scholarly journals High prevalence of Plasmodium falciparum pfcrt K76T mutation in children with sickle cell disease at a tertiary hospital in north-western Tanzania

2014 ◽  
Vol 16 (4) ◽  
Author(s):  
Stella Mongella ◽  
Nizar Enweji ◽  
Naizihjwa Mnong'one ◽  
Mercy Minde ◽  
Erasmus Kamugisha ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Tertiary Hospital ◽  
Cell Disease ◽  
High Prevalence ◽  
North Western ◽  
Western Tanzania

Prevalence of significant bacteriuria among symptomatic and asymptomatic homozygous sickle cell disease patients in a tertiary hospital in Lagos, Nigeria

2014 ◽  
Vol 17 (2) ◽  
pp. 163 ◽  
Author(s):  
AA Akinbami ◽  
S Ajibola ◽  
I Bode-Shojobi ◽  
O Oshinaike ◽  
A Adediran ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Tertiary Hospital ◽  
Cell Disease ◽  
Significant Bacteriuria ◽  
Homozygous Sickle Cell Disease

scholarly journals High prevalence of tuberculosis among adults with fever admitted at a tertiary hospital in north-western Tanzania

2012 ◽  
Vol 14 (3) ◽  
Author(s):  
Stephen E. Mshana ◽  
Alfred Meremo ◽  
Benson R. Kidenya ◽  
Rodrick Kabangila ◽  
Johannes Kataraihya
Keyword(s):  
Tertiary Hospital ◽  
High Prevalence ◽  
North Western ◽  
Western Tanzania

scholarly journals Pulmonary hypertension in sickle cell disease: diagnosis and management

Hematology ◽  
2014 ◽  
Vol 2014 (1) ◽  
pp. 425-431 ◽  
Author(s):  
Kenneth I. Ataga ◽  
Elizabeth S. Klings
Keyword(s):  
Pulmonary Hypertension ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Disease Diagnosis ◽  
Adult Patients ◽  
Heart Catheterization ◽  
Cell Disease ◽  
Risk Of Death ◽  
Increased Risk ◽  
High Prevalence

Abstract The increased survival of patients with sickle cell disease (SCD) into adulthood is associated with an increased incidence of multiorgan dysfunction and a progressive systemic and pulmonary vasculopathy. The high prevalence of an elevated tricuspid regurgitant jet velocity and its association with an increased risk of death in adult patients is well established. However, there has been controversy regarding the prevalence of pulmonary hypertension (PH) and its association with mortality in SCD. Multiple recently published reports demonstrate that PH as diagnosed by right heart catheterization is common in adult SCD patients, with a prevalence of 6%–11%. Furthermore, PH is associated with an increased risk of death in SCD patients. In this chapter, we provide evidence for the high prevalence of PH in SCD and its association with mortality and make recommendations for its evaluation and management. Finally, we provide the rationale for screening for this life-threatening complication in adult patients with SCD.

Prevalence of Thrombophilia In Patients with Sickle Cell Disease and Osteonecrosis

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 3184-3184
Author(s):  
Murtadha K. Al-Khabori ◽  
Anil Pathare ◽  
Khalil Al Farsi ◽  
Mohammed Al Huneini ◽  
Salam Alkindi
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Research Funding ◽  
Protein C ◽  
Dna Analysis ◽  
White Cell Count ◽  
Protein S ◽  
Cell Disease ◽  
High Prevalence ◽  
Low Levels

Abstract Abstract 3184 Background: Osteonecrosis (ON) of the femoral and humeral heads is frequently seen in patients with sickle cell disease (SCD). Earlier studies reported a high prevalence of thrombophilia in patients with ON. Aims: To study the prevalence of thrombophilia in patients of SCD with ON. Methods: Case records of SCD patients with ON were retrospectively reviewed for protein S, protein C, and anti-thrombin deficiency, along with activated protein C resistance (APCR). Results: A total of sixty-three patients were identified, 35 of whom were males, with a median age of 21 years (range 15to 46). Median haemoglobin, total white cell count and platelet counts were 10 g/dL (range 7.7to 13.3), 7.5 ×109/L (range 3.4 to 16.7) and 302 ×109/L (range 72 to 1101) respectively. Twenty-eight patients were on hydroxyurea. Thrombophilia testing showed that 29% (95% confidence interval: 17–40), 47% (95% CI: 29–64) and 79% (95% CI: 65–93) of the patients had low levels of functional (<60 unit/dl), total antigenic (<70 unit/dl) and free antigenic (<70 unit/dl) protein S respectively, while 21% (95% CI: 10–31) and 67% (95% CI: 46–87) had low levels of functional (<70 unit/dl) and antigenic (<70 unit/dl) protein C respectively. In addition, 14% (95% CI: 5–23) and 22% (95% CI: 0–56) of the patients had low levels of functional (<80 unit/dl) and antigenic (<80 unit/dl) anti-thrombin levels respectively. Only 2% (95% CI: 0–5) of these patients had an abnormally low APCR (APCR ratio ≤2.3). Summary/Conclusions: Patients with SCD and ON have a high prevalence of thrombophilia. These results indicate that a prospective study with more detailed thrombophilia work-up, along with confirmatory DNA analysis, as well as a study of the role of prophylactic anticoagulation in such patients is highly warranted. Disclosures: Pathare: Sultan Qaboos University: Employment, Research Funding. Alkindi:Sultan Qaboos University: Employment, Research Funding.

High Prevalence of Pulmonary Hypertension in Children With Sickle Cell Disease

2007 ◽  
Vol 29 (5) ◽  
pp. 334-337 ◽  
Author(s):  
Stephen C. Nelson ◽  
Beverly B. Adade ◽  
Elizabeth A. McDonough ◽  
Kristin L. Moquist ◽  
Jane M. Hennessy
Keyword(s):  
Pulmonary Hypertension ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
High Prevalence ◽  
Hypertension In Children

scholarly journals Epidemiology of hereditary anemias in Saudi Arabia

2021 ◽  
Author(s):  
Shada Murshed Alharbi ◽  
Jawad Hussain Alshaiti ◽  
Jamila Mofareh Ghazwani ◽  
Afia Mofareh Ghazwani ◽  
Nawaf Mohammed Abushelwah ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Dehydrogenase Deficiency ◽  
Epidemiological Studies ◽  
Cell Disease ◽  
The Past ◽  
Prevalence Trends ◽  
High Prevalence ◽  
Glucose 6 Phosphate Dehydrogenase

The prevalence rates of hereditary anemias in Saudi Arabia are remarkably high when compared to other countries. For instance, estimates show that the prevalence of thalassemia constitutes one of the highest rates globally. Furthermore, it has been demonstrated that epidemiology significantly differs between the different regions across the Kingdom. Therefore, many epidemiological investigations were conducted. In this context, it has been demonstrated that the prevalence of thalassemia ranges from 0.4% to 5.9% in the Northern and Eastern regions, respectively. In the present literature review, we have discussed the different findings of epidemiological studies that studied the epidemiology of hereditary anemias in Saudi Arabia. We mainly discussed the epidemiology of glucose-6-phosphate dehydrogenase deficiency (G6PD), sickle cell disease, and thalassemia. Recent evidence indicates that the trends of β-thalassemia are significantly decreasing over the past years. On the other hand, it has been demonstrated that the prevalence trends of sickle cell disease is constant over the past years. G6PD is also highly prevalent in Saudi Arabia. However, recent evidence is lacking in the literature and needs to be updated by future investigations. Consanguineous marriage has been reported to be an important risk factor for the high prevalence of β-thalassemia and sickle cell disease across the Kingdom.

scholarly journals Sickle cell disease and malaria: decreased exposure and asplenia can modulate the risk from Plasmodium falciparum

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Richard O. Mwaiswelo ◽  
William Mawala ◽  
Per O. Iversen ◽  
Mariane de Montalembert ◽  
Lucio Luzzatto ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease

The incidence of malaria and the comparison of hematological and biochemical indices of Plasmodium falciparum-parasitemic and aparasitemic sickle cell disease (SCD) patients

2010 ◽  
Vol 32 (6p1) ◽  
pp. e197-e207 ◽  
Author(s):  
K. NSIAH ◽  
V. P. DZOGBEFIA ◽  
D. ANSONG ◽  
H. BOATENG ◽  
D. OCLOO ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Biochemical Indices
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