A new bioerodible system for sustained local drug delivery based on hydrolytically activated in situ macromolecular association

A novel local drug delivery system composed of docetaxel loaded micelles and an oxaliplatin loaded hydrogel was fabricated and proved to be potentially useful in the treatment of colorectal peritoneal carcinomatosis.

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Novel in situ forming hydrogel based on xanthan and chitosan re-gelifying in liquids for local drug delivery

Carbohydrate Polymers ◽

10.1016/j.carbpol.2018.01.025 ◽

2018 ◽

Vol 186 ◽

pp. 54-63 ◽

Cited By ~ 40

Author(s):

Jinjian Huang ◽

Youming Deng ◽

Jianan Ren ◽

Guopu Chen ◽

Gefei Wang ◽

...

Keyword(s):

Drug Delivery ◽

Local Drug Delivery ◽

In Situ Forming

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Poly(isosorbide succinate)-based in situ forming implants as potential systems for local drug delivery: Preliminary studies

Materials Science and Engineering C ◽

10.1016/j.msec.2018.05.046 ◽

2018 ◽

Vol 91 ◽

pp. 311-317 ◽

Cited By ~ 4

Author(s):

Monika Śmiga-Matuszowicz ◽

Anna Korytkowska-Wałach ◽

Bożena Nowak ◽

Ryszard Pilawka ◽

Marta Lesiak ◽

...

Keyword(s):

Drug Delivery ◽

Local Drug Delivery ◽

In Situ Forming ◽

In Situ Forming Implants

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Promising Polymeric Drug Carriers for Local Delivery: The Case of in situ Gels

Current Drug Delivery ◽

10.2174/1567201817666200608145748 ◽

2020 ◽

Vol 17 (8) ◽

pp. 675-693 ◽

Cited By ~ 1

Author(s):

Neslihan Üstündağ Okur ◽

Ayşe Pınar Yağcılar ◽

Panoraia I. Siafaka

Keyword(s):

Drug Delivery ◽

Drug Carriers ◽

Local Delivery ◽

Basic Knowledge ◽

Local Drug Delivery ◽

Gelation Mechanism ◽

Promising Alternative ◽

Administration Routes ◽

Polymeric Gels

Background: At present, the controlled local drug delivery is a very promising approach compared to systemic administration, since it mostly targets the affected tissue. In fact, various drug carriers for local delivery have been prepared with improved therapeutic efficacy. Objective: in situ polymer gels are drug delivery systems that not only present liquid characteristics before their administration in body, but once they are administered, form gels due to gelation. Their gelation mechanism is due to factors such as pH alteration, temperature change, ion activation or ultraviolet irradiation. in situ gels offer various advantages compared to conventional formulations due to their ability to release drugs in a sustainable and controllable manner. Most importantly, in situ gels can be used in local drug delivery applications for various diseases. Methods: This review includes the basic knowledge and theory of in situ gels as well as their various applications according to their administration route. Results: Various natural, semisynthetic, and synthetic polymers can produce in situ polymeric gels. For example, natural polysaccharides such as alginic acid, chitosan, gellan gum, carrageenan etc. have been utilized as in situ gels for topical delivery. Besides the polysaccharides, poloxamers, poly(Nisopropylacrylamide), poly(ethyleneoxide)/ (lactic-co-glycolic acid), and thermosensitive liposome systems can be applied as in situ gels. In most cases, in situ polymeric gels could be applied via various administration routes such as oral, vaginal, ocular, intranasal and injectable. Conclusion: To conclude, it can be revealed that in situ gels could be a promising alternative carrier for both chronic and immediate diseases.

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Formulation and Physical Characterization of Bio-Degradable Chitosan-Poloxamer Gel Base for Local Drug Delivery

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v10i4.4216 ◽

2020 ◽

Vol 10 (4) ◽

pp. 59-66 ◽

Cited By ~ 1

Author(s):

Prasanna T. Dahake ◽

Sudhindra M Baliga ◽

Triveni Punse ◽

Dinesh M Biyani ◽

Neha Raut ◽

...

Keyword(s):

Drug Delivery ◽

Physical Properties ◽

Physical And Mechanical Properties ◽

Local Drug Delivery ◽

Mechanical And Physical Properties ◽

In Situ Hydrogel ◽

The Mean ◽

Poloxamer Gel

Objective: Thermo-modulated in-situ hydrogel (TSHG) are formulated routinely utilizing poloxamer for extended drug release. However physical properties of such formulations may have some flaws, which can be rectified using a combination of polymers with better physical properties such as chitosan. The purpose of the present study was to fabricate biodegradable chitosan-poloxamer-based in-situ drug delivery systems and assessment of their physical properties. Methods: The present chitosan-poloxamer gel base was formulated using a two-stage method. Initially, chitosan gel was prepared by dissolving 1% w/w chitosan in glacial acetic acid. The poloxamer gel was prepared using “cold method”. The final chitosan-poloxamer gel base was prepared by mixing equal amounts of both solutions and evaluated for physical and mechanical properties. Result and Discussion: The DSC thermogram demonstrated no obvious interactions among ingredients or micellization temperature. The gelation temperature of the gel was between 27 and 330C. The pH was 7 with slight clarity. The viscosity of the gel ranged from 15.14 to 41.19 pa.s. The gel was syringable between 4-300C and biodegradable under physiological conditions. The mean particle size of the gel under SEM was found in the range of 300-554 nm. Conclusion: After the evaluation of the formulation, it can be concluded that all the ingredients in the gel showed good compatibility with each other, which could form a stable and homogeneous gel with favorable mechanical and physical properties. Keywords: chitosan, drug delivery system, hydrogels, poloxamer

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Modern Possibilities of Organ-Preserving Treatment in Children with Intraocular Retinoblastoma

Oncopediatrics ◽

10.15690/onco.v5i3.1935 ◽

2018 ◽

Vol 5 (3) ◽

pp. 175-187 ◽

Cited By ~ 1

Author(s):

O. V. Gorovtsova ◽

T. L. Ushakova ◽

V. G. Polyakov

Keyword(s):

Drug Delivery ◽

Survival Rate ◽

Cancer Therapy ◽

Neoadjuvant Chemotherapy ◽

Patient Survival ◽

Focal Therapy ◽

Local Drug Delivery ◽

Large Size ◽

Intraocular Retinoblastoma

Retinoblastoma is one of highly curable diseases; today the total 5-year survival rate in patients with retinoblastoma exceeds 95%. The article summarizes the current world experience on treatment of patients with intraocular retinoblastoma. The treating skills of intraocular malignant tumor in children are a balance between the patient’s life and the preservation of an eye and its visual functions. The complex and challenging task is the treatment of common intraocular retinoblastoma groups «C», «D», «E» when the large size or localization of the tumor does not allow performing the local (focal) destruction of the tumor. As a rule, in such cases neoadjuvant chemotherapy (CT) is performed at the first stage in order to reduce the size of the tumor for further focal therapy. However, the analysed data on the effectiveness of neoadjuvant CT in combination with focal or radiotherapy demonstrated the limited possibilities of the proposed therapy. Local drug delivery in cancer therapy became a real breakthrough in the organ-preserving treatment of children with large intraocular retinoblastoma. The most widely used current methods of local drug delivery are intravitreal (IVitC) and selective intra-arterial chemotherapy (SIAC) as monotherapy or in combination with neoadjuvant CT and focal therapy which significantly increased the percentage of preserved eyes without radiotherapy administration or damage to the patient survival. The review discusses the different IVitC and SIAC techniques, chemotherapy schemes, dosages of chemotherapy, immediate and long-term complications of treatment.

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Connexin43 Mimetic Peptide-Loaded Light Responsive In Situ Forming Injectable Implants for Effective Drug Delivery to the Posterior Segment of the Eye

10.26226/morressier.57d6b2b6d462b8028d88dc20 ◽

2016 ◽

Author(s):

Rohit Bisht

Keyword(s):

Drug Delivery ◽

Posterior Segment ◽

Effective Drug ◽

Mimetic Peptide ◽

In Situ Forming

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Scaffolds for Drug Delivery in Tissue Engineering

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2008.1.2.1 ◽

2008 ◽

Vol 1 (2) ◽

pp. 113-123 ◽

Cited By ~ 2

Author(s):

Vikas V. Gaikwad ◽

Abasaheb B. Patil ◽

Madhuri V. Gaikwad

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Heart Diseases ◽

Cartilage Regeneration ◽

Tissue Growth ◽

The Body ◽

Patient Specific ◽

In Situ Gel ◽

Heart Muscle Cells

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth. Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.

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