scholarly journals Hepatic Lipid Peroxide Profile on Inflamation Rats with Nanocurcuminoid Treatment

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Waras Nurcholis ◽  
Chelsea ◽  
Laksmi Ambarsari
Keyword(s):  
Free Radicals ◽  
Palmitic Acid ◽  
Liver Lipid ◽  
Lipid Peroxide ◽  
Hepatic Lipid ◽  
Lipid Peroxide Level ◽  
Average Size ◽  
532 Nm

Inflammation can cause the formation of prostaglandin and free radicals. In addition, overcome inflammation, a drug used also needs to have an effect as antioxidants to treat the free radicals. This problem can be solved by curcuminoid nanoparticles covered with palmitic acid. This research aims to test the antioxidants effect of curcuminoid nanoparticles covered with palmitic acid from Curcuma to lipid peroxide levels on inflammation rats liver. Antioxidants effect of nanocurcuminoid tested on rats that induced by 1% carrageenan and the liver lipid peroxide measured after 24 hours. Lipid peroxide level was measured with a spectrophotometer in 532 nm wavelength. The average size of curcuminoid nanoparticle covered with palmitic acid is 561.53 nm with an IP score of 0.309. Lipid peroxide level of inflammation rats liver given curcuminoids extract 100 mg/kg BW is 0.27x10-4 nmol/g. It was lower from the nanocurcuminoids 250 mg/kg BW groups which are 1.22 x10-4 nmol/g. Nanocurcuminoids 250 mg/kg BW is 114 times more efficient as an antioxidant than curcuminoids extract 100 mg/kg BW. Keywords: antioxidant, lipid peroxide, nanocurcuminoids

scholarly journals Effect of Catecholestrogens on Mortality and Liver Lipid Peroxide Level of Mice Irradiated with 60Co .GAMMA.-Ray.

1993 ◽  
Vol 15 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Akira TOMATSU ◽  
Sadaaki KOMURA ◽  
Nobuko OHISHI ◽  
Masami NAKANISHI ◽  
Kunio YAGI
Keyword(s):  
Gamma Ray ◽  
Liver Lipid ◽  
Lipid Peroxide ◽  
Lipid Peroxide Level ◽  
60Co Gamma

scholarly journals Time Course of Change in Hepatic Lipid Peroxide Level in Iron-Deficient Rats.

1998 ◽  
Vol 51 (4) ◽  
pp. 201-206 ◽  
Author(s):  
Hiroshige CHIBA ◽  
Misao TAKASAKI ◽  
Ritsuko MASUYAMA ◽  
Mariko UEHARA ◽  
Yusuke KANKE ◽  
...  
Keyword(s):  
Time Course ◽  
Lipid Peroxide ◽  
Hepatic Lipid ◽  
Lipid Peroxide Level ◽  
Iron Deficient

scholarly journals Aqueous Extract of Pepino Leaves Ameliorates Palmitic Acid-Induced Hepatocellular Lipotoxicity via Inhibition of Endoplasmic Reticulum Stress and Apoptosis

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 903
Author(s):  
Jen-Ying Hsu ◽  
Hui-Hsuan Lin ◽  
Charng-Cherng Chyau ◽  
Zhi-Hong Wang ◽  
Jing-Hsien Chen
Keyword(s):  
Fatty Acid ◽  
Palmitic Acid ◽  
Er Stress ◽  
Lipid Accumulation ◽  
Hepg2 Cells ◽  
Target Genes ◽  
Liver Lipid ◽  
Antioxidant Response ◽  
Long Chain Fatty Acid ◽  
Nrf2 Expression

Saturated fatty acid is one of the important nutrients, but contributes to lipotoxicity in the liver, causing hepatic steatosis. Aqueous pepino leaf extract (AEPL) in the previous study revealed alleviated liver lipid accumulation in metabolic syndrome mice. The study aimed to investigate the mechanism of AEPL on saturated long-chain fatty acid-induced lipotoxicity in HepG2 cells. Moreover, the phytochemical composition of AEPL was identified in the present study. HepG2 cells treated with palmitic acid (PA) were used for exploring the effect of AEPL on lipid accumulation, apoptosis, ER stress, and antioxidant response. The chemical composition of AEPL was analyzed by HPLC-ESI-MS/MS. AEPL treatment reduced PA-induced ROS production and lipid accumulation. Further molecular results revealed that AEPL restored cytochrome c in mitochondria and decreased caspase 3 activity to cease apoptosis. In addition, AEPL in PA-stressed HepG2 cells significantly reduced the ER stress and suppressed SREBP-1 activation for decreasing lipogenesis. For defending PA-induced oxidative stress, AEPL promoted Nrf2 expression and its target genes, SOD1 and GPX3, expressions. The present study suggested that AEPL protected from PA-induced lipotoxicity through reducing ER stress, increasing antioxidant ability, and inhibiting apoptosis. The efficacy of AEPL on lipotoxicity was probably concerned with kaempferol and isorhamnetin derived compounds.

scholarly journals Comparison of free radicals in blood in pre-operative and post-operative phases of breast malignancies: a clinicopathological study

2019 ◽  
Vol 7 (1) ◽  
pp. 210
Author(s):  
Abhishek Jina ◽  
U. C. Singh
Keyword(s):  
Breast Cancer ◽  
Free Radicals ◽  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Lipid Peroxide ◽  
P Value ◽  
Breast Cancer Patients ◽  
Medical College ◽  
Surgery Department

Background: Various factors have been identified as influencing factors of breast cancer. The free radicals can cause increased oxidative stress by negatively affecting the body’s nucleic acids, lipids and proteins leading to various illnesses including cancer. Therefore, this study was aimed at discovering the progress of treatment of breast carcinoma by exploring the connections of the disease with free radical injury.Methods: The present study was conducted among 30 breast carcinoma patients received in the surgery department of BRD Medical College Gorakhpur. Determination of the levels superoxide dismutase (SOD) (the procedure of photoluminescence), catalase (method of Cavarochi) and the lipid peroxidise was done. The results were presented as mean and standard error (SE). P value of <0.05 was considered as statistically significant.Results: Among the total participants, 73% patients had infiltrating ductal carcinoma and 27% patients had intraductal carcinoma. The dismutase levels showed an increase in the post-operative patients for both the groups. The catalase levels and the lipid peroxide levels showed a reduction in the postoperative patients (p<0.05).Conclusions: The present study result showed that the low amounts of SOD and catalase may not be sufficient to detoxify high amounts of free radicals. The administration of catalase could help in reducing the symptoms. Though, low amounts of SOD and catalase may not be sufficient to detoxify high amounts of free radicals. The administration of enzymes could help in the treatment of breast cancer patients.

Biochemical Analysis of Hepatic Lipid in Alcoholic and Diabetic and Control Subjects

1983 ◽  
Vol 65 (6) ◽  
pp. 645-652 ◽  
Author(s):  
S. R. Cairns ◽  
T. J. Peters
Keyword(s):  
Free Cholesterol ◽  
Biochemical Analysis ◽  
Essential Fatty Acids ◽  
Liver Lipid ◽  
Alcoholic Cirrhosis ◽  
Diabetic Patients ◽  
Hepatic Lipid ◽  
And Control ◽  
Detailed Nature

1. Percutaneous needle biopsy specimens of liver were obtained from alcoholic, diabetic and control patients. Micro-methods of lipid separation and quantification were employed to determine the detailed nature of hepatic lipid. 2. Triglyceride is the major accumulating liver lipid in both alcoholic and diabetic patients. Cholesteryl ester levels were raised in both alcoholic and diabetic patients but only diabetic patients had significantly increased free cholesterol and phospholipid levels. Determination of phospholipid/free cholesterol ratios revealed a significant decrease in alcoholic cirrhosis compared with controls. 3. Fatty acid ester analysis of hepatic phospholipid and triglyceride revealed significant differences between alcoholic patients and controls but not between diabetic patients and controls. An increased ratio of non-essential/essential fatty acids was found in the patients with alcoholic liver disease whereas those of diabetic patients were similar to the controls.

The effect of epidermal growth factor on liver lipid peroxidation and glutathione levels in lobectomized rats

1992 ◽  
Vol 70 (3-4) ◽  
pp. 259-262 ◽  
Author(s):  
Nahide Gokcora ◽  
Sadi Gundogdu ◽  
Aysel Aricioglu ◽  
Deniz Erbas ◽  
Osman Durmus ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Liver Lipid ◽  
Lipid Peroxide ◽  
Submaxillary Gland ◽  
Control Group ◽  
Key Factor ◽  
Male Wistar Rats ◽  
Epidermal Growth

Epidermal growth factor (EGF) is a growth-promoting polypeptide which is found in highest levels in male mice in the submaxillary gland. It may also be a key factor in regeneration of the liver. We performed experiments with 18 male Wistar rats, divided into three groups. Hepatic left lobectomy (%30) was performed on the first group of rats. This group received an intraperitoneal injection of EGF for 7 days. The second group was the control group into which normal saline was injected for 7 days. The third group was sham-operated. On days 5 and 7 tomographic studies of liver were performed. On day 7 EGF levels, lipid peroxidation, and glutathione in liver were measured in all of the rats. While serum EGF levels did not show any significant change, the levels of lipid peroxide were decreased and glutathione was increased. Tomographic measurements indicated that administration of EGF increased the amount of regeneration.Key words: epidermal growth factor, liver lobectomy, lipid peroxide, glutathione, radioimmunoassay.

Liver Lipid Peroxide Levels in Carbon Tetrachloride Poisoning.

1962 ◽  
Vol 111 (1) ◽  
pp. 50-51 ◽  
Author(s):  
R. E. Priest ◽  
E. A. Smuckler ◽  
O. A. Iseri ◽  
E. P. Benditt
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Lipid ◽  
Lipid Peroxide ◽  
Carbon Tetrachloride Poisoning
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