scholarly journals Time Course of Change in Hepatic Lipid Peroxide Level in Iron-Deficient Rats.

1998 ◽  
Vol 51 (4) ◽  
pp. 201-206 ◽  
Author(s):  
Hiroshige CHIBA ◽  
Misao TAKASAKI ◽  
Ritsuko MASUYAMA ◽  
Mariko UEHARA ◽  
Yusuke KANKE ◽  
...  
Keyword(s):  
Time Course ◽  
Lipid Peroxide ◽  
Hepatic Lipid ◽  
Lipid Peroxide Level ◽  
Iron Deficient

scholarly journals Hepatic Lipid Peroxide Profile on Inflamation Rats with Nanocurcuminoid Treatment

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Waras Nurcholis ◽  
Chelsea ◽  
Laksmi Ambarsari
Keyword(s):  
Free Radicals ◽  
Palmitic Acid ◽  
Liver Lipid ◽  
Lipid Peroxide ◽  
Hepatic Lipid ◽  
Lipid Peroxide Level ◽  
Average Size ◽  
532 Nm

Inflammation can cause the formation of prostaglandin and free radicals. In addition, overcome inflammation, a drug used also needs to have an effect as antioxidants to treat the free radicals. This problem can be solved by curcuminoid nanoparticles covered with palmitic acid. This research aims to test the antioxidants effect of curcuminoid nanoparticles covered with palmitic acid from Curcuma to lipid peroxide levels on inflammation rats liver. Antioxidants effect of nanocurcuminoid tested on rats that induced by 1% carrageenan and the liver lipid peroxide measured after 24 hours. Lipid peroxide level was measured with a spectrophotometer in 532 nm wavelength. The average size of curcuminoid nanoparticle covered with palmitic acid is 561.53 nm with an IP score of 0.309. Lipid peroxide level of inflammation rats liver given curcuminoids extract 100 mg/kg BW is 0.27x10-4 nmol/g. It was lower from the nanocurcuminoids 250 mg/kg BW groups which are 1.22 x10-4 nmol/g. Nanocurcuminoids 250 mg/kg BW is 114 times more efficient as an antioxidant than curcuminoids extract 100 mg/kg BW. Keywords: antioxidant, lipid peroxide, nanocurcuminoids

Time course of structure, function, and metabolic changes due to an exogenous source of oxygen metabolites in rat heart

1989 ◽  
Vol 67 (12) ◽  
pp. 1549-1559 ◽  
Author(s):  
Madhu Gupta ◽  
Pawan K. Singal
Keyword(s):  
Time Course ◽  
Active Oxygen Species ◽  
Lipid Peroxide ◽  
High Energy ◽  
Active Oxygen ◽  
High Energy Phosphates ◽  
Oxygen Species ◽  
Peroxide Content ◽  
Resting Tension ◽  
Contractile Failure

Effects of xanthine (2 mM) and xanthine oxidase (10 U/L) perfusion on myocardial function, lipid peroxide content, high-energy phosphates and their metabolites, and ultrastructure were examined in isolated perfused rat hearts to define the time course of myocardial injury due to exogenous supply of active oxygen species. Peak-developed force and dF/dt showed a decline within 5 min and complete contractile failure was seen at 20 min. Resting tension was higher at 10 min and reached a maximum value of 400% at 40 min. These changes in contractile parameters were reduced by superoxide dismutase (1.2 × 105 U/L), catalase (2 and 4 × 104 U/L), and mannitol (10 and 20 mM). Lipid peroxide content was significantly higher at 5 min and rose continuously with xanthine – xanthine oxidase (X–XO) perfusion. A close correlation was noted (r = 0.935) between increased lipid peroxide content and a decrease in peak-developed force. Creatine phosphate and adensoine triphosphate (ATP) showed a time-dependent decrease due to X–XO perfusion. Loss of ATP also correlated (r = 0.819) with the contractile failure. Adenosine diphosphate showed an increase at 5 min followed by a decrease at 20 and 40 min. Adenosine monophosphate, adenosine, and creatine content increased with X–XO perfusion. In a semiquantitative morphometric study, significant myocardial and vascular changes became apparent only after 10 min of X–XO perfusion. When a 5-min perfusion with X–XO was followed by a control perfusion, a recovery of developed force and normal structure was noted at 40 min. These data show that X–XO induced contractile failure involves partially reduced forms of oxygen such as superoxide, hydroxyl radicals, and hydrogen peroxide. The negative inotropic effect of a vascular supply of these active oxygen species may be related to increased lipid peroxidation as well as the loss of high-energy phosphates. Structural damage to myocytes and blood vessels and a rise in resting tension were delayed events requiring a continuous and longer exposure to radical species.Key words: myocardial failure, oxygen radicals, lipid peroxidation, myocardial high-energy phosphates, myocardial cell damage, antioxidant protection.

Lipid peroxide level in plasma of diabetic patients

1979 ◽  
Vol 21 (1) ◽  
pp. 104-107 ◽  
Author(s):  
Yuzo Sato ◽  
Nigishi Hotta ◽  
Nobuo Sakamoto ◽  
Shigeru Matsuoka ◽  
Nobuko Ohishi ◽  
...  
Keyword(s):  
Lipid Peroxide ◽  
Diabetic Patients ◽  
Lipid Peroxide Level

Effect of pre-exposure to beta rays of tritium on some biochemical parameters measured in organs of rats subsequently irradiated with fast neutrons

2002 ◽  
Vol 80 (7) ◽  
pp. 742-749 ◽  
Author(s):  
Ileana Petcu ◽  
Nicoleta Moisoi ◽  
Diana Savu ◽  
B Constantinescu
Keyword(s):  
Bone Marrow ◽  
Small Intestine ◽  
Protective Effect ◽  
Bone Marrow Cells ◽  
Lipid Peroxide ◽  
Lipid Peroxides ◽  
Fast Neutrons ◽  
Thymidine Uptake ◽  
Lipid Peroxide Level

The experiment examined biological responses produced by combined sequential exposure to low-level tritium contamination, followed by challenging irradiation with fast neutrons. Modifications of endogenous antioxidant potential of different organs in rats were discussed in relation to tissue radiosensitivity. Rats pre-contaminated to 7 cGy and 35 cGy have been additionally irradiated to 1 Gy with fast neutrons. Lipid peroxide level was determined in liver, kidney, small intestine, spleen, bone marrow, and plasma. Reduced glutathione (GSH) level and glucose-6-phosphate dehydrogenase (G6PDH) activity were determined in erythrocytes. An in vitro thymidine uptake assay was performed in isolated bone marrow cells. The lipid peroxide level decreased significantly only in liver and kidney from rats pre-exposed to 35 cGy. For small intestine and spleen, tissues of comparatively higher radiosensitivity, no induced radioprotection was observed, as reflected in the homeostasis of the lipid peroxides. The same behavior was observed in bone marrow, the most radiosensitive tissue studied. However, the bone marrow thymidine-incorporation assay revealed a possible adaptive-type reaction in rats pre-exposed to 35 cGy. We conclude that for radiosensitive tissues pre-exposure to chronic low doses of low linear energy transfer (LET) irradiation has no protective effect on their antioxidant status, whereas a protective effect is observed in radioresistent tissues.Key words: induced radioprotection, tritium contamination, lipid peroxides, thymidine uptake, tissue radiosensitivity, antioxidant defense.

Sign in / Sign up

Export Citation Format

Share Document