-Vis, AAS, 1H NMR, 13C NMR and mass spectrometry. The proposed geometries of the Schiff base metal complexes were established on the basis of metal / ligand ratio, through AAS/ICP, electronic spectroscopy and magnetic data. The synthesized Schiff base and its complexes were further investigated for their anti-inflammatory and anticancer activity which exhibited relatively pronounced activity for metal complexes than Schiff base.

scholarly journals Synthesis, Physical Characterization and Biological Activity of Some Schiff Base Complexes

2008 ◽  
Vol 5 (3) ◽  
pp. 620-626 ◽  
Author(s):  
R. Rajavel ◽  
M. Senthil Vadivu ◽  
C. Anitha
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Schiff Base ◽  
Organic Molecule ◽  
Structural Modification ◽  
Antimicrobial Agents ◽  
Biological Activities ◽  
Molar Conductance ◽  
Molar Conductivity ◽  
Schiff Base Complexes

Structural modification of organic molecule has considerable biological relevance. Further, coordination of a biomolecules to the metal ions significantly alters the effectiveness of the biomolecules. In view of the antimicrobial activity ligand [bis-(2-aminobenzaldehyde)] malonoyl dihydrazone], metal complexes with Cu(II), Ni(II), Zn(II) and oxovanadium(IV) have been synthesized and found to be potential antimicrobial agents. An attempt is also made to correlate the biological activities with geometry of the complexes. The complexes have been characterized by elemental analysis, molar conductance, spectra and cyclicvoltammetric measurements. The structural assessment of the complexes has been carried out based on electronic, infrared and molar conductivity values.

scholarly journals Synthesis, characterization and antimicrobial activity of Mn(II), Co(II) and Ni(II) complexes with schiff base derived from 4-chloroaniline and salicylaldehyde

2018 ◽  
Vol 11 (1) ◽  
pp. 61-66
Author(s):  
A.K. Ibrahim ◽  
B.A. Yusuf ◽  
B.U. Sambo
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Metal Complexes ◽  
Infrared Spectra ◽  
Free Ligand ◽  
Conductivity Measurement ◽  
Moderate Activity ◽  
Ligand Ratio ◽  
Metal Ligand

Transition Metal Complexes of Mn(II),Co(II) and Ni(II) with Schiff base derived from 4- chloroaniline and Salicylaldehyde were synthesized and characterized by conductivity measurement, magnetic susceptibility, infrared spectra, metal-ligand ratio determination and solubility test. The Schiff base and its metal complexes were tested for antibacterial activity against Staphylococcus aureus and Escherichia coli and fungal activity against Aspergillus flavus and Mucor species. The low molar conductance values range (16-28.1Ohm- cm2 mol-1) indicated that all the complexes are non electrolytes. The magnetic susceptibility revealed that all the complexes are paramagnetic in nature. The metal-ligand ratio was found to be 1:2 in all the complexes. The infrared spectra suggested that the Schiff base behaves as a bidentate ligand. The antimicrobial studies revealed moderate activity against the tested organism when compared with the standards (Ciprofloxacin and Ketoconazole), and this activity increases by increasing concentration. And also the Metal Complexes showed higher activity than free Ligand due to chelation.Keywords: Salicyldehyde, 4-chloroaniline, Mn(II), Co(II), Zn(II) complexes, antimicrobial activity

scholarly journals Biological Applications of Isoniazid Derived Schiff Base Complexes: An Overview

2020 ◽  
pp. 17-31
Author(s):  
Ashrafuzzaman . ◽  
Ekhlass Uddin ◽  
Raisul Islam ◽  
Nur Amin Bitu ◽  
Saddam Hossain ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Isonicotinic Acid ◽  
Biological Activities ◽  
Inorganic Compounds ◽  
Acid Hydrazide ◽  
New Drugs ◽  
Schiff Base Complexes ◽  
Significant Activity ◽  
Bacterial Strains ◽  
Day By Day

Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. In this sense there is a strong need to synthesis new substances that not only have good field of activity, but having new appliances of action. Inorganic compounds particularly metal complexes have played a significant role in the development of new metal based drugs. Like few compounds, isonicotinic acid hydrazide (Isoniazid INH) is well known as first-line anti-tuberculosis (TB) drug to treat TB infection worldwide for more than 60 years. Unfortunately, people are only dependent on this drug and consequently, the rate of use of this drug has been increasing day by day. As the bacterial strains resistant to isoniazid are getting same for the long-term extensive use and even abuse so there is an urgent need to synthesis new drugs not only for anti-tuberculosis properties but also for having significant activity in various biological areas with mechanisms of action. Isoniazid derivatives and their metal complexes, particularly medicinal inorganic metal complexes have been considered as new drugs for their antimicrobial activities like anti-bacterial, anti-fungal, anti-tuberculosis, DNA binding, antioxidant, cytotoxic, scavenging and antiviral activities. In this review, we have focused on the various synthesized metal complexes of isoniazid and its hydrazones and have compared their biological activities which are more or less strong against microorganisms. It is found that INH has moderate to strong antimicrobial activity.

Iron (III) and zinc (II) monodentate Schiff base metal complexes: Synthesis, characterisation and biological activities

2021 ◽  
Vol 1231 ◽  
pp. 129946
Author(s):  
Bushra Naureen ◽  
G.A. Miana ◽  
Khadija Shahid ◽  
Mehmood Asghar ◽  
Samreen Tanveer ◽  
...  
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Base Metal ◽  
Biological Activities ◽  
Schiff Base Metal Complexes

Syntheses, characterizations, crystal structures, and biological activities of two new mixed ligand Ni(II) and Cu(II) Schiff base complexes

2015 ◽  
Vol 68 (4) ◽  
pp. 632-649 ◽  
Author(s):  
S. Yousef Ebrahimipour ◽  
Maryam Mohamadi ◽  
Jesús Castro ◽  
Nasrin Mollania ◽  
Hadi Amiri Rudbari ◽  
...  
Keyword(s):  
Schiff Base ◽  
Crystal Structures ◽  
Biological Activities ◽  
Mixed Ligand ◽  
Schiff Base Complexes

scholarly journals Structural and Biological Studies on Transition Metal Complexes of 4-Aminoantipyrine Derivative

2020 ◽  
Vol 32 (11) ◽  
pp. 2846-2854
Author(s):  
V. Soundaranayaki ◽  
A. Kulandaisamy
Keyword(s):  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Antimicrobial Activities ◽  
Esr Spectra ◽  
Molar Conductance ◽  
Schiff Base Complexes ◽  
Binding Potential ◽  
Planar Geometry ◽  
Pyramidal Geometry ◽  
Biological Studies

Novel tetra dentate Cu(II), Ni(II), Co(II), VO(II) and Zn(II) Schiff base complexes have been synthesized from salicylidene-4-iminoantipyrine and tyrosine. The synthesized Schiff base complexes was characterized by powder X-ray diffraction studies (XRD), scanning electron microscopy (SEM), FT-IR, ESR, 1H NMR, 13C NMR, UV-vis, molar conductance and magnetic susceptibility measurements. The general formula of complexes was confirmed as [ML] type [M = Cu(II), Co(II), Zn(II), Ni(II) and VO(II); L = C27H24N4O4]. Magnetic susceptibility, IR and UV-vis, spectral data showed that all the complexes have square planar geometry except vanadyl complex which suggests square pyramidal geometry. Lower molar conductance values proved that all the chelates were non-electrolytic nature. The X-band ESR spectra of [CuL] and [VOL] complexes in DMSO solution suggest that the complexes were predominant covalent character. Powder XRD and SEM image pattern evidenced that all the compounds were crystalline in nature and their size ranges from 100-40 nm. Calf thymus DNA binding potential of [CuL] and [VOL] complexes shows that the binding occurs through intercalation mode with low binding constant. The analgesic, CNS, antiulcer and antimicrobial activities of the investigated compounds report reveals that the chelates were significant effect than free Schiff base.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of N1-[(1E)-1-(2-Hydroxyphenyl) ethylidene]-2-oxo-2H-chromene-3-carbohydrazide and its Metal Complexes

2009 ◽  
Vol 6 (3) ◽  
pp. 615-624 ◽  
Author(s):  
K. Siddappa ◽  
K. Mallikarjun ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Metal Complexes ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML, MʹL and M″L [where M=Cu(II), Co(II), Ni(II) and Mn(II), Mʹ=Fe(III) and M″=Zn(II), Cd(II) and Hg(II) and L=N1-[(1E)-1-(2-hydroxyphenyl)ethylidene]-2-oxo-2H-chromene- 3-carbohydrazide (HL)] Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HL acts as doubly monodentate bridge for metal ions and form mononuclear complexes. The complexes Ni(II), Co(II), Cu(II) Mn(II) and Fe(III) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal complexes were screened for their antimicrobial activity.

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