scholarly journals In situ epicatechin-loaded hydrogel implants for local drug delivery to spinal column for effective management of post-traumatic spinal injuries

2016 ◽  
Vol 15 (7) ◽  
pp. 1369
Author(s):  
Jun Lu ◽  
You-ting Ju ◽  
Shou-lin Chen ◽  
Jun-ying Cai ◽  
Guo-hai Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Spinal Column ◽  
Spinal Injuries ◽  
Local Drug Delivery ◽  
Effective Management ◽  
Post Traumatic

Elaboration of radiopaque iodinated nanoparticles for in situ control of local drug delivery

Biomaterials ◽  
2009 ◽  
Vol 30 (29) ◽  
pp. 5667-5674 ◽  
Author(s):  
Damia Mawad ◽  
Hanna Mouaziz ◽  
Alexandra Penciu ◽  
Henri Méhier ◽  
Bernard Fenet ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Local Drug Delivery ◽  
In Situ Control

Local Drug Delivery Based Treatment Approaches for Effective Management of Periodontitis

2019 ◽  
Vol 14 (2) ◽  
pp. 135-152 ◽  
Author(s):  
Geeta Aggarwal ◽  
Sonia Verma ◽  
Madhu Gupta ◽  
Manju Nagpal
Keyword(s):  
Drug Delivery ◽  
Periodontal Disease ◽  
Antimicrobial Agents ◽  
Delivery Systems ◽  
Local Delivery ◽  
Local Drug Delivery ◽  
Prolonged Treatment ◽  
Effective Management ◽  
Pocket Depth ◽  
Mechanical Removal

Background: Periodontal disease is an immuno-inflammatory condition of tissues that surround and hold the teeth. It is the disease which succeeds in all races, groups and both genders. Almost 10 to15% of the global population gets suffered from severe periodontitis as per WHO reports. Periodontal disease may likely cause other systemic diseases such as cardiovascular disease and pre-term low birth weight infants. Mechanical removal of plaques and calculus deposits from supra and subgingival environment is the backbone of periodontal treatment till date whereas complete elimination of these deleterious agents is quite unrealistic as the pocket depth increases. Recent Approaches: Recently controlled local drug delivery application is more encouraging in comparison to systemic approach as it mainly targets to enhance the therapeutic efficacy by maintaining site-specificity, avoiding first pass metabolism, reduction in gastrointestinal (GI) side effects and decreasing the dose. Several drugs such as antiseptics and antibiotics alongwith various carriers are being formulated as local drug delivery systems for effective management of the disease. Various local delivery systems reported are fibers, films, strips, compacts, injectables, microparticles, vesicular carriers, gels and nanoparticles. These local carriers provide effective prolonged treatment at the site of infection at reduced doses. This review enlightens detailed pathophysiology and various phases of periodontitis, challenges in treatment of disease and various antimicrobial agents (along with their marketed formulations) used. The main emphasis of the review is to cover all carrier systems developed so far for local delivery application in the effective management of periodontitis, as a patient compliant drug therapy.

In situ gel-forming dual drug delivery system for synergistic combination therapy of colorectal peritoneal carcinomatosis

RSC Advances ◽  
2015 ◽  
Vol 5 (123) ◽  
pp. 101494-101506 ◽  
Author(s):  
Xiaoling Li ◽  
Rangrang Fan ◽  
Yuelong Wang ◽  
Min Wu ◽  
Aiping Tong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Combination Therapy ◽  
Peritoneal Carcinomatosis ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
In Situ Gel ◽  
Local Drug Delivery System ◽  
Dual Drug

A novel local drug delivery system composed of docetaxel loaded micelles and an oxaliplatin loaded hydrogel was fabricated and proved to be potentially useful in the treatment of colorectal peritoneal carcinomatosis.

Novel in situ forming hydrogel based on xanthan and chitosan re-gelifying in liquids for local drug delivery

2018 ◽  
Vol 186 ◽  
pp. 54-63 ◽  
Author(s):  
Jinjian Huang ◽  
Youming Deng ◽  
Jianan Ren ◽  
Guopu Chen ◽  
Gefei Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Local Drug Delivery ◽  
In Situ Forming

Poly(isosorbide succinate)-based in situ forming implants as potential systems for local drug delivery: Preliminary studies

2018 ◽  
Vol 91 ◽  
pp. 311-317 ◽  
Author(s):  
Monika Śmiga-Matuszowicz ◽  
Anna Korytkowska-Wałach ◽  
Bożena Nowak ◽  
Ryszard Pilawka ◽  
Marta Lesiak ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Local Drug Delivery ◽  
In Situ Forming ◽  
In Situ Forming Implants

In Situ Gel Delivery System of Methylprednisolone for Post Traumatic Spinal Injuries

2015 ◽  
Vol 5 (7) ◽  
pp. 552-556 ◽  
Author(s):  
Yan-Jun Che ◽  
Liang Chen ◽  
Guo-Hua Lv ◽  
Xiao-Bin Wang
Keyword(s):  
Delivery System ◽  
Spinal Injuries ◽  
Post Traumatic

Promising Polymeric Drug Carriers for Local Delivery: The Case of in situ Gels

2020 ◽  
Vol 17 (8) ◽  
pp. 675-693 ◽  
Author(s):  
Neslihan Üstündağ Okur ◽  
Ayşe Pınar Yağcılar ◽  
Panoraia I. Siafaka
Keyword(s):  
Drug Delivery ◽  
Drug Carriers ◽  
Local Delivery ◽  
Basic Knowledge ◽  
Local Drug Delivery ◽  
Gelation Mechanism ◽  
Promising Alternative ◽  
Administration Routes ◽  
Polymeric Gels

Background: At present, the controlled local drug delivery is a very promising approach compared to systemic administration, since it mostly targets the affected tissue. In fact, various drug carriers for local delivery have been prepared with improved therapeutic efficacy. Objective: in situ polymer gels are drug delivery systems that not only present liquid characteristics before their administration in body, but once they are administered, form gels due to gelation. Their gelation mechanism is due to factors such as pH alteration, temperature change, ion activation or ultraviolet irradiation. in situ gels offer various advantages compared to conventional formulations due to their ability to release drugs in a sustainable and controllable manner. Most importantly, in situ gels can be used in local drug delivery applications for various diseases. Methods: This review includes the basic knowledge and theory of in situ gels as well as their various applications according to their administration route. Results: Various natural, semisynthetic, and synthetic polymers can produce in situ polymeric gels. For example, natural polysaccharides such as alginic acid, chitosan, gellan gum, carrageenan etc. have been utilized as in situ gels for topical delivery. Besides the polysaccharides, poloxamers, poly(Nisopropylacrylamide), poly(ethyleneoxide)/ (lactic-co-glycolic acid), and thermosensitive liposome systems can be applied as in situ gels. In most cases, in situ polymeric gels could be applied via various administration routes such as oral, vaginal, ocular, intranasal and injectable. Conclusion: To conclude, it can be revealed that in situ gels could be a promising alternative carrier for both chronic and immediate diseases.

scholarly journals Formulation and Physical Characterization of Bio-Degradable Chitosan-Poloxamer Gel Base for Local Drug Delivery

2020 ◽  
Vol 10 (4) ◽  
pp. 59-66 ◽  
Author(s):  
Prasanna T. Dahake ◽  
Sudhindra M Baliga ◽  
Triveni Punse ◽  
Dinesh M Biyani ◽  
Neha Raut ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Physical Properties ◽  
Physical And Mechanical Properties ◽  
Local Drug Delivery ◽  
Mechanical And Physical Properties ◽  
In Situ Hydrogel ◽  
The Mean ◽  
Poloxamer Gel

Objective: Thermo-modulated in-situ hydrogel (TSHG) are formulated routinely utilizing poloxamer for extended drug release. However physical properties of such formulations may have some flaws, which can be rectified using a combination of polymers with better physical properties such as chitosan. The purpose of the present study was to fabricate biodegradable chitosan-poloxamer-based in-situ drug delivery systems and assessment of their physical properties. Methods: The present chitosan-poloxamer gel base was formulated using a two-stage method. Initially, chitosan gel was prepared by dissolving 1% w/w chitosan in glacial acetic acid. The poloxamer gel was prepared using “cold method”. The final chitosan-poloxamer gel base was prepared by mixing equal amounts of both solutions and evaluated for physical and mechanical properties. Result and Discussion: The DSC thermogram demonstrated no obvious interactions among ingredients or micellization temperature. The gelation temperature of the gel was between 27 and 330C. The pH was 7 with slight clarity. The viscosity of the gel ranged from 15.14 to 41.19 pa.s. The gel was syringable between 4-300C and biodegradable under physiological conditions. The mean particle size of the gel under SEM was found in the range of 300-554 nm. Conclusion: After the evaluation of the formulation, it can be concluded that all the ingredients in the gel showed good compatibility with each other, which could form a stable and homogeneous gel with favorable mechanical and physical properties. Keywords: chitosan, drug delivery system, hydrogels, poloxamer

Modern Possibilities of Organ-Preserving Treatment in Children with Intraocular Retinoblastoma

2018 ◽  
Vol 5 (3) ◽  
pp. 175-187 ◽  
Author(s):  
O. V. Gorovtsova ◽  
T. L. Ushakova ◽  
V. G. Polyakov
Keyword(s):  
Drug Delivery ◽  
Survival Rate ◽  
Cancer Therapy ◽  
Neoadjuvant Chemotherapy ◽  
Patient Survival ◽  
Focal Therapy ◽  
Local Drug Delivery ◽  
Large Size ◽  
Intraocular Retinoblastoma

Retinoblastoma is one of highly curable diseases; today the total 5-year survival rate in patients with retinoblastoma exceeds 95%. The article summarizes the current world experience on treatment of patients with intraocular retinoblastoma. The treating skills of intraocular malignant tumor in children are a balance between the patient’s life and the preservation of an eye and its visual functions. The complex and challenging task is the treatment of common intraocular retinoblastoma groups «C», «D», «E» when the large size or localization of the tumor does not allow performing the local (focal) destruction of the tumor. As a rule, in such cases neoadjuvant chemotherapy (CT) is performed at the first stage in order to reduce the size of the tumor for further focal therapy. However, the analysed data on the effectiveness of neoadjuvant CT in combination with focal or radiotherapy demonstrated the limited possibilities of the proposed therapy. Local drug delivery in cancer therapy became a real breakthrough in the organ-preserving treatment of children with large intraocular retinoblastoma. The most widely used current methods of local drug delivery are intravitreal (IVitC) and selective intra-arterial chemotherapy (SIAC) as monotherapy or in combination with neoadjuvant CT and focal therapy which significantly increased the percentage of preserved eyes without radiotherapy administration or damage to the patient survival. The review discusses the different IVitC and SIAC techniques, chemotherapy schemes, dosages of chemotherapy, immediate and long-term complications of treatment.

Sign in / Sign up

Export Citation Format

Share Document