Genetic testing and risk perception in the context of personalized medicine

2020 ◽  
pp. 79-98
Author(s):  
Sabine Wöhlke ◽  
Marie Falahee ◽  
Katharina Beier
Keyword(s):  
Genetic Testing ◽  
Risk Perception ◽  
Personalized Medicine

scholarly journals PERSONALIZED MEDICINE: FROM SCIENCE TO PRACTICE

2016 ◽  
Vol 7 (4) ◽  
pp. 73-74
Author(s):  
A G Nikitin
Keyword(s):  
Genetic Testing ◽  
Personalized Medicine ◽  
Early Diagnosis ◽  
Molecular Genetic ◽  
Genomic Data ◽  
Routine Practice ◽  
Molecular Genetic Testing ◽  
Federal Research ◽  
Modern Methods ◽  
Clinical Centre

In 2012, in Federal research and clinical centre of FMBA of Russia the laboratory of genetics was established, which conducts scientific research in the field of genetic predisposition to socially significant diseases, early diagnosis of oncopathology, as well as methods for processing genomic data. Significant experience in molecular genetic testing have allowed to help to implement a routine practice of a multiprofile hospital modern methods of genetic analysis that were previously available only to large specialized centers.

scholarly journals Preoperative Genetic Testing and Personalized Medicine: Changing the Care Paradigm

2017 ◽  
Vol 41 (12) ◽  
Author(s):  
Rodney A. Gabriel ◽  
Jesse M. Ehrenfeld ◽  
Richard D. Urman
Keyword(s):  
Genetic Testing ◽  
Personalized Medicine ◽  
And Personalized Medicine

Valuing personalized medicine: willingness to pay for genetic testing for colorectal cancer risk

2007 ◽  
Vol 4 (3) ◽  
pp. 341-350 ◽  
Author(s):  
Stephanie L Van Bebber ◽  
Su-Ying Liang ◽  
Kathryn A Phillips ◽  
Deborah Marshall ◽  
Judith Walsh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Genetic Testing ◽  
Personalized Medicine ◽  
Cancer Risk ◽  
Willingness To Pay ◽  
Colorectal Cancer Risk

Syntropy, genetic testing and personalized medicine

2010 ◽  
Vol 7 (4) ◽  
pp. 399-405 ◽  
Author(s):  
Valery P Puzyrev ◽  
Oksana A Makeeva ◽  
Maxim B Freidin
Keyword(s):  
Genetic Testing ◽  
Personalized Medicine ◽  
And Personalized Medicine

scholarly journals Attitudes of Patients With Cancer About Personalized Medicine and Somatic Genetic Testing

2012 ◽  
Vol 8 (6) ◽  
pp. 329-335 ◽  
Author(s):  
Stacy W. Gray ◽  
Katherine Hicks-Courant ◽  
Christopher S. Lathan ◽  
Levi Garraway ◽  
Elyse R. Park ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Personalized Medicine ◽  
Patients With Cancer ◽  
Psychological Harm

Patients have relayed misunderstandings about somatic testing and a reluctance to have full sequencing; oncologists must consider how they present testing to patients so concerns over discrimination and psychological harm do not hinder test uptake.

Effects of gene penetrance on adherence to breast cancer screening recommendations (BCSR) among high-risk women.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 1515-1515 ◽  
Author(s):  
Jacqueline Talea Desjardin ◽  
Mallika Sachdev Dhawan ◽  
Amie Blanco ◽  
Pamela N. Munster
Keyword(s):  
Genetic Testing ◽  
Cancer Screening ◽  
Risk Perception ◽  
High Risk ◽  
Perceived Risk ◽  
Moderate Risk ◽  
High Risk Women ◽  
Mutation Carriers ◽  
Chi Squared ◽  
Post Test

1515 Background: Adherence to cancer screening depends on the interplay between risk perception and convenience. For instance, high perceived risk is likely what motivates high-risk mutation carriers (HRMC) to adhere well to rather inconvenient BCSR. While the NCCN offers BCSR for moderate-risk genes, adherence in moderate-risk mutation carriers (MRMC) and non-carriers with negative multigene panels (NC) is unknown. Methods: Screening behavior was examined in 120 women (15 HRMC, 20 MRMC, 85 NC) 20-65 years old (y) without cancer who received genetic testing and counseling. The groups did not differ in age or family history (fhx). Medical records were reviewed pre- and post-testing to determine adherence. Average follow up was 15 months. Data were analyzed by Chi-squared test. Results: Prior to genetic testing, 93% of women were adherent to general population BCSR, and 58% were already screening in accordance with post-test counseled BCSR. Testing altered adherence to counseled BCSR for HRMC (p<0.01), but not for MRMC (p=0.21) or NC (p=0.86). HRMC had better post-test adherence than MRMC (p<0.05). Conclusions: MRMC are often told to follow similar BCSR to HRMC, namely annual mammogram and MRI, but MRMC may be less motivated to adhere to these BCSR due to lower risk perception. We found adherence was high in HRMC, likely due to high risk perception; intermediate in NC, likely due to manageable BCSR; and comparably low in MRMC, possibly because their risk perception was insufficient to motivate biannual imaging studies. Understanding how genetic testing influences adherence is essential to ensuring proper surveillance in high-risk women. [Table: see text]

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