The Effect Of <i>Tetracera potatoria</i> And Its Constituent Betulinic Acid On Gastric Acid Secretion And Experimentally- Induced Gastric Ulceration

Purpose – The purpose of this paper is to study the effect of chronic consumption of fresh palm oil (FPO) and thermoxidized palm oil (TPO) diet on gastric acid secretion, pepsin secretions, gastric mucus output and gastric cytoprotection. Design/methodology/approach – Adult Wistar rats were randomly assigned into three groups, i.e. control, FPO and TPO groups (n = 10 in each). The control group was fed with normal rat chow only, the FPO group was fed on diet containing 15 per cent v/w FPO and the TPO group was fed with diet containing v/w of thermally oxidized palm oil. All animals had free access to feed and water, and the feeding lasted for 14 weeks. At the end of the feeding period, gastric acid secretion, pepsin secretion, mucus output and gastric ulceration were measured following standard methods. Findings – There was increase in histamine-stimulated gastric acid output in the TPO diet-fed group (p < 0.01) compared with the control and FPO diet-fed groups. No significant change in the mucus output was observed across all the experimental groups; whereas, pepsin secretion was significantly higher (p < 0.05) in the TPO diet-fed group (0.46 ± 0.27) compared with the control (0.14 ± 0.05) and FPO diet-fed groups (0.25 ± 0.01). Ulcer scores in the TPO diet-fed group (15.5 ± 0.33) was significantly higher (p < 0.01) compared with the control (10.0 ± 0.05) and FPO diet-fed (5.0 ± 0.04) groups. Originality/value – Chronic consumption of TPO increased gastric acid and pepsin secretion (gastric-aggressive factors) without a change in the mucus output. This can bring about gastric ulceration; therefore, the liberal use of TPO should be discouraged.

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Differences in action of topical and systemic cysteamine on gastric blood flow, gastric acid secretion and gastric ulceration in the rat

Journal of Physiology-Paris ◽

10.1016/0928-4257(96)89609-4 ◽

1996 ◽

Vol 90 (2) ◽

pp. 63-73 ◽

Cited By ~ 7

Author(s):

O.M.E Abdel-Salam ◽

J Szolcsányi ◽

G Mózsik

Keyword(s):

Blood Flow ◽

Acid Secretion ◽

Gastric Acid Secretion ◽

Gastric Acid ◽

Gastric Ulceration ◽

Gastric Blood Flow

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The preventive effect of Nigella sativa seed on gastric ulcer induced by indomethacin in rat

Journal of Herbmed Pharmacology ◽

10.15171/jhp.2020.02 ◽

2020 ◽

Vol 9 (1) ◽

pp. 12-19

Author(s):

Maryam Paseban ◽

Saeed Niazmand ◽

Mohammad Soukhtanloo ◽

Naser Tayyebi Meybodi

Keyword(s):

Gastric Ulcer ◽

Acid Secretion ◽

Protein Content ◽

Gastric Acid Secretion ◽

Gastric Acid ◽

Nigella Sativa ◽

Gastric Ulceration ◽

Gastric Mucus ◽

Ulcer Index ◽

Nigella Sativa Seed

Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered as one of the most administrated groups of medications worldwide. Due to the role of NSAIDs in inducing gastric ulceration, their clinical applications are still challenging. Nigella sativa seed is widely used as an herbal medication against gastrointestinal complications. The present experiment was carried out to investigate the impact of N. sativa seed hydro-alcoholic extract on gastric ulcer induced by indomethacin (IND) and to evaluate its possible mechanisms in rat. Methods: This study was performed on 48 male Wistar rats. Acute gastric ulceration was induced by IND (35 mg/kg). N. sativa seed extract (100, 200, 400 mg/kg) and ranitidine (50 mg/kg) were administered orally for five days before the induction ulcer. Ulcer index, gastric acid secretion, gastric mucus content, glutathione (GSH), malondialdehyde (MDA), total hexose, gastric juice protein content were determined on the fifth day. Results: The ulcer index in all groups of N. sativa seed was significantly lower than that of the IND group. N sativa seed considerably decreased MDA and protein content, but increased total thiol, total hexose, and mucus content compared to the IND group. N. sativa seed did not affect gastric acid secretion. Conclusion: These findings were indicative of the gastroprotective effect of N. sativa seed against the IND-induced ulcer, suggesting that it can mainly be exerted through the anti-oxidant activity of the extract as well as its role in stimulating gastric mucus secretion and increasing total hexose in the gastric mucosa.

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