scholarly journals Protective Effect of Celastrus paniculatus Seed Extract against Lead Acetate Induced Nephrotoxicity in Wistar Rats

2021 ◽  
Vol 55 (4) ◽  
pp. 1107-1114
Author(s):  
Karunakaran Balaji ◽  
J Vijayakumar J Vijayakumar ◽  
Sivanesan Senthilkumar ◽  
Rajagopalan Vijayaraghavan ◽  
Viswanathan Naveenkumar
Keyword(s):  
Protective Effect ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Seed Extract ◽  
Celastrus Paniculatus

NEPHROPROTECTIVE EFFECT OF CELASTRUS PANICULATUS SEED EXTRACT AGAINST LEAD ACETATE INDUCED TOXICITY IN WISTAR RATS

2021 ◽  
Vol 23 (23) ◽  
Author(s):  
Karunakaran Balaji ◽  
J. Vijayakumar ◽  
Raghunath Gunapriya ◽  
V Naveen Kumar ◽  
Swaminathan Madhankumar ◽  
...  
Keyword(s):  
Lead Acetate ◽  
Wistar Rats ◽  
Seed Extract ◽  
Celastrus Paniculatus ◽  
Nephroprotective Effect

scholarly journals Protective Effect of Rasayana Herbs on Lead Acetate-induced Testicular Toxicity in Wistar Rats

2021 ◽  
Vol 35 (1) ◽  
pp. 9-15
Author(s):  
Vikas Sharma ◽  
Nagendra S Chauhan ◽  
Umesh K Patil ◽  
Vinod Kumar Dixit
Keyword(s):  
Protective Effect ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Testicular Toxicity

Experimental Studies on Effect of Chlorpyrifos and Lead Acetate on the Activity of Cholinesterase in Wistar Rats: Possible Protective Effect of Vitamin C

2016 ◽  
Vol 18 (2) ◽  
pp. 131
Author(s):  
Nisar Ahmad Nisar ◽  
Mudasir Sultana ◽  
Parveez Ahmad Para ◽  
Subha Ganguly ◽  
Shabu Showkat
Keyword(s):  
Vitamin C ◽  
Protective Effect ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Experimental Studies

scholarly journals Molecular Studies on the Nephroprotective Potential of Celastrus paniculatus against Lead-Acetate-Induced Nephrotoxicity in Experimental Rats: Role of the PI3K/AKT Signaling Pathway

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6647
Author(s):  
Karunakaran Balaji ◽  
Jagadish Vijayakumar ◽  
Ponnusamy Kasirajan Sankaran ◽  
Sivanesan Senthilkumar ◽  
Rajagopalan Vijayaraghavan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Lead Acetate ◽  
Akt Signaling ◽  
Seed Extract ◽  
Control Group ◽  
Renal Tubules ◽  
Mrna Levels ◽  
Akt Signaling Pathway ◽  
Standard Drug ◽  
Celastrus Paniculatus

Chemicals can induce nephrotoxicity, with damage to different segments of the nephron and deterioration of renal function. Nephrotoxicity due to exposure to a toxin such as carbon tetrachloride, sodium oxalate, or heavy metals is the most common cause of kidney injury. The current study aimed to evaluate the protective effects of Celastrus paniculatus seed extract against lead-acetate-induced nephrotoxicity by evaluating the histopathology, immunohistochemistry, ultrastructure, and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. Twenty-four rats were divided into four groups (n = 6 per group): group 1 contained normal animals and served as the control; group 2 received lead acetate (30 mg/kg body weight (b.w.)/day, oral); group 3 received lead acetate and the standard drug N-acetylcysteine (NAC, 200 mg/kg b.w./day, oral); and group 4 received lead acetate and the ethanolic extract of C. paniculatus seed (EECP; 800 mg/kg b.w./day, oral). Treatment was given for 28 consecutive days. The data were analyzed using one-way analysis of variance with SIGMA PLOT 13 using SYSTAT software followed by Newman–Keul’s test for comparison between the groups. EECP ameliorated the adverse changes caused by lead acetate. PI3K and AKT messenger RNA (mRNA) levels were diminished in lead-acetate-treated rats. Treatment with EECP inhibited the occurrence of shrunken cells, the atrophy of glomeruli, and degenerative changes in renal tubules caused by lead acetate. Interestingly, the PI3K and AKT mRNA levels were significantly increased in EECP-treated animals. Our results clearly evidence for the first time that C. paniculatus seed extract inhibits lead-acetate-induced detrimental changes in kidneys by regulating PI3K/AKT signaling pathways.

Evaluation of protective effect of rutin on lead acetate-induced testicular toxicity in Wistar rats

Toxin Reviews ◽  
2015 ◽  
Vol 34 (4) ◽  
pp. 195-199 ◽  
Author(s):  
Sabah Ansar ◽  
Haneem T AlGhosoon ◽  
Sharefa Hamed
Keyword(s):  
Protective Effect ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Testicular Toxicity

scholarly journals Protective effect of curcumin on lead acetate-induced testicular toxicity in Wistar rats

2017 ◽  
Vol 12 (5) ◽  
pp. 381 ◽  
Author(s):  
SriAgus Sudjarwo ◽  
GiftaniaWardani Sudjarwo ◽  
Koerniasari
Keyword(s):  
Protective Effect ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Testicular Toxicity

Beneficial Protective Effect of Troxerutin on Nickel-Induced Renal Dysfunction in Wistar Rats

2018 ◽  
Vol 37 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Perumal Elangovan ◽  
Ramalingam Ramakrishnan ◽  
Kasinathan Amudha ◽  
Abdulkadhar Mohamed Jalaludeen ◽  
Gunasekaran Karuna Sagaran ◽  
...  
Keyword(s):  
Protective Effect ◽  
Renal Dysfunction ◽  
Wistar Rats

Cocos nucifera L. oil alleviates lead acetate-induced reproductive toxicity in sexually-matured male Wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Olugbemi T. Olaniyan ◽  
Olakunle A. Ojewale ◽  
Ayobami Dare ◽  
Olufemi Adebayo ◽  
Joseph E. Enyojo ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Histological Analysis ◽  
Cocos Nucifera ◽  
Reproductive Toxicity ◽  
Positive Control ◽  
Negative Control ◽  
Male Wistar Rats ◽  
Cocos Nucifera L

Abstract Objectives Lead primarily affects male reproductive functions via hormonal imbalance and morphological damage to the testicular tissue with significant alteration in sperm profile and oxidative markers. Though, different studies have reported that Cocos nucifera L. oil has a wide range of biological effects, this study aimed at investigating the effect of Cocos nucifera L. oil on lead acetate-induced reproductive toxicity in male Wistar rats. Methods Twenty (20) sexually matured male Wistar rats (55–65 days) were randomly distributed into four groups (n=5). Group I (negative control)—distilled water orally for 56 days, Group II (positive control)—5 mg/kg bwt lead acetate intraperitoneally (i.p.) for 14 days, Group III—6.7 mL/kg bwt Cocos nucifera L. oil orally for 56 days and Group IV—lead acetate intraperitoneally (i.p.) for 14 days and Cocos nucifera L. oil for orally for 56 days. Rats were sacrificed by diethyl ether, after which the serum, testis and epididymis were collected and used for semen analysis, biochemical and histological analysis. Results The lead acetate significantly increases (p<0.05) testicular and epididymal malondialdehyde (MDA) levels, while a significant reduction (p<0.05) in sperm parameters, organ weight, testosterone and luteinizing hormone was observed when compared with the negative control. The coadministration of Cocos nucifera oil with lead acetate significantly increases (p<0.05) testosterone, luteinizing hormone, sperm parameters and organ weight, with a significant decrease (p<0.05) in MDA levels compared with positive control. Histological analysis showed that lead acetate distorts testicular cytoarchitecture and germ cell integrity while this was normalized in the cotreated group. Conclusions Cocos nucifera oil attenuates the deleterious effects of lead acetate in male Wistar rats, which could be attributed to its polyphenol content and antioxidant properties.

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