scholarly journals TESTICULO-PROTECTIVE EFFECT OF MORINGAOLEIFERA SEED EXTRACT ON COPPER SULPHATE INDUCED INJURY IN WISTAR RATS

2016 ◽  
Vol 36 (2) ◽  
pp. 26
Author(s):  
F. O. Agoreyo ◽  
E. L. Isalar ◽  
B. O. Agoreyo
2021 ◽  
Vol 55 (4) ◽  
pp. 1107-1114
Author(s):  
Karunakaran Balaji ◽  
J Vijayakumar J Vijayakumar ◽  
Sivanesan Senthilkumar ◽  
Rajagopalan Vijayaraghavan ◽  
Viswanathan Naveenkumar

Author(s):  
Perumal Elangovan ◽  
Ramalingam Ramakrishnan ◽  
Kasinathan Amudha ◽  
Abdulkadhar Mohamed Jalaludeen ◽  
Gunasekaran Karuna Sagaran ◽  
...  

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Fatemeh Akbari ◽  
Mohammad Azadbakht ◽  
Kanu Megha ◽  
Ayat Dashti ◽  
Lale Vahedi ◽  
...  

Abstract Background Benign prostatic hyperplasia (BPH) is a common disease which causes various health problems for elderly men such as urinary retention, recurring urinary tract infection and bladder stones. The aim of this study is to evaluate the therapeutic effects of Juniperus communis L. seed extract (JCS) on BPH in male Wistar rats. Methods To this end, 30 rats were divided into 5 groups (N = 6): group 1 (vehicle), group 2 (disease control), group 3 (standard medicine; 10 mg/kg finasteride), and groups 4 and 5 were treated with 300 mg/kg and 600 mg/kg of the hydroalcoholic JCS seed extract, respectively. Groups 2, 3, 4 and 5 received testosterone enanthate to induce prostatic hyperplasia. At the end of experimental period (28 days), prostate glands were cut off under anesthesia. Histopathological examination was done and biochemical parameters such as Malondialdehyde, Glutathione and protein carbonyl were also measured. Their body weights were also observed during the study. At the end of the experiment, prostate weights and prostate specific antigen (PSA) levels were measured. Prostate index, inhibition prostate weight and inhibition prostate index were also calculated. Results Both histopathological examination and biochemical parameter results showed significant improvements in rats treated with finasteride and 600 mg/kg JCS extract (p < 0.01). In addition, PSA levels showed significant decrease in comparison with the disease group. But acute toxicity test indicated that using JCS extract resulted in an increase in liver enzymes (ALP, LDH, SGOT, SGPT). As a result, the extract should be used with caution. Conclusions Oral administration of JCS extract is effective on preventing testosterone-induced benign prostatic hyperplasia.


Molecules ◽  
2012 ◽  
Vol 17 (5) ◽  
pp. 6033-6045 ◽  
Author(s):  
Olorunnisola Sinbad Olorunnisola ◽  
Graeme Bradley ◽  
Anthony Jide Afolayan

2014 ◽  
Vol 8 (9) ◽  
pp. 158-165 ◽  
Author(s):  
O. Akomolafe Rufus ◽  
S. Olukiran Olaoluwa ◽  
E. Imafidon Chris ◽  
A. Ayannuga Olugbengba ◽  
A. Oyekunle John ◽  
...  

2021 ◽  
Vol 35 (1) ◽  
pp. 9-15
Author(s):  
Vikas Sharma ◽  
Nagendra S Chauhan ◽  
Umesh K Patil ◽  
Vinod Kumar Dixit

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